Psychiatry and Clinical Psychopharmacology最新文献

{"title":"Abnormal Functional Connectivity Pattern of the Reward Circuitry Is Associated with Negative Symptoms and Cognitive Functions in First-Episode Schizophrenia.","authors":"Yunyi Han, Fuchun Zhou, Xue Yang, Yueying Zhang, Qijing Bo, Chuanyue Wang","doi":"10.5152/pcp.2025.241055","DOIUrl":"10.5152/pcp.2025.241055","url":null,"abstract":"<p><p>Background: This study aimed to investigate the relationship between abnormal functional connectivity (FC) patterns in the reward circuitry of the brain and negative symptoms and cognitive impairment in individuals with first-episode schizophrenia (FES). Methods: Fifty-two FES patients and 59 healthy controls (HCs) were recruited for this cross-sectional study. Thirteen brain regions associated with the reward circuitry were defined as regions of interest (ROIs), and FCs between each ROI and the whole brain were analyzed. Cognitive function was assessed by the MATRICS Consensus Cognitive Battery. Results: Within-network analyses indicated that, compared to HCs, FES patients exhibited increased FCs between the left ventrolateral prefrontal cortex and left thalamus, which negatively correlated with negative symptoms. Whole-brain analyses revealed some weakened FCs in FES patients compared to those in HCs. The FCs between the right nucleus accumbens and right insular lobe and between the right putamen and both the left anterior cingulate cortex and left precentral gyrus positively correlated with attention/vigilance only in HCs. Additionally, the FC between the left putamen nucleus and left inferior frontal gyrus positively correlated with verbal and visual learning only in HCs. Conclusion: These findings highlight the differential FC patterns in the reward circuitry in FES patients and indicate that the enhanced within-network FC observed in these patients may contribute to their negative symptoms. The absence of correlations between certain FCs and attention, verbal learning, and visual learning can be explained by decoupling of the reward circuitry from the cognitive control brain regions.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"198-207"},"PeriodicalIF":0.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Health Guidance and Psychological Nursing Intervention: Effects on Emotions, Sleep Quality, and Self-Efficacy in Cerebral Hemorrhage Patients.","authors":"Xin Wang, He Lin, Qi Chen","doi":"10.5152/pcp.2025.24929","DOIUrl":"10.5152/pcp.2025.24929","url":null,"abstract":"<p><strong>Background: </strong>To explore the impact of systematic health guidance combined with psychological nursing intervention on negative emotions, sleep quality, and self-efficacy of patients with cerebral hemorrhage.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 100 patients with cerebral hemorrhage admitted to our hospital from March 2023 to March 2024, including 48 cases in the control group (CG) treated with routine nursing methods and 52 cases in the observation group (OG) treated with psychological nursing combined with systematic health guidance. The negative emotion scores, disease awareness, and sleep quality before and after intervention were compared between the 2 groups. The self-management ability, incidence of complications, quality of life, and nursing satisfaction were evaluated and compared between the 2 groups after the intervention.</p><p><strong>Results: </strong>After the intervention, both groups showed improvements in negative emotion scores, disease awareness, and sleep quality. However, the OG exhibited significantly more improvement than the CG, demonstrating higher self-management ability, lower incidence of complications, and higher life quality and nursing satisfaction (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Systematic health guidance combined with psychological nursing intervention can effectively improve the negative emotions, sleep quality, and self-efficacy of patients with cerebral hemorrhage, reduce the incidence of complications during hospitalization, and improve patient satisfaction with nursing, which is worthy of clinical promotion.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"149-154"},"PeriodicalIF":0.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CANFOR Scale for the Assessment of Needs of Forensic Psychiatric Patients: Preliminary Report on the Polish Version of the Scale and Its Reliability.","authors":"Mikołaj Trizna, Anna Jeleń, Paweł Dębski, Joanna Smolarczyk, Magdalena Piegza, Andrzej Kiejna, Tomasz Adamowski","doi":"10.5152/pcp.2025.23711","DOIUrl":"10.5152/pcp.2025.23711","url":null,"abstract":"<p><strong>Background: </strong>The constantly growing number of patients in psychiatric wards (including forensic wards) is a serious social, medical, and economic problem. Therefore, it is necessary to study the needs of these patients. The aim of the study was to adapt and test the reliability of the Polish version of the scale for the assessment of needs of forensic psychiatric patients-Camberwell Assessment of Need-Forensic Version (CANFOR).</p><p><strong>Methods: </strong>The scale was translated into Polish and then back-translated. The study was conducted among 60 patients of basic and enhanced security level forensic psychiatry wards at the Provincial Specialist Mental Health Hospital in Poland.</p><p><strong>Results: </strong>When analyzing the reproducibility of the responses in terms of assessing the reliability of the CANFOR questionnaire, perfect agreement of 100% was obtained in 22 areas of need. Similarly, in the repeatability study of the CANFOR questionnaire after 2 weeks, perfect agreement-100%-was obtained in 24 areas of need. In the correlation analysis of the CANFOR with another measurement tool-LSP, significant values at the <i>P</i> < .05 level were obtained when measuring several variables.</p><p><strong>Conclusions: </strong>The study resulted in high reliability of the Polish version of the CANFOR scale. It is advisable to continue research in the area of psychometric properties of the scale, including the validity of the tool.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"132-140"},"PeriodicalIF":0.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluttering and Working Memory in Attention Deficit and Hyperactivity Disorder.","authors":"Saniye Tülin Fidan, Merve Nur Sarıyer","doi":"10.5152/pcp.2025.241035","DOIUrl":"10.5152/pcp.2025.241035","url":null,"abstract":"<p><p>Background: This study aims to explore cluttering and working memory in children and adolescents diagnosed with different subtypes of Attention Deficit Hyperactivity Disorder (ADHD) and to compare them with typically developing (TD) children and adolescents. Methods: The sample included 200 ADHD participants and a control group of 49 TD participants. All participants completed the Working Memory Scale and Predictive Cluttering Inventory-revised ). Data were analyzed using SPSS, and Mann-Whitney U and Kruskal-Wallis tests were performed to assess differences between the groups. A significance level of P < .05 was used for all analyses. Results: Significant differences were observed in the Working Memory, Visual Memory, and Verbal Memory scores across the Typically Developed ADHD-Inattentive type and ADHD-Combined type groups (P < .001). Additionally, there were significant differences in the PCI-TR scores, including motor speech, language planning, attention, motor planning, and total scores, between the 3 groups. The findings indicated significant differences between the groups across all variables (p < .001). Conclusion: The study concluded that cluttering is present in both the ADHD Inattentive and Combined types. It is recommended that children diagnosed with ADHD undergo more comprehensive assessments of their language and speech capabilities.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"234-244"},"PeriodicalIF":0.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Cytokines as Biomarkers for Comorbid Anxiety in Postpartum Depression: A Machine Learning Approach.","authors":"Ping Fang, Guo-Hao Li, Ying-Bo Rao, Chen Cheng, Wen-Li He, Jiejie Wang, Xiang-Yao Li, Yun-Rong Lu","doi":"10.5152/pcp.2025.241043","DOIUrl":"10.5152/pcp.2025.241043","url":null,"abstract":"<p><p>Background: This study aimed to investigate the serum levels of interleukin 2, interleukin 6 (IL-6), interleukin 10, and tumor necrosis factor-alpha in patients with postpartum depression (PPD) and to explore their potential as biomarkers for PPD and comorbid anxiety using machine learning techniques. Methods: Serum samples were collected from 53 patients diagnosed with PPD and 35 healthy controls. Cytokine levels were measured using a flow cytometer analyzer. Machine learning models, including Multinomial Logistic Regression, Decision Trees, Random Forest, and Support Vector Machines (SVMs), were developed to predict PPD and comorbid anxiety based on cytokine levels. Results: Patients with PPD exhibited significantly elevated serum levels of IL-6 compared to the control group. A positive correlation was found between psychological anxiety scores and IL-6 levels (r = 0.483, P < .001). Machine learning models, particularly the Random Forest and SVMs, demonstrated high accuracy in predicting PPD and comorbid anxiety, with IL-6 being identified as a key predictor. Conclusion: The activation of serum cytokines is evident in PPD patients, with IL-6 potentially serving as an auxiliary biomarker for the diagnosis of PPD and comorbid anxiety. The incorporation of machine learning techniques has enhanced the understanding of the complex relationships between cytokines and PPD, with IL-6 levels showing a correlation to the severity of clinical symptoms.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"245-252"},"PeriodicalIF":0.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Independent Risk Factors of Anxiety and Depression Symptoms in Glioma Patients: A Cross-Sectional Analysis.","authors":"Xingyun Zheng, Weizhen Zhang, Yinyou Li, Xiancong Lai, Qingqing Fan, Yueling Xu, Xilong Yin","doi":"10.5152/pcp.2025.241021","DOIUrl":"10.5152/pcp.2025.241021","url":null,"abstract":"<p><strong>Background: </strong>To investigate the current status of anxiety and depression symptoms in patients with brain glioma and identify the risk factors associated with anxiety and depression symptoms.</p><p><strong>Methods: </strong>A total of 105 patients diagnosed with glioma at Longgang Central Hospital of Shenzhen from January 2021 to April 2024 were included in this study. The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression symptoms of the patients, who were then grouped based on their scores. Chi-square tests and binary logistic regression analyses were performed to identify the independent risk factors for anxiety and depression symptoms in glioma patients.</p><p><strong>Results: </strong>The average HADS-Anxiety score among glioma patients was 8.72 ± 3.41, with an anxiety symptoms prevalence of 61.90% (65/105). The average HADS-Depression score was 7.73 ± 2.91, with a depression symptoms prevalence of 55.24% (58/105). Among them, 58 patients (55.24%) had both anxiety and depression symptoms, seven patients (6.67%) had only anxiety symptoms, and 40 patients (38.10%) had neither anxiety nor depression. The results of binary tic regression analysis showed that family monthly income, seizures, sleep quality, and cognitive function impairment were independent risk factors for anxiety and depression symptoms (<i>P</i> < .05). Marital status was an independent risk factor for depression symptoms (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Glioma patients exhibit a high incidence of anxiety and depression symptoms. The occurrence of these conditions is significantly associated with lower monthly household income, seizure occurrence, sleep disturbances, and cognitive impairment.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"155-164"},"PeriodicalIF":0.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Illness Duration and Social Cognitive Abilities in Schizophrenia Spectrum Disorder.","authors":"Gülsüm Zuhal Kamış, Özge Selin Özen Sekmek, Bedirhan Şenol, Özgecan Özgün Erol","doi":"10.5152/pcp.2025.241037","DOIUrl":"10.5152/pcp.2025.241037","url":null,"abstract":"<p><p>Background: Social cognition can be defined as the ability to perceive and interpret others' thoughts, intentions, and behaviors. It is known that there are deficiencies in social cognitive skills in schizophrenia. This study aims to evaluate the social cognitive skills of schizophrenia spectrum disorder patients from the very early stages using theory of mind and emotion identification/discrimination tests and to examine the changes in these skills during schizophrenia. Methods: Seventy-nine patients who met the schizophrenia criteria according to Diagnostic and Statistical Manual of Mental Disorders-5 , except for duration, and were diagnosed with schizophrenia were divided into 3 groups according to the duration of illness: less than 6 months (n = 18), 6-24 months (n= 35), and more than 24 months (n = 26). The participants were administered the Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning Scale (GAF), the Reading the Mind in the Eyes Test (RMET), and the Facial Identification and Discrimination Tests (FEIT and FEDT), and the test scores were compared between the 3 groups. Results: There was no significant difference between the groups regarding PANSS, GAF and RMET, FEIT, and FEDT scores (P > .05). There was also no significant relationship between the illness duration and RMET, FEIT, and FEDT scores (P > .05). Conclusion: There was no significant relationship between disease duration and social cognitive skills in schizophrenia spectrum disorder patients. This finding suggests that social cognitive deficits may be a trait marker of schizophrenia.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"208-215"},"PeriodicalIF":0.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Hotspots in Research on Exercise and Alzheimer's Disease: A Decade of Bibliometric Review on Prevention and Molecular Mechanisms.","authors":"Xinge Yang, Keke Li, Yimin Zhang, Ruizhe Sun, Jingjing Yu","doi":"10.5152/pcp.2025.241016","DOIUrl":"10.5152/pcp.2025.241016","url":null,"abstract":"<p><p>With the rapid acceleration of global aging, the prevalence of Alzheimer's disease (AD) continues to rise, exerting a profound impact on elderly individuals' physical health, lifestyle, and quality of life. Exercise has demonstrated significant research value and broad application potential in AD as a non-pharmacological preventive and therapeutic approach. This study aims to provide a bibliometric and visual analysis of research related to exercise and AD over the past decade. It seeks to identify research hotspots and development trends, explore the layers of research on exercise's impact on AD, and clarify its preventive effects and molecular mechanisms. The Web of Science Core Collection database was used as the data source for this study. A comprehensive search was conducted using the topic \"exercise for Alzheimer's disease,\" covering the period from January 1, 2014, to August 31, 2024. CiteSpace and Python were employed to perform bibliometric and visual analyses on these publications, including assessments of publication trends, keyword co-occurrence, clustering analysis, timeline analysis, burst detection analysis, and the distribution and growth trends of molecular mechanisms related to exercise and AD. 1. Annual publication trends: 6134 articles were included in the analysis. The number of publications on exercise and AD increased steadily from 2014 to 2024 (<i>β</i> = 53.23,<i>P</i> < .001). 2. Keyword co-occurrence and clustering analysis: research on exercise and AD primarily focuses on themes related to cognitive decline, risk factors, exercise-induced energy metabolism, exercise intensity, and molecular mechanisms. 3. Keyword timeline and burst analysis: epidemiological and clinical studies maintained high activity levels in the early and mid-stages of the research timeline, whereas molecular-level studies exhibited increased activity in the later stages. 4. Molecular mechanisms distribution: analysis of molecular mechanisms reveals that amyloid-beta deposition and oxidative stress remain the predominant research areas. Meanwhile, research on neuroinflammation, brain-derived neurotrophic factor (BDNF), Tau pathology, and other related mechanisms has been further explored. The findings demonstrate a progressive shift in research focus from general epidemiological patterns to more in-depth investigations of molecular biological mechanisms. Exercise has been shown to play a preventive role at the clinical level by improving cognitive function and mitigating risk factors and at the molecular level by modulating key pathological mechanisms, including β-amyloid deposition, oxidative stress, BDNF, tau pathology, and others. Through the coordinated regulation of multiple targets and pathways, exercise exerts a neuroprotective effect against AD.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"185-197"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic and Clinical Characteristics of Children Who Lose the Autism Spectrum Disorder Diagnosis.","authors":"Börte Gürbüz Özgür, Serhat Nasıroğlu, Hasan Can Özbay, Hatice Aksu","doi":"10.5152/pcp.2025.241070","DOIUrl":"10.5152/pcp.2025.241070","url":null,"abstract":"<p><p>Background: The objective of this research is to present the demographic and clinical features of children diagnosed with autism spectrum disorder (ASD) in the past, who have achieved an optimal level of improvement. One of the recurrent inquiries of the parents of children with an ASD diagnosis pertains to the prognosis of their offspring and the potential for improvement. This study aims to investigate children who lose the ASD diagnosis (LAD). Methods: This study retrospectively reviewed the medical records of 1465 children and adolescents aged 0-18 who were diagnosed with ASD between December 2017 and June 2021, and followed up by a child and adolescent psychiatrist. The files of a total of 50 LAD patients were analyzed. In addition to sociodemographic information, the patient's educational background, prenatal and postnatal complications, developmental milestones, other medical conditions, medications used, symptoms at the time of ASD diagnosis, and developmental/mental assessment results were also examined. Results: A sample of 50 cases was obtained and analyzed. The majority of the sample consisted of males, with a median age of 2.45 (min 1.17-max 7) years at the time of receiving the ASD diagnosis, and 5.5 (min 2.25-max 11.3) years at the time of losing the diagnosis. There was a positive and moderately significant relationship between the age of receiving the diagnosis and the age of losing the diagnosis (r=0.634, P < .001). Ninety-two percent of the sample received a mean of 2.29 ± 1.77 years of special education. Additionally, 26% of the sample still had an additional psychiatric diagnosis, with attention deficit hyperactivity disorder and speech sound disorder being the most common. Eighteen percent of the sample was found to be taking medication, primarily risperidone. Conclusion: This study shows that a subset of monitored children may lose their diagnosis, but further research to determine the clinical characteristics, symptomatology, and biological factors of this group of children will be more informative regarding optimal outcome processes.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"253-260"},"PeriodicalIF":0.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Poisonings, Suicidality and Systemic Inflammatory Load in Pregnant Women.","authors":"Şenay Koçakoğlu, Hasan Büyükaslan","doi":"10.5152/pcp.2025.24962","DOIUrl":"10.5152/pcp.2025.24962","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy can be challenging for women in various manners and can boost the risk of intentional self-poisonings. The aim of the study is to evaluate the occurrence and clinical characteristics of poisonings and the relationship between suicidal tendency and increased systemic inflammatory load during pregnancy.</p><p><strong>Methods: </strong>This study was performed in a tertiary hospital emergency department using 10 years of data. The study covered 69 female individuals, 35 pregnant and 34 non-pregnant, with acute poisoning diagnoses. The cases' sociodemographic and clinical features, as well as routine blood results, were evaluated. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) markers were calculated to assess systemic inflammatory load.</p><p><strong>Results: </strong>The intentional suicide rate in pregnant women was 85.71% (n = 30). Pregnant individuals had significantly higher PLR (<i>P < .</i>001) and NLR (<i>P = .</i>001) levels compared to the control group. The NLR values in intentional poisonings and the PLR in accidental poisonings were found to be proportionally higher, but the difference between both groups was not statistically significant (<i>P = .</i>448 and <i>P = .</i>701, respectively).</p><p><strong>Conclusion: </strong>The vast majority of acute poisonings in pregnant women were intentional. Although the inflammatory burden values were significantly higher in pregnant women than in controls, there was not enough strong evidence to establish a link between increased inflammatory burden and suicidal tendencies in pregnant women.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"141-148"},"PeriodicalIF":0.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}