Wenhui Zhai, Mingchao Li, Zou Su, Qiuming Ji, Zijun Xiong, Yijing Zhao, Yuhong Yang, Dan Liao, Chi Li, Cairong Wang
{"title":"The effect of repetitive transcranial magnetic stimulation on the negative symptoms of chronic schizophrenia and serum brain-derived neurotrophic factor.","authors":"Wenhui Zhai, Mingchao Li, Zou Su, Qiuming Ji, Zijun Xiong, Yijing Zhao, Yuhong Yang, Dan Liao, Chi Li, Cairong Wang","doi":"10.12740/PP/153375","DOIUrl":"https://doi.org/10.12740/PP/153375","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on the negative symptoms of chronic schizophrenia and serum brainderived neurotrophic factor (BDNF).</p><p><strong>Methods: </strong>A total of 86 patients with chronic schizophrenia hospitalised from March to October 2019 were randomly assigned to the active rTMS group or the sham rTMS group, with 43 patients in each group. All patients were administered paliperidone orally at a dose of 3-6 mg/d, and rTMS treatment was given to the active rTMS group. The Positive and Negative Syndrome Scale (PANSS) score and the serum BDNF concentration were calculated in both groups at baseline and after two and four weeks of treatment.</p><p><strong>Results: </strong>There were no statistically significant differences in the PANSS scores and serum BDNF concentrations between the two groups before treatment (p > 0.05). However, after four weeks of treatment, the change in the score on the negative symptom scale in the active rTMS group was greater than in the sham rTMS group (p < 0.05), and the serum BDNF levels in the active rTMS group were higher than in the sham rTMS group (p < 0.05).</p><p><strong>Conclusions: </strong>Four weeks of continuous rTMS treatment can effectively improve the negative symptoms of schizophrenia, and the serum concentration of BDNF increases as the duration of rTMS treatment increases.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1293-1303"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Motives of abstinence versus metacognition and self-conscious emotions in people addicted to alcohol.","authors":"Mateusz Wojtczak, Sławomir Ślaski","doi":"10.12740/PP/152400","DOIUrl":"https://doi.org/10.12740/PP/152400","url":null,"abstract":"<p><strong>Objectives: </strong>The target of the present study was to show the relationship between time and motives for maintaining abstinence and metacognitive beliefs about alcohol and self-conscious emotions.</p><p><strong>Methods: </strong>Ninety-one alcohol-dependent individuals who are currently maintaining abstinence participated in the study. Three instruments were used to measure individual variables: RALD was used to examine motives for maintaining abstinence, MPA was used to measure the level of individual metacognitive beliefs about alcohol, and SUM 5 was used to measure the level of self-conscious emotions in addicts who maintain abstinence. Correlation analyses were performed and differences in mean ranks of metacognition and self-awareness emotions were examined for the two independent samples.</p><p><strong>Results: </strong>All metacognitive beliefs were shown to negatively correlate with abstinence time. Some metacognitive beliefs were negatively associated with abstinence motives. Moreover, positive associations of self-conscious emotions and metacognitive beliefs with time and abstinence motives were found. Both metacognitive beliefs and self-conscious emotions have different mean levels depending on the duration of abstinence.</p><p><strong>Conclusions: </strong>The study revealed that both psychological constructs are related to abstinence maintenance and can be creatively used in further analyses of addiction recovery and relapse prevention.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1277-1291"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatria polskaPub Date : 2023-12-31DOI: 10.12740/PP/OnlineFirst/151570
Anna Julia Krupa, Krzysztof Wojtasik-Bakalarz, Marcin Siwek
{"title":"Vortioxetine - pharmacological properties and use in mood disorders. The current state of knowledge.","authors":"Anna Julia Krupa, Krzysztof Wojtasik-Bakalarz, Marcin Siwek","doi":"10.12740/PP/OnlineFirst/151570","DOIUrl":"10.12740/PP/OnlineFirst/151570","url":null,"abstract":"<p><p>Vortioxetine is an antidepressant with a unique profile of receptor activity. The pharmacodynamic spectrum of vortioxetine activity is linked to the modulation of not only serotoninergic but also noradrenergic and dopaminergic transmission. At the same time, its pharmacokinetic properties determine good tolerance and safety, which are also observed in elderly patients and those burdened with somatic comorbidity. This work aims to sum up the knowledge coming from the most recent studies assessing the efficacy of vortioxetine. The efficacy of vortioxetine in the treatment of depression was confirmed in a large number of open studies, randomized controlled studies with placebo control, and meta-analyses thereof. What is more, the latest research shows that this drug allows depressed patients to achieve not only symptomatic remission but also an improvement of anhedonia and recovery in cognitive and occupational function. Furthermore, there are studies showing that vortioxetine is efficacious in the treatment of elderly patients, as well as subjects who have experienced trauma or suffer from bipolar depression. Vortioxetine is characterized by a good tolerance profile and safety; rarely does it cause severe adverse effects.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"1109-1126"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10430373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polish adaptation and validation of the Short Inventory of Problems (SIP-2L).","authors":"Kamila Morawska, Jan Chodkiewicz","doi":"10.12740/PP/153433","DOIUrl":"https://doi.org/10.12740/PP/153433","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the research was to present the Polish adaptation and validation of the Short Inventory of Problems (SIP-2L) by Miller et al. (1995). The SIP-2L is a popular selfreport measure used to assess the negative consequences of alcohol use in 5 domains with negative consequences: physical, interpersonal, intrapersonal, social and impulse control. The adapted version of SIP assesses lifetime consequences of using alcohol.</p><p><strong>Methods: </strong>A total of 256 participants diagnosed with alcohol dependence (71 women and 185 men) completed an assessment battery that included SIP-2L and Polish versions of AUDIT, MAST and KOEP-R, which is a modified Polish adaptation of CEAQ - Comprehensive Effects of Alcohol Questionnaire.</p><p><strong>Results: </strong>Confirmatory factor analysis demonstrated the hypothesized 5-factor model produced the best fit. Reliability of the entire method (Cronbach's α = 0.868) and for all factors was satisfactory, as was convergent validity.</p><p><strong>Conclusions: </strong>The results support that the Polish version of the SIP-2L has good psychometric properties and can successfully assess the consequences of drinking among patients diagnosed with alcohol dependence.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1263-1276"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatria polskaPub Date : 2023-12-31DOI: 10.12740/PP/OnlineFirst/151961
Alicja Kawalec, Krzysztof Maria Wilczyński, Adrianna Biecka, Dominika Krupnik, Wojciech Grabowski, Małgorzata Janas-Kozik
{"title":"Coping methods among Polish students during Covid-19 pandemic.","authors":"Alicja Kawalec, Krzysztof Maria Wilczyński, Adrianna Biecka, Dominika Krupnik, Wojciech Grabowski, Małgorzata Janas-Kozik","doi":"10.12740/PP/OnlineFirst/151961","DOIUrl":"10.12740/PP/OnlineFirst/151961","url":null,"abstract":"<p><strong>Objectives: </strong>The Covid-19 pandemic changed daily routines and forced people to develop various coping methods. University students were a social group that suffered due to a drastic change in their daily routine. The analysis of adaptation to chronic stress may help in developing more individualized care for people affected by it.</p><p><strong>Methods: </strong>The examination of coping methods and aggression level was conducted using Brief COPE and STAXI-2 questionnaires on a group of 283 participants, extracted from the initial group of 906 tested students. The study was conducted between the second and the third wave of pandemic in Poland.</p><p><strong>Results: </strong>The positive coping methods were dominant among the examined group. The most used were active coping, use of informational support and planning. The negative coping methods were inextricably linked to a higher aggression level, and were more prevailing in the female students.</p><p><strong>Conclusions: </strong>The first symptoms of maladaptive behaviors may be hidden in presumably usual activities and attitudes. It is important to be aware of them in order to provide support for students and other social groups affected by chronic stress.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"1151-1167"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10598841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatria polskaPub Date : 2023-12-31DOI: 10.12740/PP/OnlineFirst/152050
Rafał Skowronek, Anna Skowronek, Sylwia Tarka, Zofia I Niemir, Jerzy Chudek, Marek Krzystanek
{"title":"A rare case of fatal poisoning during long-term therapy with lithium carbonate - chronic poisoning, suicide or psychiatric malpractice?","authors":"Rafał Skowronek, Anna Skowronek, Sylwia Tarka, Zofia I Niemir, Jerzy Chudek, Marek Krzystanek","doi":"10.12740/PP/OnlineFirst/152050","DOIUrl":"10.12740/PP/OnlineFirst/152050","url":null,"abstract":"<p><p>The study aims to present a case of atypical poisoning with lithium carbonate in a 57-year-old woman treated for bipolar affective disorder with lithium carbonate for about 30 years. The patient was admitted to the hospital with significant agitation. An important finding obtained from the family interview was the patient's significant weight loss over the past year. In the hospital, the patient received haloperidol and clonazepam. Laboratory tests showed a very high blood lithium concentration of 3.79 mmol/l [N: 0.6─1.2 mmol/l] and elevated serum concentrations of creatinine (3.6 mg/dl) and urea (110 mg/dl). The patient was transferred to the toxicology department, where hemodialysis was performed and intensive treatment initiated. Despite the rapid decrease in lithium levels, her condition gradually deteriorated. The patient died on the fifth day of hospitalization. The autopsy revealed polycystic kidney disease (PKD). During the preparation of the medico-legal report on the correctness of the medical treatment, it was assumed that the cause of death was lithium carbonate poisoning in the course of advanced chronic kidney disease due to PKD, probably a consequence of long-term lithium therapy. The analysis of medical records revealed that despite her psychiatrist's recommendation, the patient had been refusing the monitoring of lithium levels for the past 18 years. This case demonstrates that both psychiatrists and toxicologists should be aware of possible lithium poisoning upon the deterioration of renal function. Therefore, assessment of renal function should be an integral part of monitoring lithium therapy.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"1127-1133"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10608484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial.","authors":"Dominika Dudek, Jerzy A Sobański, Katarzyna Klasa","doi":"10.12740/PP/183125","DOIUrl":"https://doi.org/10.12740/PP/183125","url":null,"abstract":"<p><p>No summary.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1105-1106"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariola Elżbieta Friedrich, Joanna Fugiel, Izabela Dziaduch
{"title":"Assessing effects of diet alteration on selected parameters of chronically mentally ill residents of a 24-hour Nursing Home. Part 3: Effects of diet modification on selected health indicators.","authors":"Mariola Elżbieta Friedrich, Joanna Fugiel, Izabela Dziaduch","doi":"10.12740/PP/156718","DOIUrl":"https://doi.org/10.12740/PP/156718","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the research was to check whether, and to what extent, dietary changes affect the selected indicators of health, including well-being.</p><p><strong>Methods: </strong>The study, lasting 3 years, included 52 chronically mentally ill people. Hand grip strength (HGS) measurements ‟before\" and ‟after\" feeding adjustments were performed using a SaehanTM pear dynamometer, blood pressure measurements were made using an Omron blood pressure monitor. Well-being was assessed using the UMACL Adjective Mood Scale. Based on the analysis of medical records, the study also included: the number of infections of the upper respiratory tract, the number of autoaggressive/aggressive behaviors and the frequency of stay of extremely offensive/agitated residents in the hospital.</p><p><strong>Results: </strong>The dietary changes were reflected in the increased value of the hand grip strength (especially in women), lowered or normalized blood pressure to normal or recommended values, lowered tension arousal, accompanied by an increase in energetic arousal and hedonic tone (translating into improved well-being and mood), and a decrease in the number of episodes of aggression/self-aggression and associated hospitalizations.</p><p><strong>Conclusions: </strong>The dietary changes resulted in an improvement in the tested parameters as well as in reduction in the amount of food wasted by the residents. There was also a decrease in the number of catarrh of the upper respiratory tract, which reduced the overall number and quantity of prescribed drugs.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1195-1211"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iga Stokłosa, Sylwia Bulanda, Karolina Lau, Jadwiga Jośko-Ochojska
{"title":"Acute psychosis in a 35-year-old woman. Could it be related to a previous COVID-19 infection? A case report.","authors":"Iga Stokłosa, Sylwia Bulanda, Karolina Lau, Jadwiga Jośko-Ochojska","doi":"10.12740/PP/152699","DOIUrl":"https://doi.org/10.12740/PP/152699","url":null,"abstract":"<p><p>The SARS-CoV-2 virus is the cause of the COVID-19 disease. Infection can take a wide variety of forms, from asymptomatic to severe, with numerous complications that can even lead to death. Since the beginning of the pandemic, numerous studies have been carried out to find out the exact expression of the virus. COVID-19 infection also increases the risk of developing neuropsychiatric symptoms, including psychosis. The paper presents the case of a 35-year-old woman with no prior psychiatric interview who developed acute psychosis after being infected with COVID-19. She was treated in the standard way: haloperidol, lorazepam and diazepam. The symptoms disappeared quickly. At the moment, the long-term consequences of SARS-CoV-2 infection are not known, therefore further observation and research in this direction is necessary. Treatment, as shown in this case report, appears to be supportive and symptomatic. The optimal antiviral treatment has yet to be clearly defined, and research into the best treatment for the virus itself is still ongoing.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1143-1149"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient with Asperger's Syndrome, with episodes of fantasizing and rocking of body, treated with aripiprazole - a case report.","authors":"Maciej Dul, Krzysztof Walczewski","doi":"10.12740/PP/152316","DOIUrl":"https://doi.org/10.12740/PP/152316","url":null,"abstract":"<p><p>In this article, we present the case of an adult patient, whose main problem is episodes of fantasizing and rocking lasting up to 12 hours a day and completely preventing school development. The nature of the disorder in the patient is related to the sinking into fantasies, and not typical obsessions as in OCD. The patient was previously treated with drugs from the SSRI group, neuroleptics (without aripiprazole) and methylphenidate. Only methylphenidate showed some improvement; however, it made the patient feel ‟stiff in thinking\". The patient was hospitalized because of a suicide attempt, which, as it later turned out, was self-harm with no intention of killing himself. During hospitalization, a differential diagnosis was performed and the diagnosis of Asperger's syndrome was made, which was accompanied by immersion in the world of one's fantasies and stereotypical behavior. The patient was administered aripiprazole at a dose of 15 mg/d and after three weeks, a significant improvement in health was achieved, including a reduction in the duration of episodes from several hours to several dozen seconds. The drug is well tolerated by the patient. The patient was discharged from the hospital and continues his school education. In the article, we present single case reports in which similar spectacular results were achieved in similar cases. We also describe a possible physiological explanation for this response to this drug.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1135-1142"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}