{"title":"Can discolored dental composites be bleached in depth?","authors":"Luca Giachetti, Daniele Scaminaci Russo, Michele Nieri, Francesca Cinelli","doi":"10.5395/rde.2024.49.e23","DOIUrl":"10.5395/rde.2024.49.e23","url":null,"abstract":"<p><strong>Objectives: </strong>Previous <i>in vitro</i> studies determined the whitening effects of bleaching products on stained resin composite surfaces. This <i>in vitro</i> study aimed to verify the effectiveness of a whitening system on composite resin previously subjected to pigmentation, specifically examining the depth of whitening effectiveness within the material structure.</p><p><strong>Materials and methods: </strong>A commercially available nano-filled composite resin was used. Specimens were stained using a coffee-based solution and a 10% carbamide peroxide-based gel was employed as the whitening agent. The pigment's penetration and the effect of the bleaching gel were evaluated by measuring color (CieLab values) from the outer edge to the inner part of the specimens. Color measurements were taken at 14 points, starting from 0.1 mm from the external perimeter up to 3.0 mm.</p><p><strong>Results: </strong>Analysis of variance tests showed a statistically significant difference between the Control Group (CG), Pigmentation Group, and Whitening Group. The whitening agent was effective up to 1.5 mm in depth, with Whiteness index (W) values not statistically different from those of CG up to 0.5 mm in depth.</p><p><strong>Conclusions: </strong>Whitening agents on nano-filled resin composite previously pigmented appear effective in restoring the W to values similar to the original, particularly in the superficial layers of the sample.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 3","pages":"e23"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alkasite restorative material for endodontically treated teeth: a randomized controlled pilot study.","authors":"Davi Ariel Nobuo Bepu, Renata Siqueira Scatolin, Natalia Saud Junqueira Franco, Luiza Pejon Sanchez, Aline Evangelista Souza-Gabriel, Silmara Aparecida Milori Corona","doi":"10.5395/rde.2024.49.e24","DOIUrl":"10.5395/rde.2024.49.e24","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the clinical performance of an alkasite restorative material in molars that had undergone root canal treatment.</p><p><strong>Materials and methods: </strong>The research was registered in Brazilian Registry of Clinical Trials. The randomized clinical trial involved 33 patients, each with at least 1 mandibular molar requiring restoration after receiving endodontic treatment. Patients were randomly assigned to receive either bulk-fill resin composite (Tetric N Ceram Bulk Fill, Ivoclar Vivadent) or the alkasite restorative material (Cention N, Ivoclar Vivadent). Upon completion of the restorations, 3 calibrated professionals utilized the United States Public Health Service criteria to assess various factors, including retention, secondary caries, marginal adaptation, restoration color, marginal pigmentation, and anatomical form. Evaluations were conducted at intervals of 7 days, 6 months, and 17 months. Additionally, the assessment encompassed the presence of radiolucent lines adjacent to the restoration, material deficiencies or excess, contact points, and caries recurrence. The data underwent analysis using the Friedman and Mann-Whitney tests (α = 0.05).</p><p><strong>Results: </strong>After 17 months, the results revealed that the alkasite restorative material exhibited greater wear of anatomical shape compared to the bulk-fill resin composite (<i>p</i> = 0.0189). Furthermore, the alkasite restorative material significantly differed from the natural tooth color in most cases (<i>p</i> = 0.0000). However, no other criteria displayed significant differences between the materials or over time (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The alkasite restorative material (Cention N) emerges as a viable option for restoring endodontically treated teeth, displaying clinically acceptable alterations after a 17-month evaluation period.</p><p><strong>Trial registration: </strong>Brazilian Registry of Clinical Trials (ReBEC) Identifier: RBR-97kx5jv.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 3","pages":"e24"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Letícia Tainá de Oliveira Lemes, Carolina Horn Troian-Michel, Theodoro Weissheimer, Marcus Vinicius Reis Só
{"title":"The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review.","authors":"Letícia Tainá de Oliveira Lemes, Carolina Horn Troian-Michel, Theodoro Weissheimer, Marcus Vinicius Reis Só","doi":"10.5395/rde.2024.49.e22","DOIUrl":"10.5395/rde.2024.49.e22","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review addressed the question: \"What is the prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation?\"</p><p><strong>Materials and methods: </strong>A systematic search was conducted in MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report. Eligibility criteria were based on the condition, content, and population strategy: the condition was the radiographic prevalence of apical periodontitis, the content comprised patients scheduled for hematopoietic stem cell transplantation, and the population consisted of adult and pediatric patients. The revised Risk of Bias in Nonrandomized Studies of Exposure tool was used to assess the quality of studies. The Grading Recommendations Assessments, Development, and Evaluation (GRADE) tool was used to assess the quality of evidence.</p><p><strong>Results: </strong>Eight studies were included in this review. The average number of patients with apical periodontitis was 15.65% (range, 2.1%-43.34%). One study was classified as having a very high risk of bias, 1 with a high risk of bias, and 6 with some concern for bias. GRADE analysis showed a very low certainty of evidence. Significant limitations concerning the absence of control over confounding variables were identified.</p><p><strong>Conclusions: </strong>With the caveat of the very low quality of evidence in the studies reviewed, there was a low to moderate prevalence of apical periodontitis in patients prior to undergoing hematopoietic cell transplantation.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e22"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An elaboration on sample size determination for correlations based on effect sizes and confidence interval width: a guide for researchers.","authors":"Mohamad Adam Bujang","doi":"10.5395/rde.2024.49.e21","DOIUrl":"10.5395/rde.2024.49.e21","url":null,"abstract":"<p><strong>Objectives: </strong>This paper aims to serve as a useful guide for sample size determination for various correlation analyses that are based on effect sizes and confidence interval width.</p><p><strong>Materials and methods: </strong>Sample size determinations are calculated for Pearson's correlation, Spearman's rank correlation, and Kendall's Tau-b correlation. Examples of sample size statements and their justification are also included.</p><p><strong>Results: </strong>Using the same effect sizes, there are differences between the sample size determination of the 3 statistical tests. Based on an empirical calculation, a minimum sample size of 149 is usually adequate for performing both parametric and non-parametric correlation analysis to determine at least a moderate to an excellent degree of correlation with acceptable confidence interval width.</p><p><strong>Conclusions: </strong>Determining data assumption(s) is one of the challenges to offering a valid technique to estimate the required sample size for correlation analyses. Sample size tables are provided and these will help researchers to estimate a minimum sample size requirement based on correlation analyses.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e21"},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoon-Joo Lee, Kyung-Mo Cho, Se-Hee Park, Yoon Lee, Jin-Woo Kim
{"title":"Nanoleakage of apical sealing using a calcium silicate-based sealer according to canal drying methods.","authors":"Yoon-Joo Lee, Kyung-Mo Cho, Se-Hee Park, Yoon Lee, Jin-Woo Kim","doi":"10.5395/rde.2024.49.e20","DOIUrl":"10.5395/rde.2024.49.e20","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the nanoleakage of root canal obturations using calcium silicate-based sealer according to different drying methods.</p><p><strong>Materials and methods: </strong>Fifty-two extracted mandibular premolars with a single root canal and straight root were selected for this study. After canal preparation with a nickel-titanium rotary file system, the specimens were randomly divided into 4 groups according to canal drying methods (1: complete drying, 2: blot drying/distilled water, 3: blot drying/NaOCl, 4: aspiration only). The root canals were obturated using a single-cone filling technique with a calcium silicate-based sealer. Nanoleakage was evaluated using a nanoflow device after 24 hours, 1 week, and 1 month. Data were collected twice per second at the nanoscale and measured in nanoliters per second. Data were statistically analyzed using the Kruskal-Wallis and Mann-Whitney <i>U</i>-tests (<i>p</i> < 0.05).</p><p><strong>Results: </strong>The mean flow rate measured after 24 hours showed the highest value among the time periods in all groups. However, the difference in the flow rate between 1 week and 1 month was not significant. The mean flow rate of the complete drying group was the highest at all time points. After 1 month, the mean flow rate in the blot drying group and the aspiration group was not significantly different.</p><p><strong>Conclusions: </strong>Within the limitations of this study, the canal drying method had a significant effect on leakage and sealing ability in root canal obturations using a calcium silicate-based sealer. Thus, a proper drying procedure is critical in endodontic treatment.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e20"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"It is normal to be \"not-normal\": reporting of correct descriptive statistics in dental research.","authors":"Snigdho Das","doi":"10.5395/rde.2024.49.e19","DOIUrl":"10.5395/rde.2024.49.e19","url":null,"abstract":"","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e19"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wilton Lima Dos Santos Junior, Marina Rodrigues Santi, Rodrigo Barros Esteves Lins, Luís Roberto Marcondes Martins
{"title":"Effects of a relined fiberglass post with conventional and self-adhesive resin cement.","authors":"Wilton Lima Dos Santos Junior, Marina Rodrigues Santi, Rodrigo Barros Esteves Lins, Luís Roberto Marcondes Martins","doi":"10.5395/rde.2024.49.e18","DOIUrl":"10.5395/rde.2024.49.e18","url":null,"abstract":"<p><strong>Objectives: </strong>This study was conducted to evaluate the mechanical properties of relined and non-relined fiberglass posts when cemented to root canal dentin using a conventional dual-cure resin cement or a self-adhesive resin cement.</p><p><strong>Materials and methods: </strong>Two types of resin cements were utilized: conventional and self-adhesive. Additionally, 2 cementation protocols were employed, involving relined and non-relined fiberglass posts. In total, 72 bovine incisors were cemented and subjected to push-out bond strength testing (<i>n</i> = 10) followed by failure mode analysis. The cross-sectional microhardness (<i>n</i> = 5) was assessed along the root canal, and interface analyses (<i>n</i> = 3) were conducted using scanning electron microscopy (SEM). Data from the push-out bond strength and cross-sectional microhardness tests were analyzed via 3-way analysis of variance and the Bonferroni <i>post-hoc</i> test (α = 0.05).</p><p><strong>Results: </strong>For non-relined fiberglass posts, conventional resin cement exhibited higher push-out bond strength than self-adhesive cement. Relined fiberglass posts yielded comparable results between the resin cements. Type II failure was the most common failure mode for both resin cements, regardless of cementation protocol. The use of relined fiberglass posts improved the cross-sectional microhardness values for both cements. SEM images revealed voids and bubbles in the incisors with non-relined fiberglass posts.</p><p><strong>Conclusions: </strong>Mechanical properties were impacted by the cementation protocol. Relined fiberglass posts presented the highest push-out bond strength and cross-sectional microhardness values, regardless of the resin cement used (conventional dual-cure or self-adhesive). Conversely, for non-relined fiberglass posts, the conventional dual-cure resin cement yielded superior results to the self-adhesive resin cement.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e18"},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulp stones: any relevance with the levels of serum calcium, parathyroid hormone, vitamin D and uric acid.","authors":"Ceyda Gürhan, Ercan Saruhan","doi":"10.5395/rde.2024.49.e17","DOIUrl":"10.5395/rde.2024.49.e17","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the effect of serum calcium, parathyroid hormone (PTH), vitamin D, and uric acid levels on pulp stone formation.</p><p><strong>Materials and methods: </strong>Patients who were admitted to the Muğla Sıtkı Koçman University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology for dental complaints were registered. Among these patients, individuals who had routine biochemical tests at the same period in the Outpatient Clinics of Muğla Sıtkı Koçman University Training and Research Hospital were included in the study. The patients with at least 1 pulp stone on panoramic radiographs recorded as the \"pulp stone group\" while patients without any pulp stones were the \"control group\". Demographic data and serum levels of calcium, PTH, vitamin D, and uric acid were retrospectively evaluated in both groups. Student <i>t</i>-test or Mann-Whitney <i>U</i> test was used to evaluate the differences between the groups.</p><p><strong>Results: </strong>Among 151 patients, dental pulp stone was detected in 53.6% of patients, and 82.7% of these patients were female. Female sex and pulp stone formation were significantly associated (<i>p</i> = 0.001). The mean age of the pulp stone group was 43.9, while it was 39.9 in the control group, without any significant correlation between age and pulp stone (<i>p</i> > 0.05). Similarly, there were no significant differences in serum levels of PTH, vitamin D, uric acid and calcium between groups (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>According to the present study, the effect of dental factors rather than systemic factors should be considered primarily in pulp stone formation.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e17"},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulrahman A Alhailaa, Saad A Al-Nazhan, Mazen A Aldosimani
{"title":"Prevalence of apical periodontitis and quality of root canal treatment in an adult Kuwaiti sub-population: a cross-sectional study.","authors":"Abdulrahman A Alhailaa, Saad A Al-Nazhan, Mazen A Aldosimani","doi":"10.5395/rde.2024.49.e16","DOIUrl":"10.5395/rde.2024.49.e16","url":null,"abstract":"<p><strong>Objectives: </strong>This cross-sectional study evaluated the prevalence of apical periodontitis (AP) and the technical quality of root canal fillings in an adult Kuwaiti subpopulation using cone-beam computed tomography (CBCT) images.</p><p><strong>Materials and methods: </strong>Two experienced examiners analyzed 250 CBCT images obtained from Kuwaiti patients aged 15-65 years who attended government dental specialist clinics between January 2019 and September 2020. The assessment followed the radiographic scoring criteria proposed by De Moor for periapical status and the technical quality of root canal filling. Chi-square and Fisher's exact tests were used for statistical analysis, with significance level set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Among the 2,762 examined teeth, 191 (6.91%) exhibited radiographic signs of AP, and 176 (6.37%) had undergone root canal filling. AP prevalence in root canal-treated teeth was 32.38%, with a significant difference between males and females. Most of the endodontically treated teeth exhibited adequate root canal filling (71.5%).</p><p><strong>Conclusions: </strong>The study demonstrated a comparable prevalence of AP and satisfactory execution of root canal treatment compared to similar studies in different countries.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e16"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thayna Carolina Zeni, Poliana Maria de Faveri Cardoso, Rafael da Silva Vanolli, Márcio José Mendonça, Julio Katuhide Ueda, Veridiana Camilotti
{"title":"Single-session associative protocol for dentin hypersensitivity management: a 1-year randomized, blinded clinical study.","authors":"Thayna Carolina Zeni, Poliana Maria de Faveri Cardoso, Rafael da Silva Vanolli, Márcio José Mendonça, Julio Katuhide Ueda, Veridiana Camilotti","doi":"10.5395/rde.2024.49.e15","DOIUrl":"10.5395/rde.2024.49.e15","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to establish a single-session associative protocol for non-restorative management of dentin hypersensitivity (DH).</p><p><strong>Materials and methods: </strong>Twenty-four individuals with DH and a minimum sensitivity level of 4 on the visual analog scale (VAS) were selected. The study was conducted in a split-mouth design, with each participant (<i>n</i> = 20) having at least 1 affected tooth in all quadrants. The management protocols consisted of control group: universal adhesive, Neural Desensitizing Protocol group: 5% potassium nitrate, Mixed Desensitizing Protocol (PAM) group: 5% sodium fluoride and 5% potassium nitrate, Remineralizing Desensitizing Protocol (PDR) group: surface-partially reacted glass technology photopolymerizable varnish. Evaluations were performed immediately after application, at 1 week, 1 month, 2 months, and 12 months using the VAS sensitivity test.</p><p><strong>Results: </strong>The scores were subjected to statistical analysis using the Friedman test (<i>p</i> < 0.05), Durbin-Conover test (<i>p</i> < 0.05), and Wilcoxon test (<i>p</i> < 0.05). At the 12-month evaluation, all groups showed statistically significant differences compared to the initial assessment. For the evaluation after 12 months, there was a statistically significant difference between the PAM group, the control group, and the PDR group.</p><p><strong>Conclusions: </strong>It can be concluded that all groups were effective in controlling DH, but there were significant results in the control group and PDR group. The clinical relevance of this study is to demonstrate that the application of single-session desensitizing protocols can be effective in controlling DH for up to 12 months.</p><p><strong>Trial registration: </strong>Brazilian Clinical Trials Registry Identifier: RBR-4r63d7s.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"49 2","pages":"e15"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}