Radiotherapy and Oncology最新文献

{"title":"Real-world outcomes of immunotherapy ± chemotherapy in older patients with head and neck cancer. A sub-analysis of the REALKEY Study","authors":"Matteo Carpani , Luigi Lorini , Andrea Alberti , Andrea Botticelli , Alessio Cirillo , Pierluigi Bonomo , Alicia Tosoni , Alessandra Cassano , Armando Di Bello , Vincenzo Formica , Maria Cossu Rocca , Giacomo Giulio Baldi , Davide Pelizzoni , Martina Napolitano , Ilaria Mascagni , Alfredo Berruti , Alvaro Garcia Bauto , Sandra Llop Serna , Marc Oliva Bernal , Paolo Bossi","doi":"10.1016/S0167-8140(26)00230-6","DOIUrl":"10.1016/S0167-8140(26)00230-6","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Pages S70-S71"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes from a multicentre study of HDR monotherapy with a single fraction of 19 Gy for localized prostate cancer","authors":"Wiwatchai Sittiwong ,&nbsp;Anna Lydon ,&nbsp;James Wylie ,&nbsp;Imtiaz Ahmed ,&nbsp;Amarnath Challapalli ,&nbsp;Peter Hoskin","doi":"10.1016/j.radonc.2026.111385","DOIUrl":"10.1016/j.radonc.2026.111385","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate long-term clinical outcomes, toxicity, and prognostic factors in patients with localized prostate cancer treated with single-fraction high-dose-rate (HDR) brachytherapy.</div></div><div><h3>Methods</h3><div>This multicentre retrospective study included patients from five UK centres who received a single 19 Gy HDR brachytherapy fraction under a standardized protocol. Kaplan-Meier estimates were calculated at median 5 and 8 years for biochemical progression-free survival (bPFS), local recurrence-free survival (LRFS), nodal recurrence-free survival (NRFS), distant metastasis-free survival (DMFS), and overall survival (OS). Prognostic factors were assessed using Cox regression. Toxicities were graded using CTCAEv3.0. Quality of life (QoL) was evaluated using IPSS, IIEF, and FACT-P questionnaires.</div></div><div><h3>Results</h3><div>A total of 320 patients were included, with a median follow-up of 94 months. Five- and 8-year rates were: bPFS 77.1%/66.5%, LRFS 96.1%/90.9%, NRFS 98.3%/97.3%, DMFS 95.9%/93.8%, and OS 91.4%/87.0%. Low-risk patients had significantly better bPFS than intermediate and high-risk (HR12.55, 95%CI:1.74–90.05,p = 0.012), though no significant differences were seen in other outcomes. Subcentimetre pelvic lymph nodes on MR scan were associated with poorer bPFS, LRFS, DMFS, and OS. GS ≥ 8 predicted worse OS. Acute and late ≥ grade 2 GU toxicities occurred in 3.1% and 19.3% of patients, respectively; GI toxicities in 0.8% and 1.5%. QoL scores worsened post-treatment: IPSS + 7 points (p &lt; 0.001), IIEF −9 points (p = 0.043), and FACT-P −3 points (p = 0.02) and returned to baseline.</div></div><div><h3>Conclusion</h3><div>Single-fraction 19 Gy HDR brachytherapy was tolerable and provided disease control, though contemporary practice favors active surveillance for most low-risk patients. For higher-risk disease, a single fraction is not equivalent to standard multifraction regimens, indicating its role should remain limited.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Article 111385"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study Incorporating AI-Avatar Based Digital Engagements for Patients In A Community Radiation Oncology Practice in the USA","authors":"Adam Raben ,&nbsp;Lindsey Romak ,&nbsp;Jon Strasser ,&nbsp;Gaurav Shukla ,&nbsp;Navroze Eduljee ,&nbsp;Tim Kegelman ,&nbsp;Lana DeSouza-Lawrence","doi":"10.1016/S0167-8140(26)00204-5","DOIUrl":"10.1016/S0167-8140(26)00204-5","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Page S43"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUTROPHIL/LYMPHOCYTE RATIO(NLR): A POTENTIAL BIOMARKER IN PATIENTS WITH H&N SQUAMOUS CELL CARCINOMA TREATED WITH IMMUNE CHECKPOINT INHIBITORS","authors":"Marianna Caterino ,&nbsp;Francesco Perri ,&nbsp;Aurora Mirabile ,&nbsp;Morena Fasano","doi":"10.1016/S0167-8140(26)00206-9","DOIUrl":"10.1016/S0167-8140(26)00206-9","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Pages S45-S46"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Patterns and Risk Factors of Hypopharyngeal Squamous Cell Carcinoma: Insights from a 400-Patient Tunisian Cohort","authors":"Alia Methnani ,&nbsp;Sawsen Dhambri ,&nbsp;Rim Brahem ,&nbsp;Mohamed Dhaha ,&nbsp;Khedija Ben Zid ,&nbsp;Rim Abidi ,&nbsp;Skander Kedous ,&nbsp;Ciraz Nasr","doi":"10.1016/S0167-8140(26)00182-9","DOIUrl":"10.1016/S0167-8140(26)00182-9","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Page S19"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Epstein Barr Virus and nasopharyngeal cancer as a predictor of treatment response and recurrence","authors":"Cristian Arias ,&nbsp;Mateo Bover ,&nbsp;Fernando García ,&nbsp;Gloria Sánchez ,&nbsp;Mariana Temes ,&nbsp;Lara C Iglesias ,&nbsp;Ana M Ruiz","doi":"10.1016/S0167-8140(26)00185-4","DOIUrl":"10.1016/S0167-8140(26)00185-4","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Pages S22-S23"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Smoking Status and Pack-Years on Outcomes in HPV-Associated Oropharyngeal Carcinoma Treated with Definitive (Chemo)Radiotherapy","authors":"Shao Hui Huang ,&nbsp;Jie Su ,&nbsp;John N Waldron ,&nbsp;Andrew N Bayley ,&nbsp;John Kim ,&nbsp;Lillian L Siu ,&nbsp;Anna Spreafico ,&nbsp;Andrew Hope ,&nbsp;Andrew McPartlin ,&nbsp;Scott Bratman ,&nbsp;Ali Hosni ,&nbsp;Ezra Hahn ,&nbsp;Enrique Sanz-Garcia ,&nbsp;Lawson Eng ,&nbsp;John de Almeida ,&nbsp;David Goldstein ,&nbsp;Nauman Malik ,&nbsp;Li Tong ,&nbsp;Wei Xu ,&nbsp;Brian O’Sullivan","doi":"10.1016/S0167-8140(26)00183-0","DOIUrl":"10.1016/S0167-8140(26)00183-0","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Pages S20-S21"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allosteric inhibition of oncogenic PIK3ca H1047R by Psorachromene disrupts membrane association: A novel therapeutic strategy in HNSCC","authors":"Zahra Yashmin Afshar ,&nbsp;Ali Goli","doi":"10.1016/S0167-8140(26)00222-7","DOIUrl":"10.1016/S0167-8140(26)00222-7","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Pages S62-S63"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes Of Transoral Laser Microsurgery In Glottic Cancer: A Single-Institution Analysis","authors":"Francesco Chu ,&nbsp;Francesco Bandi ,&nbsp;Marta Tagliabue ,&nbsp;Stefano Zorzi ,&nbsp;Mohssen Ansarin","doi":"10.1016/S0167-8140(26)00251-3","DOIUrl":"10.1016/S0167-8140(26)00251-3","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Pages S93-S94"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Diagnostic Modalities for Oral Cancer Detection: A Systematic Review in the Indian Scenario","authors":"Ajay Kumar Kondeti ,&nbsp;Kesava Ramgopal Adavikolanu ,&nbsp;Chandramouli Ramalingam","doi":"10.1016/S0167-8140(26)00181-7","DOIUrl":"10.1016/S0167-8140(26)00181-7","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Page S18"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}