Psychiatry and Clinical Psychopharmacology最新文献

{"title":"COVID-19 Vaccine Hesitancy and Its Relationship With Illness Risk Perceptions, Affect, Worry, and Public Trust: An Online Serial Cross-Sectional Survey From Turkey.","authors":"Melike Kuçukkarapinar, Filiz Karadag, Irem Budakoglu, Selçuk Aslan, Onder Ucar, Ayşegul Yay, Utku Timurcin, Selim Tumkaya, Cicek Hocaoglu, Ilknur Kiraz","doi":"10.5152/pcp.2021.21017","DOIUrl":"10.5152/pcp.2021.21017","url":null,"abstract":"<p><strong>Objective: </strong>A better understanding of public attitudes towards vaccination and recognition of associated factors with vaccine hesitancy or refusal is important regarding the control of the pandemic. Our aim was to analyze the public's attitudes toward COVID-19 vaccines and to identify factors affecting them.</p><p><strong>Materials and methods: </strong>Data were drawn from the Turkish COVID-19 Snapshot Monitoring, between July-December 2020, a serial online cross-sectional survey. The sample comprised 3888 adult respondents. Attitudes to vaccines and trust were investigated in 3 periods corresponding to the timeline of pandemic-related events in Turkey.</p><p><strong>Results: </strong>In the third period of our study, in parallel with the increase in the spread of COVID-19, vaccine hesitancy/refusal increased significantly from 43.9% to 58.9% (<i>P</i> < .001). The significant predictors of vaccine refusal were female gender, being elder, and conspiracy thinking. Having a chronic illness, worrying more about loved ones and the health system being overloaded were significant predictors of vaccine willingness. Less compliance with preventive measures, less knowledge of prevention, reduced risk perception, and higher perception of media hype were COVID-19 variables that correlated with vaccine refusal. Trust in the Ministry of Health and medical professional organizations (e.g., Turkish Medical Association) was the lowest in the third period and vaccine refusal was significantly related to the decreased trust (<i>P</i> < .001, <i>P</i> = .002).</p><p><strong>Conclusion: </strong>Most respondents (approximately 60%) refused or hesitated to get a COVID-19 vaccine, though acceptability should be monitored when a vaccine becomes available. Health authorities should consider public trust, risk perception, and behavioral factors to improve COVID-19 vaccine acceptability.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"1 1","pages":"98-109"},"PeriodicalIF":0.5,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86706347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Readiness to Change Among Hazardous Drinkers in South Korea.","authors":"Ok-Jin Jang, Yang-Tae Kim, Hyun-Woo Park, Ho-Chan Kim","doi":"10.5152/pcp.2021.20104","DOIUrl":"10.5152/pcp.2021.20104","url":null,"abstract":"<p><p><b>The present study was conducted to identify clinical factors influencing the readiness to change (RTC) among hazardous drinkers. The data were derived using the Korean Research for Development of Alcohol Addiction Diagnosis and Assessment System. We investigated RTC using a questionnaire on subjects who had never sought help for an alcohol problem. Subjects were then divided into two groups:</b> the precontemplation group (those who had never considered that they had a problem) and the more than contemplation group (those who were at least open to the idea they might have a problem). Measured variables were personal characteristics, lifetime alcohol use history, and responses to the Drinker Inventory of Consequences, Alcohol Use Disorder Identification Test, Alcohol Dependence Scale, Motivational Structure Questionnaire for Alcoholics, and the Alcohol Outcome Expectancies Scale. Behavioral, psychiatric, and psychological factors were evaluated according to the responses to the Rosenberg Self-Esteem Scale, Zung Self-Rating Depression Scale, Barratt Impulsiveness Scale, State-Trait Anxiety Inventory, and State-Trait Anger Expression Inventory. The valid sample comprised 129 hazardous drinkers, of which 74 were classified as precontemplation, and 55 were in the contemplation group. The results of the binary logistic analysis showed that being unmarried or separated as well as having higher scores for impulse control and social responsibility were independently associated with an increased likelihood of hazardous drinkers being in the contemplation group, and the final model explained 30.5% (Nagelkerke R²) of the variation in membership of the contemplation group.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"113 1","pages":"110-116"},"PeriodicalIF":0.5,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81015636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Schizophrenia with Glioblastoma Cells: In Vitro Analysis of Risperidone Treatment on Glial Spheroids.","authors":"Ozge Sezin Somuncu, Irem Karaman, Hilal Piril Saracoglu, Erdem Yilmaz, Demet Akin","doi":"10.5152/pcp.2021.20181","DOIUrl":"10.5152/pcp.2021.20181","url":null,"abstract":"<p><strong>Objective: </strong>Glioblastoma is the most malicious type of glioma presenting a genetic background via diverse mutations and exhibits differential sensitivity to treatment. Meanwhile, schizophrenia is a heterogeneous disease with a complex etiology. Studies report an elevation in pro-inflammatory cytokines in patients with schizophrenia and changes in biochemical metabolism. In the present study, the tumor spheroid technology is applied to two different glioblastoma lines which resemble schizophrenia manifestation along with the investigation of the potential anti-tumor effect of an atypical antipsychotic drug, risperidone. Our hypothesis built on case reports showing patients with schizophrenia being treated with risperidone that turned out to have glioblastoma in post-mortem evaluation. Risperidone has been suggested to carry therapeutic effects for glioblastoma and elongated lifespan after the diagnosis of cancer.</p><p><strong>Materials and methods: </strong>In this current study, 3D models using C6 and U87 glioblastoma cells and monocytes for representing the disease grown as multicellular spheroids were established. Spheroids were treated with the anti-schizophrenic agent risperidone and indicated almost similar results to the clinics suggesting that glioblastoma and schizophrenia share mutual physiological characteristics.</p><p><strong>Results: </strong>U87 and C6 spheroid systems were analyzed molecularly after the treatment of risperidone where U87 spheroid models were found highly resembling the overall behavior of schizophrenia. This present work correlated the stated two diseases in molecular level to encourage the efforts for personalized medicine.</p><p><strong>Conclusion: </strong>The anti-tumor effects of risperidone on glioblastoma is not very well established yet. It should not be missed that a picture of schizophrenia in clinics may be the result of an underlying lesion in a specific brain area. Thus, especially schizophrenia patients who may be at risk for developing brain tumors should be further investigated and treated accordingly.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"13 1","pages":"48-59"},"PeriodicalIF":0.5,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86252480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Study of Diagnostic Value of Bipolarity Index for Bipolar Disorder in China: Meta-analysis of Sensitivity and Specificity","authors":"Fengli Sun, Zhu Jianfeng, Tao Hejian, J. Weidong","doi":"10.21203/rs.3.rs-76951/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-76951/v1","url":null,"abstract":"\u0000 BackgroundThe diagnosis of bipolar disorder is still one of the key problems in psychiatric clinic. Although DSM-5 has made some important changes, it has not completely changed the missed diagnosis and misdiagnosis of bipolar disorder.It was very important that diagnostic scale was used in clinic.But the study results of assist diagnostic scale for bipolar disorder should been concluded and analyzed.Bipolarity index was one of assist diagnostic scale,which should be analyzed comprehensively.MethodsWe searched CBM, CNKI , WANFANG and CSSCI in Chinese to find literature from Julyr 31 2004 to July 31 2020 related to Bipolarity Index in diagnosis for bipolar disorder ,among which results such as comments, letters, reviews and case reports were excluded. The rate of sensitivity,specificity,accuracy,positive predictive value and negative predictive value in diagnosis was synthesized and discussed.ResultsA total of 1237 subjects were included in 5 studies. Random effect model is used to account for the data by Revman 5.2. The results showed that the sensitivity of BI in diagnostic was 0.93 (95% CI: 0.93–1.00), the specificity was 85% (95% CI: 0.69–0.96). the positive predict value was 74% (95% CI: 0.53–0.91).the negative predict value was 95% (95% CI: 0.81–1.00).and accuracy was 86% (95% CI: 0.77–0.93). Significant heterogeneity was detected across studies regarding these incidence estimates. ConclusionThe idea diagnostic value of BI was found. although the significant heterogeneity detected in studies.We must interpret the results with caution and also put attention to this result,which include comparison to other diagnostic scale,perfecting sue of BI in clinical psychiatry.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"18 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87516280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Effective Method to Facilitate Personalized and Precise Medicine for Schizophrenia Treatment Based on Pharmacogenomics","authors":"Yixiang Shi, Xiong Zhang, Xiaoping Gu, Chen-ping Huang, Yue Zhang, Dong-dong Qi","doi":"10.21203/rs.3.rs-64915/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-64915/v1","url":null,"abstract":"\u0000 Background: Schizophrenia is a serious mental illness affecting 0.3% - 0.7% of people in the whole world. It is a classic quantitative genetic disease and is affected by a variety of common and rare genetic variants. Methods: To facilitate personalized and precise medicine for schizophrenia treatment, we designed a program by genotyping a panel of related genes, including cytochrome P450 genes CYP1A2, CYP2D6, CYP3A4, dopamine 2 receptor gene (DRD2), 5-Hydroxytryptamine Receptor 1A and 2C genes (HTR1A and HTR2C) as well as melanocortin4 receptor (MC4R) gene, for the schizophrenia patients using MassArray time-of-flight mass spectrometry. Results: The program is tested in an observational clinical study conducted at the Hulunbuir Mental Health Center of China. In the study, a total of 254 patients diagnosed with schizophrenia were recruited and genotyped. The genotyping results were used to generate reports listing where the 16 included antipsychotics should be placed: 'Use as directed', 'Use with caution' or 'Use with caution and with frequent blood concentration monitoring' columns. However, the medication would not change regardless. 72 of the patients completed the 24-week follow-up observation, during which their PANSS scores were assessed at eight time points. For all of them, the PANSS scores dropped significantly, showing the effectiveness of the treatments. The treatments for those cohorts initially in the 'Use with caution' or 'Use with caution and with frequent blood concentration monitoring' categories were more effective than those in the 'Use as directed' category in a shorter term sense, up to three months. However, in the longer term, it was still those who were initially in the 'Use as directed' column fared better, whose PANSS scores dropped more significantly. Conclusions: This research indicated that our pharmacogenomic-based program could be a suitable and effective tool to facilitate precise medicine in schizophrenia treatment.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"43 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90412992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wallerian Degeneration of the Bilateral Middle Cerebella Peduncles Secondary to Unilateral Pontine Hemorrhage","authors":"Dawei Chen, Jin Shi","doi":"10.5455/pcp.20200907082126","DOIUrl":"https://doi.org/10.5455/pcp.20200907082126","url":null,"abstract":"The bilateral and symmetrical Wallerian degeneration (WD) of the middle cerebellar peduncles (MCPs) is rarely reported in pontine hemorrhage. We described a patient with WD of bilateral MCPs secondary to a strip of unilateral and transversal pontine hemorrhage. Magnetic Resonance Imaging showed hyperintensity on T2-weighted, fluid attenuation inversion recovery and diffusion weighted image, and hypointensity on T1-weighted and apparent diffusion co-efficient map, and no enhancement in bilateral MCPs. These abnormal signals existed over 6 months and subsided gradually. The patients didn’t present with new symptoms when WD happened, the initial clinical manifestations related to pontine hemorrhage persisted for more than one year. In conclusion, a single unilateral pontine stroke along “cross” or “trident” line may cause WD of the bilateral MCPs in the below slice. Although this pathological change brings no additional new symptoms, it is related to the short‑term of poor neurological prognosis after pontine stroke. In addition, since this lesion appears restricted diffusion in the imaging, we should avoid misdiagnosing it as new infarction","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"54 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90058084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Visual Hallucinations be Among the Neuropsychological Manifestations of Systemic Mastocytosis?: A Geriatric Case","authors":"O. Kilic, U. Yilmaz, Zeynep Komesli, A. Ercan, M. Çetiner","doi":"10.5455/pcp.20200316094036","DOIUrl":"https://doi.org/10.5455/pcp.20200316094036","url":null,"abstract":"Mast cells are considered sensors of environmental and emotional stress, exist in all body parts and are related to the pathway from stress to inflamamation. Mastocytosis defines a rare disease, characterized by accumulation of abnormal mast cells in multiple organs. Here, we present a 77-year-old woman with a background of aggressive systemic mastocytosis who developed impaired cognition, depression, anxiety, visual hallucinations, delusions and insomnia. Symptoms alleviated only after initiating midostaurin, a tyrosine kinase inhibitor. Systemic mastocytosis should be kept in mind when visual hallucinations are concomitant with chronic or recurrent multi-system disturbances and do not benefit from treatment as usual.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86424829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Picking Impact Scale: Reliability and Validity Study of Turkish Version","authors":"J. Kenar, E. Aydın, D. Aker, I. Altunay, Ömer Özer","doi":"10.5455/pcp.20200906091647","DOIUrl":"https://doi.org/10.5455/pcp.20200906091647","url":null,"abstract":"Abstract Background: In this study, we aimed to perform the validity and reliability study for Turkish version of Skin Picking Impact Scale (SPIS). Methods: This study included 80 patients diagnosed with SPD according to DSM-5 diagnostic criteria. Patients were given Sociodemographic Data Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Short Form-36 Quality of Life Scale (SF-36), Yale-Brown Obsessive Compulsive Scale Modified for Neurotic Excoriation (NE-YBOCS) and Turkish version of SPIS. Cronbach’s alpha coefficient and item-total correlation were examined for the reliability of the scale. Confirmatory factor analysis (CFA) was used to examine the factor structure of the scale and ROC (Receiver Operating Characteristics) was performed to the discriminatory validity analysis. Results: Cronbach’s alpha internal consistency coefficient was determined to be 0.942. Item-total correlation coefficients of all questions ranged between 0.665 and 0.849. The one-factor structure showed a good model fit in CFA. Good correlations were observed between SPIS and number of sites of picking (r=0.265, p=0.037), duration of skin picking per day (r=0.453, p","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84525785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Complex Relationship Between Sleep, Depression and the Immune System","authors":"F. Aricioglu, M. Cetin","doi":"10.5455/pcp.20201207094228","DOIUrl":"https://doi.org/10.5455/pcp.20201207094228","url":null,"abstract":"Sleeping has a critical function to promote health. Studies over the past ten years has documented that sleeping disorders has a strong influence on the risk of infectious diseases and in particular occurrence and progression associated with several major health issues including depression. Recent studies have focused on elucidating the underlying mechanisms that play a role in this situation. This article has been written to review the dynamics of sleep disturbance, sleep restriction, and insomnia on depression and the immune system. Also aimed to discuss the multi-faceted relationship that connect sleep disorder and immunity in terms of the neurobiology of sleep, inflammation and depression. In this context, what is known about the role of sleep on the immune system and the relationship between sleep disorder and depression and the immune system of depression will be reviewed.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"8 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90187651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Turkish version of the Thought-Action Fusion-Child Version (TAFIC)","authors":"M. Tarakçıoğlu, M. Boysan, Yasin Caliskan, Ö. Demirel, N. C. Memik, M. Kadak","doi":"10.5455/pcp.20200212074140","DOIUrl":"https://doi.org/10.5455/pcp.20200212074140","url":null,"abstract":"OBJECTIVE: The concept of thought-action fusion has long been recognized as a cognitive vulnerability factor for psyhopathology that given its clinical relevance and importance reliable assessment of this phenomenon seems to be essential. The aim of this study was to investigate the psychometric properties of the Thought-Action Fusion Inventory for Children (TAFIC) among Turkish children and adolescents. METHODS: Five hundred and ninety-one subjects (mean age=14.16±2.08 years) participated in the study. Voluntered subjects completed the TAFIC, Magical Ideation Scale (MIS), Child Depression Inventory (CDI), Screen for Child Anxiety Related Emotional Disorders Revised–Child Self-Report (SCARED-R-CV), and Metacognitions Questionnaire for Children (MCQ-C). RESULTS: Confirmatory factor analysis revealed the original four-factor structure excellently fit the data on the Turkish version of the TAFIC. Internal reliability of the instrument was acceptable to excellent, with Kuder-Richardson coefficients ranging from 0.70 to 0.89. The convergent validity of the TAFIC was adequate, with significant correlation coefficients with magical ideation, meta-cognitions, depression, and anxiety related emotional problems. CONCLUSIONS: Based on these findings, we concluded that the Turkish version of the TAFIC has promising psychometric properties in assessing thought-action fusion among children and adolescents.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"142 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76745289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}