Psychiatry and Clinical Neurosciences最新文献

{"title":"Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with moderate to severe cognitive impairment: A randomized controlled trial.","authors":"Jing Li, Dan Jiang, Xingyu Huang, Xiao Wang, Tingting Xia, Wei Zhang","doi":"10.1111/pcn.13779","DOIUrl":"10.1111/pcn.13779","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to assess the therapeutic effects of intermittent theta burst stimulation (iTBS) targeting the bilateral dorsomedial prefrontal cortex (DMPFC) on negative symptoms in patients with schizophrenia, utilizing functional near-infrared spectroscopy for evaluation.</p><p><strong>Methods: </strong>Thirty-five schizophrenia patients with negative symptoms and moderate to severe cognitive impairment were randomly assigned to a treatment group (n = 18) or a control group (n = 17). The treatment group received iTBS via bilateral DMPFC. Negative symptoms, cognitive function, emotional state, and social function were assessed using Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Montreal Cognitive Assessment (MoCA), Calgary Depression Scale for Schizophrenia (CDSS), and Social Dysfunction Screening Questionnaire (SDSS) scales at pretreatment, posttreatment, and follow-up at 4, 8, and 12 weeks. Brain activation in regions of interest (ROIs) was evaluated through verbal fluency tasks.</p><p><strong>Results: </strong>Prior to treatment there was no significant difference in the two groups. After 20 iTBS sessions, a significant difference was observed in SANS total score, its related subscales, PANSS total score, and PANSS-negative symptoms (all P < 0.05). The group-by-time interaction showed statistical significance, indicating improvements in negative symptoms and related dimensions over time, with therapeutic effects persisting for at least 8 weeks posttreatment. Prior to treatment, there were no significant differences in activation across all ROIs between the two groups. Posttreatment, the activation of right inferior frontal gyrus (t = 2.19, P = 0.036) and right frontal eye field (t = 2.14, P = 0.04) in the treatment group was significantly higher than in the control group.</p><p><strong>Conclusions: </strong>iTBS stimulation of bilateral DMPFC demonstrates therapeutic effects in improving negative symptoms in schizophrenia patients, and this treatment approach has the potential to enhance activation within the prefrontal cortex.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"147-157"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Hikikomori: A systematic review and meta-analysis of 19 studies.","authors":"Wei Zhang, Meng-Yi Chen, Yuan Feng, Zhaohui Su, Teris Cheung, Todd Jackson, Qinge Zhang, Yu-Tao Xiang","doi":"10.1111/pcn.13768","DOIUrl":"10.1111/pcn.13768","url":null,"abstract":"<p><strong>Aim: </strong>Hikikomori, a severe form of social withdrawal, has been recognized as an important global public health problem. However, estimates of the worldwide Hikikomori prevalence have been inconsistent. This study aimed to provide a comprehensive assessment of the cross-cultural prevalence of Hikikomori through a meta-analysis and systematic review.</p><p><strong>Methods: </strong>We systematically searched multiple databases (including PubMed, EMBASE, PsycINFO, and Web of Science) for relevant studies. Pooled prevalence estimates were calculated using a random-effects model. Subgroup analyses for categorical variables and meta-regression analyses for continuous variables were performed to identify potential moderators of Hikikomori prevalence estimates.</p><p><strong>Results: </strong>A total of 19 studies based on 58,229 participants were included for analysis. The overall prevalence of Hikikomori was 8.0% (95% CI, 4.9%-12.9%). The prevalence of Hikikomori did not differ significantly between regions (East Asia and Western), time periods (pre- and post-COVID-19 pandemic), sex, sample size, or presence versus absence of psychiatric disorders. In contrast, higher prevalence rates were reported in studies using the 25-item Hikikomori Questionnaire (HQ-25) (21.7%; 95% CI, 11.8%-36.4%) versus other questionnaires (5.0%; 95% CI, 3.1%-7.9%, [P < 0.01]) and nonprobability sampling (12.5%; 95% CI, 7.9%-19.2%) versus probability sampling methods (3.1%; 95% CI, 1.4%-6.9% [P < 0.01]). Lower study quality (coefficient = -0.45, P = 0.03) and older age were also linked to higher prevalence (coefficient = 0.10, P = 0.01).</p><p><strong>Conclusion: </strong>This meta-analysis suggests that Hikikomori is a common problem globally. The results highlight the importance of using standardized diagnostic tools as well as further research on moderating factors and intervention methods to alleviate disabling experiences associated with Hikikomori.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"138-146"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic approach for neuropsychiatric symptoms using neuroimage.","authors":"Shinsuke Koike","doi":"10.1111/pcn.13801","DOIUrl":"https://doi.org/10.1111/pcn.13801","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"79 4","pages":"137"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCN Art Brut Series No. 44, Artwork Description.","authors":"Kenjiro Hosaka","doi":"10.1111/pcn.13820","DOIUrl":"https://doi.org/10.1111/pcn.13820","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":"79 4","pages":"209"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year impact of COVID-19: Longitudinal MRI brain changes and neuropsychiatric trajectories.","authors":"Ravi Dadsena, Julia Walders, Ana S Costa, Sophie Wetz, Sandro Romanzetti, Stella Andrea Lischewski, Christina Krockauer, Josephine Heine, Lars Schlenker, Pia Klabunn, Katia Schwichtenberg, Tim J Hartung, Christiana Franke, Carolin Balloff, Ferdinand Binkofski, Jörg B Schulz, Carsten Finke, Kathrin Reetz","doi":"10.1111/pcn.13789","DOIUrl":"10.1111/pcn.13789","url":null,"abstract":"<p><strong>Aim: </strong>Up to 10% of SARS-CoV-2 infected individuals suffer from post-COVID-19 condition, marked by fatigue and cognitive dysfunction as major symptoms. Longitudinal studies on neuropsychological and clinical trajectories and related brain changes are scarce. Here, we aimed to examine their evolution up to 2 years post-infection.</p><p><strong>Methods: </strong>In a multi-center, longitudinal study of 79 post-COVID patients (mean age 46, 48 female) with persistent symptoms and 21 age- and sex-matched never-infected, healthy controls (mean age 42, eight female), we analyzed neuropsychological performance, self-reported outcomes and associated neuroimaging alterations of resting-state functional and structural magnetic resonance imaging data 23 months post-infection.</p><p><strong>Results: </strong>In post-COVID patients 23 months after SARS-CoV-2 infection we observed (1) that fatigue severity had reduced but still remained present in most patients, (2) widespread brain changes involving the brainstem, the pre- and postcentral gyrus and the limbic olfactory network, (3) a weakening of self-reported fatigue and its cerebral associations. Notably, findings of brain aberrations were more pronounced in hospitalized patients.</p><p><strong>Conclusion: </strong>Our findings indicate that complex brain adaptations take place up to 2 years following SARS-CoV-2 infection. Some regions manifest enduring abnormalities while others undergo restitution. The attenuation of radio-clinical associations suggests a compensatory function for these regions, pointing to non-brain intrinsic factors to sustain persistent fatigue.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"176-186"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of kynurenine pathway metabolites in the severity of patients with obsessive-compulsive disorder.","authors":"Hamit Hakan Alp, Faruk Kurhan, Halil İbrahim Akbay","doi":"10.1111/pcn.13819","DOIUrl":"https://doi.org/10.1111/pcn.13819","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by repetitive thoughts and behaviors. The kynurenine pathway has been increasingly implicated in psychiatric disorders. This study aimed to investigate the predictive value of kynurenine pathway metabolites, including serotonin and tryptophan, in patients with varying degrees of OCD.</p><p><strong>Methods: </strong>One hundred fifty OCD patients and 30 healthy controls were included in this study. Patients were divided into mild-moderate, severe, and extremely severe OCD groups based on their Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores. Serum levels of serotonin, tryptophan, kynurenine, kynurenic acid, indolamine 2,3-dioxygenase (IDO), tryptophan 2,3-dioxygenase (TDO), 3-hydroxykynurenine, quinolinic acid and picolinic acid were measured using enzyme-linked immunosorbent assay. Logistic regression and receiver operating characteristic (ROC) analysis were performed to evaluate the predictive value of these analytes for OCD severity.</p><p><strong>Results: </strong>Serotonin and tryptophan levels were significantly decreased in OCD patients compared to healthy controls, while kynurenine pathway metabolites were significantly increased in patients with OCD. Serum levels of kynurenine pathway metabolites increased with severity in OCD patients. As a result of ROC analysis, serotonin, tryptophan and kynurenine pathway metabolites had higher AUC values in distinguishing OCD patients from healthy volunteers, while kynurenine and tryptophan had higher AUC values in distinguishing disease severity.</p><p><strong>Conclusion: </strong>This study clarifies the role of the kynurenine pathway in the pathophysiology of OCD and suggests that kynurenine pathway metabolites, especially kynurenine, may serve as useful biomarkers to diagnose and differentiate OCD severity. Further research is needed to confirm these findings and explore therapeutic implications.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of schizophrenia in relation to course of social recovery and prescribed antipsychotics: A 10-year follow-up study at a single university hospital in Japan.","authors":"Yuhei Mori, Risa Shishido, Mizuki Hino, Akiko Sato, Atsuko Nagaoka, Hiroshi Hoshino, Masataka Hatano, Yuto Hosogai, Itaru Miura, Yasuto Kunii","doi":"10.1111/pcn.13803","DOIUrl":"10.1111/pcn.13803","url":null,"abstract":"","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"205-207"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric symptoms and neuroimaging-based brain age in mild cognitive impairment and early dementia: A multicenter study.","authors":"Daichi Sone, Iman Beheshti, Kenji Tagai, Hiroshi Kameyama, Emi Takasaki, Tetsuo Kashibayashi, Ryuichi Takahashi, Kazunari Ishii, Hideki Kanemoto, Manabu Ikeda, Masahiro Shigeta, Shunichiro Shinagawa, Hiroaki Kazui","doi":"10.1111/pcn.13777","DOIUrl":"10.1111/pcn.13777","url":null,"abstract":"<p><strong>Aim: </strong>Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, the underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging-derived brain-age estimation by machine-learning analysis has shown promise as an individual-level biomarker. We investigated the relationship between NPS and brain-age in amnestic mild cognitive impairment (MCI) and early dementia.</p><p><strong>Methods: </strong>In this cross-sectional study, clinical data, including neuropsychiatric inventory (NPI), and structural brain MRI of 499 individuals with clinical diagnoses of amnestic MCI (n = 185), early Alzheimer's disease (AD) (n = 258) or dementia with Lewy bodies (DLB) (n = 56) were analyzed. We established a brain-age prediction model using 694 healthy brain MRIs and a support vector regression model and applied it to the participants' data. Finally, the brain-predicted age difference (brain-PAD: predicted age minus chronological age) was calculated.</p><p><strong>Results: </strong>All groups showed significantly increased brain-PAD, and the median (IQR) brain-PAD was 4.3 (5.4) years in MCI, 6.3 (6.2) years in AD, and 5.0 (6.5) years in DLB. The NPI scores were subdivided into the following four categories: (i) Agitation and Irritability, (ii) Depression and Apathy, (iii) Delusions and Hallucinations, and (iv) Euphoria and Disinhibition. We found a significantly positive correlation between brain-PAD and the depression/apathy factor (Spearman's rs = 0.156, FDR-corrected P = 0.002), whereas no significance was shown for the other NPS factors.</p><p><strong>Conclusion: </strong>Higher brain-age may be associated with depression and apathy symptoms presented in MCI to early dementia stages, and brain-age analysis may be useful as a novel biomarker for the assessment or monitoring of NPS.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"158-164"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Mental Disorders, Personality Disorders, and Filicide-Suicide and Parental Suicide: A Nationwide Cohort Study.","authors":"Cheng-Fang Yen, Yi-Lung Chen","doi":"10.1111/pcn.13790","DOIUrl":"10.1111/pcn.13790","url":null,"abstract":"<p><strong>Aim: </strong>Filicide-suicide represents a critical intersection of psychiatric and familial crises, yet the literature remains scant on differentiated risk profiles among family members. This study addresses a gap in understanding the specific mental health correlates of filicide-suicide, especially within a comprehensive family context, distinct from traditional parental or child-focused perspectives.</p><p><strong>Method: </strong>This study used the Taiwan National Health Insurance Research Database to identify a nationally representative sample of families from 2004 to 2020, with continuous monitoring extending into 2021. Families were classified into those affected by filicide-suicide, parental suicide, and those without such incidents. Multinomial logistic regression was conducted to explore the association between family status and mental health. Analyses of effect modification were conducted to evaluate whether low-income status modified these relationships.</p><p><strong>Results: </strong>The study encompassed 1,898,299 families, revealing that filicide-suicide is notably rare, with an incidence of 1.64 deaths per 100,000 newborn children from 2004 to 2020, with an increasing trend observed after 2014. Fathers and children in filicide-suicide families had the highest prevalence of mental disorders, followed by those in parental-suicide families and then other families (those where no child has been recorded as a homicide victim and no parent has committed suicide). There was a tendency for stronger associations between filicide-suicide families and paternal schizophrenia as well as autistic spectrum disorder in children among low-income families.</p><p><strong>Conclusion: </strong>The findings underscore the profound impact of severe mental disorders within the familial framework, emphasizing the need for an integrated approach to mental health care that considers the familial context in order to better predict and prevent such devastating events.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"197-203"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing treatment response prediction in first-episode psychosis: integrating clinical and electroencephalography features.","authors":"Livia Dominicus, Melissa Zandstra, Josephine Franse, Wim Otte, Arjan Hillebrand, Simone de Graaf, Karen Ambrosen, Birte Yding Glenthøj, Andrew Zalesky, Kirsten Borup Bojesen, Mikkel Sørensen, Floortje Scheepers, Cornelis Stam, Bob Oranje, Bjorn Ebdrup, Edwin van Dellen","doi":"10.1111/pcn.13791","DOIUrl":"10.1111/pcn.13791","url":null,"abstract":"<p><strong>Aims: </strong>Prompt diagnosis and intervention are crucial for first-episode psychosis (FEP) outcomes, but predicting the response to antipsychotics remains challenging. We studied whether adding electroencephalography (EEG) characteristics improves clinical prediction models for treatment response and whether EEG-based predictors are influenced by initial treatment.</p><p><strong>Methods: </strong>We included 115 antipsychotic-naïve patients with FEP. Positive and Negative Syndrome Scale (PANSS) and sociodemographic items were included as clinical features. Additionally, we analyzed resting-state EEG data (n = 45) for (relative) power, functional connectivity, and network organization. Treatment response, measured as change in PANSS positive subscale scores (∆PANSS+), was predicted using a random forest regression model. We analyzed whether the most predictive EEG characteristics were influenced after treatment.</p><p><strong>Results: </strong>The clinical model explained 12% variance in symptom reduction in the training set and 32% in the validation set. Including EEG variables in the model led to a nonsignificant increase of 2% (total 34%) explained variance in symptom reduction. High hallucination symptom scores and a more hierarchical organization of alpha band networks (tree hierarchy) were associated with ∆PANSS+ reduction. The tree hierarchy in the alpha band decreased after medication. EEG source analysis revealed that this change was driven by alterations in the degree and centrality of frontal and parietal nodes in the functional brain network.</p><p><strong>Conclusions: </strong>Both clinical and EEG characteristics can inform treatment response prediction in patients with FEP, but the combined model may not be beneficial over a clinical model. Nevertheless, adding a more objective marker such as EEG could be valuable in selected cases.</p>","PeriodicalId":20938,"journal":{"name":"Psychiatry and Clinical Neurosciences","volume":" ","pages":"187-196"},"PeriodicalIF":5.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}