Psychiatry and Clinical Neurosciences最新文献

{"title":"PCN Art Brut Series No. 53, Artwork Description.","authors":"Kenjiro Hosaka","doi":"10.1111/pcn.70150","DOIUrl":"https://doi.org/10.1111/pcn.70150","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"80 10","pages":"872"},"PeriodicalIF":5.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe, protracted lithium intoxication with delayed serum surge after 5 days of low-dose exposure: A case report.","authors":"Yan Qi Lim, Jia-Ru Li, Kai-Chun Yang","doi":"10.1111/pcn.70123","DOIUrl":"10.1111/pcn.70123","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"868-869"},"PeriodicalIF":5.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bodily self in fibromyalgia: A systematic review and meta-analysis of body image, body representation, and interoceptive dysfunction.","authors":"Martina Mesce, Matteo Scalzeri, Carmen M Galvez-Sánchez, Julio A Camacho-Ruiz, Rosa M Limiñana-Gras, Federica Galli","doi":"10.1111/pcn.70099","DOIUrl":"10.1111/pcn.70099","url":null,"abstract":"<p><p>Fibromyalgia is a complex chronic pain condition associated with widespread symptoms and perceptual distortions beyond nociception. Alterations in body image, body representation, and interoception may contribute to symptom severity and reduced quality of life. This review synthesizes evidence related to body image in adults with fibromyalgia. A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. PubMed, Scopus, and Web of Science were searched. Eligible studies included quantitative and qualitative designs examining body image, body awareness, and body esteem in adults with fibromyalgia. Risk of bias was assessed using the Newcastle-Ottawa Scale and the CASP checklist. A random-effects meta-analysis was performed. Meta-regression and subgroup analyses explored sources of variance. Twenty-five studies were included. Patients with fibromyalgia showed significant impairments in body image, body awareness, and body esteem compared to healthy controls and other rheumatic conditions (pooled ES = 0.99; 95% CI [0.64-1.35]). These disturbances were positively associated with pain intensity and disease impact, and negatively with quality of life, anxiety, depression, and alexithymia. Qualitative findings described bodily alienation and transformation of bodily identity. Evidence was limited by cross-sectional designs and variability in outcome measures. Fibromyalgia involves multidimensional disturbances of the bodily self with perceptual, cognitive, and affective components, associated with greater symptom burden and poorer quality of life. Longitudinal and mixed-methods research integrating neurobiological and subjective measures is needed, alongside standardized tools and targeted interventions for body awareness and interoceptive regulation.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"813-829"},"PeriodicalIF":5.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From entertainment to clinical exposure: AI companions in Taiwanese psychiatric risk assessment.","authors":"Chuan Yen Hsu, Lien-Chung Wei","doi":"10.1111/pcn.70102","DOIUrl":"10.1111/pcn.70102","url":null,"abstract":"<p><p>This article relates to AI companions and synthetic intimacy: An emerging blind spot in psychiatric risk assessment.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"870-871"},"PeriodicalIF":5.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to translating social incentive deficits in treatment-resistant schizophrenia into rehabilitation targets.","authors":"Simon S Y Lui, Raymond C K Chan","doi":"10.1111/pcn.70140","DOIUrl":"https://doi.org/10.1111/pcn.70140","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct pattern in bipolar depression and major depressive disorder: A multiscale imaging-transcriptomic analysis.","authors":"Guangwei Sun, Taipeng Sun, Yucheng Yuan, Yubo Zhang, Yue Zhou, Shiyi Ye, Yingying Yue, Wenbin Guo, Wenhao Jiang, Chenguang Jiang, Yonggui Yuan","doi":"10.1111/pcn.70137","DOIUrl":"https://doi.org/10.1111/pcn.70137","url":null,"abstract":"<p><strong>Aim: </strong>Bipolar depression (BDD) and major depressive disorder (MDD) share similar depressive symptoms but differ in diagnosis, treatment, and prognosis. Clarifying their neurobiological distinctions may improve diagnostic characterization and mechanistic understanding.</p><p><strong>Methods: </strong>We studied 453 participants, including 85 patients with BDD, 190 with MDD, and 178 healthy controls. Individual morphometric similarity networks (MSN) were constructed using seven structural and diffusion MRI features. Regional MSN differences between BDD and MDD were examined at the parcel level. To characterize the biological relevance of the distinct MSN pattern, we performed imaging-transcriptomic analysis using Allen Human Brain Atlas data, followed by gene enrichment, cell-type enrichment, receptor/transporter dominance analysis, and cognitive meta-analytic decoding. Sensitivity analyses evaluated the effects of medication exposure and demographic imbalance.</p><p><strong>Results: </strong>Compared with MDD, BDD showed distinct MSN alterations mainly in parietal and occipital regions, including higher MSN in the left lateral occipital cortex and lower MSN in the right inferior and superior parietal cortices. The spatial transcriptomic pattern was enriched for ribosomal and protein synthesis/modification pathways. Cell-type enrichment analyses showed that the transcriptomic pattern associated with the MSN differences was enriched for microglial and inhibitory-neuron gene signatures, while receptor dominance analysis identified the 5-HT_2A density map as having the largest relative contribution to the explained spatial variance.</p><p><strong>Conclusion: </strong>Our findings identify distinct cortical morphometric organization in BDD and MDD, and these differences are linked to transcriptomic, cellular, and neurotransmitter-related annotations, providing multiscale insights into the neurobiological divergence between the two disorders.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Practice Guidelines for Bipolar Disorder by the JSMD (Japanese Society of Mood Disorders)\".","authors":"","doi":"10.1111/pcn.70135","DOIUrl":"https://doi.org/10.1111/pcn.70135","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental validation of neurofilament light chain for methamphetamine recurrence risk.","authors":"Yu-Chun Tsai, Lien-Chung Wei","doi":"10.1111/pcn.70138","DOIUrl":"https://doi.org/10.1111/pcn.70138","url":null,"abstract":"<p><p>This article relates to Incremental validation of neurofilament light chain for methamphetamine recurrence risk.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hitting and missing on consciousness.","authors":"Tomoya Nakamura, Matthias Michel, Hakwan Lau","doi":"10.1111/pcn.70136","DOIUrl":"https://doi.org/10.1111/pcn.70136","url":null,"abstract":"<p><p>Disturbances of conscious experience are central features of many psychiatric and mental health disorders. Experimental studies of conscious perception are therefore increasingly cited in clinical and translational work under the assumption that they identify neural mechanisms specific to subjective experience. Over the past decades, recording and analysis techniques have advanced substantially and many candidate neural markers of consciousness have been proposed; however, these markers may not genuinely reflect consciousness per se unless the underlying experimental paradigms are sufficiently stringent. We focus on one of the most widely used paradigms in basic and clinical research on consciousness: contrasting successful and unsuccessful detection of near-threshold sensory stimuli (\"Hit & Miss\" paradigms). Reporting stimulus presence depends not only on subjective experience but also on decision criteria that can vary independently of any genuine conscious threshold, as well as on fluctuations in perceptual processing capacity and prestimulus cognitive states. We explain why proposed refinements, such as the Perceptual Awareness Scale, binocular rivalry, and no-report paradigms, do not fully resolve these problems, and why many putative \"neural correlates of consciousness\" may instead index more general cognitive/perceptual capacities. These confounds have important implications for how basic consciousness research is interpreted in relation to hallucinations, flashbacks, and other disorders of experience. We outline alternative experimental strategies, inspired in part by blindsight and related dissociation paradigms, that more cleanly separate conscious perception from decision criteria and perceptual capacity, and may therefore provide a more reliable foundation for linking neural data to subjective experience in psychiatry and clinical neuroscience.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Levels of Blood Neurofilament Light Chain in Substance-Using Populations: A Systematic Review and Meta-Analysis.","authors":"João Antônio Valadão Leal, Thiago Wendt Viola, Rodrigo Grassi-Oliveira","doi":"10.1111/pcn.70134","DOIUrl":"https://doi.org/10.1111/pcn.70134","url":null,"abstract":"<p><p>Substance-use disorders are increasingly linked to structural and functional brain alterations consistent with neuroaxonal injury. Neurofilament light chain (NfL) is a sensitive blood-based marker of axonal damage, but evidence in substance-using populations remains fragmented. We systematically reviewed and meta-analyzed blood NfL levels in individuals who use psychoactive substances compared with controls. This PRISMA-guided systematic review and meta-analysis was registered in PROSPERO (CRD420251270728). MEDLINE, PubMed, Embase, and Scopus were searched from inception through August 23, 2026, without language or publication-date restrictions. Eligible observational studies measured blood NfL in plasma, serum, or whole blood among individuals with psychoactive substance use and controls. Effect sizes were calculated as geometric mean ratios (GMRs). Multilevel random-effects models accounted for correlated comparisons within studies, and meta-regression explored demographic, clinical, and methodological moderators. Eleven studies comprising 16 comparisons were included. Overall, individuals who use substances had significantly higher blood NfL levels than controls (GMR = 1.81, 95% CI: 1.49-2.20). Alcohol-specific analyses showed a larger pooled effect (GMR = 2.09, 95% CI: 1.62-2.70). In studies restricted to SIMOA assays, the association remained significant, although attenuated (GMR = 1.64, 95% CI: 1.41-1.91). Meta-regression indicated that higher male representation was associated with larger effect sizes, while most clinical and methodological moderators were nonsignificant. Graphical diagnostics did not suggest marked publication bias. Overall, substance use was associated with higher circulating NfL, a non-specific signal consistent with increased neurobiological burden but not sufficient on its own to establish the presence, anatomical source, or cause of neuroaxonal injury.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}