EVALUATION OF SEVERE RADIATION INDUCED SKIN TOXICITY (RIST) IN BLACK WOMEN RECEIVING ADJUVANT RADIOTHERAPY FOR BREAST CANCER IN ZIMBABWE. A PROSPECTIVE COHORT STUDY

IF 5.3 1区 医学 Q1 ONCOLOGY
Melinda Mushonga , Shirley Chibonda , Anna Mary Nyakabau , Danielle Rodin , Philip Ye , Zhihui Amy Liu , Mercia Mutimuri , Ntokozo Ndlovu , Webster Kadzatsa , Albert Nyamhunga , Nomsa Tsikai , Nothando Mutizira , Edith Matsikidze , Tinashe Mazhindu , Patience Musiwa , Silas Mafuhure
{"title":"EVALUATION OF SEVERE RADIATION INDUCED SKIN TOXICITY (RIST) IN BLACK WOMEN RECEIVING ADJUVANT RADIOTHERAPY FOR BREAST CANCER IN ZIMBABWE. A PROSPECTIVE COHORT STUDY","authors":"Melinda Mushonga ,&nbsp;Shirley Chibonda ,&nbsp;Anna Mary Nyakabau ,&nbsp;Danielle Rodin ,&nbsp;Philip Ye ,&nbsp;Zhihui Amy Liu ,&nbsp;Mercia Mutimuri ,&nbsp;Ntokozo Ndlovu ,&nbsp;Webster Kadzatsa ,&nbsp;Albert Nyamhunga ,&nbsp;Nomsa Tsikai ,&nbsp;Nothando Mutizira ,&nbsp;Edith Matsikidze ,&nbsp;Tinashe Mazhindu ,&nbsp;Patience Musiwa ,&nbsp;Silas Mafuhure","doi":"10.1016/S0167-8140(25)04705-X","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose:</h3><div>Radiotherapy is an essential component of breast cancer treatment, but fear of radiation induced skin toxicity (RIST) in Zimbabwe has been suggested to be associated with hesitancy to undergo treatment. This study sought to determine the incidence of severe RIST in Black women and identify modifiable predictive factors to allow development of patient-oriented strategies to mitigate negative perceptions of radiotherapy which potentially reduce compliance to treatment.</div></div><div><h3>Materials and Methods:</h3><div>A prospective cohort study of Zimbabwean women undergoing adjuvant radiotherapy for breast cancer was conducted. Patient reported and Physician reported skin toxicity assessments were completed using validated skin toxicity scoring tools during radiotherapy. The level of agreement between patient and physician reported incidence of RIST was tested using kappa statistics. Predictive factors for severe RIST were analyzed using a univariate logistics regression.</div></div><div><h3>Results:</h3><div>Fifty-six patients met eligibility criteria. The most common physician and patient reported skin type was type V at 65% and 85% respectively. A total of 54 (96%) patients had at least 2 patient reported assessments and 46 (82%) had at least 2 physician reported assessments. The incidence of physician reported severe RIST was 12.8%, lower than patient reported one (26.8%), p=0.09. There was a low level of agreement between the patient and physician reported severe RIST, kappa= -0.08 (-0.31, 0.14). No patient characteristics were predictive of severe patient reported RIST. More patients with severe RIST had higher median fraction number, 25 (16.0-30.) (p=.05), total dose, 5500 cGy (4250-60000) (p=.016) and maximum dose 6023.5 cGy (5101-6580) (p=.045). Total dose was predictive of severe patient reported RIST, OR 1.12 (1.01-1.25) p=0.038. More patients using a cream had severe patient reported toxicity when compared to patients who did not report severe RIST, 93% compared to 34% (p=&lt;0.001).</div></div><div><h3>Conclusions:</h3><div>The patient’s reported incidence of severe RIST was higher than the physician reported. Radiotherapy prescription, maximum dose and use of a cream were associated with worse patient reported toxicity. Findings support consideration of hypo fractionated treatment regiments in patients receiving adjuvant radiotherapy and exploration of ideal skin care creams/ interventions for use during treatment are needed to improve treatment experience mitigating negative perceptions associated with radiotherapy.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"210 ","pages":"Pages S20-S21"},"PeriodicalIF":5.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiotherapy and Oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016781402504705X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose:

Radiotherapy is an essential component of breast cancer treatment, but fear of radiation induced skin toxicity (RIST) in Zimbabwe has been suggested to be associated with hesitancy to undergo treatment. This study sought to determine the incidence of severe RIST in Black women and identify modifiable predictive factors to allow development of patient-oriented strategies to mitigate negative perceptions of radiotherapy which potentially reduce compliance to treatment.

Materials and Methods:

A prospective cohort study of Zimbabwean women undergoing adjuvant radiotherapy for breast cancer was conducted. Patient reported and Physician reported skin toxicity assessments were completed using validated skin toxicity scoring tools during radiotherapy. The level of agreement between patient and physician reported incidence of RIST was tested using kappa statistics. Predictive factors for severe RIST were analyzed using a univariate logistics regression.

Results:

Fifty-six patients met eligibility criteria. The most common physician and patient reported skin type was type V at 65% and 85% respectively. A total of 54 (96%) patients had at least 2 patient reported assessments and 46 (82%) had at least 2 physician reported assessments. The incidence of physician reported severe RIST was 12.8%, lower than patient reported one (26.8%), p=0.09. There was a low level of agreement between the patient and physician reported severe RIST, kappa= -0.08 (-0.31, 0.14). No patient characteristics were predictive of severe patient reported RIST. More patients with severe RIST had higher median fraction number, 25 (16.0-30.) (p=.05), total dose, 5500 cGy (4250-60000) (p=.016) and maximum dose 6023.5 cGy (5101-6580) (p=.045). Total dose was predictive of severe patient reported RIST, OR 1.12 (1.01-1.25) p=0.038. More patients using a cream had severe patient reported toxicity when compared to patients who did not report severe RIST, 93% compared to 34% (p=<0.001).

Conclusions:

The patient’s reported incidence of severe RIST was higher than the physician reported. Radiotherapy prescription, maximum dose and use of a cream were associated with worse patient reported toxicity. Findings support consideration of hypo fractionated treatment regiments in patients receiving adjuvant radiotherapy and exploration of ideal skin care creams/ interventions for use during treatment are needed to improve treatment experience mitigating negative perceptions associated with radiotherapy.
津巴布韦接受乳腺癌辅助放疗的黑人妇女严重辐射诱发皮肤毒性(rist)的评估。一项前瞻性队列研究
目的:放疗是乳腺癌治疗的重要组成部分,但津巴布韦对辐射诱发皮肤毒性(RIST)的恐惧被认为与接受治疗的犹豫有关。本研究旨在确定黑人妇女中严重RIST的发生率,并确定可改变的预测因素,以便制定以患者为导向的策略,以减轻对放疗的负面看法,这些负面看法可能会降低对治疗的依从性。材料和方法:对津巴布韦接受乳腺癌辅助放疗的妇女进行前瞻性队列研究。患者报告和医生报告的皮肤毒性评估在放疗期间使用经过验证的皮肤毒性评分工具完成。使用kappa统计检验患者和医生报告的RIST发病率之间的一致性水平。使用单变量logistic回归分析严重RIST的预测因素。结果:56例患者符合入选标准。最常见的医生和患者报告的皮肤类型分别为65%和85%的V型。共有54例(96%)患者至少有2例患者报告评估,46例(82%)患者至少有2例医生报告评估。医师报告的严重RIST发生率为12.8%,低于患者报告的26.8%,p=0.09。患者和医生报告的严重RIST之间的一致性较低,kappa= -0.08(-0.31, 0.14)。没有患者特征预测严重患者报告的RIST。严重的RIST患者中位分数越高,25(16.0 ~ 30)。总剂量为5500 cGy (4250 ~ 60000) (p= 0.016),最大剂量为6023.5 cGy (5101 ~ 6580) (p= 0.045)。总剂量预测严重患者报告的RIST, OR为1.12 (1.01-1.25)p=0.038。与未报告严重RIST的患者相比,使用乳霜的患者报告毒性更严重,93%比34% (p=<0.001)。结论:患者报告的严重RIST发生率高于医生报告的发生率。放疗处方、最大剂量和乳膏的使用与患者报告的毒性较差有关。研究结果支持在接受辅助放疗的患者中考虑低分级治疗方案,并探索治疗期间使用的理想护肤霜/干预措施,以改善治疗体验,减轻与放疗相关的负面看法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Radiotherapy and Oncology
Radiotherapy and Oncology 医学-核医学
CiteScore
10.30
自引率
10.50%
发文量
2445
审稿时长
45 days
期刊介绍: Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modality treatment, translational studies, epidemiological outcomes, imaging, dosimetry, and radiation therapy planning, experimental work in radiobiology, chemobiology, hyperthermia and tumour biology, as well as data science in radiation oncology and physics aspects relevant to oncology.Papers on more general aspects of interest to the radiation oncologist including chemotherapy, surgery and immunology are also published.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信