Restorative Dentistry & Endodontics最新文献

{"title":"Restorative Dentistry and Endodontics 2025 annual highlights: gratitude to our reviewers and achievement of the first journal impact factor.","authors":"Kyung-San Min","doi":"10.5395/rde.2025.51.e14","DOIUrl":"https://doi.org/10.5395/rde.2025.51.e14","url":null,"abstract":"","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147309631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex vivo comparative analysis of retrievability among four calcium silicate-based sealers for regaining apical patency.","authors":"Darian Shomali, Timothy Kirkpatrick, Sang Won Kwak, Hyeon-Cheol Kim, Ji Wook Jeong","doi":"10.5395/rde.2026.51.e3","DOIUrl":"10.5395/rde.2026.51.e3","url":null,"abstract":"<p><strong>Objectives: </strong>: Efficient retrievability is a key requirement for endodontic sealers. This study evaluated the retrievability of four different calcium silicate-based sealers (CSS).</p><p><strong>Methods: </strong>A total of 153 single-rooted human teeth with straight canals were decoronated to a standardized working length of 12 mm. The canals were negotiated to working length using K files up to size 15/.02, followed by rotary instrumentation up to 35/.04, 2 mm short of working length. The teeth were randomly assigned to five groups: NeoSEALER Flo (NEO; Avalon Biomed), Ceraseal (CS; Meta Biomed), Endosequence BC Sealer (BC; Brasseler USA), AH Plus Bioceramic Sealer (AHB; Dentsply Sirona), and a negative control group. Sealer application and obturation with a 35/.04 gutta-percha cone were performed. After incubation at 37°C in 100% humidity for 7 days, retreatment was performed until apical patency was obtained, with retrievability assessed by regaining apical patency. One-way analysis of variance and Tukey contrast test were used to determine whether there was a significant difference among the four different CSS (p < 0.05).</p><p><strong>Results: </strong>Success rates in regaining apical patency were NEO (79.4%), CS (37.0%), BC (50.0%), and AHB (69.7%). NEO demonstrated the highest retrievability, while CS had the lowest (p < 0.01).</p><p><strong>Conclusions: </strong>The type of CSS used has a considerable impact on retreatment difficulty. Among the tested sealers, Neo- SEALER Flo showed the highest retrievability, making it the most retrievable CSS in terms of retreatment efficacy.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"51 1","pages":"e3"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147309618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropeptide Y regulation of dental pulp neurogenic inflammation provoked by tooth bleaching agents: a descriptive comparative clinical study.","authors":"Javier Caviedes-Bucheli, Néstor Ríos-Osorio, Mario Pérez-Villota, Karolina Aucú-Miño, Diana Escobar-Mafla, Hernán Darío Muñoz-Alvear, José Francisco Gomez-Sosa, Luis Diaz-Barrera, Edgar Güiza-Cristancho, Hugo Roberto Munoz","doi":"10.5395/rde.2026.51.e10","DOIUrl":"10.5395/rde.2026.51.e10","url":null,"abstract":"<p><strong>Objectives: </strong>: This study aimed to assess the expression of neuropeptide Y (NPY) in human dental pulp after tooth bleaching with three in-office hydrogen peroxide (H2O2)-based systems.</p><p><strong>Methods: </strong>Forty pulps were collected from premolars scheduled for extraction and divided into four groups (n = 10): Control (no bleaching; basal NPY values); Pola Office (35% H2O2, 8 minutes); Opalescence Boost (40% H2O2, 20 minutes); and Zoom (25% H2O2 + cold blue light, 15 minutes). After extraction, pulps were fixed in 4% formaldehyde and processed. NPY levels were quantified using enzyme-linked immunosorbent assay. Data distribution was assessed with the Shapiro-Wilk test. One-way analysis of variance and Tukey post-hoc test with Bonferroni correction were applied (p < 0.05).</p><p><strong>Results: </strong>NPY expression differed significantly among groups (p = 0.0097). The control group showed the lowest mean expression (0.026 ± 0.002 pmol/mg of pulp tissue), followed by Zoom (0.031 ± 0.005 pmol/mg), Pola Office (0.040 ± 0.004 pmol/mg), and Opalescence Boost, which exhibited the highest NPY expression (0.044 ± 0.004 pmol/mg). Post-hoc analysis revealed a statistically significant difference between the control and Opalescence Boost groups (p = 0.0122).</p><p><strong>Conclusions: </strong>The increase in NPY expression-particularly with Opalescence Boost-indicates that in-office bleaching agents can elicit measurable neurobiological responses in pulp tissue after a single application. The significant difference between the control and Opalescence Boost groups suggests a possible H2O2 concentration- or formulation-dependent effect on pulpal neuropeptide activity, underscoring the need for further research on the biological impact of bleaching treatments.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":" ","pages":"e10"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of adjacent restorative material and distance on the accuracy of inlay cavity impressions with intraoral scanner: an in vitro study.","authors":"So-Yeon Lee, Sung-Ae Son, Jae-Hoon Kim, Deog-Gyu Seo, Jeong-Kil Park","doi":"10.5395/rde.2026.51.e6","DOIUrl":"10.5395/rde.2026.51.e6","url":null,"abstract":"<p><strong>Objectives: </strong>: This study aimed to evaluate the influence of adjacent restorative material and interproximal distance on the accuracy of digital impressions of inlay cavities obtained using an intraoral scanner.</p><p><strong>Methods: </strong>A disto-occlusal inlay cavity was prepared on a mandibular right first molar model, and digital scans were performed using a CEREC Primescan (Dentsply Sirona). The adjacent restorative materials used were Lava (3M ESPE), ENAMIC (VITA Zahnfabrik), Celtra Duo (Dentsply Sirona), and DMAX (DMAX), and the interproximal distances were set to 0.6 mm, 0.8 mm, and 1.0 mm. The obtained scan data were analyzed using GOM Inspect software (GOM GmbH).</p><p><strong>Results: </strong>Trueness, maximum positive and negative deviations, and precision were significantly influenced by both the adjacent restorative material and the interproximal distance, while their interaction showed a significant effect only on precision. Celtra Duo demonstrated the highest trueness, with mean deviation values decreasing from 7.8 μm at a 0.6 mm interproximal distance to 7.3 μm at 1.0 mm. ENAMIC showed the best precision, presenting mean deviations of 2.6 μm at 0.6 mm, 2.9 μm at 0.8 mm, and 2.4 μm at 1.0 mm. A narrow interproximal distance of 0.6 mm resulted in lower trueness, measured at 8.3 μm, and the highest precision deviation of 3.4 μm. In contrast, an interproximal distance of 1.0 mm yielded improved scan accuracy, with increased trueness and reduced precision variation.</p><p><strong>Conclusions: </strong>Digital impression accuracy of inlay cavities was influenced by adjacent restorative material and interproximal distance, suggesting clinical consideration is needed in CAD/CAM workflows to optimize restoration fit.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":" ","pages":"e6"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing antimicrobial properties of a resin-based material via incorporation of a powdered phytotherapeutic extract: an in vitro experimental study.","authors":"Rodolfo Xavier de Sousa-Lima, Maria Eduarda Lima do Nascimento Marinho, Janielly Cristina Costa da Silva, Moan Jéfter Fernandes Costa, Pedro Henrique Sette-de-Souza, Giana da Silveira Lima, Boniek Castillo Dutra Borges","doi":"10.5395/rde.2026.51.e2","DOIUrl":"10.5395/rde.2026.51.e2","url":null,"abstract":"<p><strong>Objectives: </strong>: This study aimed to evaluate the degree of conversion (DC), immediate enamel bond strength (IEBS), antimicrobial activity, and release of the active principle of a resin-based material (RBM) enriched with the powdered Schinopsis brasiliensis (Braúna) stem antibacterial extract.</p><p><strong>Methods: </strong>The RBM was enriched with 0, 1.25, 2.5, 5, 10, and 20 wt% powdered Braúna extract. The DC (n = 7) was assessed using micro-Raman spectroscopy. The IEBS (n = 7) was determined through the microshear test until failure, and failure modes were examined under a stereomicroscope. The antimicrobial activity (n = 15) was assessed by quantifying colony-forming units, and the release of the active principle was determined using ultra-high-performance liquid chromatography. One-way analysis of variance/Tukey and Kruskal-Wallis/Dunn tests were utilized to analyze the data (p < 0.05).</p><p><strong>Results: </strong>Materials with 10 wt% and 20 wt% extract showed the lowest DC statistically. However, for IEBS, there were no statistically significant differences among the different groups. All materials released the active principle, but only those with 20 wt% and 10 wt% extract could inhibit biofilm formation similarly to 0.12% chlorhexidine.</p><p><strong>Conclusions: </strong>Adding powdered Braúna extract between 10 wt% and 20 wt% is a promising alternative to provide an antimicrobial function to RBMs.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":" ","pages":"e2"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restorative Dentistry and Endodontics news: celebrating the 50th anniversary of the journal.","authors":"Yeon-Jee Yoo","doi":"10.5395/rde.2026.51.e13","DOIUrl":"10.5395/rde.2026.51.e13","url":null,"abstract":"","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"51 1","pages":"e13"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147309615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restorative Dentistry and Endodontics 2025 annual highlights: gratitude to our reviewers and achievement of the first journal impact factor.","authors":"Kyung-San Min","doi":"10.5395/rde.2026.51.e14","DOIUrl":"10.5395/rde.2026.51.e14","url":null,"abstract":"","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"51 1","pages":"e14"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147309666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of combined application of premixed bioceramic paste and diode laser in vital pulp therapy: an immunohistochemical randomized controlled split-mouth in vivo animal experiment.","authors":"Mo'men A Salama, Dalia M Fayyad, Mohamed I Rabie, Manar A A Selim, Mahmoud F Ahmed","doi":"10.5395/rde.2026.51.e4","DOIUrl":"10.5395/rde.2026.51.e4","url":null,"abstract":"<p><strong>Objectives: </strong>: This study aimed to evaluate the effect of premixed bioceramic paste (Well-Root PT; Vericom) compared to mineral trioxide aggregate (MTA) on the expression of the mineralization-related marker dentin sialoprotein (DSP) in dental pulp following direct pulp capping, with or without prior diode laser application.</p><p><strong>Methods: </strong>Direct pulp exposures were performed in the upper and lower incisors of eight dogs (n = 96 teeth). Cavities (Class V) were created and received pulp capping with either Well-Root PT (n = 32), MTA (n = 32), or no capping material (polytetrafluoroethylene disc only) (n = 32), with or without the application of a diode laser. Immunohistochemical analysis of DSP expression was conducted and quantified as the mean area percentage using ImageJ software at 2 and 8 weeks posttreatment.</p><p><strong>Results: </strong>Both the Well-Root PT and MTA groups showed significantly increased DSP expression compared to the control group at both 2 and 8 weeks (p < 0.05). No significant difference in the mean area percentage of DSP expression was found between the Well-Root PT and MTA groups. The diode laser application did not produce a significant effect on DSP expression. Within-group comparison revealed a significant increase in DSP expression between the 2- and 8-week follow-up periods (p < 0.05).</p><p><strong>Conclusions: </strong>Well-Root PT demonstrated comparable efficacy to MTA in promoting DSP expression, supporting its use as an effective direct pulp capping material. Diode laser application prior to capping had no effect on DSP expression in this experimental model.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":" ","pages":"e4"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological mechanisms underlying the inflammatory radicular cyst formation-focus on epithelial proliferation: a systematic review of experimental cell and tissue models.","authors":"Néstor Ríos-Osorio, Sandra Briñez-Rodríguez, David Betancur-Calle, Marggie Grajales, Óscar Mauricio Jiménez-Peña, Mario Guerrero-Torres, Rafael Fernández-Grisales","doi":"10.5395/rde.2026.51.e7","DOIUrl":"10.5395/rde.2026.51.e7","url":null,"abstract":"<p><strong>Objectives: </strong>: This study aimed to assess the molecular and cellular mechanisms involved in the epithelial proliferation that leads to the transformation of periapical granulomas (PGs) into inflammatory radicular cysts (IRCs).</p><p><strong>Methods: </strong>A comprehensive search was conducted in three databases. Experimental, observational, or descriptive studies using human or animal tissue samples, or epithelial cell cultures that assessed the molecular and/or cellular mechanisms driving the proliferation of epithelial rests of Malassez and their role in the transformation of PGs into IRCs were included. The risk of bias and applicability of the included studies were assessed using the QUADAS-2.</p><p><strong>Results: </strong>Fourteen studies (including 399 samples) met the inclusion criteria for qualitative synthesis. The studies highlight the role of pro-inflammatory cytokines (IL-1β, IL-6), growth factors (EGF, KGF, TGF-β, and IGF), and signaling pathways (NF-κB, MAPK/ERK, PI3K/AKT, and Smad) in the progression of PG to IRC. Biomarkers of epithelial proliferation, such as Ki-67, PCNA, and CD34, are consistently associated with this process, while MMP-13 emerges as a key regulator of epithelial behavior and matrix remodeling.</p><p><strong>Conclusions: </strong>IRC development arises from a transition from homeostatic to pathological signaling, in which pro-inflammatory mediator levels inside the periapical chronic inflammation override regulatory checkpoints.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":" ","pages":"e7"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of optimal horizontal beam angulations for canal separation in mandibular molars using cone-beam computed tomography: a retrospective image-based analysis.","authors":"Benedikt Schneider, Tamina Tepe, Daniel Rapp, Wilhelm Frank, Maria Lessani, Constantin von See, Sebastian Fitzek, Jörg Philipp Tchorz","doi":"10.5395/rde.2026.51.e9","DOIUrl":"10.5395/rde.2026.51.e9","url":null,"abstract":"<p><strong>Objectives: </strong>: Two-dimensional intraoral radiographs often obscure canals due to superimposition, especially in mandibular molars with complex anatomy. This cone-beam computed tomography (CBCT) study identified the horizontal beam angles at which first and second molar canals overlap and derived clinically applicable angulations for enhanced canal separation.</p><p><strong>Methods: </strong>Eighty-five CBCT datasets from 100 patients met the inclusion criteria, yielding 318 mandibular molars (160 first, 158 second). Using ImageJ, absolute horizontal overlap angles (α) were measured to determine the corresponding theoretical separation angles defined as δ* = 90° - α. Separability was modeled across horizontal beam angulation increments from -45° to +45° in five steps, and Wilson's 95% confidence intervals were computed. Group comparisons used the Mann-Whitney U and independent t-tests (p ≤ 0.05).</p><p><strong>Results: </strong>Minimal mesial beam angulations for effective canal separability (δ* = 90° - α) ranged from approximately 7° to 15° for mesial roots and approximately 10° to 13° for distal roots. No significant mesial differences were observed between first and second molars (p > 0.30). Distal roots of second molars exhibited significantly higher angulations (p = 0.003 coronal, p < 0.001 apical). Mesial canals achieved ≥95% separability at approximately 25° and ≥99% at approximately 35°; distal canals required approximately 30° and approximately 40°.</p><p><strong>Conclusions: </strong>A mesial beam angulation of 30° to 35° provides probable canal differentiation in mandibular molars, separating mesial canals in ≥99% and distal canals in ≥95% of cases. This range refines previous recommendations and supports the as low as reasonably achievable (ALARA) principle.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"51 1","pages":"e9"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147309624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}