Regenerative Engineering and Translational Medicine最新文献_第10页

The Role of Nanomaterials and Biological Agents on Rotator Cuff Regeneration. 纳米材料和生物制剂在肩袖再生中的作用。

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-12-01 Epub Date: 2020-09-23 DOI: 10.1007/s40883-020-00171-1

Kenyatta S Washington, Nikoo Saveh Shemshaki, Cato T Laurencin

引用次数: 9

Ligament Regenerative Engineering: Braiding Scalable and Tunable Bioengineered Ligaments Using a Bench-Top Braiding Machine. 韧带再生工程：使用台式编织机编织可扩展和可调节的生物工程韧带。

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-12-01 Epub Date: 2020-10-06 DOI: 10.1007/s40883-020-00178-8

Paulos Y Mengsteab, Joseph Freeman, Mohammed A Barajaa, Lakshmi S Nair, Cato T Laurencin

{"title":"Ligament Regenerative Engineering: Braiding Scalable and Tunable Bioengineered Ligaments Using a Bench-Top Braiding Machine.","authors":"Paulos Y Mengsteab, Joseph Freeman, Mohammed A Barajaa, Lakshmi S Nair, Cato T Laurencin","doi":"10.1007/s40883-020-00178-8","DOIUrl":"10.1007/s40883-020-00178-8","url":null,"abstract":"Anterior cruciate ligament (ACL) injuries are common sports injuries that typically require surgical intervention. Autografts and allografts are used to replace damaged ligaments. The drawbacks of autografts and allografts, which include donor site morbidity and variability in quality, have spurred research in the development of bioengineered ligaments. Herein, the design and development of a cost-effective bench-top 3D braiding machine that fabricates scalable and tunable bioengineered ligaments is described. It was demonstrated that braiding angle and picks per inch can be controlled with the bench-top braiding machine. Pore sizes within the reported range needed for vascularization and bone regeneration are demonstrated. By considering a one-to-one linear relationship between cross-sectional area and peak load, the bench-top braiding machine can theoretically fabricate bioengineered ligaments with a peak load that is 9× greater than the human ACL. This bench-top braiding machine is generalizable to all types of yarns and may be used for regenerative engineering applications.","PeriodicalId":20936,"journal":{"name":"Regenerative Engineering and Translational Medicine","volume":"7 4","pages":"524-532"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734580/pdf/nihms-1635563.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39802556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing cell instructive biomaterials through increased understanding of cell receptor spacing and material surface functionalization. 通过增加对细胞受体间距和材料表面功能化的理解，推进细胞指导性生物材料。

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-12-01 Epub Date: 2020-11-20 DOI: 10.1007/s40883-020-00180-0

Stephanie A Maynard, Charles W Winter, Eoghan M Cunnane, Molly M Stevens

{"title":"Advancing cell instructive biomaterials through increased understanding of cell receptor spacing and material surface functionalization.","authors":"Stephanie A Maynard, Charles W Winter, Eoghan M Cunnane, Molly M Stevens","doi":"10.1007/s40883-020-00180-0","DOIUrl":"https://doi.org/10.1007/s40883-020-00180-0","url":null,"abstract":"Regenerative medicine is aimed at restoring normal tissue function and can benefit from the application of tissue engineering and nano-therapeutics. In order for regenerative therapies to be effective, the spatiotemporal integration of tissue engineered scaffolds by the native tissue, and the binding/release of therapeutic payloads by nano-materials, must be tightly controlled at the nanoscale in order to direct cell fate. However, due to a lack of insight regarding cell-material interactions at the nanoscale and subsequent downstream signaling, the clinical translation of many regenerative therapies is limited due to poor material integration, rapid clearance and complications such as graft-versus-host disease. This review paper is intended to outline our current understanding of cell-material interactions with the aim of highlighting potential areas for knowledge advancement or application in the field of regenerative medicine. This is achieved by reviewing the nanoscale organization of key cell surface receptors, the current techniques used to control the presentation of cell-interactive molecules on material surfaces, as well as the most advanced techniques for characterizing the interactions that occur between cell surface receptors and materials intended for use in regenerative medicine.","PeriodicalId":20936,"journal":{"name":"Regenerative Engineering and Translational Medicine","volume":"7 4","pages":"553-547"},"PeriodicalIF":2.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40883-020-00180-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39645397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Review of Biological Augmentation for Rotator Cuff Repair: a Single Laboratory’s History 回顾生物增强肩袖修复:单一实验室的历史

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-11-29 DOI: 10.1007/s40883-021-00240-z

Bennett E. Propp, C. Uyeki, Michael R. Mancini, Benjamin C. Hawthorne, M. Mccarthy, A. Mazzocca

引用次数: 0

The Iranian National Guideline for Cell Therapy and Regenerative Medicine 伊朗国家细胞治疗和再生医学指南

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-11-05 DOI: 10.1007/s40883-021-00239-6

J. Verdi, Mahdi Shadnoush, G. Janbabai, Alireza Shoae-Hassani, Seyed Abdolreza Mortazavi-Tabatabei, Iman Seyhoun, S. Sharif

引用次数: 0

Micro-Osteo Tubular Scaffolds: a Method for Induction of Bone Tissue Constructs 微骨管支架:一种诱导骨组织构建的方法

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-11-03 DOI: 10.1007/s40883-021-00236-9

Tharwat Haj Khalil, A. Zoabi, M. Falah, Nora Nseir, Dror Ben David, Ilana Laevsky, E. Zussman, O. Ronen, Idan Redenski, S. Srouji

引用次数: 0

Current Status of Stem Cell Therapy and Nanofibrous Scaffolds in Cardiovascular Tissue Engineering 干细胞治疗和纳米纤维支架在心血管组织工程中的研究现状

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-10-26 DOI: 10.1007/s40883-021-00230-1

Aliakbar Yousefi-Ahmadipour, Fatemeh Asadi, Ali Pirsadeghi, N. Nazeri, R. Vahidi, M. Abazari, Ali Afgar, Mohamad Javad Mirzaei-Parsa

引用次数: 2

News and Views December 2021 新闻与观点2021年12月

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-10-13 DOI: 10.1007/s40883-021-00235-w

Bernard Gordon, L. Griffith

引用次数: 0

Design and Characterization of Maltose-Conjugated Polycaprolactone Nanofibrous Scaffolds for Uterine Tissue Engineering 用于子宫组织工程的麦芽糖共轭聚己内酯纳米纤维支架的设计与表征

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-10-01 DOI: 10.1007/s40883-021-00231-0

Srividya Hanuman, M. Nune

引用次数: 6

Green Synthesis, Characterization, and Application of Ascophyllum Nodosum Silver Nanoparticles 藤茎银纳米颗粒的绿色合成、表征及应用

IF 2.6

Regenerative Engineering and Translational Medicine Pub Date : 2021-09-29 DOI: 10.21203/rs.3.rs-944036/v1

S. K. Mishra, Saket Sinha, Ashutosh Kumar Singh, P. Upadhyay, Diya Kalra, P. Kumar, K. Tiwari, R. Singh, R. Singh, Arvind Kumar, Alok M. Tripathi

{"title":"Green Synthesis, Characterization, and Application of Ascophyllum Nodosum Silver Nanoparticles","authors":"S. K. Mishra, Saket Sinha, Ashutosh Kumar Singh, P. Upadhyay, Diya Kalra, P. Kumar, K. Tiwari, R. Singh, R. Singh, Arvind Kumar, Alok M. Tripathi","doi":"10.21203/rs.3.rs-944036/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-944036/v1","url":null,"abstract":"Purpose Green nanotechnology as a field has emerged and gained popularity amongst biologists due to its cost-effective and environment-friendly advancements. The most preferred is the biological method which involves plants and their extracts. Methods The silver nanoparticles were synthesized by a sunlight-driven aqueous extract (AE) of whole plant powder of Ascophyllum nodosum . Advanced techniques like high-resolution scanning electron microscopy (HRSEM), energy dispersive X-ray (EDX), high-resolution transmission electron microscopy (HRTEM), and particle size analysis were used to determine the nature of nanoparticles. Antioxidant, anti-fungal, and anti-leishmanial activities were evaluated. Result The techniques confirmed the formation of spherical particles of the desired range of size. Silver nanoparticles exhibited a much greater DPPH (2,2-diphenyl-1-picryl-hydrazine-hydrate) radical scavenging activity which was almost six to seven folds more than that exhibited by the AE alone. The anti-leishmanial and cytotoxic activities were evaluated on Leishmania donovani promastigote and amastigote. Conclusion The synthesized AgNPs showed remarkable DPPH radical scavenging ability owing to their antioxidant properties. The anti-leishmanial activity was exceptionally viable in both AE and AgNPs. The findings all together support the tendency of Ascophyllum nodosum to efficiently synthesized AgNPs which could be utilized for its anti-leishmanial properties. Graphical Abstract","PeriodicalId":20936,"journal":{"name":"Regenerative Engineering and Translational Medicine","volume":"29 1 1","pages":"1-15"},"PeriodicalIF":2.6,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91069817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3