Psychiatry and Clinical Psychopharmacology最新文献

{"title":"Antineuronal antibodies and 8-OHdG an indicator of cerebellar dysfunction in autism spectrum disorder: a case–control study","authors":"F. Kılıçaslan, Hamza Ayaydın, H. Çelik, M. Kutuk, H. Kandemir, I. Koyuncu, A. Kirmit","doi":"10.1080/24750573.2019.1674241","DOIUrl":"https://doi.org/10.1080/24750573.2019.1674241","url":null,"abstract":"ABSTRACT Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, that starts in early childhood and presents with deficiencies in social-communicational domains along with restricted and repetitive behaviours/interests. While genetic factors are dominant in its pathogenesis, many factors, including neurological, environmental and immunological have been identified. Furtheremore, although cerebellar dysfunction in the etiology of autism has been shown in different studies, the possible causes of the dysfunction and the role of neuroinflammation among these causes have not been clarified yet. Anti-Yo, anti-Hu, anti-Ri and anti-Amphiphysin antibodies have been found to be associated with cerebellar degeneration. The aim of the present study was to compare anti-Yo, anti-Hu, anti-Ri and anti- Amphiphysin antibodies and 8-OHdG values in blood using the ELISA method between ASD patients and healthy children to demonstrate the role of neuroinflammation as a potential cause of cerebellar dysfunction and DNA damage and evaluate the relationship between Childhood Autism Rating Scale (CARS) scores in children diagnosed with ASD and these parameters. Methods: Thirty-five consecutive children between the ages of 3 and 12 referred to the Child and Adolescent Psychiatry Outpatient Clinic of Harran University Hospital and diagnosed with ASD according to the DSM-5 diagnostic criteria were included in the study. The children did not have any chronic physical disorders and were treatment naive. Thirty-three healthy children between the ages of 3 and 12 without any physical or psychiatric disorders were included as the healthy control group. For psychiatric evaluation, a sociodemographic form and to measure the severity of autism, CARS was used. In the study, anti-Yo, anti-Hu, anti-Ri and anti-Amphiphysin antibodies and 8-OHdG values in blood were investigated using the ELISA method. Results: Thirty-five cases with autism (62.9% males) and thirty-three healthy controls (72.7% males) were included in the present study (p = 0.385). The median age was 6.0 in the ASD group and 7.0 in the control group (p = 0.146). Among ASD patients, anti-Ri antibody positivity was detected, while no anti-Ri antibody positivity was found in the control group (p = 0.002). In the ASD group, the anti-Hu and 8-OHdG values were found to be significantly higher than those of the controls (p < 0.001, p = 0.001); no significant difference was found between the ASD and control groups with regard to the anti-Yo and anti-Amphiphysin values (p = 0.113, p = 0.275). Conclusions: The results of the present study suggest that antibodies against cerebellum may be present among children with ASD and DNA damage may occur due to oxidative stress.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"37 1","pages":"840 - 846"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75643993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyberbullying among a clinical adolescent sample in Turkey: effects of problematic smartphone use, psychiatric symptoms, and emotion regulation difficulties","authors":"Hesna Gül, S. Fırat, M. Sertçelik, A. Gül, Yusuf Gürel, B. Kılıç","doi":"10.1080/24750573.2018.1472923","DOIUrl":"https://doi.org/10.1080/24750573.2018.1472923","url":null,"abstract":"ABSTRACT BACKGROUND: Cyberbullying, has concerned professionals due to increased use of media over time and as predicted, this type of bullying is fairly common among adolescents. We aimed to define the prevalence of cyberbullying and cyber victimization, examine relationships between problematic smartphone (SP) use (PSU), psychiatric symptoms and emotion regulation difficulties in a clinical adolescent sample. Also, we aimed to predict risk factors of being an E-Victim and E-Bully. METHODS: One hundred and fifty adolescents have recruited the study. Demographic Information Form, Problematic Mobile Phone Usage Scale, Brief Symptom Inventory, Difficulties in Emotion Regulation Scale, E-Victimization–E-Bullying Scale were filled out by adolescents. RESULTS: Our results indicated that the prevalence of cybervictimization and cyberbullying were 62.6% and 53.3%, respectively. BEVEB (Both E-Victim and E-Bully) group adolescents were older than NVB (Non-Victim/Bully) groups. Access internet via own SP, PSU, problems in strategies and impulse control and were significantly higher and “lack of awareness” scores were significantly lower in BEVEB group than others. In addition, when compared with OEV (only E-Victims) group, BEVEB group had also higher hostility scores. Logistic regression analysis revealed that high scores of “lack of awareness” and higher E-bullying scores increase the risk of being an E-Victim; and higher scores of hostility and E-victimization and lower scores of “lack of awareness” (in other words being more aware of feelings) increase the risk of being an E-bully. CONCLUSIONS: According to analyses, contrary to our expectations, PSU was important but not an independent predictor of being an E-Victim/E-Bully. Our results also demonstrated an interesting finding: lack of awareness is a risk factor for being an E-victim. We interpreted this result as could not be aware of feelings increase the victimization risk. On the other hand, E-Bullies have higher hostility and victimization while having lower “lack of awareness” scores. It could be speculated that, re-victimization and being aware of hostility feelings could increase the cyberbullying among adolescents. In addition being an E-Bully could be a consequence of being an E-victim and increasing hostility and awareness over time. These results should be re-examined in larger clinical samples.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"1 1","pages":"547 - 557"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81552451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Birth order and reproductive stoppage in families of children with autism spectrum disorder","authors":"Ç. Uğur, A. Tonyali, Z. Goker, O. Uneri","doi":"10.1080/24750573.2018.1457489","DOIUrl":"https://doi.org/10.1080/24750573.2018.1457489","url":null,"abstract":"ABSTRACT OBJECTIVES: The objective of the study was to evaluate the birth order of children with Autism Spectrum Disorder (ASD) and ways of delivery at birth, together with the phenomenon of reproductive stoppage and the number of siblings in the case families (families of children with ASD in the study). METHODS: One hundred and ninety-six subjects with ASD and 54 healthy children were included into the study. Demographics were collected. Autism Behaviour Checklist (ABC), Aberrant Behaviour Checklist (AbBC), and Childhood Autism Rating Scale (CARS) were administered. Depending on the type of data and on the objective of the assessment, Mann–Whitney U-test, chi-square test, and Spearman tests were used for statistical analysis. A p-value smaller than .05 was considered to be statistically significant. RESULTS: In the study group consisting of children with ASD, the rate of being the first-born child was determined to be more frequent, significantly, compared to the rate in the control group (p = .001). It was also found that 86.7% (n = 170) of the children in the ASD group had at least one sibling compared to the rate of 81.5% (n = 44) for their counterparts in the control group. CONCLUSIONS: Our study compared ASD group to controls in terms of birth order, demonstrating a significant difference for being the first-born child in the ASD group. Birth order can be considered to be one of the several environmental factors that will help in understanding ASD, in which environmental factors can be the cause of phenotypic complexity. For all that, in our study, it was observed that having a child with autism in the Turkish sample did not affect the decision for the next pregnancy.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"69 3 1","pages":"509 - 514"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89117782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early effects of selective serotonin reuptake inhibitors (SSRIs) on cornea and lens density in patients with depression","authors":"Yalçın Karaküçük, A. Beyoğlu, Ayşegül Çömez, F. Orhan, Merve Demir","doi":"10.1080/24750573.2019.1673944","DOIUrl":"https://doi.org/10.1080/24750573.2019.1673944","url":null,"abstract":"ABSTRACT PURPOSE: To investigate the effects of SSRIs on cornea and lens density, intraocular pressure (IOP) and anterior chamber parameters, including anterior chamber volume (ACV), anterior chamber depth (ACD), corneal volume (CV) and central corneal thickness (CCT), in patients with depression during a three-month follow-up period. METHOD: In this prospective study, 31 total patients, who were prescribed SSRIs for depression, were recruited. Sertraline, 50 mg/daily, was given to ten patients; 11 received Escitalopram, 10 mg/daily; and ten were treated with Fluoxetine, 20 mg/daily. The parameters recorded were corneal density (CD), lens density (LD), IOP, ACV, ACD, CV and CCT at the start of treatment, as well as at one-week, one-month, and three-month follow-ups. RESULTS: The study revealed that there was no risk of cataract development from three months of SSRI intake. Significant decrease in ACD was recorded at the one-week follow up; however, after three months, this decrease was insignificant compared to the baseline. ACV, CV, CCT, CD and LD showed no significant alterations in any of the follow up examinations over the three-month period. IOP, however, significantly fell (a P value of 0.004). CONCLUSION: In this study, SSRI use does not seem to be associated with an increased risk of cataract or glaucoma or with changes in CD and LD. Long-term follow-up is necessary to determine the actual risk of cataract or glaucoma with SSRI intake.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"11 1","pages":"387 - 393"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81631854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The psychometric properties of the Generalized Anxiety Disorder scale (GAD-7) among Korean university students","authors":"Boram Lee, Yang-Eun Kim","doi":"10.1080/24750573.2019.1691320","DOIUrl":"https://doi.org/10.1080/24750573.2019.1691320","url":null,"abstract":"ABSTRACT OBJECTIVE: The seven-item Generalized Anxiety Disorder scale (GAD-7) is a practical self-report measure that screens for the severity of Generalized Anxiety Disorder in primary care. Previous studies have shown that the GAD-7 is theoretically sound, but the results regarding its psychometric properties have been somewhat inconsistent with both adult and student samples. Despite these findings, the psychometric properties of the GAD-7 have remained untested among Korean university students, for whom the identification of efficient measures of these constructs is especially important. To determine the psychometric properties of the GAD-7, the present study examined the internal consistency, convergent validity, and underlying factor structure of the GAD-7 with a sample of Korean university students. METHODS: The sample consisted of 582 students attending a four-year university in South Korea. All participants completed the Korean version of the GAD-7, the Depression Anxiety, and Stress Scale–21 (DASS-21), and the Patient Health Questionnaire (PHQ-9). The factor structure of the GAD-7 was assessed by exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), and its convergent validity was determined by investigating its correlations with the DASS-21 and PHQ-9. RESULTS: CFA procedures confirmed that a modified one-factor model was an acceptable solution. The internal consistency of the scale was excellent. The GAD-7 showed a moderate to strong correlation with the three subscales of the DASS-21 and with the PHQ-9, confirming convergent validity. CONCLUSIONS: The findings indicate that the modified GAD-7 is a reliable and valid instrument for assessing generalized anxiety symptoms in university students. Its use for research and health care practice is warranted.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"38 1","pages":"864 - 871"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82194592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder","authors":"B. Güngör, Nalan Öztürk, Ayça Öngel Atar, N. Aydın","doi":"10.1080/24750573.2019.1673936","DOIUrl":"https://doi.org/10.1080/24750573.2019.1673936","url":null,"abstract":"ABSTRACT Objective: The literature provides very limited information on mirtazapine usage in the pregnancy period. The groups including pregnant women who used SSRI or mirtazapine as a single treatment, SSRI–mirtazapine combination treatment and unmedicated groups were compared with respect to illness severity and birth outcomes. Method: The study sample included 120 pregnant women; 40 women with SSRI usage, 16 women with mirtazapine usage, 18 women with combined SSRI- mirtazapine usage, 23 women with unmedicated psychiatric disorder and who elected not to take medication during their pregnancy or discontinued antidepressants by themselves, and 23 healthy control women. Results: No difference was obtained with regard to the gestation week of birth, birth weight, the duration of stay in the neonatal care unit among the SSRI, mirtazapine, SSRI–mirtazapine combination, unmedicated patient and control groups. The likelihood of a new diagnosis was highest in the mirtazapine group. The majority of pregnant women whose psychiatric disorders were more severe and more relapsed used SSRI–mirtazapine combination treatment. Conclusion: No difference was observed between the SSRI and mirtazapine usage in the pregnancy period with regard to the birth outcomes. Similar birth outcomes could present clinicians with the option of prescribing mirtazapine as a safe alternative to SSRI in the treatment of antenatal psychiatric patients.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"67 1","pages":"822 - 831"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81124150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant-like activities of extracts of the fungus Paecilomyces tenuipes M98","authors":"Yaying Li, Long Han, Tong Lu, M. Noman, Weidong Qiang, Xinxin Lan, Tingting Gao, Jinnan Guo, Xiaomei Zhang, Haiyan Li, Jing Yang, Linna Du","doi":"10.1080/24750573.2019.1691352","DOIUrl":"https://doi.org/10.1080/24750573.2019.1691352","url":null,"abstract":"ABSTRACT Objective: Depression is an disease that seriously endangers the physical and mental health of human body. However, in view of the limitation of existing antidepressants, it's urgent to find new antidepressants from natural products. The aim of this study was to evaluate the effect of Paecilomyces tenuipes, which is an important entomogenous fungus in China. Methods: This research was intent to investigate the antidepressant actions of P. tenuipes M98 extracts using a battery of behavioural models including tail suspension test (TST) and forced swimming test (FST), 5-HTP-induced head twitch response and chronic unpredictable mild stress (CUMS) in mice. Results: Fifteen days treatment with aqueous and ethanol extracts signifificantly decreased the duration of immobility in TST and FST, without signifificant changes in locomotor activity. Moreover, chronic application of extracts for 21 days signifificantly improved the depressive-like behaviours of CUMS mice, including reduced body weight and sucrose preference and lengthened immobility time in TST and FST. In addition, extracts produced a signifificant increase in 5-hydroxytryptamine and dopamine, but not noradrenaline, levels in hypothalamus. These fifindings suggested that this action of P. tenuipes might be related to the regulation of serotonergic and dopaminergic systems, which were further confirmed via 5-HTP induced head-twitch test. In addition, P. tenuipes M98 extracts also displayed anti-oxidative effffects. Conclusion: P. tenuipes M98 extracts present excellent antidepressant-like activities, which might be explained by regulation of neurotransmitters and alleviation of oxidative stress.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"181 1","pages":"872 - 879"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80197188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer's disease","authors":"B. Elibol, Sule Terzioglu-Usak, M. Beker, Ç. Şahbaz","doi":"10.1080/24750573.2019.1673945","DOIUrl":"https://doi.org/10.1080/24750573.2019.1673945","url":null,"abstract":"ABSTRACT OBJECTIVES: Alzheimer’s disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in Aβ(1–42) infused rat model of AD. METHODS: A rat model of AD was established in 6 month-old rats (n = 23) by intra-hippocampal infusion during 14 days via a micro-osmotic pump containing aggregated Aβ(1–42). After model establishment, TQ at a dosage of 20 mg/kg/day was intubated intragastrically for 15 days. The functional recovery was determined using the Morris Water Maze task by measuring memory consolidation. The content of cytokine levels of Tumour Necrosis Factor-alpha (TNF-α), Interleukin-1 beta (IL-1β), Interleukin-1 alpha (IL-1α) and Interferon-gamma (IFN-γ) in the hippocampus was assessed by Magnetic Luminex assay. In order to reveal the functional molecular changes in hippocampal tissue upon TQ administration, the protein expression profile of neuronal migration protein Doublecortin (DCX), synaptic plasticity marker Mitogen Activated Protein Kinase2 (MAP2) and apoptosis related protein Poly (ADP-ribose) Polymerase (PARP) was analyzed by Western blotting. RESULTS: Aβ(1–42) infused group had worse memory performance than sham control group on Day 4 with an amelioration in this behaviour by TQ. In our study, the levels of TNF-α, IL-1α and IL-1β did not significantly alter among groups. On the other hand, Aβ(1–42) infusion slightly decreased the level of IFN-γ compared to sham control group. TQ treatment ameliorated both impaired memory performance and IFN-γ levels. It was found that TQ treatment increased the protein levels of DCX compared to the sham control group. Also, the levels of MAP2 and the activation of PARP protein markedly decreased in both Aβ(1–42) and Aβ(1–42)+TQ groups compared to the sham control groups Pearson’s correlation test showed a positive relation between IL-1β and DCX in the Aβ(1–42) group. DISCUSSION: Our data suggested that TQ-related functional improvement might result from the increasing level of neurogenesis and ameliorating the level of IFN-γ in the Aβ(1–42) infused rat model of AD.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"103 1","pages":"379 - 386"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80655572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maculopapular rash associated with risperidone in a child","authors":"H. Güler, S. Türkoğlu, D. Güler","doi":"10.1080/24750573.2018.1468639","DOIUrl":"https://doi.org/10.1080/24750573.2018.1468639","url":null,"abstract":"ABSTRACT Risperidone is an atypical antipsychotic that antagonizes 5HT2A and D2 receptors. Risperidone is used for many indications in children and adolescents. These indications include bipolar mania, schizophrenia, disruptive behaviour disorders, and aggression associated with autism spectrum disorder/mental retardation. Although it is usually well tolerated, weight gain, somnolence, rhinitis, headache, and rising appetite are among the most noticed side effects. Here we present a 5-year-old boy who developed diffuse nonpruritic maculopapular skin rash with a stable dosage of risperidone in the eighth month of treatment.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"74 1","pages":"527 - 528"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79689421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered cooperativeness in patients with polycystic ovary syndrome","authors":"Erson Aksu, Elmas Beyazyüz, Y. Albayrak, Nihan Potas, F. Durankuş, Gamze Uvaçin, M. Beyazyüz","doi":"10.1080/24750573.2019.1691357","DOIUrl":"https://doi.org/10.1080/24750573.2019.1691357","url":null,"abstract":"ABSTRACT OBJECTIVE: In the present study, we aimed to compare temperament and character traits between patients with polycystic ovary syndrome (PCOS) and age-body mass index-matched healthy controls (HC). We hypothesized that patient with PCOS would differ in terms of temperament and character traits compared with HCs. MATERIAL AND METHODS: Fifty patients who were diagnosed with PCOS and 42 age-body mass index-matched healthy controls (HC) were included in the study. The groups were compared in terms of temperament and character traits and anxiety status with the Temperament and Character Inventory (TCI) and State-Trait Anxiety Inventory (STAI-1 and STAI-2). FINDINGS: There was a statistically significant difference between patient and the control group in terms of cooperativeness dimension (t = −2.81; p = 0.006). It was a lower mean in the PCOS group (20.98 2.992). In addition, scores of STAI-1 and STAI-2 were significantly higher in the PCOS group compared with the HC group (respectively; t = 5.70; p < 0.001; t = 2.12; p = 0.037). The score of cooperativeness and multivariate analysis of variance was found to be significantly lower in the PCOS group. CONCLUSIONS: Patients with PCOS had significant a different character trait such as lower cooperativeness compared with HC. Additionally, we found that this different character dimension would be a trait in PCOS after covariant analysis. We suggest that our result supported the psychiatric background of PCOS.","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"76 1","pages":"880 - 886"},"PeriodicalIF":0.7,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91227289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}