Psychiatry and Clinical Neurosciences最新文献

{"title":"Serotonin syndrome induced through a combination of oxycodone and amitriptyline: A case report.","authors":"Ryo Asada, Hiroko Sugawara, Shun Inoue, Hikaru Hori","doi":"10.1111/pcn.13828","DOIUrl":"https://doi.org/10.1111/pcn.13828","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is clozapine use a risk of hematological malignancies? Insights from a meta-analysis \"Clozapine and Malignancy Risk\".","authors":"Omar Kassar, Moaz Elsayed Abouelmagd, Muataz Kashbour, Omar Shaheen, Sheikh Shoib","doi":"10.1111/pcn.13827","DOIUrl":"https://doi.org/10.1111/pcn.13827","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Examining the therapeutic potential and risks of multivoxel neuroreinforcement for specific phobias.","authors":"Cody A Cushing, Hakwan Lau, Mitsuo Kawato, Michelle G Craske, Vincent Taschereau-Dumouchel","doi":"10.1111/pcn.13815","DOIUrl":"https://doi.org/10.1111/pcn.13815","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of time perception in adolescents with non-suicidal self-injury and psychiatric disorders comorbidity.","authors":"Jie Li, Yu-Jing Wang, Xiao-Li Liu, Yi Zhang, Xiao-Na Zhu, Di Zhao, Ti-Fei Yuan, Dong-Sheng Zhou","doi":"10.1111/pcn.13825","DOIUrl":"https://doi.org/10.1111/pcn.13825","url":null,"abstract":"<p><strong>Aim: </strong>Non-suicidal self-injury (NSSI) is a prevalent behavior that is associated with various mental disorders characterized by self-injury without suicidal intent. However, both the neurobiological bases and indicators of suicidal risk remain elusive, impeding the intervention of this disorder. NSSI is regulated by the reward system, which also regulates time perception. This study aimed to investigate time perception characteristics in NSSI patients and to evaluate their potential for identifying suicidal thoughts and behaviors (STBs).</p><p><strong>Methods: </strong>A cohort study was conducted, which involved 93 NSSI and psychiatric disorders comorbidity (NPC) patients and 84 healthy controls. Participants completed psychological scales and temporal reproduction tasks to determine the characteristics of time perception in adolescents with NPC. Follow-up assessments were conducted 3 months later to evaluate the emergence of STBs. Logistic regression and nomograms were utilized to explore the predictive value of time perception characteristics on STBs.</p><p><strong>Results: </strong>Adolescents with NPC demonstrated significant characteristics in time perception, with a lower reproduction ratio (DRR) and higher coefficient of variation (CV). Notably, lower CV at baseline was associated with a higher probability of STBs during follow-up. The study revealed that time perception effectively predicts the risk of subsequent STBs in NPC patients.</p><p><strong>Conclusion: </strong>This study identifies characteristics of time perception in adolescent NPC patients, which may serve as a novel behavioral indicator for the early identification of risk for suicide. The findings contribute to a better understanding of the neurobiological bases of NSSI and highlight the potential of time perception tasks in the early identification of adverse outcomes, offering novel insights for intervention strategies.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a mobile application game (NDTx-01) in enhancing social communication skills in adolescents with autism spectrum disorder or social communication disorder: A randomized controlled pilot trial.","authors":"Jae Hyun Yoo, Enn Young Lee, Jung-Won Lee, Hahn Kim, Sung Ja Cho, Ran Ju, Hyun Jae Kim, Jung Yeon Moon, Tae Young Choi, Junho Lee, Changwon Jang, Seong Hee Park, Bum Joon Seok, Yoo-Sook Joung","doi":"10.1111/pcn.13824","DOIUrl":"https://doi.org/10.1111/pcn.13824","url":null,"abstract":"<p><strong>Aim: </strong>Adolescents diagnosed with autism spectrum disorder (ASD) or social communication disorder (SCD) experience social communication difficulties. Social skills training (SST) for this population has proven effective, although its use remains restricted due to limited accessibility. This multicenter, parallel, open-label, assessor-blinded, randomized controlled pilot trial evaluated the efficacy of NDTx-01, a mobile application game integrating SST, in patients aged 10 to 18 years diagnosed with ASD or SCD.</p><p><strong>Methods: </strong>A total of 39 participants fulfilled the eligibility criteria and were randomly assigned to two groups. While the control group received treatment as usual (TAU), the intervention group (INT + TAU) engaged with TAU plus NDTx-01 for 10 minutes, five times per week, for 6 weeks. The primary outcome measure included changes in the adaptive behavior composites (ABC) of the Korean Vineland Adaptive Behavior Scale-II. Secondary measures included Social Responsiveness Scale-2 (SRS-2) scores, anxiety levels, and parenting stress.</p><p><strong>Results: </strong>One participant in the INT + TAU group withdrew consent. Thirty-eight patients remained for analysis. Compared with the TAU group (n = 19, 18 males; age, 13.58 ± 2.14 years), the INT + TAU group (n = 19, 16 males; age, 13.42 ± 2.36 years) exhibited significant improvements (INT + TAU 5.89 ± 5.61 vs TAU 1.21 ± 5.99) in the ABC (P = 0.037) after 6 weeks. Additionally, a significant reduction in restricted interests and repetitive behaviors (INT + TAU -9.11 ± 10.26 vs TAU -2.89 ± 7.13) in SRS-2 scores was found (P = 0.037). No adverse events were reported in participants.</p><p><strong>Conclusion: </strong>The mobile game-based SST has demonstrated effectiveness in adaptive functioning in young patients with ASD or SCD. A further confirmatory study with power estimate is required to validate the effects of NDTx-01.</p><p><strong>Clinical trial registration information: </strong>This randomized controlled study was registered in Clinical Research Information Service, National Center for Medical Information and Knowledge, Republic of Korea (Registration Number: KCT0009140, https://cris.nih.go.kr/cris/search/detailSearch.do?seq=26713&search_page=L).</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Hikikomori: A systematic review and meta-analysis of 19 studies.","authors":"Wei Zhang, Meng-Yi Chen, Yuan Feng, Zhaohui Su, Teris Cheung, Todd Jackson, Qinge Zhang, Yu-Tao Xiang","doi":"10.1111/pcn.13768","DOIUrl":"10.1111/pcn.13768","url":null,"abstract":"<p><strong>Aim: </strong>Hikikomori, a severe form of social withdrawal, has been recognized as an important global public health problem. However, estimates of the worldwide Hikikomori prevalence have been inconsistent. This study aimed to provide a comprehensive assessment of the cross-cultural prevalence of Hikikomori through a meta-analysis and systematic review.</p><p><strong>Methods: </strong>We systematically searched multiple databases (including PubMed, EMBASE, PsycINFO, and Web of Science) for relevant studies. Pooled prevalence estimates were calculated using a random-effects model. Subgroup analyses for categorical variables and meta-regression analyses for continuous variables were performed to identify potential moderators of Hikikomori prevalence estimates.</p><p><strong>Results: </strong>A total of 19 studies based on 58,229 participants were included for analysis. The overall prevalence of Hikikomori was 8.0% (95% CI, 4.9%-12.9%). The prevalence of Hikikomori did not differ significantly between regions (East Asia and Western), time periods (pre- and post-COVID-19 pandemic), sex, sample size, or presence versus absence of psychiatric disorders. In contrast, higher prevalence rates were reported in studies using the 25-item Hikikomori Questionnaire (HQ-25) (21.7%; 95% CI, 11.8%-36.4%) versus other questionnaires (5.0%; 95% CI, 3.1%-7.9%, [P < 0.01]) and nonprobability sampling (12.5%; 95% CI, 7.9%-19.2%) versus probability sampling methods (3.1%; 95% CI, 1.4%-6.9% [P < 0.01]). Lower study quality (coefficient = -0.45, P = 0.03) and older age were also linked to higher prevalence (coefficient = 0.10, P = 0.01).</p><p><strong>Conclusion: </strong>This meta-analysis suggests that Hikikomori is a common problem globally. The results highlight the importance of using standardized diagnostic tools as well as further research on moderating factors and intervention methods to alleviate disabling experiences associated with Hikikomori.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"138-146"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with moderate to severe cognitive impairment: A randomized controlled trial.","authors":"Jing Li, Dan Jiang, Xingyu Huang, Xiao Wang, Tingting Xia, Wei Zhang","doi":"10.1111/pcn.13779","DOIUrl":"10.1111/pcn.13779","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to assess the therapeutic effects of intermittent theta burst stimulation (iTBS) targeting the bilateral dorsomedial prefrontal cortex (DMPFC) on negative symptoms in patients with schizophrenia, utilizing functional near-infrared spectroscopy for evaluation.</p><p><strong>Methods: </strong>Thirty-five schizophrenia patients with negative symptoms and moderate to severe cognitive impairment were randomly assigned to a treatment group (n = 18) or a control group (n = 17). The treatment group received iTBS via bilateral DMPFC. Negative symptoms, cognitive function, emotional state, and social function were assessed using Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Montreal Cognitive Assessment (MoCA), Calgary Depression Scale for Schizophrenia (CDSS), and Social Dysfunction Screening Questionnaire (SDSS) scales at pretreatment, posttreatment, and follow-up at 4, 8, and 12 weeks. Brain activation in regions of interest (ROIs) was evaluated through verbal fluency tasks.</p><p><strong>Results: </strong>Prior to treatment there was no significant difference in the two groups. After 20 iTBS sessions, a significant difference was observed in SANS total score, its related subscales, PANSS total score, and PANSS-negative symptoms (all P < 0.05). The group-by-time interaction showed statistical significance, indicating improvements in negative symptoms and related dimensions over time, with therapeutic effects persisting for at least 8 weeks posttreatment. Prior to treatment, there were no significant differences in activation across all ROIs between the two groups. Posttreatment, the activation of right inferior frontal gyrus (t = 2.19, P = 0.036) and right frontal eye field (t = 2.14, P = 0.04) in the treatment group was significantly higher than in the control group.</p><p><strong>Conclusions: </strong>iTBS stimulation of bilateral DMPFC demonstrates therapeutic effects in improving negative symptoms in schizophrenia patients, and this treatment approach has the potential to enhance activation within the prefrontal cortex.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"147-157"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic approach for neuropsychiatric symptoms using neuroimage.","authors":"Shinsuke Koike","doi":"10.1111/pcn.13801","DOIUrl":"https://doi.org/10.1111/pcn.13801","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"79 4","pages":"137"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCN Art Brut Series No. 44, Artwork Description.","authors":"Kenjiro Hosaka","doi":"10.1111/pcn.13820","DOIUrl":"https://doi.org/10.1111/pcn.13820","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"79 4","pages":"209"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of kynurenine pathway metabolites in the severity of patients with obsessive-compulsive disorder.","authors":"Hamit Hakan Alp, Faruk Kurhan, Halil İbrahim Akbay","doi":"10.1111/pcn.13819","DOIUrl":"https://doi.org/10.1111/pcn.13819","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by repetitive thoughts and behaviors. The kynurenine pathway has been increasingly implicated in psychiatric disorders. This study aimed to investigate the predictive value of kynurenine pathway metabolites, including serotonin and tryptophan, in patients with varying degrees of OCD.</p><p><strong>Methods: </strong>One hundred fifty OCD patients and 30 healthy controls were included in this study. Patients were divided into mild-moderate, severe, and extremely severe OCD groups based on their Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores. Serum levels of serotonin, tryptophan, kynurenine, kynurenic acid, indolamine 2,3-dioxygenase (IDO), tryptophan 2,3-dioxygenase (TDO), 3-hydroxykynurenine, quinolinic acid and picolinic acid were measured using enzyme-linked immunosorbent assay. Logistic regression and receiver operating characteristic (ROC) analysis were performed to evaluate the predictive value of these analytes for OCD severity.</p><p><strong>Results: </strong>Serotonin and tryptophan levels were significantly decreased in OCD patients compared to healthy controls, while kynurenine pathway metabolites were significantly increased in patients with OCD. Serum levels of kynurenine pathway metabolites increased with severity in OCD patients. As a result of ROC analysis, serotonin, tryptophan and kynurenine pathway metabolites had higher AUC values in distinguishing OCD patients from healthy volunteers, while kynurenine and tryptophan had higher AUC values in distinguishing disease severity.</p><p><strong>Conclusion: </strong>This study clarifies the role of the kynurenine pathway in the pathophysiology of OCD and suggests that kynurenine pathway metabolites, especially kynurenine, may serve as useful biomarkers to diagnose and differentiate OCD severity. Further research is needed to confirm these findings and explore therapeutic implications.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}