{"title":"About the Authors","authors":"I. Shmulevich","doi":"10.1177/1529100612459637","DOIUrl":"https://doi.org/10.1177/1529100612459637","url":null,"abstract":"Mining large datasets using machine learning approaches often leads to models that are hard to interpret and not amenable to the generation of hypotheses that can be experimentally tested. Finding ‘actionable knowledge’ is becoming more important, but also more challenging as datasets grow in size and complexity. We present ‘Logic Optimization for Binary Input to Continuous Output’ (LOBICO), a computational approach that infers small and easily interpretable logic models of binary input features that explain a binarized continuous output variable. Although the continuous output variable is binarized prior to optimization, the continuous information is retained to find the optimal logic model. Applying LOBICO to a large cancer cell line panel, we find that logic combinations of multiple mutations are more predictive of drug response than single gene predictors. Importantly, we show that the use of the continuous information leads to robust and more accurate logic models. LOBICO is formulated as an integer programming problem, which enables rapid computation on large datasets. Moreover, LOBICO implements the ability to uncover logic . CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/036970 doi: bioRxiv preprint first posted online Jan. 15, 2016;","PeriodicalId":20879,"journal":{"name":"Psychological Science in the Public Interest","volume":"13 1","pages":"104 - 104"},"PeriodicalIF":25.4,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1529100612459637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65439638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"About the Authors","authors":"J. Bew","doi":"10.1177/1529100612448321","DOIUrl":"https://doi.org/10.1177/1529100612448321","url":null,"abstract":"John Krogstie has a PhD (1995) and an MSc (1991) in Information Systems, both from the Norwegian University of Science and Technology (NTNU). He is currently a senior research scientist at SINTEF. He is also a part-time professor at NTNU and was employed as a manager at Accenture (1991-2000). Dr. Krogstie is the Norwegian representative for IFIP TC8 and a member of IFIP WG 8.1 on Information Systems Design and Evaluation, where he is the initiator and leader of the task group for Mobile Information Systems. He has published approximately 50 refereed papers in journals, books, and archival proceedings since 1991.","PeriodicalId":20879,"journal":{"name":"Psychological Science in the Public Interest","volume":"13 1","pages":"72 - 72"},"PeriodicalIF":25.4,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1529100612448321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65439632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"About the Authors","authors":"Jüri Talvet","doi":"10.12697/il.2011.16.2.22","DOIUrl":"https://doi.org/10.12697/il.2011.16.2.22","url":null,"abstract":"Stephen J. Ceci is the Helen L. Carr Professor of Psychology at Cornell University where he studies memory development, intelligence, and various professional issues such as free speech, viewpoint diversity, and women in science. He is the author of approximately 500 publications and is the recipient of numerous lifetime achievement awards from the Association for Psychological Science, the American Psychological Association, and the Society for Research on Child Development. He has served as president of the Society for Experimental Psychology & Cognitive Science and the Society for General Psychology, and in 2016, he was elected as a member of the American Academy of Arts & Sciences.","PeriodicalId":20879,"journal":{"name":"Psychological Science in the Public Interest","volume":"24 1","pages":"iii - iv"},"PeriodicalIF":25.4,"publicationDate":"2011-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66672047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"About the Authors","authors":"P. A. Crowl","doi":"10.1177/1529100611430200","DOIUrl":"https://doi.org/10.1177/1529100611430200","url":null,"abstract":"Philip Kotler (M.A., University of Chicago; Ph.D., MIT) is the S. C. Johnson Distinguished Professor of International Marketing at the Kellogg School of Management, Northwestern University. He has published the 13th edition of Marketing Management, the world’s leading textbook on teaching marketing to MBAs. He has also published Strategic Marketing for Nonprofit Organizations, Social Marketing, Corporate Social Responsibility, Marketing in the Public Sector, and 30 other books. His research covers social marketing, strategic marketing, innovation, services marketing, and Internet marketing. He has received 12 honorary doctorate degrees from major universities in the U.S. and abroad.","PeriodicalId":20879,"journal":{"name":"Psychological Science in the Public Interest","volume":"12 1","pages":"ii - ii"},"PeriodicalIF":25.4,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1529100611430200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65439073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"About the Authors","authors":"Katerina Evers","doi":"10.1177/1529100611424127","DOIUrl":"https://doi.org/10.1177/1529100611424127","url":null,"abstract":"Katinka Evers conducted her doctoral studies in philosophy at Balliol College, University of Oxford, at the Research School of Social Sciences, Australian National University Canberra, and at Lund University, Sweden, where she received her doctoral degree in 1991. She has been a research fellow at Balliol College, University of Oxford (1994), at the Department of Philosophy and Human Rights Centre, University of Essex (1996-1997), invited professor at the University of Tasmania Hobart (1999), at École Normale Suprieure Paris (2002), and at Collège de France Paris (2006-2007). From 1997 to 2002 she was the executive director for the Standing Committee on Responsibility and Ethics in Science of the International Council for Science. Today she leads the neuroethics research team at the Centre for Research Ethis and Bioethics at Uppsala University, where her main interests are neuroethics and the neural basis of consciousness. She has recently been appointed honorary professor at Universidad Central de Chile. Address: Prof. Dr. Katinka Evers, Centre for Research Ethics and Bioethics, Husargatan 3, Uppsala University, 75122 Uppsala, Sweden; email: Kathinka.Evers@crb.uu.se","PeriodicalId":20879,"journal":{"name":"Psychological Science in the Public Interest","volume":"12 1","pages":"92 - 92"},"PeriodicalIF":25.4,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1529100611424127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65439033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"About the Authors","authors":"","doi":"10.1177/152910061101200101","DOIUrl":"https://doi.org/10.1177/152910061101200101","url":null,"abstract":"","PeriodicalId":20879,"journal":{"name":"Psychological Science in the Public Interest","volume":"12 1","pages":"2 - 2"},"PeriodicalIF":25.4,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/152910061101200101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65439393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"About the Authors","authors":"J. Rath","doi":"10.2752/9781847888945/UNRAVRAG0014","DOIUrl":"https://doi.org/10.2752/9781847888945/UNRAVRAG0014","url":null,"abstract":"Parasitology publishes definitive papers on all aspects of pure and applied parasitology including biochemistry, molecular biology, immunology, genetics, ecology and physiology and also the application of new techniques, long term epidemiology studies, advances in the understanding of life-cycles, chemotherapy and major systematic revisions. Papers should normally be full length with an explanatory introduction and detailed discussion of the findings reported. Shorter reports of particularly important findings will also be considered.","PeriodicalId":20879,"journal":{"name":"Psychological Science in the Public Interest","volume":"23 1","pages":"iii - iv"},"PeriodicalIF":25.4,"publicationDate":"2002-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69400831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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