Radiotherapy and Oncology最新文献

{"title":"Aims+Scope/Editorial Board/ Publication information","authors":"","doi":"10.1016/S0167-8140(24)00758-8","DOIUrl":"10.1016/S0167-8140(24)00758-8","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0167814024007588/pdfft?md5=378eb4afbeb16e489b32dd5336747b51&pid=1-s2.0-S0167814024007588-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of mediastinal tumor burden and lymphatic spread in locally advanced non-small-cell lung cancer: A secondary analysis of the multicenter randomized PET-Plan trial","authors":"Eleni Gkika ,&nbsp;Cas Stefaan Dejonckheere ,&nbsp;Jörg Sahlmann ,&nbsp;Simeon Ari Barth ,&nbsp;Tanja Schimek-Jasch ,&nbsp;Sonja Adebahr ,&nbsp;Markus Hecht ,&nbsp;Matthias Miederer ,&nbsp;Alexander Brose ,&nbsp;Harald Binder ,&nbsp;Jochem König ,&nbsp;Anca-Ligia Grosu ,&nbsp;Ursula Nestle ,&nbsp;Andreas Rimner","doi":"10.1016/j.radonc.2024.110521","DOIUrl":"10.1016/j.radonc.2024.110521","url":null,"abstract":"<div><h3>Purpose</h3><p>The aim of this secondary analysis of the prospective randomized phase 2 PET-Plan trial (ARO-2009-09; NCT00697333) was to evaluate the impact of mediastinal tumor burden and lymphatic spread in patients with locally advanced non-small-cell lung cancer (NSCLC).</p></div><div><h3>Methods</h3><p>All patients treated per protocol (<em>n</em> = 172) were included. Patients received isotoxically dose-escalated chemoradiotherapy up to a total dose of 60–74 Gy in 30–37 fractions, aiming as high as possible while adhering to normal tissue constraints. Radiation treatment (RT) planning was based on an ¹⁸F-FDG PET/CT targeting all lymph node (LN) stations containing CT positive LNs (i.e. short axis diameter &gt; 10 mm), even if PET-negative (arm A) or targeting only LN stations containing PET-positive nodes (arm B). LN stations were classified into echelon 1 (ipsilateral hilum), 2 (ipsilateral station 4 and 7), and 3 (rest of the mediastinum, contralateral hilum). The endpoints were overall survival (OS), progression-free survival (PFS), and freedom from local progression (FFLP).</p></div><div><h3>Results</h3><p>The median follow-up time (95 % confidence interval [CI]) was 41.1 (33.8 − 50.4) months. Patients with a high absolute number of PET-positive LN stations had worse OS (hazard ratio [HR] = 1.09; 95 % CI 0.99 − 1.18; <em>p</em> = 0.05) and PFS (HR = 1.12; 95 % CI 1.04 − 1.20; <em>p</em> = 0.003), irrespective of treatment arm allocation. The prescribed RT dose to the LNs did not correlate with any of the endpoints when considering all patients. However, in patients in arm B (i.e., PET-based selective nodal irradiation), prescribed RT dose to each LN station correlated significantly with FFLP (HR=0.45; 95 % CI 0.24–0.85; <em>p</em> = 0.01). Furthermore, patients with involvement of echelon 3 LN stations had worse PFS (HR = 2.22; 95 % CI 1.16–4.28; <em>p</em> = 0.02), also irrespective of allocation.</p></div><div><h3>Conclusion</h3><p>Mediastinal tumor burden and lymphatic involvement patterns influence outcome in patients treated with definitive chemoradiotherapy for locally advanced NSCLC. Higher dose to LNs did not improve OS, but did improve FFLP in patients treated with PET-based dose-escalated RT.</p></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Call For Papers: Radiotherapy & Oncology and The Lancet Oncology collaboration","authors":"Pierre Blanchard (Editor-in-Chief of Radiotherapy & Oncology),&nbsp;David Collingridge (Editor-in-Chief of The Lancet Oncology)","doi":"10.1016/j.radonc.2024.110504","DOIUrl":"10.1016/j.radonc.2024.110504","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"49 Stereotactic Ablative Radiotherapy for Oligoprogressive Solid Tumours: A Systematic Review and Meta-Analysis","authors":"Vivian S. Tan,&nbsp;Jerusha Padayachee,&nbsp;George B. Rodrigues,&nbsp;Inmaculada Navarro,&nbsp;Prakesh S. Shah,&nbsp;David A. Palma,&nbsp;Aisling Barry,&nbsp;Rouhi Fazelzad,&nbsp;Jacques Raphael,&nbsp;Joelle Helou","doi":"10.1016/S0167-8140(24)03705-8","DOIUrl":"10.1016/S0167-8140(24)03705-8","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"62 The Incidence and Factors Associated with Pulmonary Toxicity in Adults After Total Body Irradiation-Based Conditioning Regimens and Bone Marrow Transplantation","authors":"Ruijia (Rachel) Jin,&nbsp;Justin Oh,&nbsp;Iman Baharmand,&nbsp;Matthew Chan,&nbsp;Jessica Chan,&nbsp;Andrea Lo,&nbsp;Abou Mourad Yasser,&nbsp;Cheryl Duzenil","doi":"10.1016/S0167-8140(24)03718-6","DOIUrl":"10.1016/S0167-8140(24)03718-6","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"57 Association of Absolute Amount of Pattern 4 Disease on Prostate Biopsy with Oncologic Outcomes in Intermediate-Risk Prostate Cancer: A Systematic Review","authors":"Melissa Sam Soon,&nbsp;Scott Morgan,&nbsp;Luke Lavallee,&nbsp;Rodney Breau,&nbsp;Trevor Flood,&nbsp;Mark Corkum","doi":"10.1016/S0167-8140(24)03713-7","DOIUrl":"10.1016/S0167-8140(24)03713-7","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"33 Radiotherapy Availability and Public Awareness: A Comparative Analysis Across Health Systems","authors":"Raphael William,&nbsp;Pierre-Yves McLaughlin,&nbsp;Jean-Marc Bourque,&nbsp;Marc Gaudet","doi":"10.1016/S0167-8140(24)03689-2","DOIUrl":"10.1016/S0167-8140(24)03689-2","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"39 Dosimetric Predictors of Toxicity and Local Control of Single-Fraction SABR for Non-Small Cell Lung Cancer","authors":"Myriam Bouchard,&nbsp;Anthony Caron,&nbsp;Guy-Anne Turgeon,&nbsp;Sawyna Provencher,&nbsp;Héloïse Lavoie-Gagnon,&nbsp;Daniel Amzallag,&nbsp;Isabelle Soucy,&nbsp;Samuel Lemaire-Paquette,&nbsp;Marc-Émile Plourde","doi":"10.1016/S0167-8140(24)03695-8","DOIUrl":"10.1016/S0167-8140(24)03695-8","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4 Treatment Toxicity and Outcomes Following Definitive Radiotherapy for Patients with Early-Stage Non-Small Cell Lung Cancers and Pre-Existing Interstitial Lung Disease: A Systematic Review","authors":"George J. Li,&nbsp;Melissa Sam Soon,&nbsp;Hanbo Chen,&nbsp;Gabriel Boldt,&nbsp;Houda Bahig,&nbsp;Patrick Cheung,&nbsp;David A. Palma,&nbsp;Christopher J. Ryerson,&nbsp;Suresh Senan,&nbsp;Alexander V. Louie","doi":"10.1016/S0167-8140(24)03578-3","DOIUrl":"10.1016/S0167-8140(24)03578-3","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"21 Early Apparent Diffusion Coefficient (ADC) Changes During Concurrent Chemoradiation: An Imaging Biomarker for Treatment Response and Recurrence Prediction in Glioblastoma","authors":"Daniel Moore-Palhares,&nbsp;Liam Lawrence,&nbsp;Hany Soliman,&nbsp;James Stewart,&nbsp;Sten Myrehaug,&nbsp;Pejman Maralani,&nbsp;Mark Ruschin,&nbsp;Jay Detsky,&nbsp;Hanbo Chen,&nbsp;Deepak Dinakaran,&nbsp;Chia-Lin (Eric) Tseng,&nbsp;Aimee Theriault,&nbsp;Arjun Sahgal,&nbsp;Angus Lau","doi":"10.1016/S0167-8140(24)03677-6","DOIUrl":"10.1016/S0167-8140(24)03677-6","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}