Psychiatry and Clinical Neurosciences最新文献

{"title":"Response to \"From public preferences to clinical tasks in anti-amyloid therapy for Alzheimer's disease\".","authors":"Aran Tajika","doi":"10.1111/pcn.70156","DOIUrl":"https://doi.org/10.1111/pcn.70156","url":null,"abstract":"<p><p>This article relates to From public preferences to clinical tasks in anti-amyloid therapy for Alzheimer's disease.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When hypnotic discontinuation follows surgery: A clinical signal, not a psychiatric verdict.","authors":"Damiano Tambasco, Roberta Albanese, Federica Tomaselli","doi":"10.1111/pcn.70153","DOIUrl":"https://doi.org/10.1111/pcn.70153","url":null,"abstract":"<p><p>This article relates to When hypnotic discontinuation follows surgery: A clinical signal, not a psychiatric verdict.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Commentary \"Model choice in meta-analysis should not be driven by Cochran's Q test\".","authors":"Qiaowei Lin, Huda F Al-Shamali, Kirandeep Shocker, Jahnvi Thakkar, Reinhard Janssen-Aguilar, Wendy Lou, Joshua Granek, Shawn Rhind, Benjamin T Dunkley, Isabelle Vallee, Mike Crouzat, Rakesh Jetly, Venkat Bhat","doi":"10.1111/pcn.70158","DOIUrl":"https://doi.org/10.1111/pcn.70158","url":null,"abstract":"<p><p>We clarify the rationale for the meta-analytic models used in our systematic review of hyperbaric oxygen therapy for psychiatric disorders and present additional sensitivity analyses.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of prucalopride on anxiety and depressive symptoms among constipated patients: A meta-analysis of randomized controlled trials.","authors":"Lucie Lebon, Denis J David, Matthieu Gasnier, Indira Mendez-David, Laurent Becquemont, Céline Verstuyft, René Hen, Emmanuelle Corruble, Romain Colle","doi":"10.1111/pcn.70151","DOIUrl":"https://doi.org/10.1111/pcn.70151","url":null,"abstract":"<p><strong>Aims: </strong>Prucalopride, a 5-HT₄ receptor agonist, has shown potential for rapid anxiolytic and antidepressant effects in preclinical studies. This meta-analysis aims to evaluate changes in anxiety and depressive symptoms after prucalopride treatment in chronically constipated adults.</p><p><strong>Methods: </strong>A systematic search of PubMed, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and reports from the Food and Drug Administration and European Medicines Agency was conducted from inception to 1 March 2026. Included studies were double-blind randomized controlled trials originally designed to assess effectiveness in treating chronic constipation in adults. As preplanned, the primary endpoint was the change in anxiety and depressive symptoms. Standardized mean differences (SMDs) were pooled and analyzed using a random-effects model. This study is registered with PROSPERO, number CRD42024602454.</p><p><strong>Results: </strong>Five randomized controlled trials, including 2,404 participants, were included. The meta-analysis revealed a significantly greater improvement in anxiety and depressive symptoms derived from quality-of-life scores with prucalopride compared with placebo in the random-effects model (SMD = -0.19, 95% confidence interval [CI] [-0.3117; -0.0707]; P = 0.0019; I² = 52%). Improvement in anxiety and depressive symptoms was associated with improvement of constipation, but not with the daily dose of prucalopride. All studies were rated as having some concerns for biais in selection of the reported result.</p><p><strong>Conclusions: </strong>Prucalopride improves anxiety and depressive symptoms in chronic constipation. Further studies are needed to explore the potential repurposing of prucalopride for anxiety and depressive disorders.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Comment on 'Cognitive & Behavioral Assessment Toolbox (CBAT): An open-source platform supporting experiments in computational psychiatry'\".","authors":"Asako Toyama, Yoshihiko Kunisato, Yuichi Yamashita, Shinsuke Suzuki","doi":"10.1111/pcn.70154","DOIUrl":"https://doi.org/10.1111/pcn.70154","url":null,"abstract":"<p><p>This article relates to Response to \"Comment on 'Cognitive & Behavioral Assessment Toolbox (CBAT): An open-source platform supporting experiments in computational psychiatry'\".</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered glymphatic system measures and functional network connectivity in autism spectrum disorder: A longitudinal study examining associations with prognosis.","authors":"Manxue Zhang, Tingting Luo, Shengnan Zhao, Lei Li, Yuchu Jiang, Xiaoxia Duan, Mingjing Situ, Yi Huang","doi":"10.1111/pcn.70139","DOIUrl":"https://doi.org/10.1111/pcn.70139","url":null,"abstract":"<p><strong>Aim: </strong>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social deficits and repetitive behaviors, yet prognostic biomarkers remain elusive. This study investigated the interplay between glymphatic function and functional network connectivity (FNC) in ASD and their longitudinal associations with clinical outcomes.</p><p><strong>Method: </strong>This combined cross-sectional and two-year prospective longitudinal study included 50 ASD children and 50 controls. Glymphatic function was assessed using the along the perivascular space (ALPS) index and global blood-oxygen-level-dependent to cerebrospinal fluid (gBOLD-CSF) coupling, alongside FNC analysis.</p><p><strong>Results: </strong>Cross-sectionally, ASD participants showed significantly reduced ALPS index, gBOLD-CSF coupling, and widespread FNC reductions. Longitudinally, among the 40 ASD participants who completed follow-up, glymphatic function increased over time. Greater increases in ALPS were correlated with greater reductions in ADOS-CSS. In the symptom-improved subgroup, four FNC connections (including DMN-DAN) increased over time. In contrast, no consistent pattern was found in the non-improved group. Baseline inter-network connectivity measures were associated with ADOS-CSS reduction in univariate analyses, but the multivariate model was not significant. Mediation analysis showed an indirect association between baseline gBOLD-CSF coupling and long-term ADOS-CSS reduction via DMN-DAN FNC reduction (indirect effect = -0.22, 95% CI [-0.42, -0.07]).</p><p><strong>Conclusion: </strong>These findings indicate that glymphatic function and FNC are altered cross-sectionally and improve longitudinally in parallel with symptom changes in ASD and suggest that baseline gBOLD-CSF coupling is indirectly associated with long-term clinical improvement through DMN-DAN connectivity. Together, these results highlight the potential of glymphatic and functional connectivity measures as prognostic imaging markers in ASD.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered prefrontal suppression of striatal activity during intrusive images in obsessive-compulsive disorder.","authors":"Anaïs Vandevelde, Sonia Dollfus, Pierre Gagnepain","doi":"10.1111/pcn.70155","DOIUrl":"https://doi.org/10.1111/pcn.70155","url":null,"abstract":"<p><strong>Background: </strong>Current models of obsessive-compulsive disorder (OCD) emphasize dysfunction in frontostriatal circuits that support flexible behavioral control, leading to impulsive and compulsive actions. However, how these disruptions contribute to obsessions and intrusive thoughts remains poorly understood. Clarifying these mechanisms is essential for understanding cognitive control deficits in OCD.</p><p><strong>Method: </strong>We examined intrusive memories elicited by emotional and neutral scenes in individuals with OCD (N = 24) and healthy controls (N = 21). Participants learned scene-cue associations and were later instructed to suppress memory retrieval when presented with reminder cues. Functional magnetic resonance imaging (fMRI) measured neural activity during suppression. Generalization of findings with alternative materials was assessed in larger samples of healthy controls (N = 73) and individuals with post-traumatic stress disorder (PTSD; N = 55).</p><p><strong>Results: </strong>fMRI analyses showed preserved activity in frontoparietal, basal ganglia, and limbic regions in individuals with OCD, even during emotional intrusion suppression. However, unlike healthy controls, individuals with OCD failed to suppress striatal activity during intrusive memory, regardless of emotional content. Connectivity analyses indicated that this hyperactivity reflected reduced top-down inhibitory control, a disruption associated with greater obsessive symptom severity. Test of generalizability confirmed the role of frontostriatal downregulation in controlling intrusive thoughts and showed that this alteration was specific to OCD.</p><p><strong>Conclusions: </strong>These findings emphasize the central role of frontostriatal circuits in regulating intrusive thinking. Obsessions in OCD may result from disrupted inhibitory mechanisms that normally restrict access to striatal-dependent information, contributing to persistent intrusive thoughts.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced engagement during infant-like robot-mediated telepsychiatry in an older patient with delirium and cognitive impairment.","authors":"Takeshi Iwanaga, Hidenobu Sumioka, Takahiro Miyashita, Taro Muramatsu, Hiroshi Ishiguro, Hirokazu Kumazaki","doi":"10.1111/pcn.70160","DOIUrl":"https://doi.org/10.1111/pcn.70160","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating neurofluid dynamics and brain network development to understand clinical trajectories in autism spectrum disorder.","authors":"Shuhei Shibukawa, Kaito Takabayashi","doi":"10.1111/pcn.70157","DOIUrl":"https://doi.org/10.1111/pcn.70157","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconciling the 'top-down or bottom-up' paradox in schizophrenia?","authors":"Jun Miyata","doi":"10.1111/pcn.70145","DOIUrl":"https://doi.org/10.1111/pcn.70145","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}