Research and Reports in Urology最新文献

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Efficacy of Three Different Injection Techniques for the Endoscopic Treatment of Vesicoureteral Reflux (VUR) in Children: A Review of 10 Years of Experience. 儿童膀胱输尿管反流(VUR)内窥镜治疗中三种不同注射技术的疗效:十年经验回顾
IF 2
Research and Reports in Urology Pub Date : 2024-07-03 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S467018
Giulia Lanfranchi, Irene Paraboschi, Ugo Maria Pierucci, Guglielmo Mantica, Sara Costanzo, Federica Marinoni, Andrea Pansini, Giorgio Giuseppe Orlando Selvaggio, Gloria Pelizzo
{"title":"Efficacy of Three Different Injection Techniques for the Endoscopic Treatment of Vesicoureteral Reflux (VUR) in Children: A Review of 10 Years of Experience.","authors":"Giulia Lanfranchi, Irene Paraboschi, Ugo Maria Pierucci, Guglielmo Mantica, Sara Costanzo, Federica Marinoni, Andrea Pansini, Giorgio Giuseppe Orlando Selvaggio, Gloria Pelizzo","doi":"10.2147/RRU.S467018","DOIUrl":"10.2147/RRU.S467018","url":null,"abstract":"<p><strong>Aim: </strong>To review our 10 years of experience with the endoscopic treatment of vesicoureteral reflux (VUR) in children, emphasizing the long-term efficacy of the \"combined STING-HIT\" technique.</p><p><strong>Materials and methods: </strong>A retrospective study was performed including all children with symptomatic VUR undergoing the cystoscopic injection of bulking agents from January 2013 to December 2022 in our pediatric tertiary referral center. Three different endoscopic techniques were adopted: the \"combined STING-HIT\" technique, the STING technique, and the HIT technique. Treatment success was defined as symptom remission and VUR resolution on the voiding cystourethrogram (VCUG) performed at the 3-month follow-up.</p><p><strong>Results: </strong>In the study period, 140 (F:M = 64:76) patients and 228 ureters were treated at a median patient age of 3 (2.0-6.0) years. After a single endoscopic treatment, VUR resolved in 203 (88%) ureters. The VUR resolution rate after a single endoscopic treatment was 95% (n=70/74) in case of I-II VUR, 88% (n=87/99) in case of III VUR; 83% (n=38/46) in case of IV VUR; 89% (n=8/9) in case of V VUR (p-value: 0.174). Overall, one or two endoscopic treatments succeeded in 219 (96%) ureters. The overall VUR resolution rate following one or two endoscopic treatments was 100% (74/74) in case of I-II VUR, 93% (n=92/99) in case of III VUR; 96% (n=44/46) in case of IV VUR; 100% (n=9/9) in case of V VUR (p-value: 0.083). Despite not being statistically significant, the VUR resolution rate was higher for the \"combined STING-HIT\" technique, both after one (92%: n=110/119; versus 85%; n=62/73 versus 86%; n=31/36; p-value: 0.225) or two (98%: n=116/119; versus 95%; n=69/73 versus 94%; n=34/36; p-value: 0.469) endoscopic treatments.</p><p><strong>Conclusion: </strong>The endoscopic approaches were highly successful for the treatment of VUR in children. The \"combined STING-HIT\" technique was a safe and effective procedure, being associated with the higher resolution rate.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"151-159"},"PeriodicalIF":2.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preconceived Impressions Regarding Holmium:YAG Laser Safety in the Urology Operating Theatre. 泌尿外科手术室中有关钬:YAG 激光安全性的先入为主的印象。
IF 2
Research and Reports in Urology Pub Date : 2024-06-17 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S457617
Mitchell Barns, Daniel Magee, Thomas England
{"title":"Preconceived Impressions Regarding Holmium:YAG Laser Safety in the Urology Operating Theatre.","authors":"Mitchell Barns, Daniel Magee, Thomas England","doi":"10.2147/RRU.S457617","DOIUrl":"10.2147/RRU.S457617","url":null,"abstract":"<p><strong>Background: </strong>Since its introduction over two decades ago, the surgical laser has served in the lithotripsy of urinary calculi, resection of bladder tumours, bladder neck incisions, and prostate enucleation. Concerns regarding the safe use of holmium lasers have resulted in potentially excessive and overly precautious theatre regulations. We aimed to evaluate the preconceived impressions and practice patterns at a single site surrounding laser use in endourology.</p><p><strong>Methods: </strong>We designed a three-part online questionnaire that could be accessed using a smart device or computer. This survey was distributed to all theatre staff involved in laser surgery at our single site, including surgical, nursing, and anaesthetic staff of varying seniority. It asked questions regarding holmium laser safety, provided an up-to-date summary of published literature surrounding the safe use of lasers, and finally gave participants further option to alter the answers to several previously encountered questions.</p><p><strong>Results: </strong>A total of 54 theatre staff completed the survey, including 17 theatre nurses (31.5%), 10 urology consultants (18.5%), 8 urology registrars (14.8%), 7 anaesthetic registrars (13%), 4 anaesthetic consultants (7.4%). About 51.9% of participants believed that current laser safety protocols were adequate, with 38.9% finding them excessive. After reading recently published information on laser safety, 22.2% thought current laser safety measures were adequate (57% decrease) and 77.8% found them to be excessive (100% increase). About 74.1% of participants found that laser safety goggles impair their vision and that 79.6% would choose not to wear them if they were optional.</p><p><strong>Conclusion: </strong>Strict laser safety guidelines reflect an overestimated risk associated with using holmium laser in operating theatres. Laser safety regulations should be re-evaluated to align with current research and potential hazards inherent to the device. In doing so, a more effective distribution of staff could enable greater access to laser surgery, thereby reducing patient morbidity and hospital wait times.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"143-150"},"PeriodicalIF":2.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11192151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report; Concomitant Left Nutcracker Syndrome and Right Ureteropelvic Junction Obstruction. 病例报告;并发左侧胡桃钳综合征和右侧输尿管盆腔交界处梗阻。
IF 1.6
Research and Reports in Urology Pub Date : 2024-06-10 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S446710
Mintesnot Yitagesu Kidane, Adugna Getachew Mideksa, Mubarek Bargicho Adem, Fitsum Gebreegziabher Gebrehiwot, Ramzi Yessuf Adem, Mensur Mohammed Ahmed, Abebe Ketema Aderu, Mintesnot Tadesse Berta
{"title":"Case Report; Concomitant Left Nutcracker Syndrome and Right Ureteropelvic Junction Obstruction.","authors":"Mintesnot Yitagesu Kidane, Adugna Getachew Mideksa, Mubarek Bargicho Adem, Fitsum Gebreegziabher Gebrehiwot, Ramzi Yessuf Adem, Mensur Mohammed Ahmed, Abebe Ketema Aderu, Mintesnot Tadesse Berta","doi":"10.2147/RRU.S446710","DOIUrl":"10.2147/RRU.S446710","url":null,"abstract":"<p><p>We report rare case of concomitant left nutcracker syndrome and right ureteropelvic junction obstruction (UPJO) on adult female patient diagnosed by CT urogram after she presented with intermittent bilateral flank pain. For this we did Anderson-Hynes pyeloplasty for right ureteropelvic obstruction, it was laparoscopic initially but due to difficulty of stenting it is changed to open. She had smooth post-op course then discharged on 3rd post-op day. Symptoms of nutcracker syndrome are not that much bothersome for the patient so we planned to follow her conservatively.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"131-135"},"PeriodicalIF":1.6,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11178079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Stone Characteristics and Laser Fiber Size Affect Ho: YAG Laser Time and Energy During Ureteroscopy? 结石特征和激光光纤尺寸是否会影响输尿管镜检查过程中的 Ho: YAG 激光时间和能量?
IF 1.6
Research and Reports in Urology Pub Date : 2024-05-27 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S464098
Abdihamid Hassan Hilowle, Abdikarim Hussein Mohamed
{"title":"Do Stone Characteristics and Laser Fiber Size Affect Ho: YAG Laser Time and Energy During Ureteroscopy?","authors":"Abdihamid Hassan Hilowle, Abdikarim Hussein Mohamed","doi":"10.2147/RRU.S464098","DOIUrl":"10.2147/RRU.S464098","url":null,"abstract":"<p><strong>Objective: </strong>To assess the correlation of attenuation value measured as HU in Non-contrast computed tomography, stone size, location, fibre size and stone composition with Holmium: yttrium-aluminium garnet (Ho: YAG) laser parameters including, cumulative laser energy and final laser time.</p><p><strong>Materials and methods: </strong> We prospectively analyzed 118 patients undergoing flexible/semirigid ureteroscopy and Holmium: YAG laser lithotripsy from October 2022 to October 2023 at Mogadishu Urological Centre. Our study parameters encompass preoperative stone characteristics determined in NCCT (stone size, attenuation value, and stone location), fibre size, cumulative laser energy and time, overall operative time, and postoperative stone composition analysis.</p><p><strong>Results: </strong>There were 118 patients eligible for our prospective study. In the logistic regression model for retrograde intrarenal surgery with a fibre size of 272<b> </b>μm, cumulative laser energy showed a significant difference among stone size, location, fibre size, and calcium oxalate stones (P > 0.05). However, no significant difference was noticed in the attenuation value (P = 0.078) (R2 = 0.053). Our analysis showed a positive significance among all the parameters (P < 0.05) for laser time. In logistic regression for a rigid ureteroscope with a fibre size of 365<b> </b>μm, cumulative laser energy showed a significant difference between the location stone and fibre size (P < 0.05) (R2 = 0.09). However, no significant difference was seen among stone size, attenuation value, and calcium oxalate stones (P > 0.05). For laser time, our analysis showed a positive significance among all parameters except the calcium oxalate stones, which showed no significant difference (P > 0.05).</p><p><strong>Conclusion: </strong>Our study showed that stone location, hardness, and fibre size are the most critical factors influencing the outcome of Ho: YAG laser parameters. The study revealed that CaOMH stones require more time to disintegrate into smaller ones, while PH-dependent stones such as carbonate apatite may require less time to fragment.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"115-121"},"PeriodicalIF":1.6,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Hypospadias Repair Based on Surgical Techniques: A 4-Year Retrospective Study. 基于手术技术的尿道下裂修复效果:一项为期 4 年的回顾性研究
IF 1.6
Research and Reports in Urology Pub Date : 2024-03-27 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S451552
Aisha Gabra, Badr Mohammed Beyari, Sara Jamal AlNuwaiser, Sarah Mamdouh Allaf, Reem Alghanmi, Rahaf Alrayiqi, Faisal Mosaad, Mazen Kurdi
{"title":"Outcomes of Hypospadias Repair Based on Surgical Techniques: A 4-Year Retrospective Study.","authors":"Aisha Gabra, Badr Mohammed Beyari, Sara Jamal AlNuwaiser, Sarah Mamdouh Allaf, Reem Alghanmi, Rahaf Alrayiqi, Faisal Mosaad, Mazen Kurdi","doi":"10.2147/RRU.S451552","DOIUrl":"10.2147/RRU.S451552","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to report the outcomes of hypospadias repair performed at a tertiary-level hospital during 2018 to 2021.</p><p><strong>Methods: </strong>A retrospective chart review of 119 patients was performed.</p><p><strong>Results: </strong>The most frequent coronal hypospadias cases were distal. However, the most common scrotal hypospadias cases were proximal. The average age at the time of the first surgery was 2.4 years (standard deviation, ±2.3 years). The tubularised incised plate technique was performed for 57 of these 119 patients. Urethral fistula was the most common complication associated with distal and proximal cases (23.96% and 30.43%, respectively). No significant correlation was observed between any complication and the surgical technique. Based on the logistic regression model, the duration of urethral stenting was statistically significant (p=0.025), indicating that a urinary catheter duration of more than 5 days resulted in a 2.9-times increased risk of postoperative urethral fistula.</p><p><strong>Conclusion: </strong>Prolonged urethral stenting for more than 5 days may result in subsequent urethral fistula development. Neither the severity of hypospadias nor the surgical technique seems to affect postoperative complications.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"79-87"},"PeriodicalIF":1.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Biomarkers and AKI: Potential to Enhance the Identification of Post-Operative Patients at Risk of Loss of Renal Function. 预后生物标志物与 AKI:提高术后肾功能丧失风险患者识别能力的潜力。
IF 1.6
Research and Reports in Urology Pub Date : 2024-03-05 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S385856
Rishabh Singh, James C Watchorn, Alexander Zarbock, Lui G Forni
{"title":"Prognostic Biomarkers and AKI: Potential to Enhance the Identification of Post-Operative Patients at Risk of Loss of Renal Function.","authors":"Rishabh Singh, James C Watchorn, Alexander Zarbock, Lui G Forni","doi":"10.2147/RRU.S385856","DOIUrl":"10.2147/RRU.S385856","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is a common complication after surgery and the more complex the surgery, the greater the risk. During surgery, patients are exposed to a combination of factors all of which are associated with the development of AKI. These include hypotension and hypovolaemia, sepsis, systemic inflammation, the use of nephrotoxic agents, tissue injury, the infusion of blood or blood products, ischaemia, oxidative stress and reperfusion injury. Given the risks of AKI, it would seem logical to conclude that early identification of patients at risk of AKI would translate into benefit. The conventional markers of AKI, namely serum creatinine and urine output are the mainstay of defining chronic kidney disease but are less suited to the acute phase. Such concerns are compounded in surgical patients given they often have significantly reduced mobility, suboptimal levels of nutrition and reduced muscle bulk. Many patients may also have misleadingly low serum creatinine and high urine output due to aggressive fluid resuscitation, particularly in intensive care units. Over the last two decades, considerable information has accrued with regard to the performance of what was termed \"novel\" biomarkers of AKI, and here, we discuss the most examined molecules and performance in surgical settings. We also discuss the application of biomarkers to guide patients' postoperative care.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"65-78"},"PeriodicalIF":1.6,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Outcome of the Miniaturized Percutaneous Nephrolithotomy in Lateral Position with Guidance of Non-Rotational C-Arm. 在非旋转 C 臂引导下侧卧位微型经皮肾镜取石术的疗效
IF 1.6
Research and Reports in Urology Pub Date : 2024-02-22 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S442145
Ngoc Hung Pham, Vuong Thang Hoang, Cong Le Kha Bui, Van Quoc Anh Nguyen, Van Can Truong, Lance J Hampton
{"title":"The Outcome of the Miniaturized Percutaneous Nephrolithotomy in Lateral Position with Guidance of Non-Rotational C-Arm.","authors":"Ngoc Hung Pham, Vuong Thang Hoang, Cong Le Kha Bui, Van Quoc Anh Nguyen, Van Can Truong, Lance J Hampton","doi":"10.2147/RRU.S442145","DOIUrl":"10.2147/RRU.S442145","url":null,"abstract":"<p><strong>Objective: </strong>Evaluation of the outcome of the miniaturized percutaneous nephrolithotomy in the treatment of nephrolithiasis with a lateral position based on the principle of a right triangle under the guidance of a C-Arm without contrast fluid.</p><p><strong>Materials and methods: </strong>Sixty-nine cases of Mini-PCNL with the assistance of a vacuum-assisted sheath in the lateral position were performed at Central Hospital from March 2021 to August 2022. Percutaneous renal access was under the guidance of a non-rotational C-arm without contrast medium, and we determined the puncture location and depth of the needle based on the principle of right triangles.</p><p><strong>Results: </strong>The median age was 51.6 ± 12.5 years, and males accounted for 68.1% of the cases. 60.9% of all patients had normal weight. The median stone surface area was 361.1mm2, and 59.4% of all cases were graded as 2 regarding Guy's stone score. The successful renal access rate was 100%. The tunnel access from the middle and lower calyx accounted for 94.2%. The median access duration, fluoroscopy duration, and hospital length of stay were 271.7 seconds, 14.79 seconds, and 6.3 days, respectively. The complete stone clearance rate was 78.3%. Bleeding complications occurred in 2 patients without mortality. Three patients required an additional procedure.</p><p><strong>Conclusion: </strong>The puncture technique into the renal calyxes based on the principle of the right triangle under the guidance of a non-rotational C-Arm without contrast medium in PCNL is a fast, exact, and safe technique.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"45-56"},"PeriodicalIF":1.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ChatGPT: Is This Patient Education Tool for Urological Malignancies Readable for the General Population? ChatGPT:这款泌尿系统恶性肿瘤患者教育工具是否适合普通人群阅读?
IF 1.6
Research and Reports in Urology Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.2147/RRU.S440633
Ivan Thia, Manmeet Saluja
{"title":"ChatGPT: Is This Patient Education Tool for Urological Malignancies Readable for the General Population?","authors":"Ivan Thia, Manmeet Saluja","doi":"10.2147/RRU.S440633","DOIUrl":"10.2147/RRU.S440633","url":null,"abstract":"<p><strong>Background: </strong>With widespread adoption of technological advancements in everyday life, patients are now increasingly able and willing to obtain information about their health conditions, treatment options, and indeed expected outcomes via the convenience of any device than can access the worldwide web. This introduces another aspect of patient care in the provision of healthcare for the modern doctor. ChatGPT is the first of an increasing number of self learning programs that have been released recently which may revolutionize and impact healthcare delivery.</p><p><strong>Methods: </strong>The aim of this study is to obtain an objective measure of the readability of information provided on ChatGPT when compared with current validated patient information sheets provided by government health institutions in Western Australia. The same structured questions were input into the program for three major urological malignancies (urothelial, renal, and prostate), with the response generated evaluated with a validated readability scoring system - Flesch-Kincaid reading ease score. The same scoring system was then applied to current patient information sheets in circulation from Cancer Council Australia and UpToDate.</p><p><strong>Results: </strong>Findings in this study looking at ease of readability of information provided on ChatGPT as compared to other government bodies and healthcare institutions confirm that they are non-inferior and may be a useful tool or adjunct to the traditional clinic based consultations. Ease of use of the information generated from ChatGPT was increased further when the question was modified to target an audience of 16 years of age, the average level of education attained by an Australian.</p><p><strong>Discussion: </strong>Future research can be done to look into incorporating the use of similar technologies to increase efficiency in the healthcare system and reduce healthcare costs.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"16 ","pages":"31-37"},"PeriodicalIF":1.6,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections 尿路感染中通过 M-PCR 检测到的不同尿路病原体的流行率及其与感染相关的尿液生物标志物的联系
IF 1.6
Research and Reports in Urology Pub Date : 2024-01-01 DOI: 10.2147/RRU.S443361
Emery Haley, N. Luke, Mohit C. Mathur, Richard Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch
{"title":"The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections","authors":"Emery Haley, N. Luke, Mohit C. Mathur, Richard Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch","doi":"10.2147/RRU.S443361","DOIUrl":"https://doi.org/10.2147/RRU.S443361","url":null,"abstract":"Background Many emerging uropathogens are currently identified by multiplex polymerase chain reaction (M-PCR) in suspected UTI cases. Standard urine culture (SUC) has significantly lower detection rates, raising questions about whether these organisms are associated with UTIs and truly cause inflammation. Objective To determine if microbes detected by M-PCR were likely causative of UTI by measuring inflammatory biomarkers in the urine of symptomatic patients. Design, Setting, and Participants Midstream voided urine was collected from subjects ≥60 years presenting to urology clinics with symptoms of UTI (n = 1132) between 01/2023 and 05/2023. Microbe detection was by M-PCR and inflammation-associated biomarker (neutrophil gelatinase-associated lipocalin, interleukin 8, and interleukin 1β) was by enzyme-linked immunosorbent assay. Biomarker positivity was measured against individual and groups of organisms, E. coli and non-E. coli cases, emerging uropathogens, monomicrobial and polymicrobial cases. Outcome Measurements and Statistical Analysis Distributions were compared using 2-sample Wilcoxon Rank Sum test with 2-tailed p-values < 0.05 considered statistically significant. Results and Limitations M-PCR was positive in 823 (72.7%) specimens with 28 of 30 (93%) microorganisms/groups detected. Twenty-six of twenty-eight detected microorganisms/groups (93%) had ≥2 biomarkers positive in >66% of cases. Both non-E. coli cases and E. coli cases had significant biomarker positivity (p < 0.05). Limitations were that a few organisms had low prevalence making inferences about their individual significance difficult. Conclusion The majority of microorganisms identified by M-PCR were associated with active inflammation measured by biomarker positivity, indicating they are likely causative of UTIs in symptomatic patients. This includes emerging uropathogens frequently not detected by standard urine culture.","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"39 8","pages":"19 - 29"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139456648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retzius-Sparing Robotic-Assisted Prostatectomy: Technical Challenges for Surgeons and Key Prospective Refinements. Retzius疏通机器人辅助前列腺切除术:外科医生面临的技术挑战和关键的前瞻性改进。
IF 1.6
Research and Reports in Urology Pub Date : 2023-12-12 eCollection Date: 2023-01-01 DOI: 10.2147/RRU.S372803
Simone Ferretti, Paolo Dell'Oglio, Davide Ciavarella, Antonio Galfano, Luigi Schips, Michele Marchioni
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