Reproductive Sciences最新文献

{"title":"Cinnamaldehyde Attenuates Dehydroepiandrosterone-induced Apoptosis and Inflammatory Responses in a KGN Cell Model of Polycystic Ovary Syndrome.","authors":"Jinyan Gao, Xiaodan Weng, Jiali Cheng","doi":"10.1007/s43032-026-02203-7","DOIUrl":"https://doi.org/10.1007/s43032-026-02203-7","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a complex reproductive and metabolic disorder characterized in part by chronic low-grade inflammation and granulosa-cell dysfunction. New interventions that protect granulosa cells from hyperandrogenic injury are needed. Cinnamaldehyde (CA), a major bioactive component of cinnamon, has anti-inflammatory and cytoprotective properties; however, its effects in PCOS-related cell models remain unclear. We evaluated CA in human KGN granulosa-like cells treated with dehydroepiandrosterone (DHEA) to establish an in vitro PCOS-like model. CA increased cell viability and EdU incorporation in DHEA-treated cells, reduced the production and expression of TNF-α, IL-1β, and IL-6, and decreased apoptosis. CA also increased PI3K and Akt phosphorylation relative to DHEA treatment alone. These findings indicate that CA attenuates DHEA-induced inflammatory and apoptotic injury in KGN cells and that its effects are associated with restoration of PI3K/Akt signaling. CA therefore warrants further mechanistic evaluation as a potential modulator of PCOS-related granulosa-cell dysfunction.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Predictive Values of Ferroptosis-Related Genes in Endometriosis Based on Integrated Bioinformatic Analysis.","authors":"Buhaiqiemu Kadeer, Shaadaiti Wufuer, Adilai Maimaitimin, Nuramatjan Ablat, Xiaopeng Li, Zhifang Chen","doi":"10.1007/s43032-026-02142-3","DOIUrl":"https://doi.org/10.1007/s43032-026-02142-3","url":null,"abstract":"<p><p>Endometriosis (EMs) is a prevalent gynecological disorder. Ferroptosis, known as a novel type of programmed cell death, contributes to EMs pathogenesis by promoting ectopic endometrial migration. This study was designed to investigate ferroptosis-related genes as diagnostic/predictive biomarkers for EMs using bioinformatics. EMs-related datasets were obtained from the Gene Expression Omnibus (GEO) database, while ferroptosis-related data were retrieved from the FerrDb database. Through differential expression analysis (Limma), weighted gene co-expression network analysis (WGCNA), functional enrichment analysis (GO, KEGG, and Metascape), protein-protein interaction (PPI) network analysis, LASSO regression, Random Forest algorithm, immune infiltration analysis, and matrix correlation analysis, miRNA-target gene regulatory network was constructed. Identification of the potential immune-related hub genes and their regulatory miRNAs was performed to develop early diagnostic strategies, prognostic biomarkers, and therapeutic targets for EMs. Bioinformatics analysis revealed 18 differentially expressed genes (DEGs) and 36 WGCNA module genes associated with ferroptosis in EMs. Eleven core genes were identified, and a multi-gene predictive logistic regression model was established. LASSO regression and Random Forest analyses refined the selection to six genes: BRD7, OSBPL9, AGPS, NRAS, PEX12, and NCOA4, with high diagnostic value. CIBERSORT analysis showed that immune microenvironment alterations in EMs may be closely related to these six hub genes. Additionally, three key miRNAs-hsa-mir-125a-5p, hsa-mir-218-5p, and hsa-mir-124-3p-were predicted. The six immune-related hub genes (BRD7, OSBPL9, AGPS, NRAS, PEX12, and NCOA4) and three regulatory miRNAs (hsa-mir-125a-5p, hsa-mir-218-5p, and hsa-mir-124-3p) may serve as promising targets for the early diagnosis, prognostic evaluation, and therapeutic intervention of EMs.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Different Patterns of Insulin Resistance With Miscarriage in Population With Miscarriage History: a Multicenter Retrospective Cohort Study.","authors":"Jing Tang, Yan Yu, Jinxin Zhang, Yujie Gan, Shangya Yuan, Zhaorui Wang, Xiaohui Ji, Hanjie Mo, QingXue Zhang, Yuhua Shi, Hui Chen","doi":"10.1007/s43032-026-02193-6","DOIUrl":"https://doi.org/10.1007/s43032-026-02193-6","url":null,"abstract":"<p><p>Insulin Resistance (IR) has been increasingly linked to adverse reproductive outcomes, with emerging evidence suggesting a positive association between IR and miscarriage risk in women undergoing infertility treatment. However, the role of IR in miscarriage among the broader population remains poorly understood, leaving critical gaps in our knowledge of its impact on reproductive health. While prior studies have predominantly focused on fasting IR, the potential influence of postprandial IR-a dynamic metabolic state reflecting post-meal glucose handling-has been largely overlooked. This study aims to investigate the association between distinct patterns of IR, including fasting and postprandial states, and miscarriage risk in women with a history of miscarriage, offering novel insights into the metabolic underpinnings of reproductive loss. The retrospective cohort study included 1,042 women with a history of miscarriage, recruited from Sun Yat-sen Memorial Hospital and Shenzhen Baoan Women's and Children's Hospital. IR is divided into fasting IR and postprandial IR. Logistic regression models were used to investigate the association between different patterns of IR and miscarriage. In the multivariable logistic regression model, homeostasis model assessment of insulin resistance (HOMA-IR) was associated with a significant increased risk of miscarriage (OR [95% CI]: 1.97[1.33,2.94], P < 0.001). Stumvoll Insulin Sensitivity Index (ISI_Stumvoll) was associated with a decreased risk of miscarriage (OR [95% CI]: 0.66[0.45,0.98], P = 0.038). In the restricted cubic spline analysis, a positive monotonic relationship between HOMA-IR、ISI_Stumvoll and miscarriage was found (P_{non-linearity} = 0.130;P_{non-linearity} = 0.940). Compared with population defined as insulin-sensitive (IS) by both HOMA-IR and ISI_Stumvoll, those defined as IR by either HOMA-IR or ISI_Stumvoll exhibit a significantly higher risk of miscarriage. (OR [95% CI]: 1.88[1.43,2.49], P < 0.001). Fasting IR indicator HOMA-IR and postprandial IR indicator ISI_Stumvoll were associated with miscarriage in population with a history of pregnancy loss. The combination of both indicators was able to identify more individuals at higher risk of miscarriage.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryopreservation of Human Spermatozoa Using Penetrating Cryoprotectant-Free Vitrification Medium Exhibits an Altered Proteomic Profile Compared to the Conventional Rapid Freezing Method.","authors":"Shobitha Padmar, Shreya Agrawal, Vanya Kadla Narayana, Akhila Balakrishna Rai, Pooja Suresh Poojary, Achsah Mary James, Keerthana Karunakar Poojary, Sandhya Kumari, Rahul Dutta, Nadeem G Khan, Shama Prasada Kabekkodu, Suresh D Kulkarni, Kshitish K Acharya, Satish Kumar Adiga, Thottethodi Subrahmanya Keshava Prasad, Guruprasad Kalthur","doi":"10.1007/s43032-026-02195-4","DOIUrl":"https://doi.org/10.1007/s43032-026-02195-4","url":null,"abstract":"<p><p>The present study aimed to assess the functional and proteomic changes in human spermatozoa cryopreserved in a vitrification medium without a penetrating cryoprotectant. Leftover ejaculates (n = 71) from men visiting the andrology laboratory for routine semen analysis were used. The liquefied semen samples were cryopreserved using rapid freezing and vitrification for a minimum of seven days. Post-thaw motility, mitochondrial function, DNA damage, and acrosomal integrity of spermatozoa were similar between the cryoprotectant-free vitrification and rapid freezing methods. However, the head morphology of spermatozoa was better preserved when cryopreserved by vitrification method. Proteomic analysis led to the identification of a total of 4378 proteins in spermatozoa. Proteomic profiling identified 760 and 1661 significantly altered proteins in the spermatozoa subjected to rapid freezing and vitrification, respectively, compared with fresh spermatozoa. Gene Ontology (GO) analysis revealed considerable overlapping functional enrichment patterns between rapid freezing and vitrification, indicating that both cryopreservation methods influence several common functional pathways in spermatozoa. Both methods resulted in differential abundance of proteins involved in cytoskeletal organization, oxidative stress response, energy metabolism, and fertilization. Although functional analyses demonstrated that the functional properties of spermatozoa cryopreserved by penetrating cryoprotectant-free vitrification is similar to those subjected to rapid freezing, proteomic analysis revealed distinct molecular alterations, warranting further investigation to establish the possible differences in fertilizing potential, long-term safety aspects and reproductive outcomes.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FFAR4 Mediates High-Altitude Hypoxia-Induced Asthenozoospermia through Oxidative Stress and Mitochondrial Dysfunction: An Integrative Bioinformatics and Experimental Study.","authors":"Jun Yin, Zhongying Yu, Dawei Liu, Shijie Tang, Jiaxin Xie","doi":"10.1007/s43032-026-02197-2","DOIUrl":"https://doi.org/10.1007/s43032-026-02197-2","url":null,"abstract":"<p><p>High-altitude hypoxia is a significant environmental factor contributing to male infertility, particularly asthenozoospermia, yet the underlying molecular mechanisms remain elusive. To address this, we performed an integrated bioinformatics analysis of transcriptome datasets (SRP418387 and SRP418442) to identify candidate genes, followed by the establishment of a high-altitude hypoxia mouse model (simulated 5000 m, 12.5% O₂) for validation. Functional mechanisms were elucidated using AAV-mediated FFAR4 knockdown and pharmacological modulation, alongside comprehensive assessments of sperm motility, oxidative stress, and mitochondrial function. Bioinformatics screening identified 142 commonly upregulated differentially expressed genes, with FFAR4, OR7D2, and CALHM6 highlighted as key candidates. Hypoxia exposure significantly impaired sperm motility and upregulated FFAR4 expression in testicular tissue. Notably, FFAR4 knockdown significantly restored progressive sperm motility and ATP production while reducing intracellular and mitochondrial reactive oxygen species (ROS) levels, whereas pharmacological activation of FFAR4 exacerbated hypoxia-induced motility defects. Mechanistically, genetic knockdown of FFAR4 restored antioxidant enzyme activities and mitochondrial respiratory chain complex functions without disrupting reproductive hormone levels. These findings suggest that FFAR4 mediates high-altitude hypoxia-induced asthenozoospermia by exacerbating oxidative stress and mitochondrial dysfunction, positioning FFAR4 as a promising therapeutic target for preserving sperm quality and motility in hypoxic environments.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Histone Deacetylase and Its Inhibitors in Endometriosis.","authors":"Shisi Xiong, Junjie Xu, Jingjing Pu, Shaojie Zhao, Liping Jiang","doi":"10.1007/s43032-026-02184-7","DOIUrl":"https://doi.org/10.1007/s43032-026-02184-7","url":null,"abstract":"<p><p>Endometriosis is a complex chronic inflammatory disease with an unclear etiology and limited treatment options, severely affecting the reproductive health and quality of life of many women. Histone deacetylases (HDACs), as key epigenetic regulatory molecules, play a significant role in the pathogenesis and progression of endometriosis. This article reviews the abnormal expression of HDACs in endometriosis and their molecular mechanisms in driving the disease by regulating processes such as cell proliferation, apoptosis, inflammation, and epithelial-mesenchymal transition (EMT). It also summarizes the therapeutic potential of histone deacetylase inhibitors (HDACis) such as Vorinostat, Romidepsin, and Butyrate demonstrated in preclinical studies, and analyzes the main challenges currently faced in clinical translation. Finally, this article discusses the challenges and future research directions for developing novel endometriosis therapies targeting HDACs, aiming to provide references for in-depth research and clinical translation in this field.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galaxamide Ameliorates Cisplatin-induced Uterine Injury via Anti‑inflammatory and Antiapoptotic Mechanisms in Mice.","authors":"Zihao Peng, Bo Yao, Ziyi Ling, Xingwei Zhang, Zehuan Chen, Shihai Xu, Hanlin Shuai, Bihui Guo, Ping Li","doi":"10.1007/s43032-026-02186-5","DOIUrl":"https://doi.org/10.1007/s43032-026-02186-5","url":null,"abstract":"<p><p>Cisplatin treatment can cause ovarian dysfunction, but its impact on uterine function remains poorly defined. Although galaxamide increases the antitumor efficacy of cisplatin and protects ovarian function, its effects on uterine health are unknown. HeLa tumor‑bearing female mice received CIS alone or in combination with galaxamide. We assessed uterine morphology, systemic inflammation, endometrial epithelial cell apoptosis, endometrial receptivity factor expression, macrophage polarization, and NF-κB signaling. Cisplatin induced epithelial thinning and glandular disorganization; promoted apoptosis; decreased the expression of receptivity markers and desmosome and tight junction integrity; and elevated the serum levels of IL-6, IL-18, and TNF-α. Moreover, M1 macrophage infiltration and NF-κB pathway activation were observed. Cotreatment with galaxamide reduced cytokine levels, preserved uterine architecture, normalized apoptotic gene expression, restored receptivity marker expression, maintained desmosome/tight junction integrity, promote M2 macrophage polarization, and inhibited NF‑κB activation. In this study, cisplatin-induced uterine injury in tumor-bearing model mice was characterized. Galaxamide was demonstrated to attenuate this damage through antiapoptotic and anti-inflammatory actions mediated by inhibition of the NF-κB signaling pathway, suggesting its potential as a protective adjuvant to mitigate uterine toxicity during CIS‑based chemotherapy.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Observation of the Cryoprotective Effect of Chlorogenic Acid on Spermatogonial Stem Cells Transplanted into of Testicular Torsion-Induced Azoospermia Model.","authors":"Sareh Khoshbakht, Azim Hedayatpour, Tayebeh Rastegar, Alireza Ebrahimzade Bideskan, Mohsen Mir, Mohammadreza Ebrahimzade, Samiullah Safi, Farnaz Khadivi","doi":"10.1007/s43032-026-02199-0","DOIUrl":"10.1007/s43032-026-02199-0","url":null,"abstract":"","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Cryopreservation Media: L-Methionine Boosts Post-Thaw Sperm Quality Across Fertility Status.","authors":"Madhan Kumar P, Parameswari R, Babujanarthanam R, Abilash D","doi":"10.1007/s43032-026-02163-y","DOIUrl":"10.1007/s43032-026-02163-y","url":null,"abstract":"<p><p>Cryopreservation, an integral aspect of assisted reproductive technology, negatively affects the sperm motility, viability, membrane integrity, and DNA stability through the induction of cryo-oxidative stress and damage to cellular function. L-methionine, a sulfur-containing amino acid with significant antioxidant potential, was examined for dose-dependent effects on post-thaw sperm quality in 85 semen samples (n = 43) fertile and (n = 42) infertile. The Fertile and Infertile semen samples were cryopreserved in media supplemented with L-methionine (1.5 mM, M1; 3 mM, M2; and 6 mM, M3) in comparison with commercial cryopreservation medium (CM). After the thawing, sperm motility, morphology, viability, plasma membrane and acrosome integrity, oxidative stress (MDA), antioxidant enzyme activity including superoxide dismutase (SOD) and catalase, and DNA fragmentation were evaluated. The 3 mM L-methionine (M2) group significantly promoted spermatozoa motility, progressive motility, viability, morphology, and acrosome integrity(p < 0.05) while reducing MDA levels and enhancing the activities of superoxide dismutase (SOD) and catalase (p < 0.001) as a strong antioxidant protection. The DNA fragmentation was lowest in the M2 group in fertile and infertile men. In contrast, the highest concentration tested (6 mM, M3) did not improve sperm quality parameters and was associated with reduced motility, viability, and increased DNA fragmentation, suggesting potential toxicity at higher concentrations. The ROC analysis showed M2 (AUC: 0.88 vs. commercial medium) to be much more sensitive for the diagnosis of sperm damage. This study suggests that supplementation with 3 mM L-methionine may serve as a promising cryoprotective strategy for improving post-thaw sperm quality, particularly in infertile men.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1714-1730"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Multi-Omics Analysis Identifies Key Molecular Targets Linking Bisphenol A Exposure to Gestational Diabetes Mellitus.","authors":"Lu Zheng, Xinying Song, Huiyan Wang, Wenbo Zhou","doi":"10.1007/s43032-026-02170-z","DOIUrl":"10.1007/s43032-026-02170-z","url":null,"abstract":"<p><p>Bisphenol A (BPA) exposure is associated with gestational diabetes mellitus (GDM); however, the underlying molecular mechanisms remain elusive. This study aimed to identify key genes mediating BPA exposure-related GDM through integrative bioinformatics analysis. We integrated BPA-related targets from multiple databases with GDM-associated genes derived from GeneCards and the GSE103552 dataset. Functional enrichment analysis was performed on the intersecting genes. A protein-protein interaction (PPI) network was constructed, and hub genes were identified using four topological algorithms. Machine learning approaches were employed for feature selection. Immune infiltration was assessed, and core gene expression was validated via reverse transcription quantitative polymerase chain reaction (RT-qPCR), additional GEO datasets, and single-cell RNA sequencing data. Thirty-four overlapping genes were identified and found to be enriched in the insulin signaling pathway, the AMPK pathway, and inflammatory responses. Following further screening, five core genes-HSPA8, NR3C1, ITGB1, NOTCH2, and POU5F1-were selected, demonstrating robust diagnostic performance. Immune analysis revealed significant correlations between hub genes and the infiltration levels of immune cells. Consistent expression patterns of ITGB1 and NOTCH2 were validated across additional GEO datasets. RT-qPCR confirmed the downregulation of HSPA8 and the upregulation of NR3C1 and NOTCH2 in GDM. Single-cell analysis corroborated cell-type-specific expression within the placenta. This study elucidates potential molecular links between BPA exposure and GDM, highlighting immune-metabolic dysregulation. The identified core genes may serve as biomarkers or therapeutic targets, thereby advancing precision environmental health strategies for pregnancy.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1674-1686"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}