Psychiatry and Clinical Neurosciences最新文献

{"title":"Depression, antidepressant use, and breast cancer incidence: results from the E3N prospective cohort.","authors":"Romain Colle, Eric Deflesselle, Océane Mohamed, Bruno Falissard, Gianluca Severi, Agnès Fournier, Marie-Christine Boutron-Ruault, Emmanuelle Corruble","doi":"10.1111/pcn.13852","DOIUrl":"https://doi.org/10.1111/pcn.13852","url":null,"abstract":"<p><strong>Aim: </strong>Depression and antidepressant drugs may both impact breast cancer incidence, potentially in opposite directions. The few epidemiological studies attempting to disentangle their effects have been inconclusive. We aimed to assess within the same prospective cohort the association between depression, antidepressant use, and breast cancer risk, while controlling for potential confounders.</p><p><strong>Methods: </strong>The study population included 47,791 women from the E3N (Etude Epidémiologique Auprès de Femmes de la Mutuelle Générale de l'Education Nationale) prospective cohort, born between 1925 and 1950 and followed for breast cancer incidence from 2005 to 2014. Depression was defined by a Center for Epidemiologic Studies-Depression Scale (CES-D) score ≥17. Exposure to antidepressants was identified from drug claims data available from 2004 onwards. Hazard ratios (HRs) and 95% confidence intervals (CIs) for invasive breast cancer were calculated using Cox proportional hazards models adjusted for breast cancer risk factors. Antidepressant exposure was time-varying.</p><p><strong>Results: </strong>During a mean follow-up of 7.2 years, 1365 breast cancers occurred. Depression was associated with a higher incidence of breast cancer (HR, 1.14 [95% CI, 1.01-1.29]), while exposure to antidepressants was associated with a lower risk (HR, 0.85 [95% CI, 0.74-0.98]). No association was observed for treatment durations <6 months (HR, 1.02 [95% CI, 0.79-1.32]), while antidepressant use for at least 24 months was associated with an HR of 0.80 (95% CI, 0.64-0.99).</p><p><strong>Conclusion: </strong>These findings from a prospective cohort suggest that depression and antidepressant drugs exert opposing effects on breast cancer incidence. While these results require replication in future studies, they could help promote adherence to antidepressant drugs in women with depression.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-acting antipsychotics and mortality in patients with schizophrenia receiving homecare case management.","authors":"Wen-Yin Chen, Po-Yu Chen, Chih-Chiang Chiu, Chun-Hung Pan, Sheng-Siang Su, Chiao-Chicy Chen, Chian-Jue Kuo","doi":"10.1111/pcn.13853","DOIUrl":"https://doi.org/10.1111/pcn.13853","url":null,"abstract":"<p><strong>Aim: </strong>Long-acting injectable antipsychotics (LAIs) offer several advantages over oral antipsychotic medications for treating schizophrenia. However, whether the benefits of LAIs extend to patients receiving homecare case management (CM) remains unclear.</p><p><strong>Methods: </strong>This cohort study used Taiwan's National Health Insurance Research Database, enrolling 19,680 nationwide patients with schizophrenia who began homecare CM between January 1, 2000, and December 31, 2019. Each patient was followed for 5 years or to the data censored, with 30-day periods serving as follow-up units. We evaluated LAI and other medication usage during each period and their associations with mortality outcomes. Additionally, we investigated whether consistent users of homecare CM services (maintenance group) receiving specific LAI treatments had better prognoses.</p><p><strong>Results: </strong>In the cohort (n = 19,680), 6428 received first-generation antipsychotic long-acting injectables (FGA-LAIs) and 4954 received second-generation antipsychotic long-acting injectables (SGA-LAIs). The FGA-LAI group had a mean age of 39.27 years (55.13% male), while the SGA-LAI group had a mean age of 41.25 years (53.75% male). Of 1366 deaths within 5 years, 980 were from natural causes and 254 from suicide. FGA-LAIs reduced natural mortality (HR: 0.67, P = 0.001) but increased suicide risk (HR: 1.52, P = 0.01). SGA-LAIs lowered all-cause (HR: 0.53, P < 0.001) and natural mortality (HR: 0.42, P < 0.001) without affecting suicide mortality (HR: 0.82, P = 0.384). In the maintenance group, FGA-LAIs showed no mortality benefit and increased suicide risk (HR: 2.07, P < 0.001), while SGA-LAIs consistently reduced all-cause (HR: 0.39, P < 0.001), natural (HR: 0.31, P < 0.001), and suicide mortality (HR: 0.54, P = 0.034).</p><p><strong>Conclusions: </strong>SGA-LAIs could be a preferable treatment for reducing mortality in patients with schizophrenia receiving homecare CM, particularly for those in the maintenance group.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the Japanese-style diet and low prevalence of depressive symptoms: Japan Epidemiology Collaboration on Occupational Health Study.","authors":"Haruka Miyake, Akiko Nanri, Hiroko Okazaki, Toshiaki Miyamoto, Takeshi Kochi, Isamu Kabe, Aki Tomizawa, Shohei Yamamoto, Maki Konishi, Seitaro Dohi, Tetsuya Mizoue","doi":"10.1111/pcn.13842","DOIUrl":"https://doi.org/10.1111/pcn.13842","url":null,"abstract":"<p><strong>Aim: </strong>The Japanese diet, rich in fish, soy products, and green tea, is associated with better mental health. However, associations between Japanese dietary patterns and depressive symptoms remain inconsistent, with limited research on predefined patterns. This study developed scores for traditional and modified Japanese diets to explore their cross-sectional associations with depressive symptoms in a large working population.</p><p><strong>Methods: </strong>As part of the Japan Epidemiology Collaboration on Occupational Health Study, we conducted a survey between 2018 and 2021. Diet was assessed using a validated food frequency questionnaire. Scores were developed for the traditional Japanese diet (9 items: white rice, miso soup, soy products, cooked vegetables, mushrooms, seaweed, fish, salty foods, green tea) and its modified version (11 items: whole or minimally processed rice instead of white rice, reverse scoring for salty foods, and adding fruits, raw vegetables, dairy products). Depressive symptoms were assessed using the 11-item Center for Epidemiological Studies-Depression Scale (cutoff ≥9). Multilevel Poisson regression with robust variance estimated prevalence ratios (PRs) and 95% confidence intervals (CIs), adjusting for confounders and accounting for study site as a random effect.</p><p><strong>Results: </strong>Among 12,499 participants (76.8% participation), 30.9% reported depressive symptoms. The PRs of depressive symptoms across quartiles of the traditional Japanese diet score were 1.00 (reference), 0.94 (95% CI, 0.88-0.99), 0.91 (95% CI, 0.85-0.98), and 0.83 (95% CI, 0.80-0.86), and those for the modified version were 1.00 (reference), 0.94 (95% CI, 0.89-0.98), 0.83 (95% CI, 0.80-0.87), and 0.80 (95% CI, 0.76-0.83).</p><p><strong>Conclusion: </strong>Close adherence to the traditional and modified Japanese diet score is associated with fewer depressive symptoms among the working population.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric-onset neuronal intranuclear inclusion disease in a psychiatry-based dementia-enriched cohort in Japan.","authors":"Tesshin Miyamoto, Kohji Mori, Shoshin Akamine, Shizuko Kondo, Shiho Gotoh, Ryota Uozumi, Sumiyo Umeda, Hanako Koguchi-Yoshioka, Satoshi Nojima, Daiki Taomoto, Yuto Satake, Takashi Suehiro, Hideki Kanemoto, Kenji Yoshiyama, Takashi Morihara, Manabu Ikeda","doi":"10.1111/pcn.13854","DOIUrl":"https://doi.org/10.1111/pcn.13854","url":null,"abstract":"<p><strong>Aim: </strong>A GGC repeat expansion in the 5' untranslated region of NOTCH2NLC is a genetic cause of Neuronal Intranuclear Inclusion Disease (NIID) that exhibits cognitive, motor, and autonomic dysfunction. Our objective is to determine whether there are undiagnosed NIID cases in a psychiatry-based dementia-enriched cohort and to identify their clinical characteristics.</p><p><strong>Methods: </strong>A retrospective clinical cohort study was conducted in an inpatient and outpatient psychiatric clinic in a University Hospital in Osaka, Japan. Genomic DNA and clinical information were collected with written informed consent. Nine hundred fifty-eight cases were clinically classified according to the International Classification of Diseases (ICD)-10 system. Genetic analysis with Repeat-Primed PCR and Amplicon-Length PCRs were performed.</p><p><strong>Results: </strong>Of the 958 cases, three were confirmed to have an aberrant GGC repeat expansion in NOTCH2NLC. Cases 1 and 2 had preceding anxiety and depressive episodes, and one of these cases also had a mild cognitive impairment. Case 3 met the diagnostic criteria for progressive supranuclear palsy. All three cases lacked hyperintensity at the corticomedullary border on diffusion-weighted MRI, which is known as a characteristic for NIID. Interestingly, one case exhibited the corticomedullary hyperintensity later in the disease course with apparent neurocognitive decline. All three cases exhibited a mix of slow waves in electroencephalogram and elevated total protein level in cerebrospinal fluid.</p><p><strong>Conclusions: </strong>NIID is a rare cause of cognitive dysfunction in a psychiatry-based dementia-enriched cohort in Japan. Our data implicates psychiatric symptoms can be prodromal or early manifestation of a subset of NIID cases, thereby extending its phenotypic spectrum.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking autism risk genes to morphological and pharmaceutical screening by high-content imaging: Future directions and opinion.","authors":"Reza K Arta, Yuichiro Watanabe, Jun Egawa, Vance P Lemmon, Toshiyuki Someya","doi":"10.1111/pcn.13847","DOIUrl":"https://doi.org/10.1111/pcn.13847","url":null,"abstract":"<p><p>Next-generation sequencing has identified risk genes with large effect sizes for autism spectrum disorders (ASD). Although functional analysis of individual risk genes has progressed, the overall picture of ASD pathogenesis is unclear. Therefore, there is a need for morphological profiling of variants in these genes to fully comprehend their pathomechanism in cultured cells. High-content analysis (HCA) is a powerful approach to thoroughly analyze cellular alterations following genetic modifications in many disorders, including ASD. We begin this review with the latest phenotypic descriptions of ASD risk variants and different ASD cell models, which provide a basis to select features for extraction in image-based analysis to best capture ASD mechanisms. We then describe recent genetic and pharmacological screening campaigns for ASD using HCA systems. Generally, HCA enables imaging of ASD-derived cell models using measurements such as cell proliferation, differentiation, process growth, synapse numbers, and other morphological changes to neurons, astrocytes, and microglia. Advances in machine learning are reducing bias in feature identification and extraction. These data can be transformed for downstream analyses and visualization, such as clustering using heatmaps for morphological profiling. This provides image-based profiling data that can be used to determine the mechanisms of action of genetic modifications. Additionally, comprehensive methods, such as mixture-based and common structure ranking approaches, which can systematically examine the effects of millions of compounds, could identify compounds that might ameliorate the effects of ASD risk gene mutations using morphological profiling.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"AST-001 versus placebo for social communication in children with autism spectrum disorder: A randomized clinical trial\".","authors":"","doi":"10.1111/pcn.13857","DOIUrl":"https://doi.org/10.1111/pcn.13857","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid neuromarker levels in patients with schizophrenia: a multiplex immunoassay study with a large sample.","authors":"Shinsuke Hidese, Kotaro Hattori, Takako Enokida, Megumi Tatsumi, Ryo Matsumura, Hiroshi Kunugi","doi":"10.1111/pcn.13848","DOIUrl":"https://doi.org/10.1111/pcn.13848","url":null,"abstract":"<p><strong>Aim: </strong>To test the hypothesis that neuromarker alternations associated with diagnosis, symptoms, or psychotropic medication use can be found in schizophrenia, we measured cerebrospinal fluid (CSF) neuromarkers in patients with schizophrenia and healthy controls.</p><p><strong>Methods: </strong>This cross-sectional study comprised 148 patients with schizophrenia (39.0 ± 11.0 years; 88 men and 60 women) and 220 healthy controls (44.6 ± 14.8 years; 135 men and 85 women), all of Japanese ethnicity. The Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity in patients with schizophrenia. The levels of eight of the 18 CSF neuromarker were successfully measured using a multiplex immunoassay. Trait and state markers were identified by patient and control groups comparison and symptom-correlation analyses, respectively.</p><p><strong>Results: </strong>CSF glial fibrillary acidic protein levels were significantly higher in patients with schizophrenia than in healthy controls. CSF neurogranin, total tau, and YKL-40 levels were significantly lower in patients with schizophrenia than in healthy controls. Particularly, in patients with schizophrenia, CSF neurogranin, total tau, and YKL-40 levels were lower in the psychotropic-medicated group than in the psychotropic-medication-free group. CSF amyloid beta _1-42 levels were significantly and negatively correlated with PANSS negative scores. CSF macrophage migration inhibitory factor levels were significantly and positively correlated with PANSS positive, general psychopathology, and total scores. CSF neural cell adhesion molecule-1 and S100 calcium-binding protein B levels were significantly and positively correlated with PANSS positive scores.</p><p><strong>Conclusion: </strong>Our findings suggest trait and state neuromarkers and antidementia-like effects of psychotropics on the pathology of schizophrenia.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closures of psychiatric units in general hospitals undermining progress in psychiatry: A stark contrast between Japan and the world.","authors":"Michitaka Funayama, Yusuke Hasegawa, Naoko Satake, Shigeki Sato, Hiraki Koishikawa, Hisashi Wada, On Kato, Masayuki Noguchi, Hirokazu Kumazaki, Katsuji Nishimura","doi":"10.1111/pcn.13851","DOIUrl":"https://doi.org/10.1111/pcn.13851","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical tactile preferences in autism spectrum disorder: Reduced pleasantness responses to soft objects resembling human body parts.","authors":"Kai Makita, Ryo Kitada, Takuya Makino, Nodoka Sakakihara, Ayaka Fukuoka, Hirotaka Kosaka","doi":"10.1111/pcn.13808","DOIUrl":"10.1111/pcn.13808","url":null,"abstract":"<p><strong>Aim: </strong>Previous studies have reported atypical sensory responses in individuals with autism spectrum disorder (ASD) and their implications for social touch. Although adults with ASD often report discomfort with being touched by others, their preferences for the physical properties of objects are less well understood. In a prior study, we observed that, in typically developed (TD) adults, compliance (a physical correlate of softness) increased tactile pleasantness for deformable surfaces up to levels comparable to those of human body parts. In the present study, we conducted psychophysical experiments to test whether individuals with ASD show atypical affective responses to soft objects resembling human body parts.</p><p><strong>Methods: </strong>Thirty-six adults with ASD and 36 TD adults numerically estimated the perceived pleasantness or softness while lightly pressing urethane rubbers with their right index fingers.</p><p><strong>Results: </strong>The results revealed that pleasantness increased as a function of compliance, but this increase was significantly smaller for patients with ASD than TD adults, particularly at compliance levels including human body parts. However, the perceived softness increased as a function of compliance highly similarly between the ASD and TD groups.</p><p><strong>Conclusions: </strong>These findings demonstrate an atypical preference of individuals with ASD for soft objects such as human body parts, which may help explain their tendency to avoid social touch.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"319-326"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCN Art Brut Series No. 45, Artwork Description.","authors":"Kenjiro Hosaka","doi":"10.1111/pcn.13844","DOIUrl":"https://doi.org/10.1111/pcn.13844","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"79 6","pages":"364"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}