Prostate Cancer最新文献_第9页

Erratum to "prostate cancer in South Africa: pathology based national cancer registry data (1986-2006) and mortality rates (1997-2009)". 对"南非前列腺癌:基于病理学的国家癌症登记数据(1986-2006年)和死亡率(1997-2009年)"的勘误。

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-12-22 DOI: 10.1155/2014/391257

Chantal Babb, Margaret Urban, Danuta Kielkowski, Patricia Kellett

引用次数: 2

Cryotherapy for primary treatment of prostate cancer: intermediate term results of a prospective study from a single institution. 用于前列腺癌初治的冷冻疗法：一家医疗机构前瞻性研究的中期结果。

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-20 DOI: 10.1155/2014/571576

S Alvarez Rodríguez, F Arias Fúnez, C Bueno Bravo, R Rodríguez-Patrón Rodríguez, E Sanz Mayayo, V Hevia Palacios, F J Burgos Revilla

{"title":"Cryotherapy for primary treatment of prostate cancer: intermediate term results of a prospective study from a single institution.","authors":"S Alvarez Rodríguez, F Arias Fúnez, C Bueno Bravo, R Rodríguez-Patrón Rodríguez, E Sanz Mayayo, V Hevia Palacios, F J Burgos Revilla","doi":"10.1155/2014/571576","DOIUrl":"10.1155/2014/571576","url":null,"abstract":"Purpose. Published data about cryotherapy for prostate cancer (PC) treatment are based on case series with a lack of clinical trials and the inexistence of a validated definition of biochemical failure. A prospective study with standardized followup protocol was conducted in our institution. Material and Methods. Prospective study of a series of cases including 108 patients diagnosed with localized PC at clinical stage T1c-T2c treated by primary cryoablation and median followup of 61 months. Criteria of biochemical recurrence were unified according to the American Society for Therapeutic Radiology and Oncology (ASTRO). End points were biochemical progression-free survival (BPFS), cancer-specific survival, and overall survival. Rate of complications was reported. Results. The BPFS for low-, medium-, and high-risk patients was 96.4%, 91.2%, and 62.2%, respectively. Cancer-specific survival was 98.1%. Overall survival reached 94.4%. Complications included incontinence in 5.6%, urinary tract obstruction in 1.9%, urethral sloughing in 5.6%, haematuria in 1.9%, perineal pain in 11.1%, and prostatorectal fistula in 0.9%. Erectile disfunction was found in 98.1%. Conclusions. Cryotherapy is an effective and minimally invasive treatment for primary PC in well-selected cases, with low surgical risk and good results in terms of BPFS, cancer-specific survival, and overall survival. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32228859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D versus 2D Systematic Transrectal Ultrasound-Guided Prostate Biopsy: Higher Cancer Detection Rate in Clinical Practice. 三维与二维系统经直肠超声引导前列腺活检:临床实践中更高的癌症检出率。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-11-17 DOI: 10.1155/2013/783243

Alexandre Peltier, Fouad Aoun, Fouad El-Khoury, Eric Hawaux, Ksenija Limani, Krishna Narahari, Nicolas Sirtaine, Roland van Velthoven

{"title":"3D versus 2D Systematic Transrectal Ultrasound-Guided Prostate Biopsy: Higher Cancer Detection Rate in Clinical Practice.","authors":"Alexandre Peltier, Fouad Aoun, Fouad El-Khoury, Eric Hawaux, Ksenija Limani, Krishna Narahari, Nicolas Sirtaine, Roland van Velthoven","doi":"10.1155/2013/783243","DOIUrl":"https://doi.org/10.1155/2013/783243","url":null,"abstract":"Objectives. To compare prostate cancer detection rates of extended 2D versus 3D biopsies and to further assess the clinical impact of this method in day-to-day practice. Methods. We analyzed the data of a cohort of 220 consecutive patients with no prior history of prostate cancer who underwent an initial prostate biopsy in daily practice due to an abnormal PSA and/or DRE using, respectively, the classical 2D and the new 3D systems. All the biopsies were done by a single experienced operator using the same standardized protocol. Results. There was no significant difference in terms of age, total PSA, or prostate volume between the two groups. However, cancer detection rate was significantly higher using the 3D versus the 2D system, 50% versus 34% (P < 0.05). There was no statistically significant difference while comparing the 2 groups in term of nonsignificant cancer detection. Conclusion. There is reasonable evidence demonstrating the superiority of the 3D-guided biopsies in detecting prostate cancers that would have been missed using the 2D extended protocol. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/783243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31964480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Urologic characteristics and sexual behaviors associated with prostate cancer in an african-Caribbean population in barbados, west indies. 西印度群岛巴巴多斯非洲-加勒比人口中与前列腺癌相关的泌尿系统特征和性行为。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-02-25 DOI: 10.1155/2013/682750

Anselm J M Hennis, Suh-Yuh Wu, Barbara Nemesure, M Cristina Leske

{"title":"Urologic characteristics and sexual behaviors associated with prostate cancer in an african-Caribbean population in barbados, west indies.","authors":"Anselm J M Hennis, Suh-Yuh Wu, Barbara Nemesure, M Cristina Leske","doi":"10.1155/2013/682750","DOIUrl":"10.1155/2013/682750","url":null,"abstract":"Prostate cancer (PC) is the principal malignancy affecting African descent men in the Caribbean and the USA. Disparities in incidence, prevalence, and mortality in these populations are poorly understood. We evaluated the urologic characteristics and sexual behaviors of men with histologically confirmed PC (cases) and age-matched controls in the nationwide Prostate Cancer in a Black Population (PCBP) study conducted in Barbados. Cases were around 1.5 to 3 times more likely to report symptoms of prostatic enlargement, hematuria/hematospermia, and previous prostatitis. Sexually transmitted infections (STIs) were similar among cases (24.5%) and controls (26.7%). First sexual intercourse before the age of 16 was associated with an increased likelihood of both low- (Gleason score < 7; OR 1.63; 95% CI: 1.03-1.66) and high-grade PC (Gleason score ≥ 7; OR 1.82; 1.11-2.99). PC risk decreased with later age of sexual debut (P-trend = 0.004). More lifetime sexual partners was associated with increased odds of high grade PC (P-trend = 0.02). The contribution of sexual behaviors to the development and the outcomes of PC is likely due to multiple mechanisms, and further study will be necessary to elucidate the underlying pathophysiologic mechanisms in this and similar populations.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40229771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells. Skip 可调控 TGF- β 1 诱导的人 PC-3 前列腺癌细胞细胞外基质降解蛋白酶的表达。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-05-20 DOI: 10.1155/2013/398253

Victor Villar, Jelena Kocic, Juan F Santibanez

{"title":"Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells.","authors":"Victor Villar, Jelena Kocic, Juan F Santibanez","doi":"10.1155/2013/398253","DOIUrl":"10.1155/2013/398253","url":null,"abstract":"Purpose. To determine whether Ski-interacting protein (SKIP) regulates TGF- β 1-stimulated expression of urokinase-type plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and uPA Inhibitor (PAI-1) in the androgen-independent human prostate cancer cell model. Materials and Methods. PC-3 prostate cancer cell line was used. The role of SKIP was evaluated using synthetic small interference RNA (siRNA) compounds. The expression of uPA, MMP-9, and PAI-1 was evaluated by zymography assays, RT-PCR, and promoter transactivation analysis. Results. In PC-3 cells TGF- β 1 treatment stimulated uPA, PAI-1, and MMP-9 expressions. The knockdown of SKIP in PC-3 cells enhanced the basal level of uPA, and TGF- β 1 treatment inhibited uPA production. Both PAI-1 and MMP-9 production levels were increased in response to TGF- β 1. The ectopic expression of SKIP inhibited both TGF- β 1-induced uPA and MMP-9 promoter transactivation, while PAI-1 promoter response to the factor was unaffected. Conclusions. SKIP regulates the expression of uPA, PAI-1, and MMP-9 stimulated by TGF- β 1 in PC-3 cells. Thus, SKIP is implicated in the regulation of extracellular matrix degradation and can therefore be suggested as a novel therapeutic target in prostate cancer treatment.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31506209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Study of Laparoscopic Doppler Ultrasound Probe to Map Arterial Vascular Flow within the Neurovascular Bundle during Robot-Assisted Radical Prostatectomy. 腹腔镜多普勒超声探头在机器人辅助根治性前列腺切除术中绘制神经血管束内动脉血流的初步研究。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-06-19 DOI: 10.1155/2013/810715

Ketan K Badani, Edan Y Shapiro, William T Berg, Sarah Kaufman, Ari Bergman, Chris Wambi, Arindam Roychoudhury, Trushar Patel

{"title":"A Pilot Study of Laparoscopic Doppler Ultrasound Probe to Map Arterial Vascular Flow within the Neurovascular Bundle during Robot-Assisted Radical Prostatectomy.","authors":"Ketan K Badani, Edan Y Shapiro, William T Berg, Sarah Kaufman, Ari Bergman, Chris Wambi, Arindam Roychoudhury, Trushar Patel","doi":"10.1155/2013/810715","DOIUrl":"https://doi.org/10.1155/2013/810715","url":null,"abstract":"Purpose. To report on the feasibility of a new Laparoscopic Doppler ultrasound (LDU) technology to aid in identifying and preserving arterial blood flow within the neurovascular bundle (NVB) during robotic prostatectomy (RARP). Materials and Methods. Nine patients with normal preoperative potency and scheduled for a bilateral nerve-sparing procedure were prospectively enrolled. LDU was used to measure arterial flow at 6 anatomic locations alongside the prostate, and signal intensity was evaluated by 4 independent reviewers. Measurements were made before and after NVB dissection. Modifications in nerve-sparing procedure due to LDU use were recorded. Postoperative erectile function was assessed. Fleiss Kappa statistic was used to evaluate inter-rater agreement for each of the 12 measurements. Results. Analysis of Doppler signal intensity showed maintenance of flow in 80% of points assessed, a decrease in 16%, and an increase in 4%. Plane of NVB dissection was altered in 5 patients (56%) on the left and in 4 patients (44%) on the right. There was good inter-rater reliability for the 4 reviewers. Use of the probe did not significantly increase operative time or result in any complications. Seven (78%) patients had recovery of erections at time of the 8-month follow-up visit. Conclusions. LDU is a safe, easy to use, and effective method to identify local vasculature and anatomic landmarks during RARP, and can potentially be used to achieve greater nerve preservation. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/810715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31586414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. 剖析前列腺癌发展过程中的主要信号通路。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-04-29 DOI: 10.1155/2013/920612

Henrique B da Silva, Eduardo P Amaral, Eduardo L Nolasco, Nathalia C de Victo, Rodrigo Atique, Carina C Jank, Valesca Anschau, Luiz F Zerbini, Ricardo G Correa

{"title":"Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer.","authors":"Henrique B da Silva, Eduardo P Amaral, Eduardo L Nolasco, Nathalia C de Victo, Rodrigo Atique, Carina C Jank, Valesca Anschau, Luiz F Zerbini, Ricardo G Correa","doi":"10.1155/2013/920612","DOIUrl":"https://doi.org/10.1155/2013/920612","url":null,"abstract":"Prostate cancer (PCa) is one of the most common malignancies found in males. The development of PCa involves several mutations in prostate epithelial cells, usually linked to developmental changes, such as enhanced resistance to apoptotic death, constitutive proliferation, and, in some cases, to differentiation into an androgen deprivation-resistant phenotype, leading to the appearance of castration-resistant PCa (CRPCa), which leads to a poor prognosis in patients. In this review, we summarize recent findings concerning the main deregulations into signaling pathways that will lead to the development of PCa and/or CRPCa. Key mutations in some pathway molecules are often linked to a higher prevalence of PCa, by directly affecting the respective cascade and, in some cases, by deregulating a cross-talk node or junction along the pathways. We also discuss the possible environmental and nonenvironmental inducers for these mutations, as well as the potential therapeutic strategies targeting these signaling pathways. A better understanding of how some risk factors induce deregulation of these signaling pathways, as well as how these deregulated pathways affect the development of PCa and CRPCa, will further help in the development of new treatments and prevention strategies for this disease.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/920612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31483822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

Androgen receptor-target genes in african american prostate cancer disparities. 非裔美国人前列腺癌差异中的雄激素受体靶基因。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-01-10 DOI: 10.1155/2013/763569

Bi-Dar Wang, Qi Yang, Kristin Ceniccola, Fernando Bianco, Ramez Andrawis, Thomas Jarrett, Harold Frazier, Steven R Patierno, Norman H Lee

{"title":"Androgen receptor-target genes in african american prostate cancer disparities.","authors":"Bi-Dar Wang, Qi Yang, Kristin Ceniccola, Fernando Bianco, Ramez Andrawis, Thomas Jarrett, Harold Frazier, Steven R Patierno, Norman H Lee","doi":"10.1155/2013/763569","DOIUrl":"https://doi.org/10.1155/2013/763569","url":null,"abstract":"The incidence and mortality rates of prostate cancer (PCa) are higher in African American (AA) compared to Caucasian American (CA) men. To elucidate the molecular mechanisms underlying PCa disparities, we employed an integrative approach combining gene expression profiling and pathway and promoter analyses to investigate differential transcriptomes and deregulated signaling pathways in AA versus CA cancers. A comparison of AA and CA PCa specimens identified 1,188 differentially expressed genes. Interestingly, these transcriptional differences were overrepresented in signaling pathways that converged on the androgen receptor (AR), suggesting that the AR may be a unifying oncogenic theme in AA PCa. Gene promoter analysis revealed that 382 out of 1,188 genes contained cis-acting AR-binding sequences. Chromatin immunoprecipitation confirmed STAT1, RHOA, ITGB5, MAPKAPK2, CSNK2A,1 and PIK3CB genes as novel AR targets in PCa disparities. Moreover, functional screens revealed that androgen-stimulated AR binding and upregulation of RHOA, ITGB5, and PIK3CB genes were associated with increased invasive activity of AA PCa cells, as siRNA-mediated knockdown of each gene caused a loss of androgen-stimulated invasion. In summation, our findings demonstrate that transcriptional changes have preferentially occurred in multiple signaling pathways converging (\"transcriptional convergence\") on AR signaling, thereby contributing to AR-target gene activation and PCa aggressiveness in AAs.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/763569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31201096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

HMGB1: A Promising Therapeutic Target for Prostate Cancer. HMGB1:前列腺癌的一个有前景的治疗靶点

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-05-12 DOI: 10.1155/2013/157103

Munirathinam Gnanasekar, Ramaswamy Kalyanasundaram, Guoxing Zheng, Aoshuang Chen, Maarten C Bosland, André Kajdacsy-Balla

引用次数: 43

Analysis of preoperative detection for apex prostate cancer by transrectal biopsy. 经直肠前列腺癌的术前活检分析。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-02-21 DOI: 10.1155/2013/705865

Tomokazu Sazuka, Takashi Imamoto, Takeshi Namekawa, Takanobu Utsumi, Mitsuru Yanagisawa, Koji Kawamura, Naoto Kamiya, Hiroyoshi Suzuki, Takeshi Ueda, Satoshi Ota, Yukio Nakatani, Tomohiko Ichikawa

{"title":"Analysis of preoperative detection for apex prostate cancer by transrectal biopsy.","authors":"Tomokazu Sazuka, Takashi Imamoto, Takeshi Namekawa, Takanobu Utsumi, Mitsuru Yanagisawa, Koji Kawamura, Naoto Kamiya, Hiroyoshi Suzuki, Takeshi Ueda, Satoshi Ota, Yukio Nakatani, Tomohiko Ichikawa","doi":"10.1155/2013/705865","DOIUrl":"https://doi.org/10.1155/2013/705865","url":null,"abstract":"Background. The aim of this study was to determine concordance rates for prostatectomy specimens and transrectal needle biopsy samples in various areas of the prostate in order to assess diagnostic accuracy of the transrectal biopsy approach, especially for presurgical detection of cancer in the prostatic apex. Materials and Methods. From 2006 to 2011, 158 patients whose radical prostatectomy specimens had been evaluated were retrospectively enrolled in this study. Concordance rates for histopathology results of prostatectomy specimens and needle biopsy samples were evaluated in 8 prostatic sections (apex, middle, base, and transitional zones bilaterally) from 73 patients diagnosed at this institution, besides factors for detecting apex cancer in total 118 true positive and false negative apex cancers. Results. Prostate cancer was found most frequently (85%) in the apex of all patients. Of 584 histopathology sections, 153 (49%) from all areas were false negatives, as were 45% of apex biopsy samples. No readily available preoperative factors for detecting apex cancer were identified. Conclusions. In Japanese patients, the most frequent location of prostate cancer is in the apex. There is a high false negative rate for transrectal biopsy samples. To improve the detection rate, transperitoneal biopsy or more accurate imaging technology is needed.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/705865","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40229770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22