Psychiatry and Clinical Neurosciences最新文献

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Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population 预测日本社区老年人痴呆症发展的血浆生物标志物
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-12 DOI: 10.1111/pcn.13661
Tomoyuki Ohara, Harutsugu Tatebe, Jun Hata, Takanori Honda, Mao Shibata, Sayo Matsuura, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Takahiko Tokuda, Toshiharu Ninomiya
{"title":"Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population","authors":"Tomoyuki Ohara, Harutsugu Tatebe, Jun Hata, Takanori Honda, Mao Shibata, Sayo Matsuura, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Takahiko Tokuda, Toshiharu Ninomiya","doi":"10.1111/pcn.13661","DOIUrl":"https://doi.org/10.1111/pcn.13661","url":null,"abstract":"To assess the association between plasma amyloid β (Aβ) 42/40, phosphorylated tau (p-τ)181, glial fibrillary acidic protein (GFAP), or neurofilament light chain (NfL) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population.","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"94 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140582943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between serum cytokines and timeframe for conversion from clinical high‐risk to psychosis 血清细胞因子与从临床高危转为精神病的时间框架之间的关系
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-09 DOI: 10.1111/pcn.13670
TianHong Zhang, YanYan Wei, LiHua Xu, XiaoChen Tang, YeGang Hu, HaiChun Liu, ZiXuan Wang, Tao Chen, ChunBo Li, JiJun Wang
{"title":"Association between serum cytokines and timeframe for conversion from clinical high‐risk to psychosis","authors":"TianHong Zhang, YanYan Wei, LiHua Xu, XiaoChen Tang, YeGang Hu, HaiChun Liu, ZiXuan Wang, Tao Chen, ChunBo Li, JiJun Wang","doi":"10.1111/pcn.13670","DOIUrl":"https://doi.org/10.1111/pcn.13670","url":null,"abstract":"AimAlthough many studies have explored the link between inflammatory markers and psychosis, there is a paucity of research investigating the temporal progression in individuals at clinical high‐risk (CHR) who eventually develop full psychosis. To address this gap, we investigated the correlation between serum cytokine levels and Timeframe for Conversion to Psychosis (TCP) in individuals with CHR.MethodsWe enrolled 53 individuals with CHR who completed a 5‐year follow‐up with a confirmed conversion to psychosis. Granulocyte macrophage‐colony stimulating factor (GM‐CSF), interleukin (IL)‐1β, 2, 6, 8, 10, tumor necrosis factor‐α (TNF‐α), and vascular endothelial growth factor (VEGF) levels were measured at baseline and 1‐year. Correlation and quantile regression analyses were performed.ResultsThe median TCP duration was 14 months. A significantly shorter TCP was associated with higher levels of TNF‐α (<jats:italic>P</jats:italic> = 0.022) and VEGF (<jats:italic>P</jats:italic> = 0.016). A negative correlation was observed between TCP and TNF‐α level (<jats:italic>P</jats:italic> = 0.006) and VEGF level (<jats:italic>P</jats:italic> = 0.04). Quantile regression indicated negative associations between TCP and GM‐CSF levels below the 0.5 quantile, IL‐10 levels below the 0.3 quantile, IL‐2 levels below the 0.25 quantile, IL‐6 levels between the 0.65 and 0.75 quantiles, TNF‐α levels below the 0.8 quantile, and VEGF levels below the 0.7 quantile. A mixed linear effects model identified significant time effects for IL‐10 and IL‐2, and significant group effects for changes in IL‐2 and TNF‐α.ConclusionsOur findings underscore that a more pronounced baseline inflammatory state is associated with faster progression of psychosis in individuals with CHR. This highlights the importance of considering individual inflammatory profiles during early intervention and of tailoring preventive measures for risk profiles.","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"94 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140582806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCN Art Brut Series No. 38, Artwork Description PCN 布鲁特艺术系列第 38 号,作品说明
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-08 DOI: 10.1111/pcn.13667
Kenjiro Hosaka, Yoji Hirano
{"title":"PCN Art Brut Series No. 38, Artwork Description","authors":"Kenjiro Hosaka, Yoji Hirano","doi":"10.1111/pcn.13667","DOIUrl":"https://doi.org/10.1111/pcn.13667","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"438 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The American Journal of Psychiatry: Table of Contents 美国精神病学杂志目录
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-08 DOI: 10.1111/pcn.13674
{"title":"The American Journal of Psychiatry: Table of Contents","authors":"","doi":"10.1111/pcn.13674","DOIUrl":"https://doi.org/10.1111/pcn.13674","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"44 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pragmatic and evidence-based approach to telepsychiatry-let's stop waiting for the future to arrive. 以实事求是和循证为基础的远程精神病学方法--让我们不再等待未来的到来。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-01-28 DOI: 10.1111/pcn.13639
Allison Crawford
{"title":"A pragmatic and evidence-based approach to telepsychiatry-let's stop waiting for the future to arrive.","authors":"Allison Crawford","doi":"10.1111/pcn.13639","DOIUrl":"10.1111/pcn.13639","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"219"},"PeriodicalIF":11.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acceptability of antipsychotic transdermal patch for acute schizophrenia: a systematic review and meta-analysis. 抗精神病药物透皮贴剂治疗急性精神分裂症的可接受性:系统综述与元分析》。
IF 5 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-01-28 DOI: 10.1111/pcn.13635
Taro Kishi, Leslie Citrome, Kenji Sakuma, Shun Hamanaka, Yasufumi Nishii, Nakao Iwata
{"title":"Acceptability of antipsychotic transdermal patch for acute schizophrenia: a systematic review and meta-analysis.","authors":"Taro Kishi, Leslie Citrome, Kenji Sakuma, Shun Hamanaka, Yasufumi Nishii, Nakao Iwata","doi":"10.1111/pcn.13635","DOIUrl":"10.1111/pcn.13635","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"260-262"},"PeriodicalIF":5.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration of cell type-specific somatic mutations in schizophrenia and the impact of maternal immune activation on the somatic mutation profile in the brain. 探索精神分裂症细胞特异性体细胞突变以及母体免疫激活对大脑体细胞突变的影响。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-02-09 DOI: 10.1111/pcn.13640
Jianbin Du, Yutaka Nakachi, Yui Murata, Emi Kiyota, Tadafumi Kato, Miki Bundo, Kazuya Iwamoto
{"title":"Exploration of cell type-specific somatic mutations in schizophrenia and the impact of maternal immune activation on the somatic mutation profile in the brain.","authors":"Jianbin Du, Yutaka Nakachi, Yui Murata, Emi Kiyota, Tadafumi Kato, Miki Bundo, Kazuya Iwamoto","doi":"10.1111/pcn.13640","DOIUrl":"10.1111/pcn.13640","url":null,"abstract":"<p><strong>Aim: </strong>Schizophrenia (SZ) is a severe psychiatric disorder caused by the interaction of genetic and environmental factors. Although somatic mutations that occur in the brain after fertilization may play an important role in the cause of SZ, their frequencies and patterns in the brains of patients and related animal models have not been well studied. This study aimed to find somatic mutations related to the pathophysiology of SZ.</p><p><strong>Methods: </strong>We performed whole-exome sequencing (WES) of neuronal and nonneuronal nuclei isolated from the postmortem prefrontal cortex of patients with SZ (n = 10) and controls (n = 10). After detecting somatic mutations, we explored the similarities and differences in shared common mutations between two cell types and cell type-specific mutations. We also performed WES of prefrontal cortex samples from an animal model of SZ based on maternal immune activation (MIA) and explored the possible impact of MIA on the patterns of somatic mutations.</p><p><strong>Results: </strong>We did not find quantitative differences in somatic mutations but found higher variant allele fractions of neuron-specific mutations in patients with SZ. In the mouse model, we found a larger variation in the number of somatic mutations in the offspring of MIA mice, with the occurrence of somatic mutations in neurodevelopment-related genes.</p><p><strong>Conclusion: </strong>Somatic mutations occurring at an earlier stage of brain cell differentiation toward neurons may be important for the cause of SZ. MIA may affect somatic mutation profiles in the brain.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"237-247"},"PeriodicalIF":11.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional brain connectivity prior to the COVID-19 outbreak predicts mental health trajectories during two years of pandemic. COVID-19 爆发前的大脑功能连接可预测大流行两年期间的心理健康轨迹。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-02-19 DOI: 10.1111/pcn.13654
María Cabello-Toscano, Lídia Vaqué-Alcázar, Ivet Bayes-Marin, Gabriele Cattaneo, Javier Solana-Sánchez, Lídia Mulet-Pons, Nuria Bargalló, Josep M Tormos, Alvaro Pascual-Leone, David Bartrés-Faz
{"title":"Functional brain connectivity prior to the COVID-19 outbreak predicts mental health trajectories during two years of pandemic.","authors":"María Cabello-Toscano, Lídia Vaqué-Alcázar, Ivet Bayes-Marin, Gabriele Cattaneo, Javier Solana-Sánchez, Lídia Mulet-Pons, Nuria Bargalló, Josep M Tormos, Alvaro Pascual-Leone, David Bartrés-Faz","doi":"10.1111/pcn.13654","DOIUrl":"10.1111/pcn.13654","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"262-264"},"PeriodicalIF":11.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restarting smoking after discharge from clozapine inpatient initiation: Elevated rehospitalization rates smoking & clozapine rehospitalization. 氯氮平住院病人出院后重新开始吸烟:再住院率升高。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-01-31 DOI: 10.1111/pcn.13629
Ryuhei So, Masaru Tsukahara, Shinichiro Nakajima, Hiroyoshi Takeuchi
{"title":"Restarting smoking after discharge from clozapine inpatient initiation: Elevated rehospitalization rates smoking & clozapine rehospitalization.","authors":"Ryuhei So, Masaru Tsukahara, Shinichiro Nakajima, Hiroyoshi Takeuchi","doi":"10.1111/pcn.13629","DOIUrl":"10.1111/pcn.13629","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"259-260"},"PeriodicalIF":11.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets. 中风的神经精神、认知和功能并发症的网络分析:对新型治疗目标的影响。
IF 11.9 3区 医学
Psychiatry and Clinical Neurosciences Pub Date : 2024-04-01 Epub Date: 2024-01-29 DOI: 10.1111/pcn.13633
Lena K L Oestreich, Jessica W Lo, Maria A Di Biase, Perminder S Sachdev, Alice H Mok, Paul Wright, John D Crawford, Ben Lam, Latchezar Traykov, Sebastian Köhler, Julie E A Staals, Robert van Oostenbrugge, Christopher Chen, David W Desmond, Kyung-Ho Yu, Minwoo Lee, Aleksandra Klimkowicz-Mrowiec, Régis Bordet, Michael J O'Sullivan, Andrew Zalesky
{"title":"Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets.","authors":"Lena K L Oestreich, Jessica W Lo, Maria A Di Biase, Perminder S Sachdev, Alice H Mok, Paul Wright, John D Crawford, Ben Lam, Latchezar Traykov, Sebastian Köhler, Julie E A Staals, Robert van Oostenbrugge, Christopher Chen, David W Desmond, Kyung-Ho Yu, Minwoo Lee, Aleksandra Klimkowicz-Mrowiec, Régis Bordet, Michael J O'Sullivan, Andrew Zalesky","doi":"10.1111/pcn.13633","DOIUrl":"10.1111/pcn.13633","url":null,"abstract":"<p><strong>Aim: </strong>Recovery from stroke is adversely affected by neuropsychiatric complications, cognitive impairment, and functional disability. Better knowledge of their mutual relationships is required to inform effective interventions. Network theory enables the conceptualization of symptoms and impairments as dynamic and mutually interacting systems. We aimed to identify interactions of poststroke complications using network analysis in diverse stroke samples.</p><p><strong>Methods: </strong>Data from 2185 patients were sourced from member studies of STROKOG (Stroke and Cognition Consortium), an international collaboration of stroke studies. Networks were generated for each cohort, whereby nodes represented neuropsychiatric symptoms, cognitive deficits, and disabilities on activities of daily living. Edges characterized associations between them. Centrality measures were used to identify hub items.</p><p><strong>Results: </strong>Across cohorts, a single network of interrelated poststroke complications emerged. Networks exhibited dissociable depression, apathy, fatigue, cognitive impairment, and functional disability modules. Worry was the most central symptom across cohorts, irrespective of the depression scale used. Items relating to activities of daily living were also highly central nodes. Follow-up analysis in two studies revealed that individuals who worried had more densely connected networks than those free of worry (CASPER [Cognition and Affect after Stroke: Prospective Evaluation of Risks] study: S = 9.72, P = 0.038; SSS [Sydney Stroke Study]: S = 13.56, P = 0.069).</p><p><strong>Conclusion: </strong>Neuropsychiatric symptoms are highly interconnected with cognitive deficits and functional disabilities resulting from stroke. Given their central position and high level of connectedness, worry and activities of daily living have the potential to drive multimorbidity and mutual reinforcement between domains of poststroke complications. Targeting these factors early after stroke may have benefits that extend to other complications, leading to better stroke outcomes.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"229-236"},"PeriodicalIF":11.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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