Prostate Cancer最新文献_第8页

Natural history of untreated prostate specific antigen radiorecurrent prostate cancer in men with favorable prognostic indicators. 预后指标良好的男性未经治疗的前列腺特异性抗原放射复发性前列腺癌的自然病史。

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-20 DOI: 10.1155/2014/912943

Neil E Martin, Ming-Hui Chen, Clair J Beard, Paul L Nguyen, Marian J Loffredo, Andrew A Renshaw, Philip W Kantoff, Anthony V D'Amico

{"title":"Natural history of untreated prostate specific antigen radiorecurrent prostate cancer in men with favorable prognostic indicators.","authors":"Neil E Martin, Ming-Hui Chen, Clair J Beard, Paul L Nguyen, Marian J Loffredo, Andrew A Renshaw, Philip W Kantoff, Anthony V D'Amico","doi":"10.1155/2014/912943","DOIUrl":"https://doi.org/10.1155/2014/912943","url":null,"abstract":"Background and Purpose. Life expectancy data could identify men with favorable post-radiation prostate-specific antigen (PSA) failure kinetics unlikely to require androgen deprivation therapy (ADT). Materials and Methods. Of 206 men with unfavorable-risk prostate cancer in a randomized trial of radiation versus radiation and ADT, 53 experienced a PSA failure and were followed without salvage ADT. Comorbidity, age and established prognostic factors were assessed for relationship to death using Cox regression analyses. Results. The median age at failure, interval to PSA failure, and PSA doubling time were 76.6 years (interquartile range [IQR]: 71.8-79.3), 49.1 months (IQR: 37.7-87.4), and 25 months (IQR: 13.1-42.8), respectively. After a median follow up of 4.0 years following PSA failure, 45% of men had died, none from prostate cancer and no one had developed metastases. Both increasing age at PSA failure (HR: 1.14; 95% CI: 1.03-1.25; P = 0.008) and the presence of moderate to severe comorbidity (HR: 12.5; 95% CI: 3.81-41.0; P < 0.001) were significantly associated with an increased risk of death. Conclusions. Men over the age of 76 with significant comorbidity and a PSA doubling time >2 years following post-radiation PSA failure appear to be good candidates for observation without ADT intervention. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2014 ","pages":"912943"},"PeriodicalIF":4.2,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/912943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32234711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Erratum to "prostate cancer in South Africa: pathology based national cancer registry data (1986-2006) and mortality rates (1997-2009)". 对"南非前列腺癌:基于病理学的国家癌症登记数据(1986-2006年)和死亡率(1997-2009年)"的勘误。

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-12-22 DOI: 10.1155/2014/391257

Chantal Babb, Margaret Urban, Danuta Kielkowski, Patricia Kellett

引用次数: 2

Cryotherapy for primary treatment of prostate cancer: intermediate term results of a prospective study from a single institution. 用于前列腺癌初治的冷冻疗法：一家医疗机构前瞻性研究的中期结果。

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-20 DOI: 10.1155/2014/571576

S Alvarez Rodríguez, F Arias Fúnez, C Bueno Bravo, R Rodríguez-Patrón Rodríguez, E Sanz Mayayo, V Hevia Palacios, F J Burgos Revilla

{"title":"Cryotherapy for primary treatment of prostate cancer: intermediate term results of a prospective study from a single institution.","authors":"S Alvarez Rodríguez, F Arias Fúnez, C Bueno Bravo, R Rodríguez-Patrón Rodríguez, E Sanz Mayayo, V Hevia Palacios, F J Burgos Revilla","doi":"10.1155/2014/571576","DOIUrl":"10.1155/2014/571576","url":null,"abstract":"Purpose. Published data about cryotherapy for prostate cancer (PC) treatment are based on case series with a lack of clinical trials and the inexistence of a validated definition of biochemical failure. A prospective study with standardized followup protocol was conducted in our institution. Material and Methods. Prospective study of a series of cases including 108 patients diagnosed with localized PC at clinical stage T1c-T2c treated by primary cryoablation and median followup of 61 months. Criteria of biochemical recurrence were unified according to the American Society for Therapeutic Radiology and Oncology (ASTRO). End points were biochemical progression-free survival (BPFS), cancer-specific survival, and overall survival. Rate of complications was reported. Results. The BPFS for low-, medium-, and high-risk patients was 96.4%, 91.2%, and 62.2%, respectively. Cancer-specific survival was 98.1%. Overall survival reached 94.4%. Complications included incontinence in 5.6%, urinary tract obstruction in 1.9%, urethral sloughing in 5.6%, haematuria in 1.9%, perineal pain in 11.1%, and prostatorectal fistula in 0.9%. Erectile disfunction was found in 98.1%. Conclusions. Cryotherapy is an effective and minimally invasive treatment for primary PC in well-selected cases, with low surgical risk and good results in terms of BPFS, cancer-specific survival, and overall survival. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2014 ","pages":"571576"},"PeriodicalIF":4.2,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32228859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice. 近红外标记psma特异性小分子在荷瘤小鼠体内的药代动力学和生物分布评价。

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-04-07 DOI: 10.1155/2014/104248

Joy L Kovar, Lael L Cheung, Melanie A Simpson, D Michael Olive

{"title":"Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice.","authors":"Joy L Kovar, Lael L Cheung, Melanie A Simpson, D Michael Olive","doi":"10.1155/2014/104248","DOIUrl":"https://doi.org/10.1155/2014/104248","url":null,"abstract":"Prostate cancer is the most frequently diagnosed cancer in men and often requires surgery. Use of near infrared (NIR) technologies to perform image-guided surgery may improve accurate delineation of tumor margins. To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. IRDye 800CW was conjugated to YC-27 or an anti-PSMA antibody used for reference. Human 22Rv1, PC3M-LN4, and/or LNCaP prostate tumor cells were exposed to the labeled compounds. In vivo targeting and clearance properties were determined in tumor-bearing mice. Organs and tumors were excised and imaged to assess probe localization. YC-27 exhibited a dose dependent increase in signal upon binding. Binding specificity and internalization were visualized by microscopy. In vitro and in vivo blocking studies confirmed YC-27 specificity. In vivo, YC-27 showed good tumor delineation and tissue contrast at doses as low as 0.25 nmole. YC-27 was cleared via the kidneys but bound the proximal tubules of the renal cortex and epididymis. Since PSMA is also broadly expressed on the neovasculature of most tumors, we expect YC-27 will have clinical utility for image-guided surgery and tumor resections. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2014 ","pages":"104248"},"PeriodicalIF":4.2,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/104248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32321447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Evaluating the Impact of PSA as a Selection Criteria for Nerve Sparing Radical Prostatectomy in a Screened Cohort. 评估PSA作为保留神经的根治性前列腺切除术的选择标准的影响。

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-04-16 DOI: 10.1155/2014/395078

Shyam K Tanguturi, Ming-Hui Chen, Marian Loffredo, Jerome P Richie, Anthony V D'Amico

{"title":"Evaluating the Impact of PSA as a Selection Criteria for Nerve Sparing Radical Prostatectomy in a Screened Cohort.","authors":"Shyam K Tanguturi, Ming-Hui Chen, Marian Loffredo, Jerome P Richie, Anthony V D'Amico","doi":"10.1155/2014/395078","DOIUrl":"https://doi.org/10.1155/2014/395078","url":null,"abstract":"Purpose. We investigated whether NS-RP increased risk of PSA failure and whether PSA should be included as a selection criterion for NS. Methods. We evaluated 357 consecutive men with screen-detected PC who underwent open RP without adjuvant radiotherapy between 9/11/2001 and 12/30/2008. Criteria for NS included Gleason score ≤3 + 4, percentage of positive biopsies (PPB) ≤50%, percentage of core involvement ≤50%, nonapical location, no perineural invasion, and no palpable disease on pre- or intraoperative exam but did not include a PSA threshold. Cox multivariable regression assessed whether increasing PSA or unilateral- or bilateral-NS versus non-NS-RP was associated with PSA failure adjusting for prognostic factors. Results. After a median follow-up of 3.96 years, 34 men sustained PSA failure (9.5%). Increasing PSA was significantly associated with increased risk of PSA failure in the interaction model (adjusted hazard ratio (AHR): 1.09 [95% CI: 1.03-1.16]; P = 0.005), whereas unilateral (AHR: 1.24 [95% CI: 0.36-4.34]; P = 0.73) or bilateral NS (AHR: 0.41 [95% CI: 0.06-2.59]; P = 0.34) versus non-NS RP was not. Conclusion. NS-RP in a screened cohort did not increase risk of PSA failure using NS criteria not including PSA. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2014 ","pages":"395078"},"PeriodicalIF":4.2,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/395078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32341970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Single high intensity focused ultrasound session as a whole gland primary treatment for clinically localized prostate cancer: 10-year outcomes. 单次高强度聚焦超声作为临床局限性前列腺癌的全腺体主要治疗:10年结果

IF 4.2

Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-06-19 DOI: 10.1155/2014/186782

Ksenija Limani, Fouad Aoun, Serge Holz, Marianne Paesmans, Alexandre Peltier, Roland van Velthoven

{"title":"Single high intensity focused ultrasound session as a whole gland primary treatment for clinically localized prostate cancer: 10-year outcomes.","authors":"Ksenija Limani, Fouad Aoun, Serge Holz, Marianne Paesmans, Alexandre Peltier, Roland van Velthoven","doi":"10.1155/2014/186782","DOIUrl":"https://doi.org/10.1155/2014/186782","url":null,"abstract":"Objectives. To assess the treatment outcomes of a single session of whole gland high intensity focused ultrasound (HIFU) for patients with localized prostate cancer (PCa). Methods. Response rates were defined using the Stuttgart and Phoenix criteria. Complications were graded according to the Clavien score. Results. At a median follow-up of 94months, 48 (44.4%) and 50 (46.3%) patients experienced biochemical recurrence for Phoenix and Stuttgart definition, respectively. The 5- and 10-year actuarial biochemical recurrence free survival rates were 57% and 40%, respectively. The 10-year overall survival rate, cancer specific survival rate, and metastasis free survival rate were 72%, 90%, and 70%, respectively. Preoperative high risk category, Gleason score, preoperative PSA, and postoperative nadir PSA were independent predictors of oncological failure. 24.5% of patients had self-resolving LUTS, 18.2% had urinary tract infection, and 18.2% had acute urinary retention. A grade 3b complication occurred in 27 patients. Pad-free continence rate was 87.9% and the erectile dysfunction rate was 30.8%. Conclusion. Single session HIFU can be alternative therapy for patients with low risk PCa. Patients with intermediate risk should be informed about the need of multiple sessions of HIFU and/or adjuvant treatments and HIFU performed very poorly in high risk patients. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2014 ","pages":"186782"},"PeriodicalIF":4.2,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/186782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32521252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

3D versus 2D Systematic Transrectal Ultrasound-Guided Prostate Biopsy: Higher Cancer Detection Rate in Clinical Practice. 三维与二维系统经直肠超声引导前列腺活检:临床实践中更高的癌症检出率。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-11-17 DOI: 10.1155/2013/783243

Alexandre Peltier, Fouad Aoun, Fouad El-Khoury, Eric Hawaux, Ksenija Limani, Krishna Narahari, Nicolas Sirtaine, Roland van Velthoven

{"title":"3D versus 2D Systematic Transrectal Ultrasound-Guided Prostate Biopsy: Higher Cancer Detection Rate in Clinical Practice.","authors":"Alexandre Peltier, Fouad Aoun, Fouad El-Khoury, Eric Hawaux, Ksenija Limani, Krishna Narahari, Nicolas Sirtaine, Roland van Velthoven","doi":"10.1155/2013/783243","DOIUrl":"https://doi.org/10.1155/2013/783243","url":null,"abstract":"Objectives. To compare prostate cancer detection rates of extended 2D versus 3D biopsies and to further assess the clinical impact of this method in day-to-day practice. Methods. We analyzed the data of a cohort of 220 consecutive patients with no prior history of prostate cancer who underwent an initial prostate biopsy in daily practice due to an abnormal PSA and/or DRE using, respectively, the classical 2D and the new 3D systems. All the biopsies were done by a single experienced operator using the same standardized protocol. Results. There was no significant difference in terms of age, total PSA, or prostate volume between the two groups. However, cancer detection rate was significantly higher using the 3D versus the 2D system, 50% versus 34% (P < 0.05). There was no statistically significant difference while comparing the 2 groups in term of nonsignificant cancer detection. Conclusion. There is reasonable evidence demonstrating the superiority of the 3D-guided biopsies in detecting prostate cancers that would have been missed using the 2D extended protocol. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2013 ","pages":"783243"},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/783243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31964480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells. Skip 可调控 TGF- β 1 诱导的人 PC-3 前列腺癌细胞细胞外基质降解蛋白酶的表达。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-05-20 DOI: 10.1155/2013/398253

Victor Villar, Jelena Kocic, Juan F Santibanez

{"title":"Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells.","authors":"Victor Villar, Jelena Kocic, Juan F Santibanez","doi":"10.1155/2013/398253","DOIUrl":"10.1155/2013/398253","url":null,"abstract":"Purpose. To determine whether Ski-interacting protein (SKIP) regulates TGF- β 1-stimulated expression of urokinase-type plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and uPA Inhibitor (PAI-1) in the androgen-independent human prostate cancer cell model. Materials and Methods. PC-3 prostate cancer cell line was used. The role of SKIP was evaluated using synthetic small interference RNA (siRNA) compounds. The expression of uPA, MMP-9, and PAI-1 was evaluated by zymography assays, RT-PCR, and promoter transactivation analysis. Results. In PC-3 cells TGF- β 1 treatment stimulated uPA, PAI-1, and MMP-9 expressions. The knockdown of SKIP in PC-3 cells enhanced the basal level of uPA, and TGF- β 1 treatment inhibited uPA production. Both PAI-1 and MMP-9 production levels were increased in response to TGF- β 1. The ectopic expression of SKIP inhibited both TGF- β 1-induced uPA and MMP-9 promoter transactivation, while PAI-1 promoter response to the factor was unaffected. Conclusions. SKIP regulates the expression of uPA, PAI-1, and MMP-9 stimulated by TGF- β 1 in PC-3 cells. Thus, SKIP is implicated in the regulation of extracellular matrix degradation and can therefore be suggested as a novel therapeutic target in prostate cancer treatment.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2013 ","pages":"398253"},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31506209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Study of Laparoscopic Doppler Ultrasound Probe to Map Arterial Vascular Flow within the Neurovascular Bundle during Robot-Assisted Radical Prostatectomy. 腹腔镜多普勒超声探头在机器人辅助根治性前列腺切除术中绘制神经血管束内动脉血流的初步研究。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-06-19 DOI: 10.1155/2013/810715

Ketan K Badani, Edan Y Shapiro, William T Berg, Sarah Kaufman, Ari Bergman, Chris Wambi, Arindam Roychoudhury, Trushar Patel

{"title":"A Pilot Study of Laparoscopic Doppler Ultrasound Probe to Map Arterial Vascular Flow within the Neurovascular Bundle during Robot-Assisted Radical Prostatectomy.","authors":"Ketan K Badani, Edan Y Shapiro, William T Berg, Sarah Kaufman, Ari Bergman, Chris Wambi, Arindam Roychoudhury, Trushar Patel","doi":"10.1155/2013/810715","DOIUrl":"https://doi.org/10.1155/2013/810715","url":null,"abstract":"Purpose. To report on the feasibility of a new Laparoscopic Doppler ultrasound (LDU) technology to aid in identifying and preserving arterial blood flow within the neurovascular bundle (NVB) during robotic prostatectomy (RARP). Materials and Methods. Nine patients with normal preoperative potency and scheduled for a bilateral nerve-sparing procedure were prospectively enrolled. LDU was used to measure arterial flow at 6 anatomic locations alongside the prostate, and signal intensity was evaluated by 4 independent reviewers. Measurements were made before and after NVB dissection. Modifications in nerve-sparing procedure due to LDU use were recorded. Postoperative erectile function was assessed. Fleiss Kappa statistic was used to evaluate inter-rater agreement for each of the 12 measurements. Results. Analysis of Doppler signal intensity showed maintenance of flow in 80% of points assessed, a decrease in 16%, and an increase in 4%. Plane of NVB dissection was altered in 5 patients (56%) on the left and in 4 patients (44%) on the right. There was good inter-rater reliability for the 4 reviewers. Use of the probe did not significantly increase operative time or result in any complications. Seven (78%) patients had recovery of erections at time of the 8-month follow-up visit. Conclusions. LDU is a safe, easy to use, and effective method to identify local vasculature and anatomic landmarks during RARP, and can potentially be used to achieve greater nerve preservation. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2013 ","pages":"810715"},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/810715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31586414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Androgen receptor-target genes in african american prostate cancer disparities. 非裔美国人前列腺癌差异中的雄激素受体靶基因。

IF 4.2

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-01-10 DOI: 10.1155/2013/763569

Bi-Dar Wang, Qi Yang, Kristin Ceniccola, Fernando Bianco, Ramez Andrawis, Thomas Jarrett, Harold Frazier, Steven R Patierno, Norman H Lee

{"title":"Androgen receptor-target genes in african american prostate cancer disparities.","authors":"Bi-Dar Wang, Qi Yang, Kristin Ceniccola, Fernando Bianco, Ramez Andrawis, Thomas Jarrett, Harold Frazier, Steven R Patierno, Norman H Lee","doi":"10.1155/2013/763569","DOIUrl":"https://doi.org/10.1155/2013/763569","url":null,"abstract":"The incidence and mortality rates of prostate cancer (PCa) are higher in African American (AA) compared to Caucasian American (CA) men. To elucidate the molecular mechanisms underlying PCa disparities, we employed an integrative approach combining gene expression profiling and pathway and promoter analyses to investigate differential transcriptomes and deregulated signaling pathways in AA versus CA cancers. A comparison of AA and CA PCa specimens identified 1,188 differentially expressed genes. Interestingly, these transcriptional differences were overrepresented in signaling pathways that converged on the androgen receptor (AR), suggesting that the AR may be a unifying oncogenic theme in AA PCa. Gene promoter analysis revealed that 382 out of 1,188 genes contained cis-acting AR-binding sequences. Chromatin immunoprecipitation confirmed STAT1, RHOA, ITGB5, MAPKAPK2, CSNK2A,1 and PIK3CB genes as novel AR targets in PCa disparities. Moreover, functional screens revealed that androgen-stimulated AR binding and upregulation of RHOA, ITGB5, and PIK3CB genes were associated with increased invasive activity of AA PCa cells, as siRNA-mediated knockdown of each gene caused a loss of androgen-stimulated invasion. In summation, our findings demonstrate that transcriptional changes have preferentially occurred in multiple signaling pathways converging (\"transcriptional convergence\") on AR signaling, thereby contributing to AR-target gene activation and PCa aggressiveness in AAs.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2013 ","pages":"763569"},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/763569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31201096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48