Psychiatry and Clinical Psychopharmacology最新文献

{"title":"Associations and Related Mechanisms of Attention-Deficit Hyperactivity Disorder and Allergic Rhinitis in Children.","authors":"Nannan Lin, Rongwang Yang, Weijia Gao","doi":"10.5152/pcp.2025.24918","DOIUrl":"https://doi.org/10.5152/pcp.2025.24918","url":null,"abstract":"<p><p>Attention-deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder that manifests in early childhood and often affects children's daily life and academic performance, impairing their psychological development and potentially influencing their personality. The concurrent yearly increase in the incidence of allergic diseases and ADHD among children has prompted researchers to explore the association between these 2 health issues. Allergic rhinitis (AR) is one of the most common allergic diseases and is characterized by chronic inflammation of the nasal mucosa. The prevalence of AR increases from infancy through adolescence and then decreases with further aging. The relationship between ADHD and AR has garnered significant attention from researchers recently, although it remains a topic of debate. Numerous studies have suggested a correlation, while some have reported conflicting results. Furthermore, the precise mechanisms underlying their coexistence have not been fully elucidated. This review summarizes the literature on ADHD and AR both domestically and internationally. It highlights their interrelationship and potential comorbid mechanisms, thereby providing new perspectives on the pathogenesis of ADHD and informing long-term treatment and management strategies.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":"69-80"},"PeriodicalIF":0.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Individualized Health Education and Cognitive Training on Clopidogrel Treatment in Elderly Stroke Patients.","authors":"Min Ning, Chunmei Zheng, Hui Wu, Huiling Zhuang, Yuduan Wang, Nuannuan Long, Ning Bei","doi":"10.5152/pcp.2025.24977","DOIUrl":"https://doi.org/10.5152/pcp.2025.24977","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the nursing effect of individualized health education combined with cognitive training on clopidogrel treatment in elderly stroke patients.</p><p><strong>Methods: </strong>One hundred and twelve elderly stroke patients treated in our neurology department from January to June 2019 were randomly divided into experimental and control groups. The control group received clopidogrel therapy, conventional nursing, rehabilitation exercises, and conventional health education. The experimental group received the same treatment plus individualized health education and cognitive training. The intervention effect was assessed using the Montreal Cognitive Assessment (MoCA), the Health Education Questionnaire, the activity of daily living scale (ADL), and the Nurse Job Satisfaction Questionnaire before intervention, at 4 weeks and at 12 weeks.</p><p><strong>Results: </strong>After 4 and 12 weeks of intervention, patients in both groups showed improvements in MoCA scores, health education awareness rate, ADL scores, and nurses' job satisfaction compared to baseline. Moreover, the experimental group exhibited higher scores than the control group (<i>P</i> < .05), with statistically significant differences (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Individualized health education combined with cognitive training effectively enhances cognitive function, stroke awareness, health education adherence, and self-care ability in elderly stroke patients receiving clopidogrel treatment, thereby improving their overall quality of life.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":"55-59"},"PeriodicalIF":0.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risperidone Augmentation in Antidepressant-Resistant Somatic Symptom Disorder.","authors":"Eun Hyun Seo, Seung-Gon Kim, Hyung-Jun Yoon","doi":"10.5152/pcp.2025.24931","DOIUrl":"https://doi.org/10.5152/pcp.2025.24931","url":null,"abstract":"<p><p>Chronic somatic symptoms are hallmarks of somatic symptom disorder (SSD), characterized by notable disruptions in the day to day lives of affected patients. Risperidone is an effective augmenting agent for treatment-resistant major depressive and obsessive-compulsive disorders. Although various antidepressants have been used for the pharmacotherapy of SSDs, no guidelines have been formulated for treatment-resistant or severe SSDs. To date, the efficacy of risperidone augmentation for the treatment of antidepressant-resistant SSD has not been reported. Here, we report the case of a 68-year-old female patient with SSD and comorbid persistent depressive disorder. Upon admission, laboratory tests revealed no abnormalities except for a high triglyceride level. Psychosocial functioning and depressive symptoms were evaluated using the Global Assessment of Functioning and Beck Depression Inventory II. The severe and persistent symptoms of the patient were remarkably alleviated following low-dose risperidone augmentation with mirtazapine combined with desvenlafaxine. Furthermore, notable therapeutic effect of risperidone augmentation was observed following a significant reduction in the subjective distress of the patient and functional recovery within a short period. Our report suggests that early augmentation with risperidone facilitates the analgesic effect of serotonergic/noradrenergic antidepressants and contributes significantly to the rapid amelioration of SSD severity.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":"88-91"},"PeriodicalIF":0.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Sleep Induction Intervention in Conjunction with Lorazepam in Managing Insomnia Disorder.","authors":"Jing Chen, Yan Zhang, Guoqing Min, Linhui Liu, Lifen Huang, Ji Chen, Jiawei Zhu","doi":"10.5152/pcp.2025.241003","DOIUrl":"https://doi.org/10.5152/pcp.2025.241003","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the clinical efficacy of a combined treatment approach involving sleep induction intervention and lorazepam in managing insomnia disorder.</p><p><strong>Methods: </strong>This study enrolled a sample of 150 individuals diagnosed with insomnia disorder, consecutively admitted to our clinic from June 2021 to June 2023. Following randomization, the participants were divided into 2 groups: observation and control groups. Both groups were administered lorazepam treatment, with the observation group receiving sleep induction intervention and the control group receiving routine nursing. After the 4-week treatment period, relevant observation indicators were assessed to evaluate the efficacy of sleep improvement in both patient intervention groups.</p><p><strong>Results: </strong>Compared to the control group that received only lorazepam treatment, the observation group, who underwent sleep induction intervention, showed a better treatment effectiveness rate, sleep quality, and psychological state regarding the treatment of sleep disorders (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Sleep induction intervention can improve the overall treatment effectiveness rate of sleep disorders, enhance sleep quality, and alleviate symptoms of anxiety and depression.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":"1-5"},"PeriodicalIF":0.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Core Beliefs Questionnaire in a Sample of Individuals with Generalized Anxiety Disorder and Non-Clinical Samples.","authors":"Erkan Kuru, İlker Özdemir, Bengü Yücens, Türkan Doğan, M Hakan Türkçapar","doi":"10.5152/pcp.2025.24971","DOIUrl":"https://doi.org/10.5152/pcp.2025.24971","url":null,"abstract":"<p><strong>Background: </strong>Core beliefs are cognitive structures that shape one's fundamental assumptions about the self, the external environment, and the future. They play a pivotal role in the development of numerous mental pathologies. The Core Beliefs Questionnaire (CBQ) is one of the inventories developed to evaluate core beliefs. It is comprised of 3 versions: \"Trait (CBQT),\" \"Contingent (CBQC),\" and \"Others (CBQO).\" This study aims to examine the validity and reliability of the CBQ in a Turkish sample.</p><p><strong>Methods: </strong>The study included 2 groups: a group of individuals diagnosed with generalized anxiety disorder (GAD) (n = 150) and a group of healthy individuals (n = 150). A \"Socio-demographic Data Form,\" the \"CBQ,\" the \"Social Comparison Scale (SCS),\" the \"State-Trait Anxiety Inventory (STAI),\" the \"Beck Depression Inventory (BDI),\" and the \"Beck Anxiety Inventory (BAI)\" were administered to the participants.</p><p><strong>Results: </strong>: Confirmatory factor analysis confirmed the construct validity of all 3 versions of the CBQ. Furthermore, Cronbach's <i>α</i> analyses showed that all three versions were highly reliable (GAD group: CBQTα = 0.93, CBQCα = 0.96, and CBQOα = 0.96, control group: CBQTα = 0.95, CBQCα = 0.98, and CBQOα = 0.94). The GAD group had significantly higher negative core beliefs compared to the healthy control group.</p><p><strong>Conclusion our research findings indicate that the cbq is a valid and reliable measure for assessing core beliefs in: </strong>clinical and non-clinical samples. While the majority of research on GAD has concentrated on particular cognitive processes, such as worry and uncertainty, this study demonstrated that individuals with GAD may have a multitude of negative core beliefs.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":"43-54"},"PeriodicalIF":0.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging the Safety Threshold: Neurotoxicity in Bipolar Disorder Treatment with Lithium at Therapeutic Serum Levels.","authors":"Jinbo Chen, Jun Zhu, Hehua Bao, Lijuan Tang, Benhan Li, Zixuan Chen, Yanli Zhang, Qiang Hu","doi":"10.5152/pcp.2025.24964","DOIUrl":"https://doi.org/10.5152/pcp.2025.24964","url":null,"abstract":"<p><p>Bipolar disorder is a complex mental disorder that often requires long-term medication management. Lithium carbonate is widely used to prevent and treat the recurrence of bipolar disorder. However, even with normal serum lithium levels, some rare but serious side effects may occur. This case report describes a 42-year-old female patient with bipolar disorder who experienced \"electrical shock-like\" convulsions after taking lithium carbonate sustained-release tablets, despite having normal serum lithium concentrations. The patient had a history of emotional instability for 27 years, and no obvious psychotic symptoms such as hallucinations or delusions were found upon psychiatric examination at admission. On the 33rd day of medication, the patient began to experience frequent rapid convulsions in the head, neck, and upper body. Considering the possibility of drug side effects, lithium carbonate was discontinued, and the convulsions subsequently subsided. Electroencephalogram (EEG) examination showed no abnormalities. After 10 days of treatment, the convulsions had essentially disappeared. This case reminds clinicians that even with normal serum lithium levels, toxic symptoms may occur, and close monitoring of the patient's clinical manifestations and serum lithium levels is essential. Additionally, poor diet and reduced sodium intake may increase the risk of lithium toxicity, so these factors should also be taken into consideration.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":"81-87"},"PeriodicalIF":0.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Impact of COVID-19: Validity and Reliability of the Turkish Fear of Illness and Virus Evaluation(FIVE) Scale.","authors":"Oğuzhan Kılınçel, Zekiye Çelikbaş, Sedat Batmaz","doi":"10.5152/pcp.2025.24963","DOIUrl":"https://doi.org/10.5152/pcp.2025.24963","url":null,"abstract":"<p><strong>Background: </strong>During the Coronavirus disease-2019 pandemic, various scales were developed to assess mental health issues linked to the virus. This study aimed to determine the validity and reliability of the Turkish adaptation of the Fear of Illness and Virus Evaluation (FIVE)-Adult Report Form (ARF).</p><p><strong>Methods: </strong>Individuals aged 18 and above who consented to participate were given access to the questionnaire after being informed about the study's objectives. Authorization for the translation was obtained from the original form's creator.</p><p><strong>Results: </strong>A total of 466 participants took part in the study. The explanatory factor analysis revealed that items 1-9 assessed fears related to contamination and illness, items 10-19 focused on fears concerning social distancing, and items 20-33 addressed behaviors associated with fears of disease and viruses. Items 34 and 35, which measured the impact of illness and virus fears, were found to load onto the factor related to fears of contamination and illness. The scale explained 44.5% of the total variance. The internal consistency reliability coefficients were 0.902 for the contamination and illness fears subscale, 0.905 for the social distancing fears subscale, 0.777 for behaviors related to illness and virus fears, and 0.916 for the scale.</p><p><strong>Conclusion: </strong>The findings indicate that the Turkish adaptation of the FIVE-ARF has a 3-factor structure and demonstrates strong validity and reliability for use within the Turkish population.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 1","pages":"31-42"},"PeriodicalIF":0.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Body Image Disturbance and Its Influencing Factors in Breast Cancer Patients Following Unilateral Mastectomy.","authors":"Weidan Xu, Liuyin Zhou, Chaofu Zhao, Yi Zhou, Shuzheng Chen, Li Yang","doi":"10.5152/pcp.2024.24953","DOIUrl":"10.5152/pcp.2024.24953","url":null,"abstract":"<p><strong>Background: </strong>Patients with unilateral breast loss after single mastectomy for breast cancer may have body image disorders such as surgical lymphedema, flap ischemia, and spinal deformity, resulting in negative emotions such as depression, inferiority, and social dysfunction. This study mainly investigated and analyzed the status quo and influencing factors of body image disorder in breast cancer patients after single mastectomy.</p><p><strong>Methods: </strong>This study is a cross-sectional study. Breast cancer patients admitted from May 2023 to April 2024 were selected as the research subjects. Data were collected with a general information questionnaire, the Body Image Scale (BIS), the Self-Image Scale, the Self-Acceptance Questionnaire, and the Perceived Social Support Scale. Based on the scores, the research subjects were divided into a body image disturbance group and a non-disturbance group. Univariate and multiple logistic regression analyses were conducted to analyze the influencing factors of body image disturbances in breast cancer patients.</p><p><strong>Results: </strong>One hundred fifty questionnaires were distributed in this study, and 146 valid questionnaires were collected. Among the 146 patients, 51 (34.93%) experienced body image disturbances after surgery, while 95 (65.07%) did not. The results of univariate and multiple logistic regression analyses showed that educational level, lymphedema in the affected limb, intimate relationships, self-image, self-acceptance, and perceived social support scores were independent risk factors for body image disturbances in breast cancer patients after surgery (P < .05).</p><p><strong>Conclusion: </strong>Body image disturbances in breast cancer patients who undergo unilateral mastectomy need further improvement. Educational level, lymphedema in the affected limb, intimate relationships, self-image, self-acceptance, and perceived social support are the main influencing factors.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"34 4","pages":"328-335"},"PeriodicalIF":0.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on Gambling Behavior in Türkiye: Perceptions, Attitudes, Thoughts, and Behaviors Toward Gambling.","authors":"Merih Altıntaş, Şaziye Senem Başgül, Akif Avcu, Ruken Macit, Şener Büyüköztürk, Duygu Dinçer, Merve Özdenler, Mücahit Öztürk","doi":"10.5152/pcp.2024.24907","DOIUrl":"10.5152/pcp.2024.24907","url":null,"abstract":"<p><strong>Background: </strong>The aim of this quantitative study conducted with 5008 individuals aged 15 and above in 12 provinces across Turkey was to determine the prevalence and significant variables of gambling behavior in our country and to examine the gambling behaviors, perceptions, thoughts, and attitudes of this population towards gambling. The goal is to generate concrete, original, culturally sensitive, feasible, and effective recommendations for preventive and risk-reducing policies. It is the first and only comprehensive investigation into gambling behavior in Turkey, offering guidance in this field.</p><p><strong>Methods: </strong>In this study, which was conducted with an epidemiological cross-sectional design, a stratified random sampling technique was employed, and data were collected using computer-assisted faceto-face interviews. Individuals to be surveyed in households were randomly selected using the Kish method.</p><p><strong>Results: </strong>Three hundred forty-one participants (6.81%) reported having gambled at least once (GALO) in their lifetime, while the remaining participants stated they had never gambled (NG). Among the GALO group, 100 individuals (29.33%) reported regular participation in gambling activities during the data collection period. The most commonly played types of gambling were sports betting (55.4%), national lottery (42.2%), numeric lottery (34.6%), and bingo (30.8%). The ages of first-time gambling ranged from 6 to 41. Tobacco, alcohol, and substance use were significantly more common in the GALO group compared to the NG group (P < .001).</p><p><strong>Conclusion: </strong>Understanding the prevalence of gambling behavior and underlying motivations is crucial for creating awareness and implementing effective preventive measures. We must determine its prevalence, examine societal attitudes, highlight its presence, and prioritize solution-oriented strategies.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"34 4","pages":"311-319"},"PeriodicalIF":0.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Expression of miR-26b-5p, EGR1, and STAT1 in Peripheral Blood of Schizophrenia Patients.","authors":"Yilin Liu, Fuyi Qin, Lei Yu, Xinling Zhao, Qing Long, Xiao Ma, Xu You, Yunqiao Zhang, Yatang Chen, Yong Zeng","doi":"10.5152/pcp.2024.24882","DOIUrl":"10.5152/pcp.2024.24882","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate miRNAs and upstream regulatory transcription factors involved in schizophrenia (SZ) pathogenesis.</p><p><strong>Methods: </strong>Differential expression of miRNAs and genes in SZ patients was investigated utilizing the gene expression omnibus dataset, gene ontology annotations, and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. Real-time quantitative polymerase chain reaction experiments were conducted to validate the predictive screening of regulatory genes in peripheral blood samples from 20 SZ patients and 20 healthy controls. The diagnostic potential of these factors within these samples was assessed via receiver operating characteristic (ROC) curve analyses.</p><p><strong>Results: </strong>Fifty-eight miRNAs were identified as differentially expressed in the peripheral blood of SZ patients. miR-26b-5p exhibited significantly reduced expression in SZ patients compared to healthy individuals. Additionally, 1422 mRNAs were differentially expressed, including 5 transcription factors potentially regulating miR-26b-5p expression. Among these, EGR1 and STAT1 displayed significantly lower expression levels in SZ patients. Receiver operating characteristic analysis revealed areas under the curve of 0.76 for miR-26b-5p, 0.74 for EGR1, 0.82 for STAT1, and 0.85 for the combined STAT1-miR-26b-5p diagnosis.</p><p><strong>Conclusion: </strong>The reduced expression of miR-26b-5p, EGR1, and STAT1 in the peripheral blood of SZ patients, compared to healthy controls, suggests a strong association with SZ. These molecules represent potential diagnostic biomarkers, with the combined marker STAT1-miR-26b-5p potentially offering enhanced diagnostic accuracy.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"34 4","pages":"275-284"},"PeriodicalIF":0.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}