Quintessence international最新文献

{"title":"The use of chlorhexidine mouthwash and diagnosis of primary hypertension in a large hospital cohort.","authors":"Joseph Katz, Isabel A Garcia","doi":"10.3290/j.qi.b5872795","DOIUrl":"https://doi.org/10.3290/j.qi.b5872795","url":null,"abstract":"<p><strong>Objectives: </strong>Small-scale studies reported increased blood pressure in patients using chlorhexidine mouthwash with the rationale that the rinse mitigates nitric oxide production by oral bacteria. The present study evaluated whether prior use of chlorhexidine mouthwash can be associated with an increased odds ratio for primary hypertension in a large hospital cohort.</p><p><strong>Materials and methods: </strong>The i2b2 NIH-established platform was used to search for deidentified medical information coded by ICD-10 for subjects with a hypertension diagnosis who have used chlorhexidine rinses before between October 2015 and May 2024. Binary statistics and logistic regression were used to calculate the odds ratio for hypertension in the group that used chlorhexidine mouth rinse before and after adjustments for demographic data, diabetes, and periodontal disease.</p><p><strong>Results: </strong>The unadjusted odds ratio for primary hypertension in subjects who used chlorhexidine gluconate mouthwash before was significantly elevated (OR 3.09, 95%CI 3.03 - 3.16, p<0.0001). It remained significant after adjusting for male gender (OR,1.44,95%CI 1.42 - 1.47, p<0.0001), age <45 years (OR 1.90 95%CI 1.86 - 1.93, p<0.0001), White race (OR 2.3, 95%CI 2.27 - 2.37, p<0.0001, diabetes (OR 1.99, 95%CI 1.93 -2.05, p< 0.001, and periodontal disease. (OR 3.28, 95%CI 3.21 - 3.34, p< 0.0001). The odds ratio for hypertension for subjects with gingivitis or periodontal disease after adjustment for chlorhexidine mouthwash was elevated. (OR 20.11, 95%CI 20.11 -21.44, p<0.0001) Conclusions: With the cavitate of a retrospective study design, the results indicate an increased odds ratio for primary hypertension for subjects with prior use of chlorhexidine mouthwash.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational prospective study to determine the association and diagnostic utility of salivary nitrites levels in periodontitis.","authors":"Leonardo Lorente, Esther Hernández Marrero, Pedro Abreu González, Angel Daniel Lorente Martín, Agustín F González-Rivero, María José Marrero González, Carmen Hernández Marrero, Olga Hernández Marrero, Alejandro Jiménez, Cándido Manuel Hernández Padilla","doi":"10.3290/j.qi.b5872791","DOIUrl":"https://doi.org/10.3290/j.qi.b5872791","url":null,"abstract":"<p><strong>Aim: </strong>There has been found that patients with chronic periodontitis showed higher salivary concentrations of reactive nitrogen species (RNS) than healthy subjects. However, only a study from elderly Koreans has reported that high salivary RNS concentrations are associated independently with periodontitis. Thus, the objective of this study was to determine whether salivary nitrites concentrations are associated with periodontitis controlling risk factors in other populations (such as European population).</p><p><strong>Methods: </strong>This was a prospective and observational study carried out in a Dental Clinic including European subjects without periodontitis (including subjects with periodontal health or with localized gingivitis in <30% sites) or with periodontitis (thus, with loss of periodontal tissue). The levels of nitrite in saliva were assessed using the Griess method. A multivariate regression analysis was performed to determine that variables were associated independently with periodontitis. To determine the association between salivary malondialdehyde levels and severity of periodontitis was used Spearman's rho correlation coefficient. A receiver operating characteristic analysis with salivary nitrites levels and periodontitis diagnostic was performed.</p><p><strong>Results: </strong>Subjects with periodontitis (n=54) in comparison to subjects without periodontitis (n=30) had higher salivary nitrites levels (p=0.003), higher rate of arterial hypertension history (p=0.02) and were older age (p<0.001). Nevertheless, differences between subject with and without periodontitis in other variables were not found. A positive correlation was found between salivary nitrites levels and periodontitis severity (rho=0.23; p=0.04). Multiple logistic regression analysis showed that elevated salivary nitrites levels > 209 nmol/mL were associated with periodontitis controlling for arterial hypertension history and age (OR=10.212; 95% CI=2.665-39.128; p=0.001) and controlling for diabetes mellitus and smoker (OR=8.793; 95% CI=3.038-24.450; p<0.001). The area under the curve for periodontitis diagnostic by salivary nitrites levels was of 69% (95% CI=58%-79%; p<0.001). The selected point of salivary nitrites levels > 209 nmol/mL for periodontitis diagnostic had 72% of sensitivity (58%-84%), 77% of specificity (58%-90%), 3.1 of p ositive likelihood ratio (1.6-6.1), 0.4 of negative likelihood ratio (0.2-0.6), 85% of positive predictive value (74%-92%) and 61% of negative predictive value (49%-71%).</p><p><strong>Conclusions: </strong>Salivary nitrites concentrations could be associated independently with periodontitis, could be associated with periodontitis severity and could help in periodontitis diagnosis in a European population according to the results of this preliminary study.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between flap microcirculation and hard tissue changes following alveolar ridge augmentation: a prospective case series.","authors":"Réka Fazekas, Bálint Molnár, Eleonóra Sólyom, Kristóf Somodi, Dániel Palkovics, Eszter Molnár, Anton Sculean, János Vág","doi":"10.3290/j.qi.b5872198","DOIUrl":"https://doi.org/10.3290/j.qi.b5872198","url":null,"abstract":"<p><strong>Objectives: </strong>To assess blood flow alterations after horizontal Guided Bone Regeneration (GBR) and to evaluate correlations between blood flow and hard tissue changes.</p><p><strong>Method and materials: </strong>Twelve mandibular surgical sites were involved in the current case series. GBR was carried out using a split-thickness flap design. Blood circulation was assessed with Laser Speckle Contrast Imaging at baseline as well as 1, 4, 6, 11, 13, 20, 27, and 34 days after the surgery, subsequently on a monthly basis until 6 months. Hard tissue alterations were measured horizontally and vertically using linear measurements. The first measurement point was 2 mm distal to the distal surface of the last tooth; additional measurement points were placed every 3 mm up to the 15th mm. Volumetric hard tissue loss and gain were also assessed.</p><p><strong>Results: </strong>Baseline blood circulation was statistically significantly higher on the buccal side. On the first postoperative day, all regions presented a statistically significant decrease in blood flow circulation. The buccal-inner region presented significant ischemia on day 6. Mean volumetric hard tissue gain and loss were 712.62 ± 317.08 mm3 and 222.431 ± 103.19 mm3, respectively. Mean baseline alveolar ridge width was 4.82 ± 1.02 mm, 6 months ridge width averaged 7.21 ± 0.99 mm. Vertical resorption measured 1.24 ± 0.5 mm. Correlations between blood flow changes and hard tissue alterations were only found on Day 34 and Day 60.</p><p><strong>Conclusion: </strong>Laser Speckle Contrast Imaging is an efficient method to measure flap microcirculation. No correlation was found between flap microcirculation changes hard tissue and alterations.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully digital workflow involving 3D printed gingivectomy guide and 3D printed waxup to restore and reshape a congenitally missing central incisor after orthodontic treatment.","authors":"Abdulaziz Alrebdi, Pablo Atria, Marie Therese Teehankee, Vania Olcay, Jeb Lopez, Camila S Sampaio","doi":"10.3290/j.qi.b5857746","DOIUrl":"https://doi.org/10.3290/j.qi.b5857746","url":null,"abstract":"<p><strong>Objective: </strong>This case report describes a multidisciplinary approach using a digital wax-up to fabricate a gingivectomy and crown lengthening guides, to reshape a lateral incisor into a central incisor and improve overall esthetics.</p><p><strong>Clinical considerations: </strong>Comprehensive treatment planning is crucial when executing a multidisciplinary workflow, with digital tools proving to be invaluable aids. In the present case, a digitally designed wax-up was employed to generate a digital surgical guide for reshaping the gingival architecture of a lateral incisor into that of a central incisor, followed by composite restorations.</p><p><strong>Conclusion: </strong>The application of a digital wax-up for the design of a surgical guide and the fabrication of a silicone index led to a predictable and successful outcome in reshaping a lateral into a central incisor.</p><p><strong>Clinical significance: </strong>Post-orthodontic reshaping using direct composite is widely accepted by patients due to its cost-effectiveness and minimally invasive nature. This approach highlights the efficacy of digital technology in achieving precise dental restorations, highlighting its growing importance in modern dental practice.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of artificial intelligence to detect dental caries on intraoral photos.","authors":"Ziyun Zeng, Ashwin Ramesh, Jinglong Ruan, Peirong Hao, Nisreen Al Jallad, Hoonji Jang, Oriana Ly-Mapes, Kevin Fiscella, Jin Xiao, Jiebo Luo","doi":"10.3290/j.qi.b5857664","DOIUrl":"https://doi.org/10.3290/j.qi.b5857664","url":null,"abstract":"<p><p>Dental caries is one of the most common diseases globally and affects children and adults living in poverty who have limited access to dental care the most. Left unexamined and untreated in the early stages, treatments for late-stage and severe caries are costly and unaffordable for socioeconomically disadvantaged families. If detected early, caries can be reversed to avoid more severe outcomes and a tremendous financial burden on the dental care system. Building upon a dataset of 50,179 intraoral tooth photos taken by various modalities, including smartphones and intraoral cameras, this study developed a multi-stage deep learning-based pipeline of AI algorithms that localize individual teeth and classify each tooth into several classes of caries. This study initially assigned International Caries Detection and Assessment System (ICDAS) scores to each tooth and subsequently grouped caries into two levels: Level-1 for white spots (ICDAS 1 and 2) and level-2 for cavitated lesions (ICDAS 3-6). The system's performance was assessed across a broad spectrum of anterior andposterior teeth photographs. For anterior teeth, 89.78% sensitivity and 91.67% specificity for level-1 (white spots) and 97.06% sensitivity and 99.79% specificity for level-2 (cavitated lesions) were achieved, respectively. For the more challenging posterior teeth due to the higher variability in the location of white spots, 90.25% sensitivity and 86.96% specificity for level-1 and 95.8% sensitivity and 94.12% specificity for level-2 were achieved, respectively. The performance of the developed AI algorithms shows potential as a cost-effective tool for early caries detection in non-clinical settings.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications and risk factors associated with zygomatic implants: retrospective analysis with 73 consecutive patients followed for 3.5 years.","authors":"Camille Leroy, Julie Longis, Hélios Bertin, Michael Mader, Raphael Bonnet","doi":"10.3290/j.qi.b5841085","DOIUrl":"https://doi.org/10.3290/j.qi.b5841085","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective study analyzed zygomatic implant (ZI) survival and implant success (based on ORIS criteria) in patients treated for maxilla atrophy or after reconstruction failure.</p><p><strong>Material and methods: </strong>Implants were placed as quads (4 ZIs) or hybrids (ZIs and conventional implants in premaxilla) in edentulous patients using various surgical approaches, evolving from the sinus slot to Chow's extended sinus lift technique with or without Bichat fat pad. The procedure was followed by immediate loading, while clinical and radiographic evaluations spanned at least 1 year after implantation. The primary outcome was the implant survival at follow-up, and the secondary was the implant success, assessed as complications according to ORIS criteria: prosthetic offset, sinus status, peri-implant soft tissue health, and implant stability.</p><p><strong>Results: </strong>A total of 73 consecutive patients, treated with 217 ZIs and 76 conventional implants, were included, with mean follow-up of 3.5 years (range, 1-9.8 years). Four ZIs failed in 3 patients, including 1 patient with a zygomatic bone fracture. The cumulative survival rate was 98.16%. Although in 2 additional cases, implants lost stability, they achieved delayed osseointegration. Other complications included 21 sinus reactions (excluding the 4 failures) and 28 peri-implant inflammatory reactions.</p><p><strong>Conclusion: </strong>ZIs offered a predictable treatment option for extreme upper jawbone atrophy with a relatively low complication rate and no severe injuries. The Chow technique with the Bichat fat pad positively impacted ZI success and survival, whereas smoking, implantation in fresh sockets, and the limited experience of the surgeon negatively affected the outcomes.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-assisted contouring combined with bone ostectomy for dental implant placement of craniofacial fibrous dysplasia involving the right maxilla.","authors":"Fares Kablan, Shadi Daoud, Iris Slutzky-Golberg, Samer Srouji, Adeeb Zoabi","doi":"10.3290/j.qi.b5826619","DOIUrl":"https://doi.org/10.3290/j.qi.b5826619","url":null,"abstract":"<p><strong>Background: </strong>Craniofacial fibrous dysplasia (CFD) affecting the jaws can result in facial asymmetry, posing a unique challenge for dental implant placement in edentulous areas. This case report introduces an innovative approach for rehabilitating the posterior maxilla affected by CFD using a computer-guided technique for maxillary recontouring and substitution bone grafting at implant sites.</p><p><strong>Case presentation: </strong>A 58-year-old edentulous female with a craniofacial fibrous dysplasia bone lesion affecting the right maxilla was referred for correction of asymmetry and dental implant placement. A computer guide was devised for shaving and contouring the right maxilla. Following virtual maxillary reduction, a second guide was created over the osteomized 3D model to plan the location of future dental implants and guide bone ostectomies for allograft substitution. Particulate bone substitute was applied to ostectomy sites in the affected maxillary alveolar ridge. Four implants were placed successfully four months post-operation, with integration confirmed by clinical examination after one year of follow-up.</p><p><strong>Conclusion: </strong>This treatment approach emerges as a reliable and effective modality for simultaneous dental implant rehabilitation in edentulous alveolar bone and jaw contouring in CFD cases.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal pain is associated with poor sleep quality and increased daytime sleepiness in dental students: a cross-sectional pilot study.","authors":"Linda Sangalli, Alberto Herrero Babiloni, Davis C Thomas, Anna Alessandri-Bonetti","doi":"10.3290/j.qi.b5826634","DOIUrl":"https://doi.org/10.3290/j.qi.b5826634","url":null,"abstract":"<p><strong>Objective: </strong>While a bidirectional relationship between sleep health and musculoskeletal (MSK)-pain have been established among chronic pain patients, few studies explored it among dental students. This cross-sectional study assessed the relationship of self-report MSK-pain with sleep health and psychological outcomes among dental students, and whether differences existed as a function of number and location of painful body-sites.</p><p><strong>Method and materials: </strong>Validated questionnaires were sent through REDCap to dental students at a predoctoral dental school, assessing presence, location (head, shoulder/neck, jaw, back, body), and intensity of MSK-pain, sleep health (risk of sleep apnea, insomnia severity symptoms, sleep quality, daytime sleepiness, and chronotype), and psychological outcomes (anxiety/depression). Differences between those with and without MSK-pain, and across participants with different number and location of painful sites were tested with t-tests and ANOVA, adjusting for age/gender.</p><p><strong>Results: </strong>Out of 80 participants (82.5% females), 76.3% reported MSK-pain (68.9% in neck/shoulders). Those with MSK-pain scored significantly worse in sleep quality (7.7±3.7 vs. 4.8±2.1, p<.001), daytime sleepiness (6.1±4.2 vs. 3.3±2.7, p<.001). Those with >3 painful body-sites reported worse sleep quality (p=.006) and daytime sleepiness (p=.003) than pain-free controls. There were no differences on sleep and psychological outcomes as a function of number of painful body-sites. Those reporting back pain scored worse in insomnia (p=.037), daytime sleepiness (p=.002), and sleep quality (p=.006) than those without back pain.</p><p><strong>Conclusion: </strong>MSK-pain is prevalent among dental students and associated with worse sleep health. While number of painful sites may not influence sleep/psychological health, specific locations (e.g., back pain) were associated with worse sleep functioning.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of two treatment modalities in the management of gingival enlargement during orthodontic treatment: a randomized clinical trial.","authors":"Hummam Rihawi, Rola Al Habashneh, Reem Abdel-Hafez, Majdi Alzoubi","doi":"10.3290/j.qi.b5809024","DOIUrl":"https://doi.org/10.3290/j.qi.b5809024","url":null,"abstract":"<p><strong>Objective: </strong>This clinical trial aimed to evaluate and compare the effectiveness of diode laser gingivectomy, conventional gingivectomy, and nonsurgical periodontal treatment (NSPT) in the management of gingival enlargement (GE) during orthodontic treatment.</p><p><strong>Materials and methods: </strong>forty-five healthy, orthodontic patients with labial gingival enlargement on the 6 anterior teeth were selected and randomly assigned to one of the groups (Conventional, Laser, and NSPT). Clinical parameters including clinical crown length (CCL) , periodontal pocket depth (PPD), and vertical gingival overgrowth index (vGOi) were recorded at baseline, 1 month, 3 months, and 6 months. Postoperative pain was evaluated at 1,3, and 7 days. Esthetic satisfaction and acceptance of the procedure were recorded on day 10 and repeated after 6 months.</p><p><strong>Results: </strong>Statistically significant results were obtained for mean reduction in PPD for conventional, laser, and NSPT groups (-1.43, -.1.75, and -0.9 mm, respectively; P < 0.001), CCL gain (1.45, 1.7, and 0.38 mm, respectively; P<0.001) and mean vGOi score (-1.14, -1.29 and -0.76, respectively; P<0.001) over 6 months. Both test groups showed greater statistically significant changes in clinical parameters over 6 months compared to NSPT (P<0.001). There was a gradual decrease in postoperative pain for all three groups over 7 days, with conventional group showing statistical difference in mean pain score on days 1 and 3 compared to other groups.</p><p><strong>Conclusion: </strong>Both conventional and laser gingivectomies were more effective in controlling enlargement over non-surgical periodontal treatment alone at 1, 3, and 6 months.</p><p><strong>Clinical significance: </strong>laser and conventional gingivectomies as adjunctive treatments achieved superior results when compared to NSPT alone in the treatment of GE and gingival inflammation during orthodontic treatment, with no significant clinical differences between the two treatments.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of photobiomodulation and/or azithromycin treatment on bone resorption biomarkers in gingival crevicular fluid from patients with stage III-IV grade C periodontitis.","authors":"Malike Aslan Kehribar, Esra Baltacıoğlu, Kıvanç Dülger, Ahmet Alver","doi":"10.3290/j.qi.b5798358","DOIUrl":"https://doi.org/10.3290/j.qi.b5798358","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the impact of photobiomodulation (PBM) and/or azithromycin (AZM) therapy in combination with full-mouth subgingival instrumentation (FSI) on receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) levels and RANKL/OPG ratios in gingival crevicular fluid (GCF) on patients with stage III-IV grade C periodontitis.</p><p><strong>Materials and methods: </strong>The study was conducted on 77 stage III-IV grade C periodontitis patients and 20 periodontally healthy controls. Patients with stage III-IV grade C periodontitis were categorized into four treatment groups: 1) only FSI (FSI) group; 2) FSI&#43;AZM (AZM) group; 3)FSI&#43;PBM (PBM) group and 4) FSI&#43;PBM&#43;AZM (AZM&#43;PBM) group. Clinical periodontalparameters and RANKL and OPG levels and RANKL/OPG ratios in GCF were measured at thebaseline and month 3rd of the therapy.</p><p><strong>Results: </strong>Compared with the periodontally healthy controls,all the baseline clinical parameters were higher in the Stage III-IV grade C periodontitis groups (P< 0.05); however, there were no statistically significant differences between the Stage III-IV gradeC periodontitis groups (P>0.05). In month 3rd, the lowest values in all clinical parameters weregenerally observed in the antibiotics groups whereas the highest values were observed in the FSIgroup. Furthermore, the highest RANKL and OPG values in antibiotic groups and the highestRANKL/OPG ratio in PBM group were observed in the third months. RANKL/OPG ratios did notchange in the FSI and antibiotics groups after the treatment, but it increased significantly in thePBM group.</p><p><strong>Conclusion: </strong>While PBM treatment combined with FSI increases the RANKL levels,AZM increases OPG levels. Also, PBM&#43;AZM treatment shows additional clinical andimmunological beneficial efficacy.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}