Psychiatry and Clinical Neurosciences最新文献

{"title":"Recurrent hypersomnia following infections: A Kleine-Levin syndrome-like presentation with thalamic hypoperfusion.","authors":"Shan Hung, Hsi Chang","doi":"10.1111/pcn.70081","DOIUrl":"10.1111/pcn.70081","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"628-629"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Durability of zuranolone in postpartum depression versus major depressive disorder.","authors":"Masaki Kato, Kazuyuki Nakagome, Takamichi Baba, Takuhiro Sonoyama, Hiroki Fukuju, Ryosuke Shimizu, Juan Carlos Gomez, Tomoko Motomiya, Takeshi Inoue","doi":"10.1111/pcn.70076","DOIUrl":"10.1111/pcn.70076","url":null,"abstract":"<p><p>This article relates to Response to Durability of zuranolone in postpartum depression versus major depressive disorder.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"631-632"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent risk of falls associated with hypnotic use in hospitalized patients.","authors":"Kazuhiro Shishida, Yutaro Shimomura, Masayuki Murayama, Kimio Yoshimura, Hiroyuki Uchida, Masaru Mimura, Hiroyoshi Takeuchi","doi":"10.1111/pcn.70057","DOIUrl":"10.1111/pcn.70057","url":null,"abstract":"<p><strong>Aim: </strong>Falls are a common and serious problem among hospitalized patients. While hypnotics are a known risk factor, it remains unclear whether fall risk varies by time of day. This study examined the time-dependent risk of falls associated with different classes of hypnotics.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of patients aged ≥20 years who had their first admission to our hospital and were discharged between April 2016 and March 2018. Time-to-fall was analyzed using stepwise Cox proportional hazards models across four time periods (0:00-5:59, 6:00-11:59, 12:00-17:59, 18:00-23:59). Covariates included hypnotic use (Z-drugs, short-acting benzodiazepines, long-acting benzodiazepines, ramelteon, suvorexant, trazodone), age, sex, body mass index (BMI), length of stay, activities of daily living score, emergency admission, and surgery.</p><p><strong>Results: </strong>Among the 22,458 patients included in the study, 268 falls occurred, with 73, 65, 56, and 74 in each time period, respectively. Association between hypnotic use and fall risk varied by time. Z-drugs were associated with falls during 18:00-23:59 (adjusted hazard ratio [aHR] 2.65, 95% confidence interval [CI] 1.29-5.45). Short-acting benzodiazepines were associated with falls during 00:00-05:59 (aHR 2.06, 95% CI 1.07-3.97). Long-acting benzodiazepines were associated with falls during 06:00-11:59 (aHR 3.37, 95% CI 1.20-9.26). No significant associations were observed for ramelteon, suvorexant, or trazodone.</p><p><strong>Conclusions: </strong>Fall risk associated with hypnotic use is not uniform throughout the day. Short-acting benzodiazepines were linked to evening and nighttime falls, while long-acting benzodiazepines increased morning fall risk. These findings highlighted the need to consider time-specific fall risks when prescribing hypnotics.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"595-602"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross-sectional study.","authors":"Minxia Jin, Adam W L Xia, Wanda M W Chau, Nancy M X Y Shi, Penny P Qin, Bella B B Zhang, Rebecca L D Kan, Alvin H P Tang, Tim T Z Lin, Sharie X Wang, Dicky W S Chung, Frank Padberg, Georg S Kranz","doi":"10.1111/pcn.70066","DOIUrl":"10.1111/pcn.70066","url":null,"abstract":"<p><strong>Background: </strong>Mounting evidence has indicated that multiple major depressive disorder (MDD) episodes are correlated with brain morphometric changes that confer an increased recurrence risk. Functional abnormalities underlying this recurrent vulnerability remain underexplored. Acute neuroplastic responses to repetitive transcranial magnetic stimulation hold promise to identify such functional alterations.</p><p><strong>Methods: </strong>This study involved 121 adults, including 39 individuals with current MDD, 41 individuals with MDD in remission, and 41 healthy controls. Cross-sectional changes in hemodynamic responses and functional connectivity induced by a single session of intermittent theta burst stimulation over the left dorsolateral prefrontal cortex (dlPFC) were measured using simultaneous functional near-infrared spectroscopy and analyzed with linear mixed models. Hierarchical regression examined the relationships between the number of prior depressive episodes and observed functional changes in patient cohorts.</p><p><strong>Results: </strong>Stimulation instantly elevated deoxyhemoglobin levels in the stimulated dlPFC across all participants, with greater increases in patient cohorts versus controls, demonstrating a persistent disease effect regardless of prior episodes or remitted state. Poststimulation increases in oxyhemoglobin concentration were current depression-dependent and associated with multiple episodes in remitted patients. Prefrontal networks were characterized by a transient reduction in global node degree during stimulation in all groups.</p><p><strong>Conclusions: </strong>Our findings align with clinical and preclinical evidence linking disrupted neurovascular function in the prefrontal cortex to depression pathophysiology. Poststimulation responses in the stimulated dlPFC, reflecting the current state and multiple prior episodes, show potential for aiding in differential diagnosis and indicating depression vulnerability. Longitudinal studies are needed to determine whether such neurological dysfunctions represent disease progression or a vulnerability biomarker.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"616-625"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of virtual reality in forensic-correctional psychiatric settings: A systematic review.","authors":"Michael Y Wang, Eric Yu, Rida Tauqir, Maya Mckeown, Shahnawaz Towheed, Mark M Kaggwa, John M Bradford, Gary A Chaimowitz, Andrew T Olagunju","doi":"10.1111/pcn.70068","DOIUrl":"10.1111/pcn.70068","url":null,"abstract":"<p><p>Virtual reality (VR) is increasingly being used as an innovative technology for assessment, treatment, and training within psychiatric settings. However, little work has been done to synthesize existing literature on the use and benefits of VR in forensic-correctional settings. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Protocol is available at Open Science Framework (https://osf.io/3m6p2). A total of 1317 articles were screened, and 32 reports were included in the final review. VR interventions were identified as effective in forensic-correctional settings for assessment of patients with pedophilic disorders, reducing aggression and stress, increasing empathy in intimate partner violence (IPV) offenders, enhancing community reintegration through education and vocational readiness, and improving patient engagement. Furthermore, VR allows innovative incorporation of biophysiological measures to support objective and quantifiable measures of risk within forensic-correctional populations. Barriers to VR use and implementation included cybersickness in users, the knowledge and technical burden to utilize interventions, and the demand for resources. The quality of the included studies was assessed as predominantly moderate. Overall, the findings in this review highlight the promising benefits of VR as an innovative tool for assessments and care in forensic-correctional settings. There is need for stakeholders' support, standardization of VR uses, and promotion of evidence-based guidelines for successful implementation and effective integration into care. As the integration of technologies into healthcare continues to advance, VR has the capacity to reshape mental health care within forensic-correctional settings and future research is needed to guide effective use.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"546-565"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbing dreams and dementia incidence across diverse cohort studies: A COSMIC collaboration study.","authors":"Darren M Lipnicki, Ashleigh S Vella, Erico Castro-Costa, Sergio Luis Blay, Maria Fernanda Lima-Costa, Karen Ritchie, Elena Rolandi, Annalisa Davin, Michele Rossi, Ki Woong Kim, Ji Won Han, Dae Jong Oh, Ding Ding, Qianhua Zhao, Xiaowen Zhou, Yen-Ching Chen, Jen-Hau Chen, Perminder S Sachdev","doi":"10.1111/pcn.70046","DOIUrl":"10.1111/pcn.70046","url":null,"abstract":"<p><strong>Aim: </strong>Distressing dreams were previously reported to predict future all-cause dementia among predominantly white US participants aged 79-89 years, particularly in men. We investigated whether disturbing dreams (nightmares and bad dreams) were associated with all-cause and Alzheimer dementia (AD) among individuals aged 60-89 years from diverse international regions.</p><p><strong>Methods: </strong>Data were from six longitudinal cohort studies across Brazil, China, France, Italy, South Korea, and Taiwan (n = 10,238, 42.5% men). Cox regressions with a random effect for study investigated associations between disturbing dreams and incident dementia, with all participants and stratified separately by sex and baseline age. Analyses examined (i) any disturbing dreams and (ii) disturbing dreams at least once a week. Fully adjusted analyses included three studies with covariates for sleep problems, medications, mental and physical health, cognition, and APOE ε4 status.</p><p><strong>Results: </strong>Disturbing dreams were reported by 24.2% overall and all-cause dementia, and AD incidence was 10.8 and 5.3 per 1000 person-years, respectively. In fully adjusted analyses, having any disturbing dreams was associated with increased incidence of all-cause dementia among 60-69-year-olds (hazard ratio [HR] 3.93, 95% confidence interval [CI] 1.32-11.67). There were no significant effects for older individuals. In fully adjusted sex-stratified analyses, having disturbing dreams at least once a week was associated with AD only among men (HR 3.59, 95% CI 1.44-8.96).</p><p><strong>Conclusions: </strong>We found some evidence for disturbing dreams being associated with incident all-cause dementia among individuals aged 60-69 years and with AD among men. The mechanisms potentially underlying these associations remain to be clarified.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"566-574"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI companions and synthetic intimacy: An emerging blind spot in psychiatric risk assessment.","authors":"Stjepan Škudar","doi":"10.1111/pcn.70078","DOIUrl":"10.1111/pcn.70078","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"626-627"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated transcriptomic and clinical analysis of autism spectrum disorder reveals structured heterogeneity and links Methyl-CpG Binding Domain Protein 2 expression with symptom severity.","authors":"Wasana Yuwattana, Chayanit Poolcharoen, Thanit Saeliw, Marlieke Lisanne van Erp, Songphon Kanlayaprasit, Natchaya Vanwong, Valerie W Hu, Pon Trairatvorakul, Weerasak Chonchaiya, Kim-Anh Lê Cao, Tewarit Sarachana","doi":"10.1111/pcn.70065","DOIUrl":"10.1111/pcn.70065","url":null,"abstract":"<p><strong>Aim: </strong>Autism spectrum disorder (ASD) remains underexplored in Southeast Asia, with limited characterization of its molecular underpinnings and clinical heterogeneity. This study investigated transcriptomic variation and its relationship to clinical diversity in Thai children with ASD using integrated molecular and phenotypic analyses.</p><p><strong>Method: </strong>Peripheral blood transcriptomic profiling was performed in 150 ASD and 70 typically developing (TD) children to identify differentially expressed transcripts (DETs), followed by pathway enrichment, unsupervised molecular clustering, and integrative multiomics modeling. Clinical data from 200 ASD and 110 TD participants were analyzed in parallel to evaluate screening performance and derive phenotype-based subgroups.</p><p><strong>Results: </strong>Differential expression analysis identified 1,407 DETs with significant enrichment of autism-associated genes. Pathway analysis consistently implicated dysregulation of protein-synthesis machinery. Unsupervised transcriptome-based clustering revealed three molecular subgroups characterized by translational, innate-immune, and interferon-associated signatures, which did not directly correspond to clinical severity, age, or cognitive level, indicating structured biological heterogeneity beyond symptom-based classification. Integration of transcriptomic and phenotypic data demonstrated moderate cross-domain correspondence. Among recurrent molecular signals, MBD2 showed consistent upregulation across subgroups and strong associations with social-interaction measures (r = 0.74). In parallel, clinical machine-learning models showed high within-cohort screening performance, while a refined 17-transcript panel achieved robust discriminative accuracy, supporting the complementary role of molecular features in ASD stratification.</p><p><strong>Conclusion: </strong>Transcriptomic stratification reveals biologically structured heterogeneity in ASD that is only partially reflected in clinical presentation, supporting a multilayered framework integrating molecular and phenotypic dimensions.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"603-615"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbing dreams and dementia risk across diverse populations.","authors":"Abidemi I Otaiku","doi":"10.1111/pcn.70074","DOIUrl":"10.1111/pcn.70074","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"535"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From relay station to circuit hub: Thalamic subnuclear precision and the major depressive disorder dysfunctome.","authors":"Yuehua Zhao, Jingjing Zhang, Chenfei Ye","doi":"10.1111/pcn.70062","DOIUrl":"10.1111/pcn.70062","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"437"},"PeriodicalIF":6.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}