Recenti progressi in medicina最新文献

{"title":"[Doula support is associated with improved maternal and neonatal health outcomes].","authors":"Alice Serafini, Linda Speer","doi":"10.1701/4518.45176","DOIUrl":"10.1701/4518.45176","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"380-381"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A colloquio con Nicola Baldi: la ricerca della conoscenza, coltivando la Medicina dell’incertezza.","authors":"","doi":"10.1701/4518.45181","DOIUrl":"10.1701/4518.45181","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"393"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the reimbursement times of antitumor drugs in Italy in relation to the clinical benefit expressed by the European Society for Medical Oncology (ESMO-MCBS)].","authors":"Alessia Romagnoli, Andrea Marcellusi, Ruggero Lasala","doi":"10.1701/4518.45175","DOIUrl":"10.1701/4518.45175","url":null,"abstract":"<p><strong>Introduction: </strong>Rapid access to safe and effective oncological therapies is crucial. In recent years, many expensive drugs have been commercialized, making it essential to prioritize those with significant clinical benefits. For this purpose, the European Society for Medical Oncology (ESMO) introduced the ESMO-MCBS (Magnitude of Clinical Benefit Scale), which assigns a score to quantify the clinical benefit of treatments. This study aims to evaluate whether there is a correlation between the ESMO-MCBS score and drug access times in Italy.</p><p><strong>Materials and methods: </strong>The clinical benefit was directly extracted from the official ESMO website, considering registrational trials. Data on drug access times included: the date of a positive opinion from the Committee for Medicinal Products for Human Use (CHMP), the date of authorization published in the European Official Journal (EU OJ), the date of submission of the drug dossier to the Italian Medicines Agency (AIFA) by the company, the date of opinions issued by AIFA's Technical Scientific Committee and pricing and reimbursement committee, and the date of publication in the Italian Official Journal (OJ). Access time was calculated as the difference in days between the publication dates in the Italian OJ and EU OJ. Subgroup analyses also considered EMA authorization procedures (accelerated approval, conditional marketing), drug classification as \"orphan drug,\" and the innovativeness requirement.</p><p><strong>Results: </strong>The analysis included 48 drugs, corresponding to 57 registrational trials, of which 4 referred to drugs not yet commercialized by AIFA, and 7 did not lead to reimbursement. The evaluation focused on 46 registrational trials. The average access time was 488 days: 480 days for drugs with significant benefit and 499 days for those without significant benefit. For orphan drugs, the average access time was 499 days. Drugs with EMA accelerated assessment showed shorter access times (440 days), while those with conditional marketing approval had longer access times (556 days). Drugs evaluated by AIFA for innovativeness were authorized faster on average.</p><p><strong>Discussion and conclusions: </strong>No significant difference in access times was observed between drugs with significant and non-significant clinical benefits. Among the analyzed subgroups, access times are better for drugs with accelerated approval and for which AIFA has expressed an opinion of innovativeness, comparable for drugs designated as \"orphan drugs\", worse when the EMA authorization occurred as conditional marketing.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"371-379"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ritratto di Peter Kurotschka.","authors":"","doi":"10.1701/4518.45180","DOIUrl":"10.1701/4518.45180","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"389-392"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bacterial vaginosis: treating the male partner may help prevent recurrence].","authors":"Viviana Forte, Mark H Ebell","doi":"10.1701/4518.45179","DOIUrl":"10.1701/4518.45179","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"386-388"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic itineraries in primary care: problem setting, selective abduction, heuristics and threshold approach].","authors":"Giuseppe Belleri","doi":"10.1701/4518.45173","DOIUrl":"10.1701/4518.45173","url":null,"abstract":"<p><p>This article offers a review of the logical-cognitive components of the diagnostic process with the aim of integrating them, depending on the characteristics of the problem, into a sequential methodological algorithm, including problem solving, circumstantial knowledge, nosographic recognition and subjective probabilistic evaluation. The article traces the diagnostic process of the practical doctor faced with a patient unknown to him, who complains of recently onset symptoms and who consults a primary care doctor or goes to the emergency room. This approach is suitable for the first diagnostic approach in the generalistic setting (including local healthcare contexts and hospital contexts). It is composed of a continuum of cognitive sub-processes in a step-by-step scheme that is articulated as follows: problem setting, selective abduction, heuristics, Bayesian approach to decision making thresholds, and background pathophysiological interpretation.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"348-356"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[In older people depression and anxiety scores can improve with group-based arts programs].","authors":"Daniele Ferrari, Allen F Shaughnessy","doi":"10.1701/4518.45177","DOIUrl":"10.1701/4518.45177","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"382-383"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dalla letteratura<br>2025 Giugno.","authors":"","doi":"10.1701/4518.45171","DOIUrl":"https://doi.org/10.1701/4518.45171","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"336-340"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In questo numero<br>2025 Giugno.","authors":"","doi":"10.1701/4518.45170","DOIUrl":"https://doi.org/10.1701/4518.45170","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"335"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Dancing has small but statistically significant effects on cognition and depression scores in adults aged 60 or over].","authors":"Mario Luciano, Henry Barry, Daniele Ferrari","doi":"10.1701/4518.45178","DOIUrl":"10.1701/4518.45178","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 6","pages":"384-385"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}