{"title":"Clinical evaluation of photobiomodulation therapy and local 1.2% atorvastatin gel as an adjunct to subgingival instrumentation in patients with stage II periodontitis: a randomized controlled trial.","authors":"Dinesh Babu Ashokan, Magesh Kumar Shekar, Kalaiselvan Dharani, Ebenezer Mani, Priyanka Pampani, Balaji Ravichandran","doi":"10.3290/j.qi.b6218534","DOIUrl":"https://doi.org/10.3290/j.qi.b6218534","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the present study is to compare the effectiveness of photobiomodulation therapy versus local 1.2% atorvastatin gel as an adjunct to subgingival instrumentation in the treatment of stage II or III periodontitis.</p><p><strong>Materials and methods: </strong>In this randomized study, a total of 60 individuals with pocket depths of 4-7mm bilaterally in both sexes (Males and Females) who were 25 years old or older, diagnosed with stage II or III periodontitis were selected. 60 Patients with at least 4 teeth demonstrating pocket depth of ≥ 4-7mm were selected. Exclusion criteria included patients with systemic conditions, smokers, pregnant or lactating women, and those who had received periodontal therapy or antibiotics within the previous six months. Baseline clinical parameters which include full mouth plaque scores, full mouth bleeding scores, probing pocket depth and clinical attachment level were recorded. All the eligible patients underwent supra and subgingival instrumentation. The patients were then randomly divided into two groups: GROUP-A: 30 Patient (120 pocket sites) received photobiomodulation (PBM) therapy with 680 nm for 60 sec(6J/cm2) with 0.1watt power GROUP-B: 30 Patient (120 pocket sites) received 1.2% Atorvastatin (ATV) gel as local drug delivery After the applications of local drug, the treated periodontal pockets were secured with N-butyl-2- cyanoacrylate. Patient were recalled at baseline and after 1 month and 3 months andClinical periodontal parameters were recorded.</p><p><strong>Results: </strong>On intergroup comparison, this trial demonstrated notable improvements in all clinical parameters at the 3 month interval after Subgingival instrumentation in combination with PBM or LDD. While in intragroup comparison, at 3 months interval, the reductions in probing depth and clinical attachment gain is more significantly evident in group-B (1.2%Atorvastatin gel) compared to group-A (PBM). These findings are consistent with the available literature, which recognizes subgingival instrumentation as an effective non-surgical therapy for periodontitis. Adjunctive treatment modalities are widely investigated to determine whether they can further enhance the clinical outcomes achieved by subgingival instrumentation.</p><p><strong>Conclusion: </strong>The principal results of this study showed improved periodontal status and a significant improvements in clinical parameters in patients in GROUP-B (1.2% Atorvastatin gel). Within the limitations of the study, it was concluded that both Photobiomodulation and 1.2% Atorvastatin gel can be effectively used as adjuncts to subgingival instrumentation in the treatment of periodontitis.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Almas Binnal, Joseph Kat, Ghaidaa Badabaan, Christian Edgar Davila, Anita Gohel
{"title":"Numb chin syndrome as initial manifestation of multiple myeloma: correlation of clinical and radiographic findings.","authors":"Almas Binnal, Joseph Kat, Ghaidaa Badabaan, Christian Edgar Davila, Anita Gohel","doi":"10.3290/j.qi.b6217927","DOIUrl":"https://doi.org/10.3290/j.qi.b6217927","url":null,"abstract":"<p><p>Multiple myeloma is a well-known hematologic malignancy. Development of multiple myeloma usually follows a spectrum of patterns over the course of the disease. Multiple myeloma is associated with higher relative mortality rates. Early diagnosis and management might help limit the disease process, reduce the associated morbidities, improve prognosis, survival, and quality of life among these patients. Multiple myeloma remains a diagnostic challenge owing to its diverse clinical presentation. Common symptoms associated with multiple myeloma are bone pain, anemia, generalized weakness, and weight loss. Numb chin syndrome characterized by numbness of lip and/or chin might be an initial presentation symptom in multiple myeloma patients. This manuscript presents two cases of multiple myeloma with numb chin syndrome and mandibular radiolucency. Correlation of CBCT findings with clinical symptoms of numb chin syndrome were instrumental in prompting diagnostic work up for multiple myeloma in these patients. The diagnosis was confirmed by bone marrow biopsy and other investigations. Early identification of these presentations might help reduce if not eliminate the delay encountered in the diagnosis of multiple myeloma. (Quintessence Int 2025;56:376-380; doi: ##.####/j.qi.a#####).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafaelly Cubas Camargo, Cristian Higashi, João Luiz Bittencourt De Abreu, Ronaldo Hirata
{"title":"Resin infiltration for the esthetic treatment of molar incisor hypomineralization: 1-year follow-up.","authors":"Rafaelly Cubas Camargo, Cristian Higashi, João Luiz Bittencourt De Abreu, Ronaldo Hirata","doi":"10.3290/j.qi.b6217993","DOIUrl":"https://doi.org/10.3290/j.qi.b6217993","url":null,"abstract":"<p><p>Molar-Incisor Hypomineralization (MIH) is a qualitative developmental defect of the enamel that affects one or more permanent first molars, with or without incisor involvement. This condition often requires esthetic treatment, and therapeutic approaches may vary considerably. The purpose of this case report is to describe a step-by-step clinical protocol for a 20-year-old female patient who presented with dissatisfaction regarding the appearance of her smile due to hypomineralized spots on the maxillary and mandibular anterior teeth. After anamnesis and clinical examination, the diagnosis of MIH was established. Treatment consisted of in-office bleaching followed by resin infiltration for the maxillary teeth, and microabrasion combined with resin infiltration for the mandibular teeth. This sequence of minimally invasive techniques effectively resolved the esthetic alterations caused by MIH, showing satisfactory results that remained stable over one year.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and associated factors of pathologic root resorption in primary molars and canines: a retrospective cross-sectional study.","authors":"Elif Ece Kalaoglu, Zeynep Ozturkmen","doi":"10.3290/j.qi.b6184182","DOIUrl":"https://doi.org/10.3290/j.qi.b6184182","url":null,"abstract":"<p><strong>Objectives: </strong>Pathological root resorption in primary teeth affects dental health and future orthodontic needs. This study aimed to evaluate the prevalence and associated factors of pathological root resorption in a paediatric population.</p><p><strong>Method and materials: </strong>A retrospective cross-sectional analysis was performed using panoramic radiographs from 691 pediatric patients aged 4-11 years at a university hospital in Türkiye. Teeth were evaluated for internal (IRR) and external pathological root resorption (ERR) by two calibrated observers, adhering to the 2023 European Society of Endodontics (ESE) Position Statement. Tooth status was categorized as healthy, carious (with or without pulp involvement), filled, or endodontically treated, and dental crowding was also recorded. Statistical analyses included chi-square tests, multiple logistic regression, and post-hoc analyses, with significance set at p < 0.05.</p><p><strong>Results: </strong>A total of 7,729 primary teeth (5,075 molars and 2,654 canines) were evaluated, with interobserver reliability of 82% and intraobserver reliability of 98.8%. The study cohort included 691 children (mean age: 7.05 ± 1.45 years; 49.8% boys, 50.2% girls). Pathological root resorption was observed in 21.2% of cases (n = 1,638), with ERR accounting for 81% and IRR for 19%. Among 2,654 healthy teeth, 3.76% exhibited pathological resorption, with no significant association with dental crowding. Significant relationships were identified between pathological root resorption and age (p = 0.000), tooth status (p = 0.049), and gender (p = 0.042).</p><p><strong>Conclusion: </strong>Reducing high caries levels in Türkiye is critical to lowering pathological root resorption and associated complications. Further studies should explore dental crowding and pathological root resorption relationships in larger samples.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leda M L Araujo, Walterson M Prado, Elton G Zenobio, Leonardo P Faverani, Joao Gabriel de Souza, Gustavo Vicentis Oliveira Fernandes, Jamil A Shibli
{"title":"Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the volumetric contraction of post-extraction sockets: a double-blinded randomized controlled clinical trial.","authors":"Leda M L Araujo, Walterson M Prado, Elton G Zenobio, Leonardo P Faverani, Joao Gabriel de Souza, Gustavo Vicentis Oliveira Fernandes, Jamil A Shibli","doi":"10.3290/j.qi.b6184324","DOIUrl":"https://doi.org/10.3290/j.qi.b6184324","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effect of recombinant human bone morphogenic protein type-2 (rhBMP-2) on the alveolar ridge in the post-extraction socket in humans.</p><p><strong>Materials and methods: </strong>20 subjects with 25 teeth of the maxilla were included (11 sockets in the control [blood clot] and 14 in the test group [rhBMP2]). The teeth were minimally and traumatically extracted. The cone-beam computed tomography (CBCT) images were obtained 2 (T0) and 120 (T1) days after extraction. The Buccal bone wall height (V Height, mm), palatal bone wall height (P Height, mm), and alveolar area (mm2) were compared between both groups as well as the volumetric contraction through overlapped images (T1-T0) using mimics software. The data was compared using the Mann-Whitney test (p<0.05).</p><p><strong>Results: </strong>The intragroup evaluation showed a significant buccal and palatal crest height resorption in the control group (p<0.05). In the intergroup assessment, the test group showed superior to the control group in maintaining the average alveolar ridge area since the control group showed an area loss of approximately 39% between T0 and T1, whereas this reduction was approximately 15% in the test group (p<0.05).</p><p><strong>Conclusion: </strong>It is possible to conclude that using rhBMP-2 after tooth extraction resulted in better socket preservation, maintaining bone availability in the alveolar ridge 2.5 times greater than that of the control group.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thermal, mechanical, and densification analysis of osteotomy drill designs for implant placement: an analysis on foam blocks representing type IV bone.","authors":"Ayşegül Öztürk, Volkan Arısan, Godoberto Guevara Rojas","doi":"10.3290/j.qi.b6184384","DOIUrl":"https://doi.org/10.3290/j.qi.b6184384","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the effects of three osteotomy drill designs (conventional [CON], reverse helix [REX], and densification [DEN]) and running directions on heat generation, primary implant stability (PS), block-to-implant contact (BIC)%, peri-implant block volume (BV), and resistance to unscrewing forces in a low-density alveolar bone model.</p><p><strong>Method and materials: </strong>Eighty-eight dental implants were inserted into artificial bone blocks using manual and computer-controlled osteotomies. Temperature changes (Δ°C), insertion torque value (ITV), resonance frequency analyses (ISQ), BIC%, and BV were measured. Statistical analyses used ANOVA and Kruskal-Wallis tests (p<0.05).</p><p><strong>Results: </strong>DEN drilling produced the lowest Δ°C (17.52±2.57°C and 28.06±4.35°C for 2nd and 3rd drills), while CON had the highest (27.53±5.17°C and 38.03±8.08°C). Counter-clockwise (CCW) CON drilling significantly reduced Δ°C compared to clockwise (CW). DEN achieved highest PS (38.01±1.87 N/cm, 65±4.69 ISQ) and removal torque (25.4±5.08 N/cm), while CON CW had lowest (33.23±2.91 N/cm, 61.83±4.28 ISQ). DEN showed the highest BV (87.71±4.23 mm³) but the lowest BIC (49.12%±2.93%). CCW CON drilling improved ITV over CW (36.21±3.63 vs 33.23±2.91 N/cm).</p><p><strong>Conclusion: </strong>DEN drilling demonstrated superior performance in heat reduction, PS, and BV, but had lower BIC%. CCW running of CON drills showed improvements over CW in several parameters. While DEN excelled in most aspects, its lower BIC% and the positive outcomes of CCW CON drilling warrant further investigation.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A comprehensive systematic review and meta-analysis comparing the comfort level of customized mouthguards to self-adapted mouthguards in athletes.","authors":"Ajinkya Ingle, Pankaj Dhawan, Sapna Rani, Uswah Khan","doi":"10.3290/j.qi.b6184319","DOIUrl":"https://doi.org/10.3290/j.qi.b6184319","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review and meta-analysis aimed to evaluate and compare the comfort levels of custom-made mouthguards and self-adapted mouthguards used by athletes. Key parameters assessed included fit, speech interference, and breathing difficulties.</p><p><strong>Materials and methods: </strong>The review was registered with the Prospective International Registration of Systematic Reviews (PROSPERO). A comprehensive literature search was conducted across PubMed, EBSCOhost, Scopus, and Google Scholar, supplemented by additional citation searches. Two independent reviewers assessed the relevance of the studies, and studies were included based on predefined eligibility criteria. Nine studies were included for qualitative analysis, with the risk of bias assessed using standard NIH and revised JBI tools. Meta-analysis was performed with three studies to synthesize the results.</p><p><strong>Results: </strong>The analysis demonstrated that custom-made mouthguards significantly outperformed self-adapted types in comfort metrics, particularly in fit (p=0.0002) and reducing speech difficulty (p<0.00001). At the same time, breathing difficulty was also less in custom-made mouthguards (p<0.00001).</p><p><strong>Conclusions: </strong>Custom-made mouthguards provide superior comfort (fit and speech) compared to self-adapted alternatives, enhancing their potential for widespread adoption. The findings highlight the need for further research as limited clinical studies were available for meta-analysis.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Märit Martha Müller, Sebastian Hahnel, Angelika Rauch, Martin Rosentritt
{"title":"The effect of surface treatment and glass-ceramic coating on the wear behavior of different types of zirconia and their antagonists.","authors":"Märit Martha Müller, Sebastian Hahnel, Angelika Rauch, Martin Rosentritt","doi":"10.3290/j.qi.b6184321","DOIUrl":"https://doi.org/10.3290/j.qi.b6184321","url":null,"abstract":"<p><strong>Objectives: </strong>In-vitro study to investigate the influence of different pre-treatments and surface coatings on the wear of different zirconia and their antagonists.</p><p><strong>Method and materials: </strong>Zirconia specimens (3-, 4- and 5-mol yttria tetragonal zirconia; n=160/material) were subjected to pre-treatment (sandblasting 50 μm Al2O3 1 bar; 120 μm Al2O3 3 bar; polishing) and surface coating (spray glazing, micro-layering, layering, veneering). References comprised no pre-treatment or coating. Wear tests were performed (50 N, 120,000 cycles). Wear (mean, maximum, antagonist) and arithmetic mean roughness Ra and average roughness depth Rz were determined.</p><p><strong>Statistics: </strong>ANOVA, Bonferroni, Pearson correlation (α=0.05).</p><p><strong>Results: </strong>Ra/Rz showed significant (p < .001) differences (Ra: 0.01 ± 0.01 μm to 0.71 ± 0.06 μm, Rz: 0.31 ± 0.09 μm to 4.33 ± 0.44 μm). Two groups could be distinguished by mean and maximum wear with significant (p < .001) differences: I.) glaze sprayed and without coating (mean wear: 9.4 ± 2.6 μm to 57 ± 21.3 μm, max. wear: 24.1 ± 6.9 μm to 125.4 ± 18.2 μm) and II.) All coating procedures (mean wear: 129.2 ± 22.8 μm to 236.5 ± 62.0 μm, max. wear: 188.7 ± 21.4 μm to 444.2 ± 110.6 μm). Antagonist wear (9.2 ± 4.5% to 29.7 ± 5.0%) showed a significant (p < .001) correlation to surface coating, mean and maximum wear, Ra and Rz. Mean wear significantly (p < .001) correlated with surface coating, maximum wear, and antagonist wear.</p><p><strong>Conclusion: </strong>Under clinical conditions, layering or veneering can lead to increased wear of the restoration, but in return reduce the abrasion of antagonists. Excessively rough surface treatments should be avoided, as they might increase antagonist wear.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transition of care and dental-medical integration: shared experiences from the complex care center.","authors":"Furqan Alwaely, Francis Coyne, Adela Planerova","doi":"10.3290/j.qi.b6168799","DOIUrl":"https://doi.org/10.3290/j.qi.b6168799","url":null,"abstract":"","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 4","pages":"258-259"},"PeriodicalIF":1.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuyan Sheng, Xinjian Ye, Hefei Yuan, Changbo Zheng, Tao Zheng, Qianming Chen, Shuli Deng
{"title":"Assessing the efficacy of nonsurgical periodontal treatment on rheumatoid arthritis: an umbrella review.","authors":"Xuyan Sheng, Xinjian Ye, Hefei Yuan, Changbo Zheng, Tao Zheng, Qianming Chen, Shuli Deng","doi":"10.3290/j.qi.b6043843","DOIUrl":"10.3290/j.qi.b6043843","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between periodontitis and rheumatoid arthritis has attracted considerable interest. However, the effect of nonsurgical periodontal treatment (NSPT) on rheumatoid arthritis remains uncertain. This umbrella review aims to consolidate current research to establish a stronger evidence base.</p><p><strong>Method and materials: </strong>Medline, Embase, and the Cochrane library were searched from inception to August 2024. Two independent reviewers handled study selection, data extraction, and quality assessment (AMSTAR 2). The qualitative analysis covered clinical activity, joint symptoms, inflammatory markers, cytokines, and autoantibodies. Quantitative results for disease activity score 28 (DAS28), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were reported as mean differences with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 2,982 records were screened, with 41 full-text articles assessed for eligibility, and 9 selected for evidence synthesis. Qualitative analysis suggests that NSPT may reduce clinical activity in patients with periodontitis and rheumatoid arthritis. Quantitative analysis provided suggestive evidence on the effects of NSPT on DAS28, with the mean difference ranging from -0.38 (95% CI -0.46 to -0.31) to -1.18 (95% CI -1.43 to -0.93). One-third of the included studies were rated as 'high' quality, while another one-third were 'critically low.'</p><p><strong>Conclusions: </strong>The present evidence suggests that NSPT may provide benefits in managing rheumatoid arthritis symptoms in patients with periodontitis; however, the potential bias of current evidence calls for further rigorous studies. Clinicians should account for the complex interplay between periodontitis and rheumatoid arthritis when devising treatment strategies.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"260-272"},"PeriodicalIF":1.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}