Quintessence international最新文献

{"title":"Management of medication-related osteonecrosis of the jaw through the association of surgical treatment with local and systemic adjuvant therapies: a case series with follow-ups of up to 3 years.","authors":"Leonardo Perez Faverani, Stefany Barbosa Alves da Cruz, Leonardo Alan Delanora, Izabela Fornazari Delamura, Mirela Caroline Silva, João Matheus Fonseca E Santos, Tiburtino José de Lima Neto, Edilson Ervolino, Valdir Gouveia Garcia, Leticia Helena Theodoro, Ana Paula Farnezi Bassi","doi":"10.3290/j.qi.b6376673","DOIUrl":"https://doi.org/10.3290/j.qi.b6376673","url":null,"abstract":"<p><p>The objective of this case series was to report the outcomes of patients diagnosed with MRONJ and seek a remission through surgical management associated with local and systemic adjuvant therapies. A total of 14 patients were followed for up to 3 years, of whom 1 had MRONJ stage Zero; 3 with stage I; 7 with stage II; and 4 with stage III. Twelve patients underwent conservative sequestrectomy. In seven of these cases, the surgery was guided by fluorescence, using doxycycline preoperatively to remove necrotic bone tissue more accurately. In four participants, platelet-rich fibrin (PRF) membranes were positioned at the surgical site before suturing. All 14 patients were instructed to perform daily mouthwashes with 0.12% chlorhexidine, and all underwent weekly sessions of antimicrobial photodynamic therapy (aPDT) according to the following protocol: Pre-irradiation with methylene blue (100 μg/ml) for 60 s, followed by irradiation with a low-level laser (600 nm; 100 mW; 214 J/cm2; 6 J/point; 60 s/point). Other adjuvant therapies were employed, such as the prescription of a combination of pentoxifylline and tocopherol, in addition to metronidazole paste. The proposed therapies led to remission in most patients, and although some of the patients did not achieve complete remission, they showed a significant reduction in pain complaints. These results demonstrate that the protocols used in this study are promising for the management of MRONJ in different stages. As such, they offer potential for the practice of surgeons and should be the object of further clinical investigations.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of postoperative bleeding severity by general dental practitioners in the National Dental Practice-Based Research Network: a survey-based assessment.","authors":"Sharon Elad, Greg C Connolly, Rita Cacciato, Rebekah Boy, Michael Leo, William R Calnon, Suzanne Gillespie, Denis B Nyongesa, Gregg H Gilbert, Cyril Meyerowitz","doi":"10.3290/j.qi.b6376527","DOIUrl":"10.3290/j.qi.b6376527","url":null,"abstract":"<p><strong>Objective: </strong>The objectives of this study were to: (1) describe how general dentists (GDs) in the National Dental Practice-Based Research Network ('Network') classify the severity of post-operative bleeding; and (2) examine the association between bleeding severity classification and whether the GD had residency training.</p><p><strong>Methods: </strong>An electronic questionnaire was developed to assess GDs' classification of bleeding severity for various scenarios following scaling or a single-tooth simple extraction, and to collect information about respondents' experience with bleeding scenarios. A total of 1815 GD members of the Network were invited to participate.</p><p><strong>Results: </strong>A total of 866 GDs responded. Strong agreement (low variability) was observed for scenarios that were classified as 'severe bleeding' (94.7-96.8%), and lower agreement (higher variability) was observed for scenarios classified as 'moderate bleeding' (53.2-65.2%). The GD's classification of bleeding severity was not correlated with training in a General Practice Residency (GPR) or Advanced Education in General Dentistry (AEGD). A minority of respondents had experience with 'major bleeding' that may lead to hemodynamic emergency (15.5%) or a referral to an emergency department (4.8%).</p><p><strong>Conclusion: </strong>This study identified scenarios for which there is high agreement and low agreement regarding bleeding severity classification among GDs in the US. A small percentage of respondents had actual experience with major bleeding in their patients. Based on these results, we propose a new tool to assess severity of oral bleeding intended to foster better communication between dental professionals. The new tool may assist GDs to standardize documentation and communication with other health care professionals.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early diagnosis of juvenile idiopathic arthritis through temporomandibular disorders symptoms: clinical insights from a longterm follow-up case series.","authors":"Byeong-Min Lee, Soo Haeng Lee, Ji Woon Park","doi":"10.3290/j.qi.b6375069","DOIUrl":"https://doi.org/10.3290/j.qi.b6375069","url":null,"abstract":"<p><p>Juvenile idiopathic arthritis (JIA) is the most prevalent chronic rheumatic disease in children. Temporomandibular joint (TMJ) involvement is common but often asymptomatic with overlapping temporomandibular disorders (TMD) making diagnosis challenging. This report describes 10 pediatric patients diagnosed with both TMD and JIA. Evaluation included clinical, psychological, hematological, and radiological assessments. TMD symptoms were assessed after six months of dental and rheumatological management. TMJ involvement in JIA frequently precedes systemic symptoms and may occur even when blood markers appear negative, highlighting the importance of imaging for early diagnosis and timely intervention. Conventional TMD treatment combined with rheumatologic interventions generally yield favorable results even when JIA underlies TMD symptoms.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal analysis of metabolites in periodontitis: a Mendelian randomization and validation study.","authors":"Min Li, Le Hong, Xiaojie Lin, Weidong Chen, Hao Li","doi":"10.3290/j.qi.b6362487","DOIUrl":"https://doi.org/10.3290/j.qi.b6362487","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the causal relationship between metabolites and periodontitis using Mendelian randomization (MR) and validate findings through gingival crevicular fluid (GCF) metabolomic profiling.</p><p><strong>Methods and materials: </strong>A two-sample MR analysis used genetic data from 486 metabolite Genome-Wide Association Study (GWAS) and periodontitis statistics, with IVW as the primary method, supported by MR-Egger, weighted median, and weighted mode. Sensitivity analyses included Cochran's Q, MR-Egger, and MR-PRESSO tests. GCF metabolomics compared 5 periodontitis patients and 5 controls, identifying differential metabolites via t-tests and PLS-DA, with KEGG pathway enrichment.</p><p><strong>Results: </strong>MR analysis identified 17 metabolites causally linked to periodontitis, spanning amino acids, lipids, energy metabolism, and cofactors/vitamins. Protective metabolites included betaine (OR: 0.478, 95% CI:0.235-0.975), laurate (0.51, 0.267-0.974), and glycerol 3-phosphate (0.312, 0.105-0.926), while phenylalanine (39.651, 2.173-723.565), pelargonate (2.527, 1.059-6.03), and 3-methylhistidine (1.481, 1.074-2.042) increased risk. Sensitivity analyses confirmed minimal heterogeneity, no pleiotropy (except 4-acetamidobutanoate), and no reverse causation. GCF metabolomics revealed 75 upregulated and 245 downregulated metabolites, with pathway enrichment in lipid, amino acid, and vitamin metabolism. Notably, betaine-protective in MR analysis-was significantly reduced in periodontitis, aligning with its anti-inflammatory role.</p><p><strong>Conclusion: </strong>This study indicates that some circulating metabolites (e.g., betaine) may protect against periodontitis. Integrating MR and GCF analyses, we identified key metabolic risk factors. Clinically, metabolites like betaine and glycerol 3-phosphate could serve as non-invasive early biomarkers, providing new avenues for personalized periodontitis prevention and treatment.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid implant-supported restorations bonded to nitride-coated titanium bases: a clinical method to address biologic, functional, and esthetic challenges in the esthetic zone.","authors":"Rafael Del Castillo, Carlo Ercoli, Rafael Valera, José María Díaz Fernández, Miguel Padial-Molina, Javier Ata-Ali","doi":"10.3290/j.qi.b6353957","DOIUrl":"https://doi.org/10.3290/j.qi.b6353957","url":null,"abstract":"<p><strong>Objective: </strong>Describe how advancements in digital technologies and material's science provide additional restorative alternatives and material combinations for single and multiple unit implant-supported restorations, such those incorporating the clinical use of nitride coated titanium bases (TiN) in combination with the 2-piece, CAD/CAM, screw-retained, zirconia-ceramic, hybrid implant-supported restoration concept.</p><p><strong>Materials and methods: </strong>Two partially edentulous patients with missing teeth in the maxillary esthetic zone were treated with a novel technical and restorative concept using the 2-piece CAD/CAM screw-retained zirconia-ceramic hybrid-abutment crown concept bonded to nitride coated titanium bases.</p><p><strong>Clinical outcomes: </strong>Biologic outcomes showed that tissues were maintained healthy with the patients showing an adequate oral hygiene level, no detectable plaque present upon probing and no bleeding on probing. Esthetic evaluation demonstrated an excellent esthetic outcome and peri-implant soft-tissue integration with adjacent natural teeth and pontic tissue areas, together with post-treatment stability of the gingival zenith position. None of the two patients showed technical complications such screw loosening or porcelain chipping/fracture. Radiographic evaluation reveals a precise fit between TiN bases and the implant connecting interfaces, no marginal bone loss and a stable implant osseointegration. The principal advantages of incorporating nitride coated titanium bases (TiN) in implant supported restorations rely on the favorable esthetic outcomes, improved technical, mechanical, and biological aspects, as well as the physicochemical characteristics of TiN hard thin film coatings and their positive impact on titanium biocompatibility.</p><p><strong>Conclusions: </strong>The short term promising clinical outcomes of the 2-piece CAD/CAM screw-retained, zirconia ceramic hybrid abutment crown concept bonded to nitride coated titanium bases, would indicate the potential clinical benefits of the described restorative alternative. However, additional in vitro investigations and randomized clinical trials are needed to validate these initial observations, especially those evaluating the 2-piece CAD/CAM screw-retained, zirconia ceramic hybrid abutment crown bonded to TiN bases when compared to the conventional 2-piece hybrid design as well as stock/custom, metal/zirconia/lithium disilicate, screw/cemented implant supported restorations.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of pathologic root resorption in primary molars and canines: a retrospective cross-sectional study.","authors":"Elif Ece Kalaoglu, Zeynep Ozturkmen","doi":"10.3290/j.qi.b6184182","DOIUrl":"10.3290/j.qi.b6184182","url":null,"abstract":"<p><strong>Objectives: </strong>Pathologic root resorption in primary teeth affects dental health and future orthodontic needs. This study aimed to evaluate the prevalence and associated factors of pathologic root resorption in a pediatric population.</p><p><strong>Method and materials: </strong>A retrospective cross-sectional analysis was performed using panoramic radiographs from 691 pediatric patients aged 4 to 11 years at a university hospital in Türkiye. Teeth were evaluated for internal (IRR) and external pathologic root resorption (ERR) by two calibrated observers, adhering to the 2023 European Society of Endodontics Position Statement. Tooth status was categorized as healthy, carious (with or without pulp involvement), filled, or endodontically treated, and dental crowding was also recorded. Statistical analyses included chi-square tests, multiple logistic regression, and post-hoc analyses, with significance set at P < .05.</p><p><strong>Results: </strong>A total of 7,729 primary teeth (5,075 molars and 2,654 canines) were evaluated, with interobserver reliability of 82% and intraobserver reliability of 98.8%. The study cohort included 691 children (mean age 7.05 ± 1.45 years; 49.8% boys, 50.2% girls). Pathologic root resorption was observed in 21.2% of cases (n = 1,638), with ERR accounting for 81% and IRR for 19%. Among 2,654 healthy teeth, 3.76% exhibited pathologic resorption, with no significant association with dental crowding. Significant relationships were identified between pathologic root resorption and age (P = .000), tooth status (P = .049), and sex (P = .042).</p><p><strong>Conclusion: </strong>Reducing high caries levels in Türkiye is critical to lowering pathologic root resorption and associated complications. Further studies should explore dental crowding and pathologic root resorption relationships in larger samples.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"500-508"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between CRP levels in systemic circulation and peri-implant bone loss.","authors":"Metin Calisir, Dicle Altindal, Ahmet Cemil Talmac, Serkan Dundar, Abdullah Seckin Ertugrul","doi":"10.3290/j.qi.b6258394","DOIUrl":"10.3290/j.qi.b6258394","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this retrospective study was to evaluate the effects of high preoperative C-reactive protein (CRP) levels on early peri-implant alveolar bone loss.</p><p><strong>Method and materials: </strong>Fifty-eight implants in 20 patients with high preoperative CRP levels and 54 implants in 20 patients with low preoperative CRP levels were evaluated. For measurement of the peri-implant alveolar bone loss, the implant platform was accepted as the reference point. On both the mesial and distal sides, the vertical distances between the reference point and the first visible bone's highest coronal level were measured. Numerical data were compared between groups using the independent sample t test or the Mann-Whitney U test. Correlations between variables were investigated with the Spearman rho test.</p><p><strong>Results: </strong>The mean CRP level of the low CRP group was 0.37 ± 0.21 mg/L, while that of the high CRP group was 1.71 ± 0.60 mg/L. In the high CRP group, implant failure was observed in two patients. The mesial bone loss and distal bone loss values in the group with high CRP levels were found to be significantly higher than the group with low CRP levels (P < .05). There was a significant positive correlation between the CRP levels, and distal bone loss and mesial bone loss measurements.</p><p><strong>Conclusion: </strong>The results show that high preoperative CRP levels result in an increased risk for peri-implant alveolar bone loss, and suggest that preoperative CRP levels can be important for early peri-implant alveolar bone loss.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"464-471"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call for a paradigm shift in managing acute dental pain: don't squash the good hurt!","authors":"Yanfang Ren, Eli Eliav","doi":"10.3290/j.qi.b6315162","DOIUrl":"10.3290/j.qi.b6315162","url":null,"abstract":"","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 6","pages":"428-430"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of surface treatment and glass-ceramic coating on the wear behavior of different types of zirconia and their antagonists.","authors":"Märit Martha Müller, Sebastian Hahnel, Angelika Rauch, Martin Rosentritt","doi":"10.3290/j.qi.b6184321","DOIUrl":"10.3290/j.qi.b6184321","url":null,"abstract":"<p><strong>Objectives: </strong>This in-vitro study aimed to investigate the influence of different pretreatments and surface coatings on the wear of different zirconia and their antagonists.</p><p><strong>Method and materials: </strong>Zirconia specimens (3-, 4- and 5-mol% yttria tetragonal zirconia; n = 160/material) were subjected to pretreatment (airborne-particle abrasion, 50 µm Al2O3, 1 bar; 120 µm Al2O3, 3 bar; polishing) and surface coating (spray glazing, micro-layering, layering, veneering). References comprised no pretreatment or coating. Wear tests were performed (50 N, 120,000 cycles). Wear (mean, maximum, antagonist) and arithmetic mean roughness Ra and average roughness depth Rz were determined. ANOVA, Bonferroni, and Pearson correlation (α = .05) were performed.</p><p><strong>Results: </strong>Ra/Rz showed significant (P < .001) differences (Ra: 0.01 ± 0.01 µm to 0.71 ± 0.06 µm; Rz: 0.31 ± 0.09 µm to 4.33 ± 0.44 µm). Two groups could be distinguished by mean and maximum wear with significant (P < .001) differences: (1) glaze sprayed and without coating (mean wear: 9.4 ± 2.6 µm to 57 ± 21.3 µm, max. wear: 24.1 ± 6.9 µm to 125.4 ± 18.2 µm) and (2) all coating procedures (mean wear: 129.2 ± 22.8 µm to 236.5 ± 62.0 µm; max. wear: 188.7 ± 21.4 µm to 444.2 ± 110.6 µm). Antagonist wear (9.2 ± 4.5 to 29.7 ± 5.0%) showed a significant (P < .001) correlation to surface coating, mean and maximum wear, and Ra and Rz. Mean wear significantly (P < .001) correlated with surface coating, maximum wear, and antagonist wear.</p><p><strong>Conclusion: </strong>Under clinical conditions, layering or veneering can lead to increased wear of the restoration, but in return reduce the abrasion of antagonists. Excessively rough surface treatments should be avoided, as they might increase antagonist wear.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"432-441"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the volumetric contraction of post-extraction sockets: a double-blinded randomized controlled clinical trial.","authors":"Leda M L Araujo, Walterson M Prado, Elton G Zenobio, Leonardo P Faverani, João Gabriel S Souza, Gustavo Vicentis Oliveira Fernandes, Jamil A Shibli","doi":"10.3290/j.qi.b6184324","DOIUrl":"10.3290/j.qi.b6184324","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effect of recombinant human bone morphogenic protein type-2 (rhBMP-2) on the alveolar ridge in the post-extraction socket in humans.</p><p><strong>Method and materials: </strong>20 subjects with 25 teeth of the maxilla were included (11 sockets in the control [blood clot] and 14 in the test group [rhBMP-2]). The teeth were minimally and traumatically extracted. CBCT images were obtained 2 (T0) and 120 (T1) days after extraction. The buccal bone wall height, palatal bone wall height, and alveolar area were compared between both groups, as well as the volumetric contraction through overlapped images (T1 - T0) using Mimics software. The data were compared using the Mann-Whitney test (P .05).</p><p><strong>Results: </strong>The intragroup evaluation showed a significant buccal and palatal crest height resorption in the control group (P .05). In the intergroup assessment, the test group was superior to the control group in maintaining the average alveolar ridge area since the control group showed an area loss of approximately 39% between T0 and T1, whereas this reduction was approximately 15% in the test group (P .05).</p><p><strong>Conclusion: </strong>It is possible to conclude that using rhBMP-2 after tooth extraction resulted in better socket preservation, maintaining 2.5 times greater bone availability in the alveolar ridge than that of the control group.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"364-374"},"PeriodicalIF":1.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}