Psychiatry and Clinical Neurosciences最新文献

{"title":"Linking autism risk genes to morphological and pharmaceutical screening by high-content imaging: Future directions and opinion.","authors":"Reza K Arta, Yuichiro Watanabe, Jun Egawa, Vance P Lemmon, Toshiyuki Someya","doi":"10.1111/pcn.13847","DOIUrl":"https://doi.org/10.1111/pcn.13847","url":null,"abstract":"<p><p>Next-generation sequencing has identified risk genes with large effect sizes for autism spectrum disorders (ASD). Although functional analysis of individual risk genes has progressed, the overall picture of ASD pathogenesis is unclear. Therefore, there is a need for morphological profiling of variants in these genes to fully comprehend their pathomechanism in cultured cells. High-content analysis (HCA) is a powerful approach to thoroughly analyze cellular alterations following genetic modifications in many disorders, including ASD. We begin this review with the latest phenotypic descriptions of ASD risk variants and different ASD cell models, which provide a basis to select features for extraction in image-based analysis to best capture ASD mechanisms. We then describe recent genetic and pharmacological screening campaigns for ASD using HCA systems. Generally, HCA enables imaging of ASD-derived cell models using measurements such as cell proliferation, differentiation, process growth, synapse numbers, and other morphological changes to neurons, astrocytes, and microglia. Advances in machine learning are reducing bias in feature identification and extraction. These data can be transformed for downstream analyses and visualization, such as clustering using heatmaps for morphological profiling. This provides image-based profiling data that can be used to determine the mechanisms of action of genetic modifications. Additionally, comprehensive methods, such as mixture-based and common structure ranking approaches, which can systematically examine the effects of millions of compounds, could identify compounds that might ameliorate the effects of ASD risk gene mutations using morphological profiling.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"AST-001 versus placebo for social communication in children with autism spectrum disorder: A randomized clinical trial\".","authors":"","doi":"10.1111/pcn.13857","DOIUrl":"https://doi.org/10.1111/pcn.13857","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid neuromarker levels in patients with schizophrenia: a multiplex immunoassay study with a large sample.","authors":"Shinsuke Hidese, Kotaro Hattori, Takako Enokida, Megumi Tatsumi, Ryo Matsumura, Hiroshi Kunugi","doi":"10.1111/pcn.13848","DOIUrl":"https://doi.org/10.1111/pcn.13848","url":null,"abstract":"<p><strong>Aim: </strong>To test the hypothesis that neuromarker alternations associated with diagnosis, symptoms, or psychotropic medication use can be found in schizophrenia, we measured cerebrospinal fluid (CSF) neuromarkers in patients with schizophrenia and healthy controls.</p><p><strong>Methods: </strong>This cross-sectional study comprised 148 patients with schizophrenia (39.0 ± 11.0 years; 88 men and 60 women) and 220 healthy controls (44.6 ± 14.8 years; 135 men and 85 women), all of Japanese ethnicity. The Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity in patients with schizophrenia. The levels of eight of the 18 CSF neuromarker were successfully measured using a multiplex immunoassay. Trait and state markers were identified by patient and control groups comparison and symptom-correlation analyses, respectively.</p><p><strong>Results: </strong>CSF glial fibrillary acidic protein levels were significantly higher in patients with schizophrenia than in healthy controls. CSF neurogranin, total tau, and YKL-40 levels were significantly lower in patients with schizophrenia than in healthy controls. Particularly, in patients with schizophrenia, CSF neurogranin, total tau, and YKL-40 levels were lower in the psychotropic-medicated group than in the psychotropic-medication-free group. CSF amyloid beta _1-42 levels were significantly and negatively correlated with PANSS negative scores. CSF macrophage migration inhibitory factor levels were significantly and positively correlated with PANSS positive, general psychopathology, and total scores. CSF neural cell adhesion molecule-1 and S100 calcium-binding protein B levels were significantly and positively correlated with PANSS positive scores.</p><p><strong>Conclusion: </strong>Our findings suggest trait and state neuromarkers and antidementia-like effects of psychotropics on the pathology of schizophrenia.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closures of psychiatric units in general hospitals undermining progress in psychiatry: A stark contrast between Japan and the world.","authors":"Michitaka Funayama, Yusuke Hasegawa, Naoko Satake, Shigeki Sato, Hiraki Koishikawa, Hisashi Wada, On Kato, Masayuki Noguchi, Hirokazu Kumazaki, Katsuji Nishimura","doi":"10.1111/pcn.13851","DOIUrl":"https://doi.org/10.1111/pcn.13851","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical tactile preferences in autism spectrum disorder: Reduced pleasantness responses to soft objects resembling human body parts.","authors":"Kai Makita, Ryo Kitada, Takuya Makino, Nodoka Sakakihara, Ayaka Fukuoka, Hirotaka Kosaka","doi":"10.1111/pcn.13808","DOIUrl":"10.1111/pcn.13808","url":null,"abstract":"<p><strong>Aim: </strong>Previous studies have reported atypical sensory responses in individuals with autism spectrum disorder (ASD) and their implications for social touch. Although adults with ASD often report discomfort with being touched by others, their preferences for the physical properties of objects are less well understood. In a prior study, we observed that, in typically developed (TD) adults, compliance (a physical correlate of softness) increased tactile pleasantness for deformable surfaces up to levels comparable to those of human body parts. In the present study, we conducted psychophysical experiments to test whether individuals with ASD show atypical affective responses to soft objects resembling human body parts.</p><p><strong>Methods: </strong>Thirty-six adults with ASD and 36 TD adults numerically estimated the perceived pleasantness or softness while lightly pressing urethane rubbers with their right index fingers.</p><p><strong>Results: </strong>The results revealed that pleasantness increased as a function of compliance, but this increase was significantly smaller for patients with ASD than TD adults, particularly at compliance levels including human body parts. However, the perceived softness increased as a function of compliance highly similarly between the ASD and TD groups.</p><p><strong>Conclusions: </strong>These findings demonstrate an atypical preference of individuals with ASD for soft objects such as human body parts, which may help explain their tendency to avoid social touch.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"319-326"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCN Art Brut Series No. 45, Artwork Description.","authors":"Kenjiro Hosaka","doi":"10.1111/pcn.13844","DOIUrl":"https://doi.org/10.1111/pcn.13844","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"79 6","pages":"364"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of each class of sleep medication for major depressive disorder with insomnia symptoms: A systematic review and meta-analysis of double-blind randomized controlled trials.","authors":"Taku Maruki, Masahiro Takeshima, Kazuhisa Yoshizawa, Yuna Maeda, Naoaki Otsuka, Yumi Aoki, Tomohiro Utsumi, Kentaro Matsui, Aran Tajika, Yoshikazu Takaesu","doi":"10.1111/pcn.13811","DOIUrl":"10.1111/pcn.13811","url":null,"abstract":"<p><p>Combination therapy with antidepressants and sleep medications is a promising candidate treatment for major depressive disorder (MDD) with insomnia. This systematic review and meta-analysis examined the efficacy and safety of combination therapy with antidepressants and sleep medication for treating MDD with insomnia compared to antidepressant monotherapy by sleep medication class (benzodiazepine, Z-drug, melatonin receptor agonist, and orexin receptor antagonist). This study was preregistered with PROSPERO (CRD42025636571). PubMed, CENTRAL, and Embase were searched for double-blind randomized controlled trials published until June 2024, resulting in eight eligible studies (1945 participants; eszopiclone = 4, zolpidem = 2, triazolam = 1, ramelteon = 1). Meta-analyses were performed based on six trials of Z-drugs. Compared with antidepressant monotherapy, combination therapy with antidepressants and Z-drugs resulted in higher remission rates from depressive symptoms (risk ratio: 1.25, 95% confidence interval [CI]: 1.08-1.45, P = 0.003), greater improvement in depressive symptoms (standardized mean difference [SMD]: 0.17, 95% CI: 0.01-0.33, P = 0.04) and insomnia symptoms (SMD: 0.43, 95% CI: 0.28-0.59, P < 0.001) in the short-term (within 12 weeks), with no difference in safety outcomes except for dizziness. Combination therapy with antidepressants and Z-drugs may be more useful for MDD with insomnia symptoms than antidepressant monotherapy in the short term. However, this study did not evaluate the benefits and harms of long-term adjunctive Z-drug therapy. Further long-term studies are needed to draw definitive conclusions regarding the efficacy and safety of combination therapy with antidepressants and Z-drugs. Moreover, further research is warranted to assess whether the findings of this study are applicable to other sleep medication classes.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"306-318"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Examining the therapeutic potential and risks of multivoxel neuroreinforcement for specific phobias.","authors":"Cody A Cushing, Hakwan Lau, Mitsuo Kawato, Michelle G Craske, Vincent Taschereau-Dumouchel","doi":"10.1111/pcn.13815","DOIUrl":"10.1111/pcn.13815","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"361-362"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CORE Solution: Protecting Youth Mental Health from the Digital Pandemic.","authors":"Kuan-Pin Su","doi":"10.1111/pcn.13816","DOIUrl":"10.1111/pcn.13816","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"297-298"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating the safety of subcutaneous and intramuscular adrenaline injection in hemodynamically stable patients receiving therapeutic doses of antipsychotic drugs.","authors":"Shotaro Fujiwara, Takuto Ishida, Masafumi Mizuno","doi":"10.1111/pcn.13818","DOIUrl":"10.1111/pcn.13818","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"357-358"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}