Radiotherapy and Oncology最新文献

{"title":"Driving innovation in radiation oncology in a changing world: The Green Journal's roadmap for the next decade.","authors":"Pierre Blanchard, Dietmar Georg, Rob P Coppes, Birgitte Vrou Offersen","doi":"10.1016/j.radonc.2024.110586","DOIUrl":"10.1016/j.radonc.2024.110586","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110586"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfect is the enemy of good: Reply to Struikmans et al.","authors":"Marianne C Aznar, Jutta Bergler-Klein, Giuseppe Boriani, David J Cutter, Coen Hurkmans, Mario Levis, Teresa López-Fernández, Alexander R Lyon, Maja V Maraldo","doi":"10.1016/j.radonc.2024.110585","DOIUrl":"10.1016/j.radonc.2024.110585","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110585"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensity-modulated proton therapy versus volumetric-modulated ARC therapy in patients with nasopharyngeal carcinoma: A long-term, multicenter cohort study.","authors":"Ching-Nung Wu, Jung-Der Wang, Wei-Chih Chen, Chung-Ying Lin, Tai-Jan Chiu, Yao-Hsu Yang, Joseph Tung-Chieh Chang, Sheng-Dean Luo, Yu-Ming Wang","doi":"10.1016/j.radonc.2024.110648","DOIUrl":"10.1016/j.radonc.2024.110648","url":null,"abstract":"<p><strong>Background: </strong>Data evaluating the impact of intensity-modulated proton therapy (IMPT) on survival among nasopharyngeal carcinoma (NPC) patients are limited. This study aims to elucidate the survival benefits and toxicity profiles of IMPT compared to modern photon therapy, volumetric-modulated arc therapy (VMAT), over an extended follow-up period.</p><p><strong>Methods: </strong>We analyzed data from NPC patients recorded in the Chang Gung Research Database. This analysis focused on individuals who received definitive radiotherapy, either IMPT or VMAT therapy, from 2016 to 2021. Patients with distant metastasis or concurrent other malignancies were excluded. We performed 1:1 matching based on stage, year of diagnosis, and age (± 10 years). Oncological outcomes and toxicities were assessed using Cox proportional hazards modeling. For sensitivity analysis, we employed inverse probability of treatment weighting and additional 1:2 matching.</p><p><strong>Results: </strong>Out of a 1,202 NPC patients' cohort, 276 were selected from a subset of 294 who received IMPT and matched with an equivalent number of patients receiving VMAT. IMPT was associated with improved oncological outcomes after matching, with an adjusted hazard ratio (aHR) of 0.31 (95% CI: 0.15-0.62) for all-cause mortality and an aHR of 0.58 (95% CI: 0.34-0.99) for disease recurrence. Additionally, IMPT was linked to a reduced incidence of feeding tube placement, with an aHR of 0.31 (95% CI: 0.18-0.55). Competing risk and sensitivity analyses corroborated these trends, though the significance for disease recurrence was not consistent.</p><p><strong>Conclusion: </strong>IMPT was associated with significantly better overall survival outcomes and a lower incidence of dysphagia compared to VMAT in NPC patients. Further randomized trials are needed to confirm these findings.</p>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110648"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing palliative radiation: Beyond dose escalation in advanced head and neck squamous cell carcinoma.","authors":"Xiaobo Shi, Beina Hui, Ying Wang, Yongkai Lu","doi":"10.1016/j.radonc.2024.110655","DOIUrl":"10.1016/j.radonc.2024.110655","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110655"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Cardiovascular toxicities of radiotherapy: From practical issues to new perspectives radiotherapy and Oncology\" Marianne C. Aznar, Jutta Bergler-Klein, Giuseppe Boriani, David, J. Cutter, Coen Hurkmans, Mario Levis, Teresa Lopez-Fernandez, Alexander R. Lyon, Maja V. Maraldo. Radiother Oncol. 2024 Aug:197:110336. https://doi.org/10.1016/j.radonc.2024.110336.Epub 2024 may 24.","authors":"Henk Struikmans, Anna Petoukhova, Mirjam Mast","doi":"10.1016/j.radonc.2024.110583","DOIUrl":"10.1016/j.radonc.2024.110583","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110583"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Optimizing palliative radiation: Beyond dose escalation in advanced head and neck squamous cell carcinoma\".","authors":"Supriya Mallick","doi":"10.1016/j.radonc.2024.110656","DOIUrl":"10.1016/j.radonc.2024.110656","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110656"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to commentary on \"Cumulative rib fracture risk after stereotactic body radiotherapy in patients with localized non-small cell lung cancer\" by Tugcu et al.","authors":"Kristian Kirkelund Bentsen, Carsten Brink, Tine Bjørn Nielsen, Rasmus Bank Lynggaard, Pernille Just Vinholt, Tine Schytte, Olfred Hansen, Stefan Starup Jeppesen","doi":"10.1016/j.radonc.2024.110538","DOIUrl":"10.1016/j.radonc.2024.110538","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110538"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on Bentsen et al.'s study of rib fracture risk after stereotactic body radiotherapy.","authors":"Ahmet Oguz Tugcu, Galip Dogukan Dogru, Cemal Ugur Dursun","doi":"10.1016/j.radonc.2024.110536","DOIUrl":"10.1016/j.radonc.2024.110536","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110536"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic models for progression-free survival in atypical meningioma: Comparison of machine learning-based approach and the COX model in an Asian multicenter study.","authors":"Dowook Kim, Yeseul Kim, Wonmo Sung, In Ah Kim, Jaeho Cho, Joo Ho Lee, Clemens Grassberger, Hwa Kyung Byun, Won Ick Chang, Leihao Ren, Ye Gong, Chan Woo Wee, Lingyang Hua, Hong In Yoon","doi":"10.1016/j.radonc.2024.110695","DOIUrl":"https://doi.org/10.1016/j.radonc.2024.110695","url":null,"abstract":"<p><strong>Background and purpose: </strong>Atypical meningiomas are prevalent intracranial tumors with varied prognoses and recurrence rates. The role of adjuvant radiotherapy (ART) in atypical meningiomas remains debated. This study aimed to develop and validate a prognostic model incorporating machine learning techniques and clinical factors to predict progression-free survival (PFS) in patients with atypical meningiomas and assess the impact of ART.</p><p><strong>Materials and methods: </strong>A retrospective review of 669 patients from five institutions in Korea and China was conducted. Cox proportional hazards, gradient boosting machine, and random survival forest models were employed for comparative analysis, utilizing both internal and external validation sets. Model performance was assessed using Harrell's concordance index and permutation feature importance.</p><p><strong>Results: </strong>Of 581 eligible patients, age, post-operative platelet count, performance status, Simpson grade, and ART were identified as significant prognostic factors across all models. In the ART subgroup, age and tumor size were the top prognostic indicators. The Cox model outperformed other methods, achieving a training C-index of 0.73 (95 % CI: 0.72-0.73) and an external validation C-index of 0.74 (95 % CI: 0.73-0.74). The model effectively stratified patients into risk categories, revealing a differential impact of ART: low-risk patients in the active surveillance group showed a 5.6 % improvement in 5-year PFS with predicted ART addition, compared to a 15.9 % improvement in the high-risk group.</p><p><strong>Conclusion: </strong>This multicenter study offers a validated prognostic model for atypical meningiomas, highlighting the need for tailored treatment plans. The model's ability to stratify patients into risk categories for PFS provides a valuable tool for clinical decision-making, potentially optimizing patient outcomes.</p>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110695"},"PeriodicalIF":4.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can knowledge-based planning models validated on ethnically diverse patients lead to global standardisation of external beam radiation therapy for locally advanced cervix cancer?","authors":"Jeevanshu Jain, Monica Serban, Marianne Sanggaard Assenholt, Varsha Hande, Jamema Swamidas, Yvette Seppenwoolde, Joanne Alfieri, Kari Tanderup, Supriya Chopra","doi":"10.1016/j.radonc.2024.110694","DOIUrl":"https://doi.org/10.1016/j.radonc.2024.110694","url":null,"abstract":"<p><strong>Background and purpose: </strong>Knowledge-based planning (KBP) can consistently and efficiently create high-quality Volumetric Arc Therapy (VMAT) plans for cervix cancer. This study describes the cross-validation of two KBP models on geographically distinct populations and their comparison to manual plans from 67 centers. The purpose was to determine the universal applicability of a generic KBP model.</p><p><strong>Materials and methods: </strong>Based on the EMBRACE-II protocol, two KBP models were developed at XXXX and YYYY using respective patient plans. The KBP models were exchanged between three institutions with different geo-ethnic populations and validated on reference manual plans of 20 node-positive and 20 node-negative patients. Additionally, one patient case was manually planned by 67 centres. These manual treatment plans were compared to the two KBP model plans using a score out of 80, based on 20 DVH parameters.</p><p><strong>Results: </strong>The manual and the KBP plans adhered to the EMBRACE II protocol. OAR sparing in KBP plans was similar or slightly improved as compared to the manual plans. The differences between the medians of manual and either KBP model plans were significant for 8 parameters among node positive patients, and 4 parameters among node negative patients. The comparison between the XXXX and YYYY KBP plans to manual plans from 67 institutions showed that the two KPBs had superior plan quality in 88 % and 99 % of instances, respectively.</p><p><strong>Conclusion: </strong>KBP has the potential to generate high-quality plans across institutions and geo-ethnic populations by reducing inter-planner variation, thereby facilitating the global standardisation of radiotherapy for cervical cancer.</p>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110694"},"PeriodicalIF":4.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}