Quintessence international最新文献

{"title":"Causal analysis of metabolites in periodontitis: a Mendelian randomization and validation study.","authors":"Min Li, Le Hong, Xiaojie Lin, Weidong Chen, Hao Li","doi":"10.3290/j.qi.b6362487","DOIUrl":"https://doi.org/10.3290/j.qi.b6362487","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the causal relationship between metabolites and periodontitis using Mendelian randomization (MR) and validate findings through gingival crevicular fluid (GCF) metabolomic profiling.</p><p><strong>Methods and materials: </strong>A two-sample MR analysis used genetic data from 486 metabolite Genome-Wide Association Study (GWAS) and periodontitis statistics, with IVW as the primary method, supported by MR-Egger, weighted median, and weighted mode. Sensitivity analyses included Cochran's Q, MR-Egger, and MR-PRESSO tests. GCF metabolomics compared 5 periodontitis patients and 5 controls, identifying differential metabolites via t-tests and PLS-DA, with KEGG pathway enrichment.</p><p><strong>Results: </strong>MR analysis identified 17 metabolites causally linked to periodontitis, spanning amino acids, lipids, energy metabolism, and cofactors/vitamins. Protective metabolites included betaine (OR: 0.478, 95% CI:0.235-0.975), laurate (0.51, 0.267-0.974), and glycerol 3-phosphate (0.312, 0.105-0.926), while phenylalanine (39.651, 2.173-723.565), pelargonate (2.527, 1.059-6.03), and 3-methylhistidine (1.481, 1.074-2.042) increased risk. Sensitivity analyses confirmed minimal heterogeneity, no pleiotropy (except 4-acetamidobutanoate), and no reverse causation. GCF metabolomics revealed 75 upregulated and 245 downregulated metabolites, with pathway enrichment in lipid, amino acid, and vitamin metabolism. Notably, betaine-protective in MR analysis-was significantly reduced in periodontitis, aligning with its anti-inflammatory role.</p><p><strong>Conclusion: </strong>This study indicates that some circulating metabolites (e.g., betaine) may protect against periodontitis. Integrating MR and GCF analyses, we identified key metabolic risk factors. Clinically, metabolites like betaine and glycerol 3-phosphate could serve as non-invasive early biomarkers, providing new avenues for personalized periodontitis prevention and treatment.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and Mediterranean fever: a systematic review and metaanalysis.","authors":"Iman Elahi Vahed, Mahtab Mottaghi, Nima Khamisi, Taymaz Shirinzadeh, Kimia Mosadeghi, Elina Almadi, Sepehr Salehi Omran, Rozhin Hedayatpour, Marieh Aalizadeh, Zohre Masoumi Shahr-E Babak, Mahta Malek, Mohammad Rahmanian","doi":"10.3290/j.qi.b6353965","DOIUrl":"https://doi.org/10.3290/j.qi.b6353965","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a severe oral health condition that damages the supporting bone and soft tissues surrounding the teeth. In recent years, it has become evident that periodontitis could increase systemic inflammatory markers. Some studies showed a potential link between periodontitis and autoinflammatory diseases, including Familial Mediterranean fever (FMF), which is a hereditary autoinflammatory condition. The current study aimed to comprehensively evaluate the association between FMF and periodontitis by analyzing clinical periodontal parameters-Plaque Index (PI), Gingival Index (GI), and Clinical Attachment Loss (CAL)-through a meta-analysis.</p><p><strong>Methods: </strong>A thorough search was conducted across different databases, including PubMed, Scopus, Web of Science, and Google Scholar, covering publications up to July 2024. Eleven studies were included, consisting of one cohort and ten case controls. Following established methods, we performed data extraction and quality assessment of the selected publications. We conducted a meta-analysis to gather the effect sizes obtained from the eligible publications.</p><p><strong>Results: </strong>The meta-analysis highlighted a statistically significant increase in PI among FMF patients compared to controls, with a pooled mean difference of 0.1833 (95% CI: 0.0012, 0.3655; p=0.0485), indicating higher plaque accumulation in FMF patients. On the other hand, CAL exhibited a non-significant mean difference of -0.0933 (95% CI: -0.2928 to 0.1062; p = 0.3596), and the GI similarly did not reach statistical significance, presenting a mean difference of 0.3223 (95% CI: -0.0713 to 0.7158; p = 0.1085).</p><p><strong>Conclusion: </strong>Our investigation underscores a potential association between FMF and periodontitis, as seen by elevated levels of PI in FMF patients. These results suggest that FMF patients experience higher levels of periodontal inflammation, emphasizing the importance of periodontal care in this population.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid implant-supported restorations bonded to nitride-coated titanium bases: a clinical method to address biologic, functional, and esthetic challenges in the esthetic zone.","authors":"Rafael Del Castillo, Carlo Ercoli, Rafael Valera, José María Díaz Fernández, Miguel Padial-Molina, Javier Ata-Ali","doi":"10.3290/j.qi.b6353957","DOIUrl":"https://doi.org/10.3290/j.qi.b6353957","url":null,"abstract":"<p><strong>Objective: </strong>Describe how advancements in digital technologies and material's science provide additional restorative alternatives and material combinations for single and multiple unit implant-supported restorations, such those incorporating the clinical use of nitride coated titanium bases (TiN) in combination with the 2-piece, CAD/CAM, screw-retained, zirconia-ceramic, hybrid implant-supported restoration concept.</p><p><strong>Materials and methods: </strong>Two partially edentulous patients with missing teeth in the maxillary esthetic zone were treated with a novel technical and restorative concept using the 2-piece CAD/CAM screw-retained zirconia-ceramic hybrid-abutment crown concept bonded to nitride coated titanium bases.</p><p><strong>Clinical outcomes: </strong>Biologic outcomes showed that tissues were maintained healthy with the patients showing an adequate oral hygiene level, no detectable plaque present upon probing and no bleeding on probing. Esthetic evaluation demonstrated an excellent esthetic outcome and peri-implant soft-tissue integration with adjacent natural teeth and pontic tissue areas, together with post-treatment stability of the gingival zenith position. None of the two patients showed technical complications such screw loosening or porcelain chipping/fracture. Radiographic evaluation reveals a precise fit between TiN bases and the implant connecting interfaces, no marginal bone loss and a stable implant osseointegration. The principal advantages of incorporating nitride coated titanium bases (TiN) in implant supported restorations rely on the favorable esthetic outcomes, improved technical, mechanical, and biological aspects, as well as the physicochemical characteristics of TiN hard thin film coatings and their positive impact on titanium biocompatibility.</p><p><strong>Conclusions: </strong>The short term promising clinical outcomes of the 2-piece CAD/CAM screw-retained, zirconia ceramic hybrid abutment crown concept bonded to nitride coated titanium bases, would indicate the potential clinical benefits of the described restorative alternative. However, additional in vitro investigations and randomized clinical trials are needed to validate these initial observations, especially those evaluating the 2-piece CAD/CAM screw-retained, zirconia ceramic hybrid abutment crown bonded to TiN bases when compared to the conventional 2-piece hybrid design as well as stock/custom, metal/zirconia/lithium disilicate, screw/cemented implant supported restorations.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of a single-visit additively manufactured flexible removable partial denture as an immediate temporary prosthetic solution.","authors":"Medhat Sameh Abdelaziz, Reham B Osman, Hossam I Nassar, Amal Ali Swelem","doi":"10.3290/j.qi.b6354176","DOIUrl":"https://doi.org/10.3290/j.qi.b6354176","url":null,"abstract":"<p><p>A technique for designing and manufacturing a single-visit temporary removable partial denture is described. This immediate provisional prosthesis is made of a newly introduced esthetic 3D-printed thermoplastic material. The arch to be restored, the antagonist, and the jaw relationship were optically scanned using an intraoral scanner (Medit i700; Medit). The removable partial denture was designed using the Exocad software program (Dental CAD; Exocad GmbH). The denture base was 3D printed in flexible gingival-colored resin, while the teeth were 3D printed in permanent tooth-colored resin. This digitally fabricated prosthesis will provide partially edentulous patients with a time- and cost-effective aesthetic temporization with adequate retention and high patient acceptance. This technique demonstrates free-form designing of the flexible clasps and their geometry. It also highlights the need to develop specialized dental software programs to include ready-made flexible clasps to cope with the continuous development of flexible 3D-printed resinous materials.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc pretreatment reduces silver diamine fluoride-induced discoloration in primary teeth: an in vitro study.","authors":"Abdullah Almulhim, Astrid C Valdivia-Tapia, Xinyue Mao, Basma Alsahan, Anderson T Hara, Tong Tong Wu, Jin Xiao, Yihong Li","doi":"10.3290/j.qi.b6335908","DOIUrl":"https://doi.org/10.3290/j.qi.b6335908","url":null,"abstract":"<p><strong>Background: </strong>Silver diamine fluoride (SDF) is increasingly recognized as a minimally invasive and effective treatment for early childhood caries (ECC). However, the dark discoloration from its application significantly limits its acceptability among parents, especially for anterior teeth. Zinc, with known antimicrobial and biofilm-modulating properties, has recently been proposed as a potential adjunct to reduce SDF-induced staining.</p><p><strong>Aim: </strong>This study aimed to evaluate the effectiveness of zinc pretreatment in reducing SDF-induced discoloration on primary tooth carious lesions that involved dentin. This study also aimed to examine surface morphology and elemental composition changes associated with Zinc adjunct SDF treatments.</p><p><strong>Methods: </strong>Extracted human primary teeth were allocated into three groups: untreated control, positive control (38% SDF alone), and experimental group (20M zinc pretreatment followed by 38% SDF). Tooth color changes were assessed using grayscale intensity analysis via standardized photography at baseline, immediately post-treatment, and up to 14 days. Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS) were employed to investigate morphological and compositional changes in both sound and naturally carious dentin areas. Statistical analyses included two-sample t-tests, linear regression, and likelihood ratio tests.</p><p><strong>Results: </strong>Teeth pretreated with zinc demonstrated less discoloration compared to the SDF-only group. Although this difference was not statistically significant (p = 0.125), it may have potential clinical relevance. SEM images revealed modified silver deposition patterns characterized by dispersed and less densely packed silver aggregates in zinc-pretreated groups. EDS analysis confirmed the presence of zinc, suggesting its interaction with silver deposition processes.</p><p><strong>Conclusion: </strong>Zinc pretreatment effectively reduces SDF-induced discoloration in primary dentition, potentially improving aesthetic outcomes and parental acceptance. This approach represents a promising advancement in minimally invasive pediatric dental care and warrants further clinical exploration.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary cytokines in Sjögren's syndrome patients and its association with caries experience, sialometry, and systemic comorbidities: a pioneering study.","authors":"Nitzan Aizenbud, Doron J Aframian, Tal Burstyn-Cohen, Rawi Saad, Aiham Hanut, Galit Almoznino","doi":"10.3290/j.qi.b6335983","DOIUrl":"10.3290/j.qi.b6335983","url":null,"abstract":"<p><strong>Background: </strong>Various salivary cytokines are overexpressed in the saliva of Sjögren's syndrome (SjS) patients. In addition, the levels of salivary cytokines can differ according to local and systemic conditions, besides SjS itself.</p><p><strong>Objectives: </strong>This study aimed to analyze the associations and correlations of caries experience, sialometry, and systemic co-morbidities with levels of the following salivary cytokines: Interleukin (IL): IL-1β, IL-6, IL-8, IL-10, TNF-α and IL-17A among SjS patients.</p><p><strong>Methods: </strong>Upon ethical approval and signed informed consent, 20 women with SjS were recruited. Clinical examinations included Decayed, Missing, and Filled Teeth (DMFT) index measurements, sialometry, and saliva sampling. Levels of salivary cytokines: IL-1β, IL-6, IL-8, IL-10, TNF-α, and IL-17A were measured by Enzyme- Linked Immunosorbent Assay (ELISA). Statistical analysis was performed using the Independent-Samples Mann-Whitney U Test for the associations between the categorial parameters, and Spearman's correlation test to analyze the correlations between continuous variables.</p><p><strong>Results: </strong>We report that Salivary cytokines are inter-correlated in a statistically significant manner (p<0.05). Age is correlated with IL-17A levels (p<0.05), and decayed teeth were cor-related with IL-6, IL-8, and IL-10 (p<0.05). The liquid fraction in the unstimulated salivary flow rate significantly correlates with all salivary cytokines that were measured. Cardiac disease is correlated with IL-10 levels, and Rheumatoid Arthritis is correlated with IL-1β levels (p<0.05).</p><p><strong>Conclusions: </strong>These results suggest that local factors such as caries experience and salivary flow rates as well as systemic factors such as co-morbidities should be taken into consideration when testing the levels of salivary cytokines in SjS.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term CBCT evaluation of bone volume stability post dental implant placement. 1 - Exploring sex as a risk factor.","authors":"David Goteiner, Ryan Levy, Shuying Jang, Marc Goldman, Steven R Singer","doi":"10.3290/j.qi.b6336017","DOIUrl":"https://doi.org/10.3290/j.qi.b6336017","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective study assesses the long-term effects of implants on alveolar and basal bone to determine if a patient's sex affects dimensional changes in the jaw and evaluate whether dental implants halt the atrophy of bone when compared to no post-extraction intervention.</p><p><strong>Methods and materials: </strong>IRB approval was obtained for this study. Of the 125 patients (432 sites) in the study, 53% were female. All had two CBCTs taken, an average of 4.7 years apart. The scans were divided into three groups. In the control group, the extraction site (first CBCT or T1) was not replaced when the second scan was taken (T2). Group 2 had no implant at T1 and an implant at T2. Group 3 had an implant at T1 and T2. Measurements were made from landmarks at predetermined levels (superior cortex of the IAN or the most inferior point in the nasal floor (NF) in the direction of the crest of bone height (Group C, 2, and 3). To avoid osseous changes due to placement, measurements were made from the inferior alveolar nerve for mandibular implants or the nasal floor for maxillary implants. Recognizing gender-based disparities in jaw size, we monitored percentage changes in bone.</p><p><strong>Results: </strong>Loss of alveolar bone width across all groups was common. When bivariate analysis was performed after Bonferroni correction (p<0.025), changes in alveolar bone width were significantly greater in females (p = 0.004). Although the loss in the basal bone was present, it was not significant between the sexes nor as great as alveolar bone resorption (p=0.880). When comparing groups using bivariate analysis, differences were not statistically significant between treatment groups and the control group (p=0.050) for basal bone and for alveolar bone (p=0.052). In the regression analysis for sex or groups, neither was statistically significant for either basal or alveolar bone (p >0.05).</p><p><strong>Conclusion: </strong>Dental implants do not arrest post-extraction atrophy in either alveolar or basal bone. Females exhibited a statistically greater rate of alveolar bone loss. Stable long-term implant success necessitates precise placement.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of low-dose naltrexone in the management of post-traumatic trigeminal neuropathic pain: a retrospective case series.","authors":"Sowmya Ananthan, Gary M Heir, Olga Korczniewska","doi":"10.3290/j.qi.b6335903","DOIUrl":"https://doi.org/10.3290/j.qi.b6335903","url":null,"abstract":"<p><strong>Introduction: </strong>Dentists provide treatment of anatomical structures innervated by the trigeminal system such as the teeth, gingiva etc., which can be subject to injury even following routine and well performed dental procedures. As a result, the dental clinician is often presented with patients with neuropathic pain or unusual sensory distortions. In addition, the dental clinician treats patients following facial and oral trauma which may result in chronic pain. Therefore, recognition of posttraumatic trigeminal neuropathic pain (PTTNP) and its management must be considered essential for the dental clinician. Painful neuropathies, including PTTNP, can present as a debilitating form of neuropathic pain that often defies treatment normally effective for other types of somatic pain disorders. Treatment of PTTNP typically involves the use of various classes of medications including antiseizure medications (AEDs) and tricyclic antidepressants (TCAs)1. Many patients suffering with PTTNP may have contraindications for these medications due to comorbidities, occupational responsibilities, or medication side effects. An alternative to AEDs and TCAs is the use of low-dose naltrexone (LDN)2.</p><p><strong>Methods: </strong>This study is a retrospective extended case series of patients with PTTNP. The records of twenty-one patients diagnosed with painful post-traumatic trigeminal neuropathic pain at the Center for Temporomandibular Disorders and Orofacial Pain of the Rutgers School of Dental Medicine. They met the criteria of PTTNP according to the ICOP and were prescribed LDN. Though a total of twenty-one patients were included, twelve with all the data present were included into the final analysis. The sex distribution was equal with 6 females and 6 males, with a combined average age of 59.33 ± 13.96 years.</p><p><strong>Results: </strong>LDN significantly reduced the patients' report of pain using a Visual Analogue Scale (VAS) 0-10 subjective pain ratings at the follow-up visits compared to the initial VAS. Interestingly, the small group of patients who used LDN in combination with Serotonin Norepinephrine Reuptake Inhibitors (SNRI), demonstrated a lower average VAS score at the first follow-up visit, compared to those who took LDN with other medications. There were no significant side effects reported by the patients. No adverse effects of LDN therapy were reported. Side effects of the medication are rare and as reported the literature, include mild abdominal distress or vivid dreams. None were reported among this group of subjects. Based on our retrospective extended case series, LDN appears to be a safe and effective medication for use in chronic PTTNP. These results, highlight the need for future studies to elucidate LDN's analgesic mechanism of actions and to decisively demonstrate the analgesic effect of LDN in larger cohorts using randomized, double blinded, placebo controlled clinical studies.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of pathologic root resorption in primary molars and canines: a retrospective cross-sectional study.","authors":"Elif Ece Kalaoglu, Zeynep Ozturkmen","doi":"10.3290/j.qi.b6184182","DOIUrl":"10.3290/j.qi.b6184182","url":null,"abstract":"<p><strong>Objectives: </strong>Pathologic root resorption in primary teeth affects dental health and future orthodontic needs. This study aimed to evaluate the prevalence and associated factors of pathologic root resorption in a pediatric population.</p><p><strong>Method and materials: </strong>A retrospective cross-sectional analysis was performed using panoramic radiographs from 691 pediatric patients aged 4 to 11 years at a university hospital in Türkiye. Teeth were evaluated for internal (IRR) and external pathologic root resorption (ERR) by two calibrated observers, adhering to the 2023 European Society of Endodontics Position Statement. Tooth status was categorized as healthy, carious (with or without pulp involvement), filled, or endodontically treated, and dental crowding was also recorded. Statistical analyses included chi-square tests, multiple logistic regression, and post-hoc analyses, with significance set at P < .05.</p><p><strong>Results: </strong>A total of 7,729 primary teeth (5,075 molars and 2,654 canines) were evaluated, with interobserver reliability of 82% and intraobserver reliability of 98.8%. The study cohort included 691 children (mean age 7.05 ± 1.45 years; 49.8% boys, 50.2% girls). Pathologic root resorption was observed in 21.2% of cases (n = 1,638), with ERR accounting for 81% and IRR for 19%. Among 2,654 healthy teeth, 3.76% exhibited pathologic resorption, with no significant association with dental crowding. Significant relationships were identified between pathologic root resorption and age (P = .000), tooth status (P = .049), and sex (P = .042).</p><p><strong>Conclusion: </strong>Reducing high caries levels in Türkiye is critical to lowering pathologic root resorption and associated complications. Further studies should explore dental crowding and pathologic root resorption relationships in larger samples.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"500-508"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between CRP levels in systemic circulation and peri-implant bone loss.","authors":"Metin Calisir, Dicle Altindal, Ahmet Cemil Talmac, Serkan Dundar, Abdullah Seckin Ertugrul","doi":"10.3290/j.qi.b6258394","DOIUrl":"10.3290/j.qi.b6258394","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this retrospective study was to evaluate the effects of high preoperative C-reactive protein (CRP) levels on early peri-implant alveolar bone loss.</p><p><strong>Method and materials: </strong>Fifty-eight implants in 20 patients with high preoperative CRP levels and 54 implants in 20 patients with low preoperative CRP levels were evaluated. For measurement of the peri-implant alveolar bone loss, the implant platform was accepted as the reference point. On both the mesial and distal sides, the vertical distances between the reference point and the first visible bone's highest coronal level were measured. Numerical data were compared between groups using the independent sample t test or the Mann-Whitney U test. Correlations between variables were investigated with the Spearman rho test.</p><p><strong>Results: </strong>The mean CRP level of the low CRP group was 0.37 ± 0.21 mg/L, while that of the high CRP group was 1.71 ± 0.60 mg/L. In the high CRP group, implant failure was observed in two patients. The mesial bone loss and distal bone loss values in the group with high CRP levels were found to be significantly higher than the group with low CRP levels (P < .05). There was a significant positive correlation between the CRP levels, and distal bone loss and mesial bone loss measurements.</p><p><strong>Conclusion: </strong>The results show that high preoperative CRP levels result in an increased risk for peri-implant alveolar bone loss, and suggest that preoperative CRP levels can be important for early peri-implant alveolar bone loss.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"464-471"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}