Psychiatry and Clinical Neurosciences最新文献

{"title":"Immune dysregulation in mania: A proof-of-concept platelet proteomics study.","authors":"Paola Magioncalda, Matteo Martino, Nhi Thao Ngoc Le, Wen-Yin Chen, Ming-Chyi Huang, David Blum, Thierry Burnouf","doi":"10.1111/pcn.70055","DOIUrl":"https://doi.org/10.1111/pcn.70055","url":null,"abstract":"<p><strong>Aims: </strong>Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data-driven, unbiased approach to uncover biological alterations. Blood platelets provide a stable and comprehensive reflection of the body's internal milieu. This proof-of-concept study explores platelet proteomic alterations in mania.</p><p><strong>Methods: </strong>High-resolution proteomic profiling was performed on platelet samples from hospitalized patients with severe mania (n = 11) and 1:1 age- and sex-matched healthy controls (n = 11) using liquid chromatography-tandem mass spectrometry. Platelet proteins were quantified, differentially expressed proteins identified, and functional enrichment analyses conducted to characterize associated biological pathways. Key proteomic predictions were validated by enzyme-linked immunosorbent assay (ELISA) in platelet and plasma samples.</p><p><strong>Results: </strong>Proteomic analysis revealed that mania is associated with proteins primarily enriched in immune activation while lacking those enriched in cell homeostasis. Among shared proteins, mania exhibited a prominent cluster of downregulated proteins, primarily converging on immune-related pathways. The most robust alteration involved deficits in MHC Class I-mediated antigen processing. Key immune regulatory hubs - transforming growth factor (TGF)-β and interleukin-4 (IL-4) - were identified, with the association of increased TGF-β levels with mania validated by ELISA.</p><p><strong>Conclusions: </strong>This study highlights platelet proteomics as a valuable tool for investigating biological alterations in psychiatric disorders. Our findings indicate deficits in MHC Class I-related pathways and immune alterations consistent with chronic low-grade inflammation, suggesting potential roles for latent viral and autoimmune-related mechanisms in BD. These results support and refine the concept of immune dysregulation in mania and BD.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of particulate matter exposures on depressive symptom trajectories: Evidence from a national longitudinal survey in China.","authors":"Hengchang Wang, Yiling Lou, Yulin Xie, Yan Guo, Linlin Wang, Chiyu Chen, Furong Wang, Qingqing Jiang, Shiyi Cao","doi":"10.1111/pcn.70058","DOIUrl":"https://doi.org/10.1111/pcn.70058","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to assess the associations between particulate matter (PM) exposures and depressive symptom trajectories, as well as the potential contributing role of loneliness in these associations.</p><p><strong>Methods: </strong>The analysis included 11,758 participants (≥45 years), with depressive symptoms and covariate data from the China Health and Retirement Longitudinal Study (2011-2020) and PM data from the ChinaHighAirPollutants dataset. Depressive symptom trajectories were identified using group-based trajectory modeling. Individual and combined effects of PM on depressive symptom trajectories were assessed using multivariable logistic regression and weighted quantile sum (WQS) regression, with results reported as odds ratio (OR) and 95% confidence interval (CI). A serial multiple mediator model was used to evaluate the contributing role of loneliness.</p><p><strong>Results: </strong>Five depressive symptom trajectories were identified: stable-low, stable-moderate, stable-high, decreasing, and increasing. PM exposures were positively associated with more severe depressive symptom trajectory groups (stable-high [PM₁₀: OR = 1.10, 95% CI 1.04-1.16; WQS: OR = 1.41, 95% CI 1.09-1.82] and increasing [PM_1.0: OR = 1.44, 95% CI 1.06-1.98; PM_2.5: OR = 1.10, 95% CI 1.02-1.19; PM₁₀: OR = 1.10, 95% CI 1.06-1.13; WQS: OR = 1.21, 95% CI 1.01-1.45]) compared to the stable-low symptoms trajectory. Loneliness contributed to 26.73%-29.73% of the associations between PM exposure and depressive symptom trajectories.</p><p><strong>Conclusion: </strong>Exposures to individual and mixed PM pollutants increase the risk of severe depressive symptom trajectory groups, and reducing loneliness alleviates these effects. The findings underscore the need for further coordinated control of PM pollutants and alleviating loneliness to prevent depressive symptoms.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From relay station to circuit hub: Thalamic subnuclear precision and the major depressive disorder dysfunctome.","authors":"Yuehua Zhao, Jingjing Zhang, Chenfei Ye","doi":"10.1111/pcn.70062","DOIUrl":"https://doi.org/10.1111/pcn.70062","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking peripheral inflammation to white matter microstructure: Implications for neuropsychiatric disorders.","authors":"Zi-Ting Guan, Yu-Xuan Zhu, Wen-Jiang Wang, Wen-Jie Zhou, Yu Zhang, Jian-Lei Shen, Xiao-Na Zhu, Ti-Fei Yuan","doi":"10.1111/pcn.70039","DOIUrl":"10.1111/pcn.70039","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"239-240"},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling causal relationships between inflammatory cytokines and neurite orientation dispersion and density imaging phenotypes: Insights from bidirectional Mendelian randomization and bibliometric analysis.","authors":"Longtao Yang, Wantong Xu, Yihui Tang, Ben Wu, Xuemei Wang, Jun Liu","doi":"10.1111/pcn.70025","DOIUrl":"10.1111/pcn.70025","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory factors interact with brain imaging-derived phenotypes (IDPs); however, the specific causal relationships between inflammatory factors and brain white matter (WM)-related IDPs remain unclear. Thus, we sought to analyze the potential causal effects of inflammatory factors on brain WM-related IDPs using Mendelian randomization (MR).</p><p><strong>Methods: </strong>We obtained the data of 41 inflammatory factors from a genome-wide association study (GWAS) from the Cardiovascular Risk in Young Finns Study and the FINRISK surveys, as well as the data of 144 neurite orientation dispersion and density imaging (NODDI) IDPs including intracellular volume fraction (ICVF), isotropic volume fraction (ISOVF), and orientation dispersion index (ODI) from the United Kingdom Biobank (UKB). We then conducted two-sample MR analyses to examine their causal interactions by employing the inverse variance weighting (IVW), MR Egger, weighted median, simple mode, and weighted mode methods, collectively enhancing the robustness of our results. Besides, bibliometric analysis was employed to investigate the overview of inflammatory factor-brain WM research.</p><p><strong>Results: </strong>Pronounced correlations are discerned between extensive inflammatory factors and NODDI IDPs, primarily involving cerebellar peduncle, corpus callosum, uncinate fasciculus, posterior thalamic radiation, posterior corona radiata, medial lemniscus, superior longitudinal fasciculus, superior fronto-occipital fasciculus, and internal capsule. Besides, bibliometric analysis demonstrates that microglia play an important role in inflammation-mediated white matter changes.</p><p><strong>Conclusions: </strong>This study identified genetic evidence indicating that dysbiosis of inflammatory factors exerts causal effects on microstructural diffusion properties of brain WM. Our findings provide novel insights into the diagnostic and therapeutic management of central nervous system (CNS) disorders.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"317-327"},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall quality of life and emotional regulation among inmates: A narrative review.","authors":"Kalliopi Megari, Eleana Argyriadou, Vasiliki Yotsidi","doi":"10.1111/pcn.70033","DOIUrl":"10.1111/pcn.70033","url":null,"abstract":"<p><p>Although there is a plethora of studies related to quality of life (QoL), little is known about QoL in prison settings. Emotions and difficulties in emotional regulation in incarcerated individuals may affect inmates' QoL and also their ability to reintegrate into society. The purpose of this review was to compile the empirical evidence and identify knowledge gaps to make suggestions for enhancing QoL in correctional environments. This narrative review includes research published between 2014 and 2024 in PubMed, Google Scholar, EBSCO, and Embase on inmates' QoL, emotion regulation, and mental health. Research on forensic patients as well as non-English articles was excluded. Emotions and emotion regulation were interlinked with mental health issues, while social support was the most eminent feature promoting overall QoL in prisoners, along with other systemic and environmental aspects. Our narrative review suggests that the research to date is limited, focused on male and young inmates, and based on self-reported cross-sectional data. From a public health perspective, identifying the impact of emotions and mental health in the prison population could help improve the QoL of prisoners and inform research, rehabilitation programs, and correctional policy.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"254-287"},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter alterations in the corpus callosum and visual cortical regions associated with depressive and psychotic symptoms in early-onset bipolar disorder.","authors":"Zheng Bi, Mengqian Li, Meng Li, Yuxi Xin, Zhaoqiang Yu, Changjian Qiu, Merita Aruci, Tara Chand, Martin Walter, Laichang He, Paulo Lizano, Yuan Cao","doi":"10.1111/pcn.70023","DOIUrl":"10.1111/pcn.70023","url":null,"abstract":"<p><strong>Aim: </strong>White matter (WM) alterations in the corpus callosum (CC) and visual cortex have been implicated in early psychosis, with the visual regions particularly linked to psychotic symptoms. Whether similar WM patterns occur in early-onset bipolar disorder (EOBD) remains unclear. This study investigated WM alterations in EOBD and their associations with psychiatric symptoms.</p><p><strong>Methods: </strong>Eighty-seven individuals with EOBD and 57 healthy controls (HCs) underwent diffusion magnetic resonance imaging (dMRI) and psychiatric assessments. Whole-brain WM changes between groups were examined using TractSeg and tract-based spatial statistics. Partial correlations with multiple comparison corrections assessed associations between altered tracts and symptoms.</p><p><strong>Results: </strong>Compared with HCs, EOBD showed widespread lower fractional anisotropy (FA) and altered other WM parameters, particularly in the CC and visual-related tracts. Lower FA in the anterior midbody CC (r = -0.307, q = 0.038), right superior longitudinal fascicle I (r = -0.305, q = 0.038), thalamo-parietal (r = -0.315, q = 0.038), and parieto-occipital pontine tracts (r = -0.329, q = 0.038) correlated with greater depressive symptoms. Lower FA in the left inferior fronto-occipital fascicle (r = -0.371, q = 0.030), left optic radiation (r = -0.381, q = 0.030), and left thalamo-occipital tract (r = -0.392, q = 0.030) were associated with greater positive symptoms. These visual-related lower FAs were found more frequently in individuals with visual hallucinations.</p><p><strong>Conclusion: </strong>EOBD was associated with WM abnormalities in the CC and visual pathways linked to depressive symptoms and visual hallucinations, supporting its characterization as a neurodevelopmentally distinct subtype with persistent WM dysconnectivity.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"298-307"},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fronto-limbic emotional-processing markers signal risk of onset rather than risk of recurrence in mood disorders: Evidence from a longitudinal twin study.","authors":"Julian Macoveanu, Hanne Lie Kjærstad, Anjali Sankar, Hartwig R Siebner, Lars Vedel Kessing, Maj Vinberg, Kamilla Miskowiak","doi":"10.1111/pcn.70026","DOIUrl":"10.1111/pcn.70026","url":null,"abstract":"<p><strong>Aims: </strong>Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are highly heritable and linked to fronto-limbic circuit dysfunction. This longitudinal fMRI study examined whether baseline responses of the amygdala, anterior cingulate cortex (ACC), and ventrolateral prefrontal cortex (vlPFC) evoked by facial emotional expressions predicted first-onset or recurrence of mood episodes over 7 years in monozygotic twins.</p><p><strong>Methods: </strong>The sample comprised 68 unaffected twins (UT) without a history of mood disorders but varying familial risk, and 62 affected twins (AT) in remission from MDD or BD. At baseline, participants underwent functional Magnetic Resonance Imaging (fMRI) of fearful and happy face processing and completed behavioral measures of emotional processing, which were repeated at follow-up.</p><p><strong>Results: </strong>Lower baseline activation of the bilateral amygdala (left hazard ratio, HR = 1.69, 95% CI 1.15-2.45; right HR = 1.80, 95% CI 1.23-2.25), dorsal ACC (HR = 1.27, 95% CI 1.02-1.57), and right anterior vlPFC (HR = 2.28, 95% CI 1.56-3.26) by fearful (vs. happy) faces was associated with higher risk of first-onset mood episodes in the UT group. In the AT group, baseline fronto-limbic emotional activations were not associated with recurrence risk. Behaviorally, the UT group that later developed a mood episode showed slower recognition of happy faces and greater avoidance of subliminal fearful faces compared with the UT group that remained well.</p><p><strong>Conclusion: </strong>Dysfunctional fronto-limbic processing of facial emotions indicates increased propensity to develop a mood disorder, but is not associated with increased risk for recurrence of mood episodes. This dissociation suggests that distinct neural mechanisms underlie the first-onset versus the recurrence of mood disorders.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"328-336"},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune involvement in neuropsychiatric disorders: Insights from single-cell transcriptomic studies.","authors":"Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan","doi":"10.1111/pcn.70018","DOIUrl":"10.1111/pcn.70018","url":null,"abstract":"<p><p>Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA-seq) has been widely used to study gene expression, it cannot resolve cell-type-specific signals or detect rare cellular subpopulations. In contrast, single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) have emerged as transformative technologies, enabling transcriptomic profiling at single-cell resolution. These approaches have revealed immunological alterations across a wide range of disorders. This review introduces recent findings from sc/snRNA-seq studies of immune-related mechanisms in psychiatric disorders-including schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder-as well as in neurological conditions such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, multiple sclerosis, and anti-NMDA receptor encephalitis. While sc/snRNA-seq overcome averaging effects of bulk RNA-seq by resolving cell types, these methods still face challenges. We outline a roadmap that integrates bulk RNA-seq and sc/snRNA-seq to mitigate the remaining gaps.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"241-249"},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autopsy case of polymicrogyria and periventricular nodular heterotopia with psychotic symptoms.","authors":"Kazuhiro Takeda, Youta Torii, Hiroaki Miyahara, Itaru Kushima, Hiroshige Fujishiro, Hirotaka Sekiguchi, Mari Yoshida, Yasushi Iwasaki, Shuji Iritani, Masashi Ikeda","doi":"10.1111/pcn.70059","DOIUrl":"https://doi.org/10.1111/pcn.70059","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}