Psychiatry and Clinical Psychopharmacology最新文献

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A Cross-Sectional Study on the Drug Use of Insomnia in a Chinese Medicine Hospital in Shenzhen. 深圳市某中医院失眠症用药的横断面研究
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-07-28 DOI: 10.5152/pcp.2025.24923
Jingfeng Lin, Zhenyi Wang, Danfeng Tian, Run Xi, Lina Zhang, Zhenyun Han
{"title":"A Cross-Sectional Study on the Drug Use of Insomnia in a Chinese Medicine Hospital in Shenzhen.","authors":"Jingfeng Lin, Zhenyi Wang, Danfeng Tian, Run Xi, Lina Zhang, Zhenyun Han","doi":"10.5152/pcp.2025.24923","DOIUrl":"10.5152/pcp.2025.24923","url":null,"abstract":"<p><p>Background: The prevalence of insomnia disorder is high among the general poulation and is a risk factor for many diseases. The rationality of drug use for insomnia in Chinese Medicine Hospital was uncertain. In order to evaluate the use of drugs in the Chinese Medicine Hospital of Longgang, Shenzhen, the authors conducted this cross-sectional research. Methods: A retrospective, cross-sectional study was conducted in Shenzhen Hospital of Beijing University of Chinese Medicine (Long Gang), Guangdong Province. Insomnia patients from January 1, 2016, to November 10, 2020, were included in the cross-sectional study. Patients corresponding to International Classification of Sleep Disorders (ISCD-3) Diagnostic Criteria for short-term and chronic insomnia were included. The authors excluded patients with severe mental disease or nervous system dysfunction or who could not correctly describe their symptoms. The characteristics of insomnia patients, survey results of drug use and symptoms of insomnia patients were collected. The authors analyzed the basic information, condition of drug use, and relationship between symptoms and drug use using R software (version 4.0.2) with the arulesViz package. Results: A total of 9439 patients were included in the study. The average age of these patients was 45.81 years (SD 13.97 years). Anxiety, dreaminess, dizziness, palpitation, headache, thirst, weakness, chest distress, annoyance, abdominal distension, bad moods, difficulty in falling asleep and bitter taste in the mouth were core symptoms of insomnia. The 10 most commonly used drugs ranged from more to less were estazolam (29.99%), Zaoren anshen capsule (15.50%), oryzanol (14.82%), diazepam (14.51%), flupentixol and melitracen (14.30%), alprazolam (8.12%), zolpidem tartrate (5.29%), vitamin B6 (4.76%), sertraline (4.03%), and clonazepam (2.97%). Conclusion: Drugs used for insomnia in the Chinese medicine hospital in Longgang, Shenzhen mainly included benzodiazepines, nonbenzodiazepines, Chinese patent medicines, anti-anxiety drugs, anti-depression drugs, oryzanol, and vitamin B6. The use of oryzanol and vitamin B6 was abused in Chinese medicine hospitals, and the use of Chinese medicine should be evaluated more rigorously. Nonbenzodiazepines should be promoted and more widely understood in the Chinese medicine hospital in Longgang, Shenzhen.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"295-303"},"PeriodicalIF":0.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of the Turkish Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (Quip-Rs). 帕金森氏病评定量表(Quip-Rs)中冲动强迫症问卷土耳其版的验证。
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-25 DOI: 10.5152/pcp.2025.241017
Ardıl Bayram Şahin, Elif Sude Özaşik, Yasemin Kadandir, Muhammet Nesip Seyidoğlu, Roza Gök, Berfu Ünal, Özgür Öztop Çakmak, Behçet Coşar, Fahriye Feriha Özer, Hale Yapici Eser
{"title":"Validation of the Turkish Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (Quip-Rs).","authors":"Ardıl Bayram Şahin, Elif Sude Özaşik, Yasemin Kadandir, Muhammet Nesip Seyidoğlu, Roza Gök, Berfu Ünal, Özgür Öztop Çakmak, Behçet Coşar, Fahriye Feriha Özer, Hale Yapici Eser","doi":"10.5152/pcp.2025.241017","DOIUrl":"10.5152/pcp.2025.241017","url":null,"abstract":"<p><p>Background: Impulse control disorders and related behaviors (ICDs-RBs) significantly affect the quality of life of Parkinson's disease (PD) patients. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) was developed to identify and monitor these behaviors. This study aimed to translate and validate the Turkish version of QUIP-RS. Methods: The translation process involved back-translation and expert review. Ninety-three patients with PD completed the Turkish QUIP-RS, Movement Disorder Society-Unified PD Rating Scale part III, Hoehn-Yahr stage, Standardized Mini-Mental State Examination, Frontal Assessment Battery, and selfreport tools for depression, anxiety, and impulsivity. Internal consistency, factor analysis, convergent and divergent validity were assessed, along with relationships between QUIP-RS domains, clinical features, and dopaminergic medication. Results: Eighty-seven patients were included in this analysis. The QUIP-RS's total Cronbach's alpha value was 0.925, demonstrating good reliability. Factor analysis showed a good model fit, reflecting different ICDs-RBs domains. Thirty-nine percent of the patients were screened with at least 1 ICDs-RB, 17.2% of participants had single ICDs-RBs, and 21.8% had multiple ICDs-RBs. The most prevalent ICDsRBs were punding, compulsive eating, and dopamine dysregulation syndrome (DDS). Total levodopa equivalent daily dose (LEDD) was related to only ICD-related behaviors (hobbyism, punding, DDS). In contrast, the dopamine agonist LEDD was significantly correlated with all ICDs-RBs except pathological gambling. Conclusion: ICD-RBs are common in the sample recruited fromTürkiye, and the Turkish version of the QUIP-RS is a valid and reliable tool for assessing ICD-RBs in Turkish-speaking groups.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"285-294"},"PeriodicalIF":0.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological and Sociodemographic Insights into Self-Esteem and Social Media Influence Among Rhinoplasty Candidates. 隆鼻手术候选人自尊和社交媒体影响的心理学和社会人口学见解。
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-25 DOI: 10.5152/pcp.2025.241063
Meltem Gürü, Banu Tijen Ceylan
{"title":"Psychological and Sociodemographic Insights into Self-Esteem and Social Media Influence Among Rhinoplasty Candidates.","authors":"Meltem Gürü, Banu Tijen Ceylan","doi":"10.5152/pcp.2025.241063","DOIUrl":"10.5152/pcp.2025.241063","url":null,"abstract":"<p><p>Background: Rhinoplasty, performed for aesthetic and functional purposes, is among the most common cosmetic procedures worldwide. While previous studies have investigated the impact of social media and self-esteem on cosmetic surgery motivations, comparisons between aesthetic and functional rhinoplasty candidates remain limited. This study evaluates the sociodemographic, psychological, and behavioral profiles of these groups, focusing on social media use and self-esteem. Methods: This cross-sectional study included 103 rhinoplasty candidates divided into 2 groups based on their primary motivation: functional (Group 1) or aesthetic (Group 2). Data were collected using a Sociodemographic Data Form, the Rosenberg Self-Esteem Scale (RSES), and the Bergen Social Media Addiction Scale (BSMAS). Statistical analyses included chi-square, Fisher's exact test, and Mann-Whitney U-tests. Results: Most participants (70.9%) sought rhinoplasty for aesthetic reasons. The median age of Group 2 (23.0) was significantly lower than that of Group 1 (29.5) (P < .001). Females and single individuals were more likely to seek aesthetic rhinoplasty (P < .001). Social media use, particularly Instagram, was significantly higher in Group 2; 53.4% spent over 3 hours daily on social media, compared to 10% in Group 1 (P < .001). Group 1 showed higher self-esteem scores than Group 2 (34.0 vs. 31.0, P < .001). Conclusion: Aesthetic rhinoplasty is associated with a younger age, female gender, lower self-esteem, and greater social media use. These findings emphasize the need for preoperative assessments addressing psychological vulnerabilities and social media influences to improve patient satisfaction and outcomes.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"304-310"},"PeriodicalIF":0.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Lurasidone in Early-Onset Schizophrenia and Obsessive-Compulsive Disorder: A Case Report. 鲁拉西酮在早发性精神分裂症和强迫症中的作用:1例报告。
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-25 DOI: 10.5152/pcp.2025.251123
Selin Balki Tekin, Ayşe Nur İnci Kenar
{"title":"The Role of Lurasidone in Early-Onset Schizophrenia and Obsessive-Compulsive Disorder: A Case Report.","authors":"Selin Balki Tekin, Ayşe Nur İnci Kenar","doi":"10.5152/pcp.2025.251123","DOIUrl":"10.5152/pcp.2025.251123","url":null,"abstract":"<p><p>The comorbidity of schizophrenia and obsessive-compulsive disorder (OCD) has been demonstrated to result in more severe symptoms and a worse prognosis for patients, as well as a more challenging treatment process for clinicians. Lurasidone is a second-generation atypical antipsychotic approved for the treatment of schizophrenia. This case report aims to share the use and treatment process of lurasidone in a 28-year-old male patient with a history of OCD and schizophrenia since childhood. The patient has had multiple hospitalizations and suicide attempts and has received ECT (electroconvulsive therapy) and TMS (transcranial magnetic stimulation) treatment on numerous occasions. The patient has been resistant to various drug treatments, including clozapine. Following the administration of lurasidone at a dosage of 80 mg/day and above, the patient exhibited a regression in their psychotic symptoms, depressive and obsessive complaints, and demonstrated a substantial enhancement in social and cognitive functioning. No adverse effects related to lurasidone were reported. These findings suggest that lurasidone may be a safe treatment option for schizophrenia and comorbid disorders. Its receptor profile suggests many advantageous features in terms of both treatment and side effect tolerability, and it provides a significant improvement in functionality.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"311-314"},"PeriodicalIF":0.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Is the Level of Language Development of Children at Risk of Developmental Language Disorder 2 Years Later? 2年后有发展性语言障碍风险的儿童的语言发展水平如何?
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-05 DOI: 10.5152/pcp.2025.241090
Demet Çelik, Mümüne Merve Parlak, Cansu Yıldırım, Ayşen Köse, Gonca Özyurt, Çağla Eliküçük, Ezgi Karagöz Tanıgör
{"title":"What Is the Level of Language Development of Children at Risk of Developmental Language Disorder 2 Years Later?","authors":"Demet Çelik, Mümüne Merve Parlak, Cansu Yıldırım, Ayşen Köse, Gonca Özyurt, Çağla Eliküçük, Ezgi Karagöz Tanıgör","doi":"10.5152/pcp.2025.241090","DOIUrl":"10.5152/pcp.2025.241090","url":null,"abstract":"<p><p>Background: This study investigates the language development of children at risk for developmental language disorder (DLD) 2 years after initial assessment and evaluates the impact of parental training on language outcomes. Methods: Sixteen children (9 boys and 7 girls) who were at risk for DLD 2 years ago and whose parents were trained after the initial assessment were re-evaluated. During the study period, children's language development was evaluated using the Denver II Developmental Screening Test and the Turkish Adaptation of the Test of Early Language Development (TEDIL). Parents' perceptions of their children's language skills were also assessed. Results: At the second evaluation, 31.25% of the children were diagnosed with DLD, while 68.75% reached a normal language development level. TEDIL test results showed a significant increase in expressive and overall spoken language scores in children without DLD. Parents reported that their children's overall levels of communication, expression, and intelligibility increased significantly over 2 years. Conclusion: In this study, it was determined that some of the children at risk of DLD were diagnosed with DLD after 2 years. Long-term follow-ups of children at risk of DLD were also observed. Early parent training is beneficial in supporting language development in children at risk for DLD, emphasizing the importance of early intervention.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"261-268"},"PeriodicalIF":0.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Empirical Study of Executive Function in College Students: The Predictive Role of Health-Promoting Behaviors and the Time-Course Effects of Motor-Cognitive Dual-Task Training. 大学生执行功能的实证研究:促进健康行为的预测作用及运动-认知双任务训练的时程效应
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-05 DOI: 10.5152/pcp.2025.251073
Yuzhou Zhao, Chun Yang
{"title":"An Empirical Study of Executive Function in College Students: The Predictive Role of Health-Promoting Behaviors and the Time-Course Effects of Motor-Cognitive Dual-Task Training.","authors":"Yuzhou Zhao, Chun Yang","doi":"10.5152/pcp.2025.251073","DOIUrl":"https://doi.org/10.5152/pcp.2025.251073","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Background: As people's quality of life improves, maintaining long-term physical, mental, and cognitive health has become a focus of attention. However, the effects of different health-promoting behaviors on executive function (EF) are still unclear. In daily life, motor-cognitive dual-tasks (MCDTs) often need to be performed simultaneously. Research on MCDT training mainly focuses on the elderly, the sick, athletes, and other groups, with a lack of research on college students, who represent a population of normal young people. Based on this, the present study investigated the predictive effects of health- promoting behaviors and their sub-items on EF in college students. In addition, this study used MCDT to assess its time-course effects on EF in college students. Methods: Eighty-six college students who met the criteria were recruited for this study, and they were randomly assigned to the MCDT group (n=30), aerobic training group (n= 28), and cognitive training group (n = 28). Participants were required to complete the Health-Promoting Lifestyle Profile II scale (HPLP-II) before receiving the intervention. The aerobic training group participated in 20 minutes stationary bike ride, the cognitive training group trained in a calculation task, the Stroop color-word task, a running memory task, and a clue prompting task, and the MCDT group was required to complete both the aerobic and cognitive training tasks. Participants' inhibition control, working memory, and cognitive flexibility were measured before training, immediately after training, 30 minutes after training, and 1 hour after training by the flanker task, 2-back task, and more-odd shifting task. Results: College students' health-promoting behaviors were positively related to the correct rate of the flanker task (r= 0.260, P =.016), the correct rate of the 2-back task (r = 0.342, P= .001), and the correct rate of the more-odd shifting task (r = 0.287, P = .007). Motor-cognitive dual-task led to significant improvements in EF among college students, with significant increases in correct rates on the flanker task (P =.030), the 2-back task (P= .005), and the shifting task (P &lt; 0.001) at 1 hour post intervention. In contrast, the time-course effects of the motor and cognitive groups were insufficient, with no significant improvement in the response time to the flanker task in the motor group (P = .278) and the response time to the shifting task in the cognitive group (P = .129) at 1 hour post intervention. Conclusion: The health-promoting behaviors positively predicted college students' EF, in which physical activity, health responsibility (HR) and spiritual growth (SG) positively predicted inhibition control; physical activity, HR, nutrition, and SG positively predicted working memory; and physical activity, HR, and nutrition positively predicted cognitive flexibility. Motor-cognitive dual-task significantly improved EF in college students and showed superior time-course effects compar","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Intrinsic Capacity and Associated Factors of the Older Adults in Kunshan Community. 昆山社区老年人内在能力及相关因素分析
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-05 DOI: 10.5152/pcp.2025.241014
Juan Xia, Yilin Yang, Qunfang Gao, Rongrong Yan, Zhengfu Wang, Dandan Xia, Ping Cao, Yao Yao, Ling Wu
{"title":"Analysis of Intrinsic Capacity and Associated Factors of the Older Adults in Kunshan Community.","authors":"Juan Xia, Yilin Yang, Qunfang Gao, Rongrong Yan, Zhengfu Wang, Dandan Xia, Ping Cao, Yao Yao, Ling Wu","doi":"10.5152/pcp.2025.241014","DOIUrl":"https://doi.org/10.5152/pcp.2025.241014","url":null,"abstract":"<p><p>Background: To analyze the intrinsic capacity and relevant factors of the older adults in Kunshan community, and to provide a basis for enhancing the intrinsic capacity and functions of the older adults and reducing care dependence. Methods: The present study retrospectively collected data on demographics, past medical history, nutritional status, and physical examination from August 2022 to September 2022 from older adults aged ≥60 years who were subjected to a field questionnaire in Kunshan town. The chi-square test was used to assess the differences between the different dimensions of intrinsic ability in different sex and age subgroups. Risk factors were recognized through univariate and multivariate logistic proportional hazard analyses. Results: A total of 329 older adults completed the questionnaire and were enrolled in this study. The intrinsic capacity declined in 68.09% of older adults regarding the prevalence of hearing, vision, mobility, cognitive ability, psychological, and nutritional dimensions, respectively. A positive 5-times sit-up test was found to be positively associated with the reduced intrinsic capacity in the context of a physical examination (odds ratio [OR], 10.309; 95% CI, 5.076 to 20.833; P < .001). Additionally, older adults with a higher waist circumference exhibited a lower probability of reduced intrinsic capacity (OR, 0.541; 95% CI, 0.314 to 0.931; P = .026). Conclusion: In the Kunshan community, 68.09% of older people were found to have reduced intrinsic capacity. A negative 5-times sit-up test and increased waist circumference have been identified as independent risk factors for reduced intrinsic capacity. This suggests that these factors have the potential to provide a quicker method of assessing intrinsic capacity.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Modulatory Effects of Vitamin B12 on Morphine-Induced Conditioned Place Preference in Rats. 探讨维生素B12对吗啡诱导的大鼠条件位置偏好的调节作用。
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-05 DOI: 10.5152/pcp.2025.241005
Tuğçe Uskur, Fatma Ünlü Taşdemir, Mehmet Aykut Öztürk, Haktan Sönmez, Zeynep Gizem Todurga Seven, Selim Gökdemir, Burak Baştan, Gökhan Faikoğlu, Saygısever Faikoğlu Kübra, Sibel Özyazgan, Dündar Okan Yıllar, Ahmet Gökhan Akkan
{"title":"Exploring the Modulatory Effects of Vitamin B12 on Morphine-Induced Conditioned Place Preference in Rats.","authors":"Tuğçe Uskur, Fatma Ünlü Taşdemir, Mehmet Aykut Öztürk, Haktan Sönmez, Zeynep Gizem Todurga Seven, Selim Gökdemir, Burak Baştan, Gökhan Faikoğlu, Saygısever Faikoğlu Kübra, Sibel Özyazgan, Dündar Okan Yıllar, Ahmet Gökhan Akkan","doi":"10.5152/pcp.2025.241005","DOIUrl":"10.5152/pcp.2025.241005","url":null,"abstract":"<p><p>Background: This study aims to investigate the effects of vitamin B12 on morphine-induced conditioned place preference (CPP), a model commonly used to assess the rewarding effects of drugs. Morphine is a potent analgesic widely used for moderate to severe pain, but it also poses a significant risk of addiction. Previous studies suggest that cyanocobalamin (vitamin B12) may enhance the analgesic effects of morphine and reduce tolerance, but its impact on morphine addiction remains unclear. Methods: The experiment followed phases of habituation, pre-conditioning, conditioning, and post conditioning. Adult male Wistar albino rats (250-300 g) were randomly divided into 3 groups (n=8 per group): control (saline), morphine (10 mg/kg), and a combination group of vitamin B12 (2 mg/kg) with morphine. The effects of saline, morphine, and the morphine-vitamin B12 combination on CPP were assessed. All drugs and saline were administered intraperitoneally (ip). Results: Morphine (10 mg/kg) significantly induced CPP compared to the saline group (P < .0001). Vitamin B12 (2 mg/kg) did not produce a statistically significant difference in morphine-induced CPP compared to the control group. Conclusion: Morphine induces a significant place preference, and vitamin B12 did not produce a statistically significant difference in reducing this effect. Further research with different doses of vitamin B12 is necessary to fully investigate these effects.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"269-274"},"PeriodicalIF":0.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Empowerment Education Concept Plus Humanistic Care on Moods and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy. 赋能教育理念加人文关怀对肺癌化疗患者情绪及生活质量的影响。
IF 0.6 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-06-05 DOI: 10.5152/pcp.2025.241011
Baoli Huang, Lijie Lv, Qiwan Zhang
{"title":"Impact of Empowerment Education Concept Plus Humanistic Care on Moods and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy.","authors":"Baoli Huang, Lijie Lv, Qiwan Zhang","doi":"10.5152/pcp.2025.241011","DOIUrl":"10.5152/pcp.2025.241011","url":null,"abstract":"<p><p>Background: To evaluate the clinical efficacy of integrating empowerment education and humanistic care in enhancing cognitive function, self-care ability, mood regulation, and quality of life among lung cancer (LC) patients undergoing chemotherapy. Methods: A total of 149 LC patients receiving chemotherapy from May 2022 to January 2024 were included in the study. They were divided into 2 groups: a control group (n=63) receiving routine care and a joint group (n= 86) receiving empowerment education and humanistic care. Outcomes measured included cognitive function, self-care ability (using the Exercise of Self-Care Agency scale), mood (using the Hospital Anxiety and Depression Scale), cancer-related fatigue (using the Revised Piper Fatigue Scale), adverse reactions, and QoL (using the Functional Assessment of Cancer Therapy-Lung scale). Results: The joint group exhibited significant improvements in cognitive function, self-care ability, and QoL compared to the control group (P < .05). They also had lower scores in anxiety, depression, and cancer-related fatigue (P < .05). The incidence of adverse reactions was markedly lower in the joint group (10.47%) compared to the control group (39.68%). Conclusion: Combining empowerment education with humanistic care effectively improves cognitive function, reduces negative emotions and adverse reactions, enhances self-care ability, and improves the overall QoL of LC patients undergoing chemotherapy.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 3","pages":"275-284"},"PeriodicalIF":0.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Risperidone Interventions in Children and Adolescents with Autism Spectrum Disorder. 利培酮干预儿童和青少年自闭症谱系障碍的有效性和安全性。
IF 0.5 4区 医学
Psychiatry and Clinical Psychopharmacology Pub Date : 2025-04-28 eCollection Date: 2025-06-01 DOI: 10.5152/pcp.2025.24944
Fei Yang, Lin Kang, ChaoJie Zou
{"title":"Efficacy and Safety of Risperidone Interventions in Children and Adolescents with Autism Spectrum Disorder.","authors":"Fei Yang, Lin Kang, ChaoJie Zou","doi":"10.5152/pcp.2025.24944","DOIUrl":"10.5152/pcp.2025.24944","url":null,"abstract":"<p><strong>Background: </strong>Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that severely impairs children's health. Current data suggest that behavioral therapies are successful. Risperidone has been approved by the US Food and Drug Administration (FDA) to moderate impulsive behavior in people with ASD. This study aimed to evaluate the efficacy and safety of risperidone in children and adolescents with ASD.</p><p><strong>Methods: </strong>This study involved searching electronic databases for relevant articles, screening them based on inclusion and exclusion criteria, and performing a combined data analysis of the selected articles using Review Manager software.</p><p><strong>Results: </strong>This meta-analysis comprised 7 articles. The pooled analysis indicated that: (1) Risperidone intervention decreased scores on the Aberrant Behavior Checklist (ABC) scale in children and adolescents with ASD, as well as reduced scores related to stereotypy, social withdrawal, hyperactivity, inappropriate speech, and irritability on the ABC scale; (2) The use of risperidone raised the risk of weight gain, tremors, upper respiratory tract infection, and increased appetite. Other adverse responses, however, did not differ significantly from the placebo group.</p><p><strong>Conclusion: </strong>Risperidone demonstrated effectiveness and safety in managing behavioral issues and decreased ABC scores in children and adolescents with ASD. However, further research is needed, and the associated risks still need to be considered.</p>","PeriodicalId":20847,"journal":{"name":"Psychiatry and Clinical Psychopharmacology","volume":"35 2","pages":"177-184"},"PeriodicalIF":0.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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