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Long-Term outcomes of ablative stereotactic body radiation therapy for inoperable, non-metastatic pancreatic cancer. 消融立体定向放射治疗不能手术的非转移性胰腺癌的长期疗效。
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-17 DOI: 10.1016/j.radonc.2025.111210
Bi-Yang Cao, Le-Tian Zhang, Chen-Chen Wu, Jing Wang
{"title":"Long-Term outcomes of ablative stereotactic body radiation therapy for inoperable, non-metastatic pancreatic cancer.","authors":"Bi-Yang Cao, Le-Tian Zhang, Chen-Chen Wu, Jing Wang","doi":"10.1016/j.radonc.2025.111210","DOIUrl":"10.1016/j.radonc.2025.111210","url":null,"abstract":"<p><strong>Purpose/objective(s): </strong>To evaluate long-term outcomes and tolerability of ablative 5-fraction stereotactic body radiation therapy (SBRT) administering a biologically effective dose (BED<sub>10</sub>, α/β = 10) ≥ 100 Gy in patients with inoperable, non-metastatic pancreatic cancer (PC).</p><p><strong>Materials/methods: </strong>We retrospectively reviewed a prospective registry of 88 patients with inoperable non-metastatic PC who underwent ablative 5-fraction SBRT using a CyberKnife with fiducial-based respiratory tracking between 2016 and 2020. The outcomes included overall survival (OS), progression-free survival (PFS), and treatment-related toxicity.</p><p><strong>Results: </strong>The cohort included 55 men and 33 women (median age, 65 years; range, 36-84 years). At diagnosis, 29 patients were medically inoperable, and 59 had locally advanced PC (LAPC). SBRT was administered at 50 Gy/5 fractions in 82 patients and 55 Gy/5 fractions in 6 patients. The median gross tumor volume was 33.6  cm<sup>3</sup> (range, 3.7-167.8). With a median follow-up of 64.0 months, the median OS (mOS) was 18.1 months (95 % confidence interval [CI], 16.6-27.1) from the time at diagnosis and 15.6 months (95 % CI, 14.1-23.4) from the start of SBRT. The 1-, 2-, and 3-year OS rates were 73.9 %, 39.8 %, and 26.1 % from diagnosis, and 64.0 %, 36.0 %, and 22.1 % from SBRT, respectively. The mOS from the time at diagnosis was 18.2 months (95 % CI, 17.0-37.1) for medically inoperable patients and 17.1 months (95 % CI, 15.9-28.9) for those with LAPC, with corresponding 1-, 2-, and 3-year OS rates of 86.2 %, 41.4 %, and 31.0 % vs. 67.8 %, 39.0 %, and 23.7 %, respectively. From the start of SBRT, corresponding mOS was 16.2 months (95 % CI, 15.0-35.9) for medically inoperable patients and 14.4 months (95 % CI, 11.0-23.7) for LAPC, with 1-, 2-, and 3-year OS rates of 75.9 %, 37.9 %, and 27.6 % vs. 57.6 %, 33.9 %, and 18.6 %, respectively. Grade 3 gastrointestinal bleeding occurred in four patients (4.5 %), with no grade ≥ 4 toxicities observed.</p><p><strong>Conclusion: </strong>Ablative 5-fraction SBRT with BED<sub>10</sub> ≥ 100  Gy results in favorable survival and acceptable toxicity in inoperable, non-metastatic PC.</p>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"111210"},"PeriodicalIF":5.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Which ‘dose rate’ definition describes the FLASH sparing effect for scanned proton beams? A meta-analysis of skin murine data 哪个“剂量率”定义描述了扫描质子束的FLASH保留效应?皮肤鼠数据的荟萃分析
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-10 DOI: 10.1016/j.radonc.2025.111206
Isabella Colizzi , Per Rugaard Poulsen , Brita Sørensen , David Meer , Antony John Lomax , Serena Psoroulas
{"title":"Which ‘dose rate’ definition describes the FLASH sparing effect for scanned proton beams? A meta-analysis of skin murine data","authors":"Isabella Colizzi ,&nbsp;Per Rugaard Poulsen ,&nbsp;Brita Sørensen ,&nbsp;David Meer ,&nbsp;Antony John Lomax ,&nbsp;Serena Psoroulas","doi":"10.1016/j.radonc.2025.111206","DOIUrl":"10.1016/j.radonc.2025.111206","url":null,"abstract":"<div><div>We compiled preclinical proton PBS skin toxicity data to assess how various dose rate definitions (field, average, and dose average) explain the FLASH sparing effect. Only average dose rate (ADR), accounting for ‘effective irradiation time,’ reliably describes it. We identified high-dose and ADR regions where the effect was consistently observed.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"213 ","pages":"Article 111206"},"PeriodicalIF":5.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prospective study of Gallium-68 ventilation and perfusion PET/CT during and after radiotherapy in patients with non-small cell lung cancer 非小细胞肺癌患者放疗期间和放疗后镓-68通气和灌注PET/CT的前瞻性先导研究
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-10 DOI: 10.1016/j.radonc.2025.111179
Neil D. Wallace , Mathias Bressel , Nick Hardcastle , Lachlan McIntosh , Nick Bucknell , Tomas Kron , Jason Callahan , Rod Hicks , David Ball , Michael MacManus , Nikki Plumridge , Mark Shaw , Daniel Steinfort , Lisa Selbie , Michael Hofman , Shankar Siva
{"title":"A prospective study of Gallium-68 ventilation and perfusion PET/CT during and after radiotherapy in patients with non-small cell lung cancer","authors":"Neil D. Wallace ,&nbsp;Mathias Bressel ,&nbsp;Nick Hardcastle ,&nbsp;Lachlan McIntosh ,&nbsp;Nick Bucknell ,&nbsp;Tomas Kron ,&nbsp;Jason Callahan ,&nbsp;Rod Hicks ,&nbsp;David Ball ,&nbsp;Michael MacManus ,&nbsp;Nikki Plumridge ,&nbsp;Mark Shaw ,&nbsp;Daniel Steinfort ,&nbsp;Lisa Selbie ,&nbsp;Michael Hofman ,&nbsp;Shankar Siva","doi":"10.1016/j.radonc.2025.111179","DOIUrl":"10.1016/j.radonc.2025.111179","url":null,"abstract":"<div><h3>Purpose</h3><div>To utilize <sup>68</sup>Gallium (Ga) Ventilation-Perfusion (V/Q) 4-dimensional (4D) PET/CT to establish the impact of curative radiotherapy (RT) doses on lung ventilation and perfusion, and to evaluate associations with clinical outcomes.</div></div><div><h3>Methods and materials</h3><div>This prospective non-randomized observational clinical trial included 67 patients undergoing definitive RT +/-chemotherapy for NSCLC. Patients underwent <sup>68</sup>Ga 4D V/Q PET/CT at baseline, mid-treatment, and at 3- and 12-months post-treatment. Pulmonary Function Tests (PFTs) and toxicities were assessed at baseline and 3 monthly after treatment. Linear mixed models were used to assess for associations between radiotherapy dose-volume, applied to ventilated and perfused lung at 5 %, 30 % and 70 % thresholds as defined by <sup>68</sup>Ga 4D V/Q PET/CT, and toxicity.</div></div><div><h3>Results</h3><div>Sixty-seven patients were evaluable, of whom 44 (66 %) were male, mean age was 68, and 61 (91 %) were ECOG 0–1. Sixty-three patients completed treatment and grade ≥2 pneumonitis occurred in 20 (32 %). Lung ventilation and perfusion, and FEV1 and DLCO, fell slightly from baseline to 3-months post treatment. V54 Gy of perfused lung at the 30 % threshold was higher in those with grade ≥2 pneumonitis (median 12.9 % (IQR 8.7–14.8 %) vs 6.3 % (IQR 3.7–8.5 %), p = 0.003). No association between grade ≥2 pneumonitis and the absolute change in ventilated (p = 0.12) or perfused (p = 0.14) lung was observed.</div></div><div><h3>Conclusions</h3><div>We observed a decrease in lung ventilation and perfusion on <sup>68</sup>Ga 4D V/Q PET/CT from baseline to 3 months after RT. The association between the volume of well-perfused lung receiving near-therapeutic RT doses and the development of grade ≥2 pneumonitis warrants future investigation.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"213 ","pages":"Article 111179"},"PeriodicalIF":5.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer – A multicenter analysis of early outcomes and toxicity 短期放疗与长期放化疗在直肠癌全新辅助治疗中的对比——早期结果和毒性的多中心分析。
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-10 DOI: 10.1016/j.radonc.2025.111194
Georg Wurschi , Miriam Kesselmeier , Melanie Schneider , Jan-Niklas Becker , Bernd Frerker , Samuel M. Vorbach , Felix Ehret , Markus Diefenhardt , Fabian Schunn , Maria-Elena von Gruben , Marcel Büttner , Elgin Hoffmann , Alexander Rühle , Josephine Beier , Simone Ferdinandus , Maike Trommer , Ezgi Ceren Sahin , Julian Hlouschek , Kynann Aninditha , Daphne Schepers von Ohlen , Klaus Pietschmann
{"title":"Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer – A multicenter analysis of early outcomes and toxicity","authors":"Georg Wurschi ,&nbsp;Miriam Kesselmeier ,&nbsp;Melanie Schneider ,&nbsp;Jan-Niklas Becker ,&nbsp;Bernd Frerker ,&nbsp;Samuel M. Vorbach ,&nbsp;Felix Ehret ,&nbsp;Markus Diefenhardt ,&nbsp;Fabian Schunn ,&nbsp;Maria-Elena von Gruben ,&nbsp;Marcel Büttner ,&nbsp;Elgin Hoffmann ,&nbsp;Alexander Rühle ,&nbsp;Josephine Beier ,&nbsp;Simone Ferdinandus ,&nbsp;Maike Trommer ,&nbsp;Ezgi Ceren Sahin ,&nbsp;Julian Hlouschek ,&nbsp;Kynann Aninditha ,&nbsp;Daphne Schepers von Ohlen ,&nbsp;Klaus Pietschmann","doi":"10.1016/j.radonc.2025.111194","DOIUrl":"10.1016/j.radonc.2025.111194","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>Total neoadjuvant therapy (TNT) improves local control and complete response (CR) rates in locally advanced rectal cancer (LARC). CR is associated with favorable local tumor control, allowing non-operative management (NOM). However, it remains unclear whether short-course radiotherapy (SCRT) or long-course chemoradiotherapy (LCRT) is preferable within TNT.</div></div><div><h3>Methods</h3><div>LARC patients undergoing TNT between 2015 and 2024 were included in this retrospective multicenter analysis (DRKS00033000). The primary endpoint was CR. Secondary endpoints comprised NOM rates, toxicity, and tumor control. Multivariable logistic regression modelling was used to assess the influence of LCRT.</div></div><div><h3>Results</h3><div>Of 295 included patients with a median age at diagnosis of 62 (Q1-Q3: 54–68) years and 210 (71.2 %) men, 172 (58.3 %) underwent LCRT. CR was achieved in 46 (37.4 %) SCRT and 96 (55.8 %) LCRT patients. Acute toxicity grade ≥ 3 occurred in 24 (20.5 %) of 117 SCRT and in 62 (36.3 %) of 171 LCRT patients. Within a median follow-up of 19.4 months (SCRT) and 19.6 months (LCRT), 23 (19.8 %) of 116 and 30 (19.4 %) of 155 patients experienced recurrence, respectively. Regression modelling revealed an increased likelihood for CR (adjusted odds ratio: 3.11; 95 % confidence interval: 1.37–7.07) and NOM (4.40; 1.46–13.21) with LCRT, whereas no significant associations of LCRT with acute toxicity (0.90; 0.40–2.02), chronic toxicity (1.16; 0.48–2.78), postoperative complications (0.89; 0.62–1.28) or recurrence (0.81; 0.31–2.16) were observed.</div></div><div><h3>Conclusion</h3><div>LCRT was associated with higher CR and NOM rates. Whether it might be preferred over SCRT for intended NOM remains a relevant question to be answered by ongoing randomized trials.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"213 ","pages":"Article 111194"},"PeriodicalIF":5.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term prediction of radiation-induced optic neuropathy: A mixed-effects analysis of visual field kinetics following proton therapy 放射诱导视神经病变的长期预测:质子治疗后视野动力学的混合效应分析。
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-08 DOI: 10.1016/j.radonc.2025.111205
Thao-Nguyen Pham , Thibaud Mathis , Nathan Azemar , Anthony Vela , Jean-Claude Quintyn , Juliette Thariat
{"title":"Long-term prediction of radiation-induced optic neuropathy: A mixed-effects analysis of visual field kinetics following proton therapy","authors":"Thao-Nguyen Pham ,&nbsp;Thibaud Mathis ,&nbsp;Nathan Azemar ,&nbsp;Anthony Vela ,&nbsp;Jean-Claude Quintyn ,&nbsp;Juliette Thariat","doi":"10.1016/j.radonc.2025.111205","DOIUrl":"10.1016/j.radonc.2025.111205","url":null,"abstract":"<div><h3>Introduction</h3><div>Radiation-induced optic neuropathy (RION) is a rare but serious complication of radiotherapy, leading to progressive vision loss. The temporal dynamics of RION are poorly understood, limiting effective monitoring and intervention. We developed a predictive mixed-effects model of visual field deterioration, a sensitive surrogate marker for clinically-reported RION, by integrating longitudinal clinical and dosimetric data, to anticipate long-term visual outcomes.</div></div><div><h3>Methods</h3><div>Out of a prospective database of 238 patients, 179 eyes from 105 patients treated with pencil beam scanning proton therapy were included. All selected eyes had no significant visual field deficit at baseline, defined as a mean visual sensitivity loss better than −6 dB. Baseline clinical characteristics, detailed dosimetric data, and longitudinal visual field assessments were collected. Temporal changes in mean visual sensitivity were analyzed using feature selection through random forest models and linear regression. A nonlinear mixed-effects model was then developed to predict the trajectory of visual field deterioration over time.</div></div><div><h3>Results</h3><div>Visual field deterioration progressed significantly over time, with a quadratic model best capturing the kinetics. Mean sensitivity loss accelerated with increasing age and clinical target volume. Incorporating the full dose-volume histogram, the volume of the optic chiasma received at least 40 Gy (V<sub>40</sub>/chiasma), improved model performance. Simulation based on this model showed that the probability of RION increased sharply over time: 4.6 % at 2 years, and 28.3 % at 5 years.</div></div><div><h3>Conclusion</h3><div>This model confirms and expands upon prior work by showing that clinical factors can outweigh dosimetric ones in predicting RION progression. Our model was capable of predicting long-term visual outcomes even in patients with limited follow-up.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"213 ","pages":"Article 111205"},"PeriodicalIF":5.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to "The role of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer at different risks of brain metastasis: A multicenter retrospective study". 致“不同脑转移风险的有限期小细胞肺癌患者预防性颅脑照射的作用:一项多中心回顾性研究”
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-07 DOI: 10.1016/j.radonc.2025.111203
Mengjiao Guo, Dongfeng Pan
{"title":"Letter to \"The role of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer at different risks of brain metastasis: A multicenter retrospective study\".","authors":"Mengjiao Guo, Dongfeng Pan","doi":"10.1016/j.radonc.2025.111203","DOIUrl":"10.1016/j.radonc.2025.111203","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"111203"},"PeriodicalIF":5.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra-hypofractionated radiotherapy combined with HDR brachytherapy: An optimized treatment. 超低分割放疗联合HDR近距离放疗:一种优化的治疗方法。
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-07 DOI: 10.1016/j.radonc.2025.111199
I Sidibé, M M Beaudry, D Carignan, M A Froment, W Foster, F Bachand, E Vigneault, S Magnan, S Aubin, J Morrier, E Poulin, F Lacroix, M C Lavallée, L Beaulieu, A G Martin
{"title":"Ultra-hypofractionated radiotherapy combined with HDR brachytherapy: An optimized treatment.","authors":"I Sidibé, M M Beaudry, D Carignan, M A Froment, W Foster, F Bachand, E Vigneault, S Magnan, S Aubin, J Morrier, E Poulin, F Lacroix, M C Lavallée, L Beaulieu, A G Martin","doi":"10.1016/j.radonc.2025.111199","DOIUrl":"https://doi.org/10.1016/j.radonc.2025.111199","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate safety and efficacy of ultra hypofractionated radiotherapy (UHF) combined with high dose rate brachytherapy boost (HDR-BB) in comparison to a moderately hypo-fractionated (MHF) regimen, in patients treated for intermediate risk prostate cancer.</p><p><strong>Materials/methods: </strong>199 patients with intermediate risk prostate cancer were recruited in the experimental UHF treatment cohort of 25 Gy in 5 fractions plus a 15 Gy HDR-BB. They were compared to two historical control groups, treated with either 36 Gy in 12 fractions (152 patients) or 37.5 Gy in 15 fractions (311 patients) with an identical HDR-BB. The study reported the biochemical cure rate (BCR) defined as PSA < 0.2 ng/ml at 4 years, as well as biochemical relapse-free survival (BRFS) and overall survival (OS). Additionally, genitourinary (GU), gastrointestinal (GI), and sexual toxicities were evaluated.</p><p><strong>Results: </strong>At the time of analysis, median follow up was respectively 36, 90 and 102 months for the UHF, 36 Gy and 37.5 Gy group. The BCR was 81.8 %, 78.4 % and 66.7 % in the UHF and both MHF groups (p = 0.11). There was no statistical difference in BRFS and OS between the three groups. There was no grade 3 toxicity in UHF group compared to 0.7 % in 36 Gy and 5.1 % in 37.5 Gy groups. No difference was found in late GU and GI toxicities between groups.</p><p><strong>Conclusion: </strong>Our study confirms UHF with HDR-BB is safe for intermediate-risk prostate cancer, reducing treatment time and patient burden. Longer follow-up is needed to confirm results.</p>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"111199"},"PeriodicalIF":5.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral vs bilateral neck irradiation in lateralized oropharyngeal carcinoma: Patient selection flaws in propensity matching undermine conclusions. 单侧与双侧颈部照射治疗侧化口咽癌:倾向匹配中的患者选择缺陷削弱了结论。
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-06 DOI: 10.1016/j.radonc.2025.111177
Max Gau, Ali Hosni
{"title":"Unilateral vs bilateral neck irradiation in lateralized oropharyngeal carcinoma: Patient selection flaws in propensity matching undermine conclusions.","authors":"Max Gau, Ali Hosni","doi":"10.1016/j.radonc.2025.111177","DOIUrl":"10.1016/j.radonc.2025.111177","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"111177"},"PeriodicalIF":5.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to commentary on "Brachial plexopathy following stereotactic body radiation therapy in apical lung malignancies: A dosimetric pooled analysis of individual patient data" by Sawada et al. 对Sawada等人发表的“肺顶端恶性肿瘤立体定向放射治疗后的臂丛病:个体患者数据的剂量学汇总分析”的评论的回应。
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-05 DOI: 10.1016/j.radonc.2025.111198
Hui Bai, Xiao-Feng Wang, Yi-Han Xu, Nicholas G Zaorsky, Huan-Huan Wang, Geng-Min Niu, Jia-Cheng Li, Yang Dong, Jun-Yi Li, Lu Yu, Mei-Feng Chen, Xiao-Tong Lu, Zhi-Yong Yuan, Ji-Long Yang, Mao-Bin Meng
{"title":"Response to commentary on \"Brachial plexopathy following stereotactic body radiation therapy in apical lung malignancies: A dosimetric pooled analysis of individual patient data\" by Sawada et al.","authors":"Hui Bai, Xiao-Feng Wang, Yi-Han Xu, Nicholas G Zaorsky, Huan-Huan Wang, Geng-Min Niu, Jia-Cheng Li, Yang Dong, Jun-Yi Li, Lu Yu, Mei-Feng Chen, Xiao-Tong Lu, Zhi-Yong Yuan, Ji-Long Yang, Mao-Bin Meng","doi":"10.1016/j.radonc.2025.111198","DOIUrl":"10.1016/j.radonc.2025.111198","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"111198"},"PeriodicalIF":5.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-dose ionizing radiation-induced ferroptosis leads to radiotherapy sensitization of nasopharyngeal carcinoma 高剂量电离辐射诱导的铁下垂导致鼻咽癌放疗致敏。
IF 5.3 1区 医学
Radiotherapy and Oncology Pub Date : 2025-10-05 DOI: 10.1016/j.radonc.2025.111166
Xianhuai Jin , Xianlin Zeng , Danwei Yang , Liao Yi , Weili Wu , Xiaoxiao Chen , Xiulin Luo , Pu Xu , Shuai Zhang , Shichao Zhang , Zuquan Hu , Zhu Zeng , Jinhua Long
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