Progress in Neurobiology最新文献_第9页

Reclusive chandeliers: Functional isolation of dentate axo-axonic cells after experimental status epilepticus 隐世吊灯：实验性癫痫持续状态后齿状轴索细胞的功能分离。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-26 DOI: 10.1016/j.pneurobio.2023.102542

Archana Proddutur , Susan Nguyen , Chia-Wei Yeh , Akshay Gupta , Vijayalakshmi Santhakumar

{"title":"Reclusive chandeliers: Functional isolation of dentate axo-axonic cells after experimental status epilepticus","authors":"Archana Proddutur , Susan Nguyen , Chia-Wei Yeh , Akshay Gupta , Vijayalakshmi Santhakumar","doi":"10.1016/j.pneurobio.2023.102542","DOIUrl":"10.1016/j.pneurobio.2023.102542","url":null,"abstract":"<div><p>Axo-axonic cells (AACs) provide specialized inhibition to the axon initial segment (AIS) of excitatory neurons and can regulate network output and synchrony. Although hippocampal dentate AACs are structurally altered in epilepsy, physiological analyses of dentate AACs are lacking. We demonstrate that parvalbumin neurons in the dentate molecular layer express PTHLH, an AAC marker, and exhibit morphology characteristic of AACs. Dentate AACs show high-frequency, non-adapting firing but lack persistent firing in the absence of input and have higher rheobase than basket cells suggesting that AACs can respond reliably to network activity. Early after pilocarpine-induced status epilepticus (SE), dentate AACs receive fewer spontaneous excitatory and inhibitory synaptic inputs and have significantly lower maximum firing frequency. Paired recordings and spatially localized optogenetic stimulation revealed that SE reduced the amplitude of unitary synaptic inputs from AACs to granule cells without altering reliability, short-term plasticity, or AIS GABA reversal potential. These changes compromised AAC-dependent shunting of granule cell firing in a multicompartmental model. These early post-SE changes in AAC physiology would limit their ability to receive and respond to input, undermining a critical brake on the dentate throughput during epileptogenesis.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"231 ","pages":"Article 102542"},"PeriodicalIF":6.7,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301008223001430/pdfft?md5=a6d446195b3bfaa5890e1fdc36d62a89&pid=1-s2.0-S0301008223001430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STED microscopy reveals dendrite-specificity of spines in turtle cortex STED显微镜显示海龟皮层棘的树突特异性。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-26 DOI: 10.1016/j.pneurobio.2023.102541

Jan A. Knobloch , Gilles Laurent , Marcel A. Lauterbach

引用次数: 0

Promising Prospects for Human Cerebral Organoids to Advance Alzheimer's Disease Research 人脑类器官促进阿尔茨海默病研究的前景

2区医学

Progress in Neurobiology Pub Date : 2023-10-19 DOI: 10.60124/j.pneuro.2023.20.05

Victoria López, Andreea Rosca, Isabel Liste, Patricia Mateos-Martínez, Raquel Coronel, Rosa Gonzalez-Sastre, Sabela Martín-Benito, Victoria López

{"title":"Promising Prospects for Human Cerebral Organoids to Advance Alzheimer's Disease Research","authors":"Victoria López, Andreea Rosca, Isabel Liste, Patricia Mateos-Martínez, Raquel Coronel, Rosa Gonzalez-Sastre, Sabela Martín-Benito, Victoria López","doi":"10.60124/j.pneuro.2023.20.05","DOIUrl":"https://doi.org/10.60124/j.pneuro.2023.20.05","url":null,"abstract":"The causes of the alterations found in the brains of patients with alzheimer's disease (AD) begin before the first signs of memory loss appear, and are still unclear. Adequate research models are essential to understand the mechanisms that cause the onset of these alterations, as well as to advance in the diagnosis, development and testing of treatments for the AD. Animal research models fail to recreate the great diversity and complexity inherent to the human brain, so in vitro systems based on human pluripotent stem cells (hPSCs) present themselves as an important alternative. Differentiation of hPSCs into two-dimensional (2D) cell culture models allows recreation of various brain functional processes and the three-dimensional (3D) cell culture models or human brain organoids (hCOs) recapitulate the cellular diversity and structure of the human brain. hCOs from human induced pluripotent stem cells (hiPSCs) from patients with familial (APP, PSEN1 and PSEN2 mutations) or sporadic AD allow identifying and studying changes due to this pathology. This review presents an overview of the research models used to study the AD, and recapitulates the advantages and discusses the challenges of the hCOs as an innovative and promising technology that will aid in the understanding of AD.","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimenting ‘In Vivo’ with Dynamic Glottal Parameters: Methodological Issues, Technical Tips & Tricks and Preventable Pitfalls 动态声门参数的“体内”实验:方法学问题，技术提示和技巧和可预防的陷阱

2区医学

Progress in Neurobiology Pub Date : 2023-10-13 DOI: 10.60124/j.pneuro.2023.20.04

Philippe DeJonckere, J. Lebacq, Philippe DeJonckere

{"title":"Experimenting ‘In Vivo’ with Dynamic Glottal Parameters: Methodological Issues, Technical Tips & Tricks and Preventable Pitfalls","authors":"Philippe DeJonckere, J. Lebacq, Philippe DeJonckere","doi":"10.60124/j.pneuro.2023.20.04","DOIUrl":"https://doi.org/10.60124/j.pneuro.2023.20.04","url":null,"abstract":"‘In vivo’ studies pertaining to dynamics of vocal fold vibration motion, to vocal fold contact and collision, to vocal onset and offset and to mechanical efficiency all need valid, sensitive and precise measurements of the different mechanical parameters involved. This is also true for investigating the physiological correlates of particular acoustic events like register breaks or diplophonia. The main physical parameters involved are: vocal fold movement and shaping, particularly the velocity of tissue displacement, glottal area, tissue distortion, intraglottal pressure, transglottal air flow, vocal fold contact and collision stress, etc. This article presents a critical review of the instruments and techniques involved in the direct measurements of the glottal dimensions and movements, the transglottal airflow, the VF contact changes, the pressures and the sound acoustic pressure. In each case are analyzed the methodological aspects that are critical for validly calibrating and synchronizing these signals, and correcting them for time delays. Moreover, it is shown how new parameters, like vocal fold velocity, intraglottal pressure, vocal fold collision stress, can be inferred from these (raw or after differentiation) signals by combining them. Finally, the discussion focuses on weighing advantages and limitations of techniques for monitoring the glottal area, i.e. photometry and the high-speed imaging, the latter involving the relevance in this scope of future developments in endoscopic and external imaging techniques, and in image processing software. Our aim is to facilitate the work of future researchers by showing how to solve important technical pitfalls, how to apply the necessary corrective measures - and which ones - where needed, and how to get the most out of combinatorial measures.","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135858973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders 氮氧化物诱导的氧化应激是主要神经退行性疾病的主要诱因。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-12 DOI: 10.1016/j.pneurobio.2023.102539

Yuri Zilberter , Dennis R. Tabuena , Misha Zilberter

{"title":"NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders","authors":"Yuri Zilberter , Dennis R. Tabuena , Misha Zilberter","doi":"10.1016/j.pneurobio.2023.102539","DOIUrl":"10.1016/j.pneurobio.2023.102539","url":null,"abstract":"<div><p>Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile, major sporadic NDDs share many risk factors and exhibit similar pathologies in their early stages, indicating the existence of common initiation pathways. Glucose hypometabolism associated with oxidative stress is one such primary, early and shared pathology, and a likely major cause of detrimental disease-associated cascades; targeting this common pathology may therefore be an effective preventative strategy for most sporadic NDDs. However, its exact cause and trigger remain unclear. Recent research suggests that early oxidative stress caused by NADPH oxidase (NOX) activation is a shared initiating mechanism among major sporadic NDDs and could prove to be the long-sought ubiquitous NDD trigger. We focus on two major NDDs - Alzheimer's disease (AD) and Parkinson's disease (PD), as well as on acquired epilepsy which is an increasingly recognized comorbidity in NDDs. We also discuss available data suggesting the relevance of the proposed mechanisms to other NDDs. We delve into the commonalities among these NDDs in neuroinflammation and NOX involvement to identify potential therapeutic targets and gain a deeper understanding of the underlying causes of NDDs.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"231 ","pages":"Article 102539"},"PeriodicalIF":6.7,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41210867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortico-spinal modularity in the parieto-frontal system: A new perspective on action control 顶额系统的皮质-脊柱模块性：动作控制的新视角。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-12 DOI: 10.1016/j.pneurobio.2023.102537

R.J. Bufacchi , A. Battaglia-Mayer , G.D. Iannetti , R. Caminiti

{"title":"Cortico-spinal modularity in the parieto-frontal system: A new perspective on action control","authors":"R.J. Bufacchi , A. Battaglia-Mayer , G.D. Iannetti , R. Caminiti","doi":"10.1016/j.pneurobio.2023.102537","DOIUrl":"10.1016/j.pneurobio.2023.102537","url":null,"abstract":"<div><p>Classical neurophysiology suggests that the motor cortex (MI) has a unique role in action control. In contrast, this review presents evidence for multiple parieto-frontal spinal command modules that can bypass MI. Five observations support this modular perspective: (i) the statistics of cortical connectivity demonstrate functionally-related clusters of cortical areas, defining functional modules in the premotor, cingulate, and parietal cortices; (ii) different corticospinal pathways originate from the above areas, each with a distinct range of conduction velocities; (iii) the activation time of each module varies depending on task, and different modules can be activated simultaneously; (iv) a modular architecture with direct motor output is faster and less metabolically expensive than an architecture that relies on MI, given the slow connections between MI and other cortical areas; (v) lesions of the areas composing parieto-frontal modules have different effects from lesions of MI. Here we provide examples of six cortico-spinal modules and functions they subserve: module 1) arm reaching, tool use and object construction; module 2) spatial navigation and locomotion; module 3) grasping and observation of hand and mouth actions; module 4) action initiation, motor sequences, time encoding; module 5) conditional motor association and learning, action plan switching and action inhibition; module 6) planning defensive actions. These modules can serve as a library of tools to be recombined when faced with novel tasks, and MI might serve as a recombinatory hub. In conclusion, the availability of locally-stored information and multiple outflow paths supports the physiological plausibility of the proposed modular perspective.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"231 ","pages":"Article 102537"},"PeriodicalIF":6.7,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301008223001387/pdfft?md5=c2a15068e4015f11115fabe569645f0c&pid=1-s2.0-S0301008223001387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41210866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse and compensatory neurophysiological slowing in Parkinson’s disease 帕金森病的不利和补偿性神经生理学减慢。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-11 DOI: 10.1016/j.pneurobio.2023.102538

Alex I. Wiesman, Jason da Silva Castanheira, Clotilde Degroot, Edward A. Fon, Sylvain Baillet, PREVENT-AD Research Group , Quebec Parkinson Network

{"title":"Adverse and compensatory neurophysiological slowing in Parkinson’s disease","authors":"Alex I. Wiesman, Jason da Silva Castanheira, Clotilde Degroot, Edward A. Fon, Sylvain Baillet, PREVENT-AD Research Group , Quebec Parkinson Network","doi":"10.1016/j.pneurobio.2023.102538","DOIUrl":"10.1016/j.pneurobio.2023.102538","url":null,"abstract":"<div><p>Patients with Parkinson’s disease (PD) exhibit multifaceted changes in neurophysiological brain activity, hypothesized to represent a global cortical slowing effect. Using task-free magnetoencephalography and extensive clinical assessments, we found that neurophysiological slowing in PD is differentially associated with motor and non-motor symptoms along a sagittal gradient over the cortical anatomy. In superior parietal regions, neurophysiological slowing reflects an adverse effect and scales with cognitive and motor impairments, while across the inferior frontal cortex, neurophysiological slowing is compatible with a compensatory role. This adverse-to-compensatory gradient is sensitive to individual clinical profiles, such as drug regimens and laterality of symptoms; it is also aligned with the topography of neurotransmitter and transporter systems relevant to PD. We conclude that neurophysiological slowing in patients with PD signals both deleterious and protective mechanisms of the disease, from posterior to anterior regions across the cortex, respectively, with functional and clinical relevance to motor and cognitive symptoms.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"231 ","pages":"Article 102538"},"PeriodicalIF":6.7,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41210865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mouse model of sleep disorders in Parkinson’s disease showing distinct effects of dopamine D2-like receptor activation 帕金森病睡眠障碍小鼠模型显示多巴胺D2样受体激活的不同影响。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-05 DOI: 10.1016/j.pneurobio.2023.102536

Daniel de Castro Medeiros , Carina Plewnia , Renan Viana Mendes , Clarissa Anna Pisanò , Laura Boi , Marcio Flávio Dutra Moraes , Cleiton Lopes Aguiar , Gilberto Fisone

{"title":"A mouse model of sleep disorders in Parkinson’s disease showing distinct effects of dopamine D2-like receptor activation","authors":"Daniel de Castro Medeiros , Carina Plewnia , Renan Viana Mendes , Clarissa Anna Pisanò , Laura Boi , Marcio Flávio Dutra Moraes , Cleiton Lopes Aguiar , Gilberto Fisone","doi":"10.1016/j.pneurobio.2023.102536","DOIUrl":"10.1016/j.pneurobio.2023.102536","url":null,"abstract":"<div><p>Excessive daytime sleepiness (EDS) and sleep fragmentation are often observed in Parkinson’s disease (PD) patients and are poorly understood despite their considerable impact on quality of life. We examined the ability of a neurotoxin-based mouse model of PD to reproduce these disorders and tested the potential counteracting effects of dopamine replacement therapy. Experiments were conducted in female mice with a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle, leading to the loss of dopamine neurons projecting to the dorsal and ventral striatum. Sham-operated mice were used as control. Electroencephalographic and electromyographic recording was used to identify and quantify awaken, rapid eye movement (REM) and non-REM (NREM) sleep states. PD mice displayed enhanced NREM sleep and reduced wakefulness during the active period of the 24-hour circadian cycle, indicative of EDS. In addition, they also showed fragmentation of NREM sleep and increased slow-wave activity, a marker of sleep pressure. Electroencephalographic analysis of the PD model also revealed decreased density and increased length of burst-like thalamocortical oscillations (spindles). Treatment of PD mice with the dopamine receptor agonist, pramipexole, but not with <span>L</span>-DOPA, counteracted EDS by reducing the number, but not the length, of NREM sleep episodes during the first half of the active period. The present model recapitulates some prominent PD-related anomalies affecting sleep macro- and micro-structure. Based on the pharmacological profile of pramipexole these results also indicate the involvement of impaired dopamine D2/D3 receptor transmission in EDS.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"231 ","pages":"Article 102536"},"PeriodicalIF":6.7,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41150051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An autonomic mode of brain activity 一种自主的大脑活动模式。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-01 DOI: 10.1016/j.pneurobio.2023.102510

Ehsan Shokri-Kojori, Dardo Tomasi, Sukru B. Demiral, Gene-Jack Wang, Nora D. Volkow

{"title":"An autonomic mode of brain activity","authors":"Ehsan Shokri-Kojori, Dardo Tomasi, Sukru B. Demiral, Gene-Jack Wang, Nora D. Volkow","doi":"10.1016/j.pneurobio.2023.102510","DOIUrl":"10.1016/j.pneurobio.2023.102510","url":null,"abstract":"<div><p>The relevance of interactions between autonomic and central nervous systems remains unclear for human brain function and health, particularly when both systems are challenged under sleep deprivation (SD). We measured brain activity (with fMRI), pulse and respiratory signals, and baseline brain amyloid beta burden (with PET) in healthy participants. We found that SD relative to rested wakefulness (RW) resulted in a significant increase in synchronized low frequency (LF, < 0.1 Hz) activity in an autonomically-related network (AN), including dorsal attention, visual, and sensorimotor regions, which we previously found to have consistent temporal coupling with LF pulse signal changes (regulated by sympathetic tone). SD resulted in a significant phase coherence between the LF component of the pulse signal and a medial network with peak effects in the midbrain reticular formation, and between LF component of the respiratory variations (regulated by respiratory motor output) and a cerebellar network. The LF power of AN during SD was significantly and independently correlated with pulse-medial network and respiratory-cerebellar network phase coherences (total adjusted <em>R</em><sup>2</sup> = 0.78). Higher LF power of AN during SD (but not RW) was associated with lower amyloid beta burden (Cohen’s <em>d</em> = 0.8). In sum, SD triggered an autonomic mode of synchronized brain activity that was associated with distinct autonomic-central interactions. Findings highlight the direct relevance of global cortical synchronization to brain clearance mechanisms.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"229 ","pages":"Article 102510"},"PeriodicalIF":6.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The state of brain activity modulates cerebrospinal fluid transport 大脑活动状态调节脑脊液运输

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2023-10-01 DOI: 10.1016/j.pneurobio.2023.102512

Leo M. Miyakoshi , Frederik F. Stæger , Qianliang Li , Chenchen Pan , Lulu Xie , Hongyi Kang , Chiara Pavan , Juliana Dang , Qian Sun , Ali Ertürk , Maiken Nedergaard

引用次数: 0