Psychiatry and Clinical Neurosciences最新文献

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Potential Role of Anti-Inflammatory Cytokines in Postpartum Depression: Considerations for Future Research and Improvement. 抗炎细胞因子在产后抑郁症中的潜在作用:未来研究和改进的考虑因素。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-03-01 DOI: 10.1111/pcn.13586
Vanessa Veltre, Lothar Vidal, David F Lo
{"title":"Potential Role of Anti-Inflammatory Cytokines in Postpartum Depression: Considerations for Future Research and Improvement.","authors":"Vanessa Veltre, Lothar Vidal, David F Lo","doi":"10.1111/pcn.13586","DOIUrl":"10.1111/pcn.13586","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa. 神经性厌食症患者海马亚区的差异纵向变化。
IF 5 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-01-03 DOI: 10.1111/pcn.13626
Klaas Bahnsen, Marie-Louis Wronski, Johanna Louise Keeler, Joseph A King, Quirina Preusker, Theresa Kolb, Kerstin Weidner, Veit Roessner, Fabio Bernardoni, Stefan Ehrlich
{"title":"Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa.","authors":"Klaas Bahnsen, Marie-Louis Wronski, Johanna Louise Keeler, Joseph A King, Quirina Preusker, Theresa Kolb, Kerstin Weidner, Veit Roessner, Fabio Bernardoni, Stefan Ehrlich","doi":"10.1111/pcn.13626","DOIUrl":"10.1111/pcn.13626","url":null,"abstract":"<p><strong>Background: </strong>Anorexia nervosa (AN) is a mental disorder characterized by dietary restriction, fear of gaining weight, and distorted body image. Recent studies indicate that the hippocampus, crucial for learning and memory, may be affected in AN, yet subfield-specific effects remain unclear. We investigated hippocampal subfield alterations in acute AN, changes following weight restoration, and their associations with leptin levels.</p><p><strong>Methods: </strong>T1-weighted magnetic resonance imaging scans were processed using FreeSurfer. We compared 22 left and right hemispheric hippocampal subfield volumes cross-sectionally and longitudinally in females with acute AN (n = 165 at baseline, n = 110 after partial weight restoration), healthy female controls (HCs; n = 271), and females after long-term recovery from AN (n = 79) using linear models.</p><p><strong>Results: </strong>We found that most hippocampal subfield volumes were significantly reduced in patients with AN compared with HCs (~-3.9%). Certain areas such as the subiculum exhibited no significant reduction in the acute state of AN, while other areas, such as the hippocampal tail, showed strong decreases (~-9%). Following short-term weight recovery, most subfields increased in volume. Comparisons between participants after long-term weight-recovery and HC yielded no differences. The hippocampal tail volume was positively associated with leptin levels in AN independent of body mass index.</p><p><strong>Conclusions: </strong>Our study provides evidence of differential volumetric differences in hippocampal subfields between individuals with AN and HC and almost complete normalization after weight rehabilitation. These alterations are spatially inhomogeneous and more pronounced compared with other major mental disorders (e.g. major depressive disorder and schizophrenia). We provide novel insights linking hypoleptinemia to hippocampal subfield alterations hinting towards clinical relevance of leptin normalization in AN recovery.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The trajectory of depressive symptoms over time and the presence of depressive symptoms at a single time point with the risk of dementia among US older adults: A national prospective cohort study. 美国老年人抑郁症状随时间的发展轨迹以及抑郁症状在单一时间点与痴呆风险的关系:一项全国前瞻性队列研究
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-03-01 Epub Date: 2023-12-07 DOI: 10.1111/pcn.13620
Min Du, Min Liu, Jue Liu
{"title":"The trajectory of depressive symptoms over time and the presence of depressive symptoms at a single time point with the risk of dementia among US older adults: A national prospective cohort study.","authors":"Min Du, Min Liu, Jue Liu","doi":"10.1111/pcn.13620","DOIUrl":"10.1111/pcn.13620","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to assess the association between trajectories of depressive symptoms and the risk of dementia, and to compare the predictive ability of trajectories using multiple data points with depressive symptoms at a single data point.</p><p><strong>Methods: </strong>We included 5306 older adults from the Health and Retirement Study. We assessed depressive symptoms using the Center for Epidemiology Depression Scale (CES-D), and identified its 8- year trajectories (2002-2010) using latent class trajectory modeling. We calculated hazard ratios (HR) using Cox proportional hazards models. The concordance index (C-index) was used to compare the discriminative power of the models.</p><p><strong>Results: </strong>We identified two trajectories of depressive symptoms, characterized by maintaining low CES-D scores, and moderate starting scores that steadily increased throughout the follow-up period. During 40,199 person-years, compared to the low trajectory, the increasing trajectory of depressive symptoms was associated with a higher risk of dementia (HR = 1.35; 95% CI: 1.09-1.67) (C-index = 0.759). For every point increase in the degree of depressive symptoms (CES-D scores) in 2010, the risk of dementia increased by 7% (95% CI: 1.03-1.12) (C-index = 0.760). The presence of depressive symptoms (CES-D scores ≥3) in 2010 was not associated with an increased risk of dementia (HR = 1.18; 95% CI: 0.98-1.43) (C-index = 0.759). The C-index values of cox models showed similar discriminative power.</p><p><strong>Conclusions: </strong>The increasing trajectory of depressive symptoms at multiple data points and the degree of depressive symptoms at a single data point were associated with an increased risk of subsequent dementia among older adults.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary role of dextromethorphan in prolonged toxic encephalopathy with intermittent rhythmic slow-wave activity on electroencephalogram: A case report. 右美沙芬在脑电图间歇性节律性慢波活动的长期中毒性脑病中的主要作用:病例报告。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-01-23 DOI: 10.1111/pcn.13634
Takeshi Sasaki, Kosuke Mizoguchi, Keiko Genda, Shoko Endo, Yuki Kondo, Tomoko Mikami, Hiroshi Arakaki
{"title":"Primary role of dextromethorphan in prolonged toxic encephalopathy with intermittent rhythmic slow-wave activity on electroencephalogram: A case report.","authors":"Takeshi Sasaki, Kosuke Mizoguchi, Keiko Genda, Shoko Endo, Yuki Kondo, Tomoko Mikami, Hiroshi Arakaki","doi":"10.1111/pcn.13634","DOIUrl":"10.1111/pcn.13634","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depressive symptoms and carotid arteriosclerosis in very old people aged 85 years and older: A cross-sectional study by the Kawasaki Aging and Wellbeing Project. 85 岁及以上高龄老人的抑郁症状和颈动脉硬化:川崎老龄化与福祉项目的横断面研究。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-01-25 DOI: 10.1111/pcn.13636
Ryo Shikimoto, Takashi Sasaki, Yukiko Abe, Yoshinori Nishimoto, Takumi Hirata, Masaru Mimura, Yasumichi Arai
{"title":"Depressive symptoms and carotid arteriosclerosis in very old people aged 85 years and older: A cross-sectional study by the Kawasaki Aging and Wellbeing Project.","authors":"Ryo Shikimoto, Takashi Sasaki, Yukiko Abe, Yoshinori Nishimoto, Takumi Hirata, Masaru Mimura, Yasumichi Arai","doi":"10.1111/pcn.13636","DOIUrl":"10.1111/pcn.13636","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the potential of machine learning in schizophrenia diagnosis: A meta-analytic study of task-based neuroimaging data. 揭示机器学习在精神分裂症诊断中的潜力:基于任务的神经成像数据的元分析研究。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-03-01 Epub Date: 2023-12-29 DOI: 10.1111/pcn.13625
Xuan Wang, Chao Yan, Peng-Yuan Yang, Zheng Xia, Xin-Lu Cai, Yi Wang, Sze Chai Kwok, Raymond C K Chan
{"title":"Unveiling the potential of machine learning in schizophrenia diagnosis: A meta-analytic study of task-based neuroimaging data.","authors":"Xuan Wang, Chao Yan, Peng-Yuan Yang, Zheng Xia, Xin-Lu Cai, Yi Wang, Sze Chai Kwok, Raymond C K Chan","doi":"10.1111/pcn.13625","DOIUrl":"10.1111/pcn.13625","url":null,"abstract":"<p><p>The emergence of machine learning (ML) techniques has opened up new avenues for identifying biomarkers associated with schizophrenia (SCZ) using task-related fMRI (t-fMRI) designs. To evaluate the effectiveness of this approach, we conducted a comprehensive meta-analysis of 31 t-fMRI studies using a bivariate model. Our findings revealed a high overall sensitivity of 0.83 and specificity of 0.82 for t-fMRI studies. Notably, neuropsychological domains modulated the classification performance, with selective attention demonstrating a significantly higher specificity than working memory (β = 0.98, z = 2.11, P = 0.04). Studies involving older, chronic patients with SCZ reported higher sensitivity (P <0.015) and specificity (P <0.001) than those involving younger, first-episode patients or high-risk individuals for psychosis. Additionally, we found that the severity of negative symptoms was positively associated with the specificity of the classification model (β = 7.19, z = 2.20, P = 0.03). Taken together, these results support the potential of using task-based fMRI data in combination with machine learning techniques to identify biomarkers related to symptom outcomes in SCZ, providing a promising avenue for improving diagnostic accuracy and treatment efficacy. Future attempts to deploy ML classification should consider the factors of algorithm choice, data quality and quantity, as well as issues related to generalization.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the performance of ChatGPT GPT-4, Bard, and Llama-2 in the Taiwan Psychiatric Licensing Examination and in differential diagnosis with multi-center psychiatrists 比较 ChatGPT GPT-4、Bard 和 Llama-2 在台湾精神科执照考试中的表现,以及与多中心精神科医生在鉴别诊断中的表现
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-02-26 DOI: 10.1111/pcn.13656
Dian-Jeng Li, Yu-Chen Kao, Shih-Jen Tsai, Ya-Mei Bai, Ta-Chuan Yeh, Che-Sheng Chu, Chih-Wei Hsu, Szu-Wei Cheng, Tien-Wei Hsu, Chih-Sung Liang, Kuan-Pin Su
{"title":"Comparing the performance of ChatGPT GPT-4, Bard, and Llama-2 in the Taiwan Psychiatric Licensing Examination and in differential diagnosis with multi-center psychiatrists","authors":"Dian-Jeng Li, Yu-Chen Kao, Shih-Jen Tsai, Ya-Mei Bai, Ta-Chuan Yeh, Che-Sheng Chu, Chih-Wei Hsu, Szu-Wei Cheng, Tien-Wei Hsu, Chih-Sung Liang, Kuan-Pin Su","doi":"10.1111/pcn.13656","DOIUrl":"https://doi.org/10.1111/pcn.13656","url":null,"abstract":"Large language models (LLMs) have been suggested to play a role in medical education and medical practice. However, the potential of their application in the psychiatric domain has not been well-studied.","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139967777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain 阿片受体μ1和儿茶酚-O-甲基转移酶的功能多态性对疼痛神经处理的影响
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-02-25 DOI: 10.1111/pcn.13648
Yongjeon Cheong, Seonkyoung Lee, Hidehiko Okazawa, Hirotaka Kosaka, Minyoung Jung
{"title":"Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain","authors":"Yongjeon Cheong, Seonkyoung Lee, Hidehiko Okazawa, Hirotaka Kosaka, Minyoung Jung","doi":"10.1111/pcn.13648","DOIUrl":"https://doi.org/10.1111/pcn.13648","url":null,"abstract":"Pain is reconstructed by brain activities and its subjectivity comes from an interplay of multiple factors. The current study aims to understand the contribution of genetic factors to the neural processing of pain. Focusing on the single-nucleotide polymorphism (SNP) of opioid receptor mu 1 (OPRM1) <i>A</i><sup><i>118</i></sup><i>G</i> (rs1799971) and catechol-O-methyltransferase (COMT) <i>val</i><sup><i>158</i></sup><i>met</i> (rs4680), we investigated how the two pain genes affect pain processing.","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139967470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma neurofilament light chain in association to late-life depression in the general population. 血浆神经丝轻链与普通人群晚期抑郁症的关系。
IF 5 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-02-01 Epub Date: 2023-11-07 DOI: 10.1111/pcn.13608
Isabel K Schuurmans, Mohsen Ghanbari, Charlotte A M Cecil, M Arfan Ikram, Annemarie I Luik
{"title":"Plasma neurofilament light chain in association to late-life depression in the general population.","authors":"Isabel K Schuurmans, Mohsen Ghanbari, Charlotte A M Cecil, M Arfan Ikram, Annemarie I Luik","doi":"10.1111/pcn.13608","DOIUrl":"10.1111/pcn.13608","url":null,"abstract":"<p><strong>Aim: </strong>Investigating what is underlying late-life depression is becoming increasingly important with the rapidly growing elderly population. Yet, the associations between plasma biomarkers of neuroaxonal damage and late-life depression remain largely unclear. Therefore, we determined cross-sectional and longitudinal associations of neurofilament light chain (NfL) with depression in middle-aged and elderly individuals, and total tau, β-amyloid 40 and 42 for comparison.</p><p><strong>Methods: </strong>We included 3,895 participants (71.78 years [SD = 7.37], 53.4% women) from the population-based Rotterdam Study. Between 2002 and 2005, NfL, total tau, β-amyloid 40 and β-amyloid 42 were determined in blood and depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Incident depressive events (clinically relevant depressive symptoms, depressive syndromes, major depressive disorders) were measured prospectively with the Center for Epidemiologic Studies Depression, a clinical interview and follow-up of medical records over a median follow-up of 7.0 years (interquartile range 1.80). We used linear and Cox proportional hazard regression models.</p><p><strong>Results: </strong>Each log<sub>2</sub> pg./mL increase in NfL was cross-sectionally associated with more depressive symptoms (adjusted mean difference: 0.32, 95% CI 0.05-0.58), as well as with an increased risk of any incident depressive event over time (hazard ratio: 1.22, 95% CI 1.01-1.47). Further, more amyloid-β 40 was cross-sectionally associated with more depressive symptoms (adjusted mean difference: 0.70, 95% CI 0.15-1.25).</p><p><strong>Conclusion: </strong>Higher levels of NfL are cross-sectionally associated with more depressive symptoms and a higher risk of incident depressive events longitudinally. The association was stronger for NfL compared to other plasma biomarkers, suggesting a potential role of neuroaxonal damage in developing late-life depression.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41238193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropsychiatric symptoms and incident Lewy body dementia in male versus female older adults with mild cognitive impairment. 老年轻度认知障碍男性与女性的神经精神症状和路易体痴呆发生率
IF 5 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-02-01 Epub Date: 2023-12-15 DOI: 10.1111/pcn.13621
Ioannis Liampas, Vasileios Siokas, Elli Zoupa, Constantine G Lyketsos, Efthimios Dardiotis
{"title":"Neuropsychiatric symptoms and incident Lewy body dementia in male versus female older adults with mild cognitive impairment.","authors":"Ioannis Liampas, Vasileios Siokas, Elli Zoupa, Constantine G Lyketsos, Efthimios Dardiotis","doi":"10.1111/pcn.13621","DOIUrl":"10.1111/pcn.13621","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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