Psychiatry and Clinical Psychopharmacology最新文献

{"title":"Efficacy and Safety of Risperidone Interventions in Children and Adolescents with Autism Spectrum Disorder.","authors":"Fei Yang, Lin Kang, ChaoJie Zou","doi":"10.5152/pcp.2025.24944","DOIUrl":"10.5152/pcp.2025.24944","url":null,"abstract":"<p><strong>Background: </strong>Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that severely impairs children's health. Current data suggest that behavioral therapies are successful. Risperidone has been approved by the US Food and Drug Administration (FDA) to moderate impulsive behavior in people with ASD. This study aimed to evaluate the efficacy and safety of risperidone in children and adolescents with ASD.</p><p><strong>Methods: </strong>This study involved searching electronic databases for relevant articles, screening them based on inclusion and exclusion criteria, and performing a combined data analysis of the selected articles using Review Manager software.</p><p><strong>Results: </strong>This meta-analysis comprised 7 articles. The pooled analysis indicated that: (1) Risperidone intervention decreased scores on the Aberrant Behavior Checklist (ABC) scale in children and adolescents with ASD, as well as reduced scores related to stereotypy, social withdrawal, hyperactivity, inappropriate speech, and irritability on the ABC scale; (2) The use of risperidone raised the risk of weight gain, tremors, upper respiratory tract infection, and increased appetite. Other adverse responses, however, did not differ significantly from the placebo group.</p><p><strong>Conclusion: </strong>Risperidone demonstrated effectiveness and safety in managing behavioral issues and decreased ABC scores in children and adolescents with ASD. However, further research is needed, and the associated risks still need to be considered.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"177-184"},"PeriodicalIF":0.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Health Guidance and Psychological Nursing Intervention: Effects on Emotions, Sleep Quality, and Self-Efficacy in Cerebral Hemorrhage Patients.","authors":"Xin Wang, He Lin, Qi Chen","doi":"10.5152/pcp.2025.24929","DOIUrl":"10.5152/pcp.2025.24929","url":null,"abstract":"<p><strong>Background: </strong>To explore the impact of systematic health guidance combined with psychological nursing intervention on negative emotions, sleep quality, and self-efficacy of patients with cerebral hemorrhage.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 100 patients with cerebral hemorrhage admitted to our hospital from March 2023 to March 2024, including 48 cases in the control group (CG) treated with routine nursing methods and 52 cases in the observation group (OG) treated with psychological nursing combined with systematic health guidance. The negative emotion scores, disease awareness, and sleep quality before and after intervention were compared between the 2 groups. The self-management ability, incidence of complications, quality of life, and nursing satisfaction were evaluated and compared between the 2 groups after the intervention.</p><p><strong>Results: </strong>After the intervention, both groups showed improvements in negative emotion scores, disease awareness, and sleep quality. However, the OG exhibited significantly more improvement than the CG, demonstrating higher self-management ability, lower incidence of complications, and higher life quality and nursing satisfaction (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Systematic health guidance combined with psychological nursing intervention can effectively improve the negative emotions, sleep quality, and self-efficacy of patients with cerebral hemorrhage, reduce the incidence of complications during hospitalization, and improve patient satisfaction with nursing, which is worthy of clinical promotion.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"149-154"},"PeriodicalIF":0.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CANFOR Scale for the Assessment of Needs of Forensic Psychiatric Patients: Preliminary Report on the Polish Version of the Scale and Its Reliability.","authors":"Mikołaj Trizna, Anna Jeleń, Paweł Dębski, Joanna Smolarczyk, Magdalena Piegza, Andrzej Kiejna, Tomasz Adamowski","doi":"10.5152/pcp.2025.23711","DOIUrl":"10.5152/pcp.2025.23711","url":null,"abstract":"<p><strong>Background: </strong>The constantly growing number of patients in psychiatric wards (including forensic wards) is a serious social, medical, and economic problem. Therefore, it is necessary to study the needs of these patients. The aim of the study was to adapt and test the reliability of the Polish version of the scale for the assessment of needs of forensic psychiatric patients-Camberwell Assessment of Need-Forensic Version (CANFOR).</p><p><strong>Methods: </strong>The scale was translated into Polish and then back-translated. The study was conducted among 60 patients of basic and enhanced security level forensic psychiatry wards at the Provincial Specialist Mental Health Hospital in Poland.</p><p><strong>Results: </strong>When analyzing the reproducibility of the responses in terms of assessing the reliability of the CANFOR questionnaire, perfect agreement of 100% was obtained in 22 areas of need. Similarly, in the repeatability study of the CANFOR questionnaire after 2 weeks, perfect agreement-100%-was obtained in 24 areas of need. In the correlation analysis of the CANFOR with another measurement tool-LSP, significant values at the <i>P</i> < .05 level were obtained when measuring several variables.</p><p><strong>Conclusions: </strong>The study resulted in high reliability of the Polish version of the CANFOR scale. It is advisable to continue research in the area of psychometric properties of the scale, including the validity of the tool.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"132-140"},"PeriodicalIF":0.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Independent Risk Factors of Anxiety and Depression Symptoms in Glioma Patients: A Cross-Sectional Analysis.","authors":"Xingyun Zheng, Weizhen Zhang, Yinyou Li, Xiancong Lai, Qingqing Fan, Yueling Xu, Xilong Yin","doi":"10.5152/pcp.2025.241021","DOIUrl":"10.5152/pcp.2025.241021","url":null,"abstract":"<p><strong>Background: </strong>To investigate the current status of anxiety and depression symptoms in patients with brain glioma and identify the risk factors associated with anxiety and depression symptoms.</p><p><strong>Methods: </strong>A total of 105 patients diagnosed with glioma at Longgang Central Hospital of Shenzhen from January 2021 to April 2024 were included in this study. The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression symptoms of the patients, who were then grouped based on their scores. Chi-square tests and binary logistic regression analyses were performed to identify the independent risk factors for anxiety and depression symptoms in glioma patients.</p><p><strong>Results: </strong>The average HADS-Anxiety score among glioma patients was 8.72 ± 3.41, with an anxiety symptoms prevalence of 61.90% (65/105). The average HADS-Depression score was 7.73 ± 2.91, with a depression symptoms prevalence of 55.24% (58/105). Among them, 58 patients (55.24%) had both anxiety and depression symptoms, seven patients (6.67%) had only anxiety symptoms, and 40 patients (38.10%) had neither anxiety nor depression. The results of binary tic regression analysis showed that family monthly income, seizures, sleep quality, and cognitive function impairment were independent risk factors for anxiety and depression symptoms (<i>P</i> < .05). Marital status was an independent risk factor for depression symptoms (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Glioma patients exhibit a high incidence of anxiety and depression symptoms. The occurrence of these conditions is significantly associated with lower monthly household income, seizure occurrence, sleep disturbances, and cognitive impairment.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"155-164"},"PeriodicalIF":0.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Hotspots in Research on Exercise and Alzheimer's Disease: A Decade of Bibliometric Review on Prevention and Molecular Mechanisms.","authors":"Xinge Yang, Keke Li, Yimin Zhang, Ruizhe Sun, Jingjing Yu","doi":"10.5152/pcp.2025.241016","DOIUrl":"10.5152/pcp.2025.241016","url":null,"abstract":"<p><p>With the rapid acceleration of global aging, the prevalence of Alzheimer's disease (AD) continues to rise, exerting a profound impact on elderly individuals' physical health, lifestyle, and quality of life. Exercise has demonstrated significant research value and broad application potential in AD as a non-pharmacological preventive and therapeutic approach. This study aims to provide a bibliometric and visual analysis of research related to exercise and AD over the past decade. It seeks to identify research hotspots and development trends, explore the layers of research on exercise's impact on AD, and clarify its preventive effects and molecular mechanisms. The Web of Science Core Collection database was used as the data source for this study. A comprehensive search was conducted using the topic \"exercise for Alzheimer's disease,\" covering the period from January 1, 2014, to August 31, 2024. CiteSpace and Python were employed to perform bibliometric and visual analyses on these publications, including assessments of publication trends, keyword co-occurrence, clustering analysis, timeline analysis, burst detection analysis, and the distribution and growth trends of molecular mechanisms related to exercise and AD. 1. Annual publication trends: 6134 articles were included in the analysis. The number of publications on exercise and AD increased steadily from 2014 to 2024 (<i>β</i> = 53.23,<i>P</i> < .001). 2. Keyword co-occurrence and clustering analysis: research on exercise and AD primarily focuses on themes related to cognitive decline, risk factors, exercise-induced energy metabolism, exercise intensity, and molecular mechanisms. 3. Keyword timeline and burst analysis: epidemiological and clinical studies maintained high activity levels in the early and mid-stages of the research timeline, whereas molecular-level studies exhibited increased activity in the later stages. 4. Molecular mechanisms distribution: analysis of molecular mechanisms reveals that amyloid-beta deposition and oxidative stress remain the predominant research areas. Meanwhile, research on neuroinflammation, brain-derived neurotrophic factor (BDNF), Tau pathology, and other related mechanisms has been further explored. The findings demonstrate a progressive shift in research focus from general epidemiological patterns to more in-depth investigations of molecular biological mechanisms. Exercise has been shown to play a preventive role at the clinical level by improving cognitive function and mitigating risk factors and at the molecular level by modulating key pathological mechanisms, including β-amyloid deposition, oxidative stress, BDNF, tau pathology, and others. Through the coordinated regulation of multiple targets and pathways, exercise exerts a neuroprotective effect against AD.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"185-197"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Poisonings, Suicidality and Systemic Inflammatory Load in Pregnant Women.","authors":"Şenay Koçakoğlu, Hasan Büyükaslan","doi":"10.5152/pcp.2025.24962","DOIUrl":"10.5152/pcp.2025.24962","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy can be challenging for women in various manners and can boost the risk of intentional self-poisonings. The aim of the study is to evaluate the occurrence and clinical characteristics of poisonings and the relationship between suicidal tendency and increased systemic inflammatory load during pregnancy.</p><p><strong>Methods: </strong>This study was performed in a tertiary hospital emergency department using 10 years of data. The study covered 69 female individuals, 35 pregnant and 34 non-pregnant, with acute poisoning diagnoses. The cases' sociodemographic and clinical features, as well as routine blood results, were evaluated. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) markers were calculated to assess systemic inflammatory load.</p><p><strong>Results: </strong>The intentional suicide rate in pregnant women was 85.71% (n = 30). Pregnant individuals had significantly higher PLR (<i>P < .</i>001) and NLR (<i>P = .</i>001) levels compared to the control group. The NLR values in intentional poisonings and the PLR in accidental poisonings were found to be proportionally higher, but the difference between both groups was not statistically significant (<i>P = .</i>448 and <i>P = .</i>701, respectively).</p><p><strong>Conclusion: </strong>The vast majority of acute poisonings in pregnant women were intentional. Although the inflammatory burden values were significantly higher in pregnant women than in controls, there was not enough strong evidence to establish a link between increased inflammatory burden and suicidal tendencies in pregnant women.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"141-148"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Concurrent Utilization of Mannitol and Nimodipine in Treating Hypertensive Intracerebral Hemorrhage and Its Effects on Neurological Function.","authors":"Chong Xiang, Bin Lu, Xuesong Yuan, Wenfeng Wei, Xiaoshan Hou","doi":"10.5152/pcp.2025.24986","DOIUrl":"10.5152/pcp.2025.24986","url":null,"abstract":"<p><strong>Background: </strong>The goal of this study was to retrospectively appraise the efficacy of the combined therapy comprising mannitol and nimodipine for hypertensive intracerebral hemorrhage (HICH) and its impact on neurological function.</p><p><strong>Methods: </strong>The study subjects encompassed 100 individuals with HICH who were admitted to the hospital from May 2021 to 2023 and were categorized into a control group and an observation group, with 50 individuals comprising each group. Intravenous mannitol infusion was administered to the control group, while the observation group received nimodipine injection in combination with mannitol, followed by a course of oral nimodipine tablets. Both groups of patients were treated for 3 months. A comparative analysis was performed to assess the clinical efficacy, neurological function, hematoma volume, serum inflammatory cytokine levels, hemodynamic parameters, and incidence of adverse reactions across the 2 groups.</p><p><strong>Results: </strong>A remarkably higher overall response rate of 92.00% was observed in the treatment group as opposed to 74.00% in the control group, with both groups exhibiting noteworthy reductions in National Institutes of Health Stroke Scale scores post-treatment, and the reduction being more pronounced in the treatment group (<i>P</i> < .05). Post-treatment, both groups exhibited decreases in hematoma volume and edema area, with the reduction in the observation group being notably more significant than in the control group (<i>P</i> < .05). Post-treatment, there was an upsurge in cerebral blood flow and blood flow velocity, coupled with a reduction in peripheral resistance and critical pressure in both groups. The observation group displayed higher blood flow velocity and lower peripheral resistance and critical pressure than the control group (<i>P</i> < .05). No notable distinction was observed in the overall incidence of adverse reactions between the groups (<i>P</i> > .05).</p><p><strong>Conclusion: </strong>The concurrent administration of mannitol and nimodipine in HICH presents substantial advantages, including enhanced clinical efficacy, improved neurological function, decreased hematoma volume, and regulation of hemodynamic parameters. This treatment approach has shown significant efficacy and is worthy of widespread promotion and application in clinical practice.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"117-123"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Novel Genetic Loci for Parkinson's Disease Using Whole-Exome and Whole-Genome Sequencing.","authors":"Qian Xu, Mei Zhou, Huixin Ni, Haixin Liu, Zhengtao Gao, Fangzhen Wu, Yao Lin","doi":"10.5152/pcp.2025.24889","DOIUrl":"10.5152/pcp.2025.24889","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by a multifaceted genetic foundation. We hypothesized that combining whole-genome sequencing (WGS) with whole-exome sequencing (WES) in a multi-generational family affected by PD could identify rare and novel variants of genes associated with PD.</p><p><strong>Methods: </strong>This study included a family showing multiple members affected by PD and exhibiting an apparent dominant inheritance pattern. Seventeen family members were genotyped by WES and 6 of them was additionally analyzed by WGS. The common variants were validated by Sanger sequencing.</p><p><strong>Results: </strong>Forty-seven genes that may be associated with PD were identified by co-separation analysis, clustering analysis, correlation analysis of resequencing data, and 2 of them were common. For these two genes, polymerase chain reaction (PCR) and Sanger sequencing were performed in family members, and quantitative PCR (qPCR) was conducted in 6 sporadic PD patients and 6 controls to detect mRNA expression. It was found that the <i>Ddx56</i> mutation frequency (chr7: 44610462) was significantly different between PD and control in the family. Additionally, the DEAD-box helicase 56(<i>Ddx56</i>) gene was down-regulated in PD patients, outside the family members, while <i>Ccdc42</i> mutation frequency and mRNAexpression had no significant difference.</p><p><strong>Conclusion: </strong>Therefore, it was speculated that the mutation of <i>Ddx56</i> in exon (chr7: 44610462) might be related to the occurrence of PD.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"92-101"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Cinepazide Maleate in Conjunction with Edaravone on Cerebral Blood Flow and Neurofunctional Parameters in Individuals with Acute Ischemic Stroke.","authors":"Deying Tian, Chaojin Luo, Yuting Zou","doi":"10.5152/pcp.2025.24987","DOIUrl":"10.5152/pcp.2025.24987","url":null,"abstract":"<p><strong>Background: </strong>This research is focused on evaluating the influence of administering cinepazide maleate and edaravone together on cerebral blood flow and neurofunctional markers in individuals who have recently suffered from an acute ischemic stroke (AIS).</p><p><strong>Methods: </strong>Included in this retrospective investigation were 100 patients diagnosed with AIS and treated at our medical center between the period of December 2022 and December 2023. These individuals were subsequently segregated into 2 cohorts according to the different treatments they received, consisting of 50 patients each, referred to as the control group and the observation group. Upon admission, standard treatment was initiated for all patients, alongside additional edaravone therapy for the control group, and concurrent administration of cinepazide maleate and edaravone for the observation group, for a consecutive period of 14 days. The study involved the assessment of cerebral blood flow in the middle cerebral artery (MCA) and anterior cerebral artery (ACA), in addition to the evaluation of neurofunctional markers, serum inflammatory factors, activities of daily living (ADL) scores, and National Institutes of Health Stroke Scale (NIHSS) scores. Adverse reactions were closely monitored to determine the treatment's efficacy.</p><p><strong>Results: </strong>Subsequent to the treatment, augmented blood flow velocities were observed in both the MCA and ACA for both groups, particularly evident in the observation group. The observation group also demonstrated raised levels of nerve growth factor and lower levels of neuron-specific enolase and S100-β, with more notable differences when contrasted with the control group. Additionally, the observation group displayed reduced levels of tumor necrosis factor-alpha and monocyte chemoattractant protein-1, and elevated levels of interleukin-10 (IL-10), with more substantial variations as opposed to the control group. Furthermore, the observation group indicated enhanced ADL scores and diminished NIHSS scores, with more notable differences compared to the control group. The overall treatment effectiveness reached 94.00% in the observation group, markedly surpassing the 74.00% achieved in the control group.</p><p><strong>Conclusion: </strong>The concurrent application of cinepazide maleate and edaravone yields notable effects on cerebral blood flow and contributes to the improvement of neurofunctional capabilities in individuals dealing with AIS.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"111-116"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Attention-Deficit/Hyperactivity Disorder Treatment on Caregiver's Burden, Anxiety, and Depression Symptoms.","authors":"Mahmut Selçuk","doi":"10.5152/pcp.2025.24935","DOIUrl":"10.5152/pcp.2025.24935","url":null,"abstract":"<p><strong>Background: </strong>Attention deficit/Hyperactivity d isorder (ADHD) affects the quality of life not only of children but also of their caregivers, particularly parents. This study investigates the effects of ADHD treatment on the burden, anxiety, and depression experienced by the parents of children with ADHD.</p><p><strong>Methods: </strong>This study involved 92 children diagnosed with ADHD, aged 6-17 years and their primary caregivers. Both children and caregivers participated in a structured psychiatric interview based on the DSM-V criteria. At the start of treatment and again 3 months later, the children's behavioral problems were assessed using the Conners' Parent Rating Scale-Revised: Short Form (CPRS-R:S). Caregiver outcomes were evaluated using the Burden Assessment Scale (BAS), the Hamilton Anxiety Rating Scale (HARS), and the Hamilton Depression Rating Scale (HDRS).</p><p><strong>Results: </strong>A statistically significant reduction in caregiver burden was observed in the BAS scores from the time of ADHD treatment initiation to 3 months later (<i>P</i> < .001, <i>r</i> ^a = 0.56). The highest BAS scores were consistently associated with hyperactivity, while the lowest scores were noted in caregivers of children with attention-deficit-dominant ADHD, both before and 3 months after treatment (<i>P</i> < .001, <i>η</i>² = 0.312; <i>P</i> < .001, <i>η</i>² = 0.314, respectively). The caregivers' HARS and HDRS scores decreased after 3 months of treatment, although this change was not statistically significant (<i>P</i> = .47 and <i>P</i> = .36, respectively).</p><p><strong>Conclusion: </strong>Attention deficit/hyperactivity disorder treatment significantly reduced the caregiver burden within 3 months, highlighting the importance of timely diagnosis and treatment of ADHD for improving children's symptoms and relieving the caregiver burden of their parents.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"124-131"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}