Research and Reports in Urology最新文献

{"title":"Enhancing Percutaneous Access: The «GENOA» Prone Modified Position.","authors":"Guglielmo Mantica, Marco Martiriggiano, Raquel Diaz, Enrico Vecchio, Lorenzo Lo Monaco, Giorgia Granelli, Benedetta Col, Francesca Ambrosini, Federica Balzarini, Rafaela Malinaric, Daniele Panarello, Carlo Terrone","doi":"10.2147/RRU.S557997","DOIUrl":"10.2147/RRU.S557997","url":null,"abstract":"<p><p>Percutaneous nephrolithotomy (PCNL) is the preferred treatment for large or complex renal stones, but the optimal patient positioning remains debated. While the traditional prone position offers excellent access to posterior calyces, it can limit ventilation and increase anesthetic complexity. Supine modifications improve airway management but may reduce access efficacy. We propose the \"GENOA\" Prone Modified Position, a novel setup combining the advantages of both approaches. In this preliminary study, three patients underwent PCNL using this technique, which involves prone positioning with a ~30-45° rotation obtained by placing gel pads under the thoracic and abdominal regions contralateral to the affected kidney. This alignment brings the renal axis parallel to the floor, facilitating a safer and more ergonomic puncture. All punctures were performed below the costal margin, accessing the lower calyces in four of six renal units. Mean operative time was 72.2 minutes, and two patients achieved complete stone clearance. No complications or opioid use were recorded, and the average hospital stay was 4.3 days. The GENOA Prone Modified Position appears to be a feasible and effective solution that enhances access to posterior calyces while minimizing ventilatory risk. Further studies are needed to validate its reproducibility and long-term benefits in larger cohorts.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"557997"},"PeriodicalIF":2.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular Cancer: Diagnosis, Treatment, and Biomarker Advances.","authors":"Pia Kraft, Ali Amiri, Ahmad Mousa, Sanchit Kaushal, Hannah Bacon, Rachel M Glicksman, Robert J Hamilton","doi":"10.2147/RRU.S511445","DOIUrl":"10.2147/RRU.S511445","url":null,"abstract":"<p><p>Recent advances in testicular cancer have led to a paradigm shift toward more precise, patient-centered care. Current challenges include the identification of accurate biomarkers, the management of incidentally detected small testicular masses (STM), the refinement of surgical techniques through robotic and modified-template approaches to minimize morbidity, and the prevention of overtreatment while maintaining oncological safety. Advanced molecular biomarkers, such as microRNA-371a-3p, currently demonstrate >90% sensitivity for detecting viable germ cell tumors, surpassing classical markers, yet remain limited by their inability to detect teratomatous components. Circulating tumor DNA have also emerged as a promising biomarker for minimal residual disease detection and personalized follow-up. The management of STMs is of growing interest, driven by the rising use of high-resolution scrotal ultrasonography and the consequent improvement in lesion detection. As most incidental findings are benign, this has prompted reconsideration of traditional radical orchiectomy as the standard intervention. STMs require careful evaluation that integrates imaging characteristics, clinical context, and intraoperative frozen section analysis to enable more tailored management. Given the high survival rates of testicular cancer, the avoidance of overtreatment and associated morbidity remains critical. Accordingly, contemporary strategies emphasize active surveillance for low-risk tumors, selective use of adjuvant therapy, and the adoption of minimally invasive surgical techniques. These advances, supported by improved imaging and biomarker profiling, facilitate more accurate patient stratification, balancing curative intent with preservation of quality-of-life.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"511445"},"PeriodicalIF":2.4,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is \"Open Stone Surgery with Intraoperative Nephroscopy\" a Better Alternative to Percutaneous Stone Removal for Complex Kidney Stones in Resource-Constrained Rural Settings?: A Retrospective Observational Cohort Study.","authors":"Joy Narayan Chakraborty, Renchamo Kikon","doi":"10.2147/RRU.S564070","DOIUrl":"10.2147/RRU.S564070","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Advances in endourology have greatly reduced open stone surgeries (OSS) worldwide. However, in some rural areas of developing countries, PNL for large, complex stones is not feasible due to limited resources and lack of angioembolisation. We share our experience in such cases.</p><p><strong>Materials and methods: </strong>Using STROCSS 2025 and PROCESS 2023 checklists, we outlined objectives and reported a case series. From January 2012 to June 2023, 2241 patients had surgery for urinary stones at a rural hospital: 286 PNL, 1625 URS, 281 RIRS, and 49 OSS. We retrospectively analysed demographic data, stone burden, surgical techniques, and outcomes.</p><p><strong>Outcomes: </strong>There were 23 men and 26 women, aged 31 to 66 (average: 52 years). CSB was included in 46 patients (93.8%), and CSB with PUJ obstruction in 3 patients (6.12%). Procedures were pyelolithotomy (26.53%), extended pyelolithotomy (38.77%), and pyelolithotomy with lower calyceal nephrotomy (24.48%). Mandatory intraoperative nephroscopy was used to remove calyceal stones. Complete stone-free status was achieved in 47 cases (95.9%) at discharge and 3-month CT. Two patients (4.08%) had residual fragments needing RIRS at 3 months. The mean operative time was 88.67 min (70-120), and hospital stay averaged 5.87 days (5-8). The follow-up period averaged 24.48 months (24-30). Intraoperative complications occurred in 10.20%, and significant postoperative complications in seven cases (14.28%), including sepsis, urinary leakage, chest effusion, and wound issues.</p><p><strong>Conclusion: </strong>Single-session OSS with Nephroscopic clearance can achieve a higher stone-free rate. Although the morbidity of OSS is considerably higher than that of PNL, it may be safe and effective for managing complex stone burdens in resource-constrained rural areas of developing countries.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"564070"},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking Elevated PSA: Prevalence and Modifiable Risk Factors in Men Aged ≥ 40 Years Attending Kabutare District Hospital in Rwanda.","authors":"Erneste Mugenzi, Jean Paul Dusengimana, Danny Habumugisha, Happy Jean Bosco Asifiwe, Anathalie Umuhoza, Diogene Rwayitare, Tiruzer Bekele, Schifra Uwamungu, Augustin Nzitakera, Cuthbert Musarurwa","doi":"10.2147/RRU.S570060","DOIUrl":"10.2147/RRU.S570060","url":null,"abstract":"<p><strong>Objective: </strong>The objective of the study was to determine the prevalence of elevated PSA levels (> 4.0 ng/mL) and examine sociodemographic and modifiable lifestyle risk factors associated with PSA elevation among asymptomatic Rwandan men aged ≥ 40 years.</p><p><strong>Material and methods: </strong>A cross-sectional study was conducted at Kabutare District Hospital in Rwanda between March and April 2025, enrolling 136 asymptomatic male participants aged ≥ 40 years. Lifestyle and anthropometric data were collected via structured interviews. Serum total PSA was measured using the enzyme linked immunosorbent assay (Fortress BXE0851A kit). Elevated PSA was defined as > 4.0 ng/mL. Statistical analyses included descriptive statistics and Chi-square/Fisher's exact tests for bivariate associations.</p><p><strong>Results: </strong>Elevated PSA was observed in 14% of participants. Chi-square analysis revealed significant associations between elevated PSA and BMI category (<i>p</i> < 0.001), smoking status (<i>p</i> < 0.001), alcohol use (<i>p</i> < 0.001), sexual activity frequency (<i>p</i> = 0.018), and occupation (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Elevated PSA prevalence among asymptomatic Rwandan men mirrors global patterns observed in Black populations. Associations with underweight status, occupational exposure, and alcohol use suggest multifactorial influences. These findings highlight the need for targeted screening strategies and community-level interventions to promote early prostate cancer detection in Rwanda.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"495-507"},"PeriodicalIF":2.7,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Age, TNM Stage, and Hospitalization on Bladder Cancer Survival: Evidence from a Hospital-Based Cohort in Eastern China.","authors":"Ling-Ling Lu, Hai-Zhen Chen, Jian-Guo Chen","doi":"10.2147/RRU.S568396","DOIUrl":"10.2147/RRU.S568396","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate survival outcomes and identify prognostic factors among bladder cancer patients.</p><p><strong>Patients and methods: </strong>A total of 488 bladder cancer patients admitted between 2007 and 2017 were followed until December 31, 2020, using both active and passive follow-up. The Kaplan-Meier method was used to estimate observed survival (OS), with group comparisons performed using the Log rank test. Variables included sex, age group, number of hospital admissions, TNM stage, and geographic origin.</p><p><strong>Results: </strong>Of 488 patients, 485 (99.38%) were successfully followed. The majority were male (80.21%) with a mean age of 66.5 years. The average number of hospital admissions was 1.81. Overall 1-, 3-, 5-, and 10-year OS rates were 79.95%, 63.50%, 56.32%, and 45.54% for males, and 69.79%, 58.33%, 56.01%, and 56.01% for females, respectively (P = 0.697). Age significantly affected prognosis (P < 0.01), with 5-year OS declining from 66.67% (age ≤34) to 29.53% (≥80). Patients with ≥3 admissions had worse survival (44.87%) than those with one (61.93%) or two admissions (58.97%) (P < 0.01). TNM stage was strongly with survival: 5-year OS rates were 86.43% (Stage I), 55.48% (Stage II), 38.25% (Stage III), and 13.85% (Stage IV) (P < 0.01). Regional differences were not statistically significant (P > 0.05).</p><p><strong>Conclusion: </strong>Advanced age and late-stage diagnosis were associated with poorer survival, while early-stage detection correlated with better outcomes. These findings underscore the importance of early screening, timely treatment, and comprehensive care strategies to improve bladder cancer survival, especially in resource-limited settings. Limitations include single-center design and absence of multivariate adjustment.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"481-493"},"PeriodicalIF":2.7,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12691630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Tying Knots: Can Venous Bypass Shape the Future of Testicular Hemodynamics in Varicocele Treatment? - A Systematic Review.","authors":"Albert Ciam, Ricky Adriansjah","doi":"10.2147/RRU.S551216","DOIUrl":"10.2147/RRU.S551216","url":null,"abstract":"<p><strong>Purpose: </strong>Varicocele, present in 15-20% of males and linked to 35-40% of primary infertility, is commonly treated with microsurgical ligation. This review compares venous shunting techniques such as spermatic-inferior epigastric vein anastomosis with ligation in terms of efficacy, safety, and clinical outcomes, especially in complex cases like recurrence or Nutcracker Syndrome.</p><p><strong>Methods: </strong>We included randomized, prospective, retrospective, and cohort studies comparing venous shunting (eg, spermatic-inferior epigastric vein anastomosis) with ligation or without control group. We searched PubMed, EBSCO, ProQuest, EMBASE, and Scopus on 31 April 2025. Risk of bias was assessed using the Newcastle-Ottawa Scale and JBI (Joanna Briggs Institute) for case series. Outcomes assessed included operative time, semen parameters, hormonal levels, recurrence, and complications. This study was registered in PROSPERO (CRD420251060842).</p><p><strong>Results: </strong>Twelve studies (n = 420 patients) were included. Shunting demonstrated improvements in semen quality (eg, sperm motility: 59.4% vs 41.6% post-ligation) and lower recurrence rates (0-5% vs 5-15%). However, operative times were longer (99-146 vs 48-92 minutes). Shunting also showed benefits in vascular parameters and testicular volume, particularly in NCS-associated cases. Complications were rare, with minor issues like scrotal edema reported.</p><p><strong>Conclusion: </strong>Venous shunting shows promise as an alternative in selected varicocele patients, with potential benefits in semen motility, pain relief, and recurrence reduction. However, the current evidence is limited, heterogeneous, and largely non-randomized. Shunting should therefore be considered experimental, requiring advanced microsurgical expertise, and further high-quality trials are needed before incorporation into standard guidelines.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"469-480"},"PeriodicalIF":2.7,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12684990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Functional Outcomes After Robot-Assisted Sacrocolpopexy versus Transvaginal Mesh Surgery for Pelvic Organ Prolapse: A Retrospective Comparative Study.","authors":"Kazushi Hanawa, Yukie Miyashita, Yoshito Usami, Keisuke Doba, Ryosuke Kimura, Takahiko Mitsui","doi":"10.2147/RRU.S554947","DOIUrl":"https://doi.org/10.2147/RRU.S554947","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare lower urinary tract symptoms (LUTS) in women with pelvic organ prolapse (POP) undergoing robot-assisted sacrocolpopexy (RSC) or transvaginal mesh surgery (TVM).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients who underwent RSC or TVM at our institution between August 2017 and December 2024. Patient demographics, surgical records, and questionnaire responses were collected. LUTS were evaluated using the Overactive Bladder Symptom Score (OABSS), International Prostate Symptom Score (IPSS), and Quality of Life (QOL) score. Preoperative and 1-month postoperative questionnaire responses were compared within each group using the Mann-Whitney <i>U</i>-test. Intergroup comparisons were performed after adjusting for baseline differences through propensity score matching, and their significance was analyzed using the Wilcoxon rank-sum test.</p><p><strong>Results: </strong>A total of 51 patients underwent RSC and 21 underwent TVM. No significant differences were observed in age, body mass index, or Pelvic Organ Prolapse Quantification stage between the groups. The RSC group had a longer operative time (273 vs 127 minutes, p < 0.01) and less blood loss (10.0 vs 150 mL, p < 0.01). Both groups showed significant improvements in IPSS and QOL scores, whereas the OABSS did not change significantly. The RSC group had a significantly lower postoperative QOL score compared with the TVM group, but no significant differences were found after propensity score matching. No significant differences were observed between the groups in either the absolute changes or relative reductions of LUTS questionnaire scores. The incidence of de novo stress urinary incontinence was similar between the groups.</p><p><strong>Conclusion: </strong>Both RSC and TVM effectively improved LUTS in women with POP. After adjusting for baseline differences, no significant differences in postoperative voiding symptoms were observed between the two procedures. These findings support flexible surgical decision-making based on patient characteristics, perioperative risks, surgeon experience, and shared decision-making.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"461-468"},"PeriodicalIF":2.7,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12649809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Management of Kidney Stone Disease - Current Insights.","authors":"Mahir Akram, Bhaskar Somani","doi":"10.2147/RRU.S517758","DOIUrl":"10.2147/RRU.S517758","url":null,"abstract":"<p><p>Nephrolithiasis is a common global urological disorder, with incidence rates being as high as 13% in some regions of North America, contributing to substantial healthcare burdens. In 2021, 106 million new cases were reported worldwide, predominantly in men, reflecting a 27% rise since 2000. Regional disparities are notable, with Eastern Europe showing the highest rates (3,560 per 100,000). Management has evolved from open surgery to minimally invasive, precision endourological techniques, driven by innovations such as advanced lasers, digital ureteroscopes, artificial intelligence, virtual reality training, and robotic-assisted procedures, these advances have enhanced stone-free rates and reduced complications This review provides a comprehensive analysis of the epidemiology and contemporary management of kidney stone disease especially analysing variables affecting the disease including gender, age, geography and climate, occupational exposure, dietary lifestyle, and systemic diseases. Understanding the multifactorial epidemiology of nephrolithiasis is essential for effective prevention, while modern technological interventions are reshaping treatment standards and improving patient outcomes by offering individualized treatment options.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"449-459"},"PeriodicalIF":2.4,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12642795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cervical Thoracic Duct Exploration in Idiopathic Chyluria: A Retrospective Comparative Study.","authors":"Jianfeng Xin, Chao Dong, Song Xia, Yuguang Sun, Jian Dong, Kun Chang, Wanchun Su, Kun Hao, Youlei Qian, Wenbin Shen","doi":"10.2147/RRU.S532806","DOIUrl":"10.2147/RRU.S532806","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to evaluate a novel surgical method for idiopathic chyluria.</p><p><strong>Methods: </strong>Data from 63 patients with idiopathic chyluria who underwent direct lymphangiography (DLG) were retrospectively analyzed. Of these, 50 patients received cervical thoracic duct exploration (CTDE) as a treatment, while 13 were managed with a low-fat diet. The treatment efficacy of the two groups was compared, and a univariate analysis of the CTDE treatment effect was performed.</p><p><strong>Results: </strong>DLG revealed that the contrast agent passed upwards and outwards through paravertebral lymphatics into the region of the renal hilum and pelvis (left: 38.10%; right: 33.33%; bilateral: 28.57%). Dilatation of retroperitoneal lymphatics was found in 90.47% of cases. Additionally, 47.6% of patients demonstrated contrast agent reflux into lymphatic trunks in the neck (the percentage of contrast agent reflux to the jugular trunk, subclavian trunk, and broncho-mediastinal trunk being 28.57%, 38.09%, and 6.34%, respectively). The effective rate in the CTDE group was higher than in the low-fat diet group (χ² = 5.893, <i>p</i>=0.015). Univariate analysis of the patients who underwent CTDE demonstrated that younger age (<i>p</i>=0.036) and Grade III chyluria were risk factors for ineffective treatment, while patients with Grade I had better treatment outcomes (<i>p</i>=0.029).</p><p><strong>Conclusion: </strong>Obstruction of the cervical thoracic duct may be a significant cause of idiopathic chyluria. Alleviating this obstruction may be an effective treatment strategy for idiopathic chyluria.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"437-447"},"PeriodicalIF":2.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Digital Flexible Ureteroscopy in Management of Renal Stones in Normal-Weight and Overweight/Obese Patients.","authors":"Nguyen Huu Thanh, Nguyen Minh Tuan, Hoang Long, Tran Quoc Khanh, Ngo Xuan Cuong, Nguyen Truong Giang, Nguyen Thanh Vinh, Dong Ngoc Minh, Duc Anh Dinh","doi":"10.2147/RRU.S557497","DOIUrl":"10.2147/RRU.S557497","url":null,"abstract":"<p><strong>Purpose: </strong>Overweight and obesity are increasingly prevalent and may influence the outcomes of surgical interventions for kidney stones. This study aimed to compare primary and secondary outcomes between normal-weight and overweight/obese patients undergoing flexible ureteroscopy lithotripsy of kidney stones.</p><p><strong>Patients and methods: </strong>A study was conducted on 114 patients (73 normal-weight, 41 overweight/obese) who underwent flexible ureteroscopy lithotripsy for kidney stones. Primary outcomes included lithotripsy durations, hospital stay, and median stone size. Secondary outcomes included the stone-free rate, quality of life (QoL) scores, and complications.</p><p><strong>Results: </strong>No significant differences were observed between the two groups in surgery duration, lithotripsy duration, or hospital stay. While the median stone size at 1-month and 3-month postoperative was comparable between both groups, the stone size exhibited a significantly smaller size at 3 months (all p-values < 0.001). The stone-free rate at 3 months trended significance, with a lower rate in the overweight/obese group (93.2% vs 70.4%, p = 0.035). QoL significantly improved over time (p < 0.001), with most patients reporting no disruption to daily activities after 1 month in all patients.</p><p><strong>Conclusion: </strong>Overweight/obesity might influencing stone-free rate in patients undergoing flexible ureteroscopy lithotripsy for kidney stones, despite similar perioperative outcomes. The flexible ureteroscopy lithotripsy is shown to be effective over time in reducing kidney stone size as well as postoperative QoL regardless of BMI. Further research is warranted to elucidate the underlying mechanisms and optimize outcomes in this patient population.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"427-436"},"PeriodicalIF":2.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}