Fatma Uçan Yarkaç, Dilek Özkan Şen, Muhammet Demir, Mehmet Gönül, Ali Rıza Tunçdemir
{"title":"Effect of music listening on anxiety, stress, and pain during frenectomy: a randomized controlled trial.","authors":"Fatma Uçan Yarkaç, Dilek Özkan Şen, Muhammet Demir, Mehmet Gönül, Ali Rıza Tunçdemir","doi":"10.3290/j.qi.b7085701","DOIUrl":"https://doi.org/10.3290/j.qi.b7085701","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate whether listening to standardized instrumental music during diode-laser maxillary frenectomy reduces dental anxiety, physiological stress responses, and early postoperative pain compared with no auditory intervention.</p><p><strong>Material and methods: </strong>In this randomized controlled clinical trial, 40 systemically healthy adults requiring maxillary frenectomy were assigned to either a Music Group (n=20), who listened to standardized instrumental music during surgery, or a Control Group (n=20), treated without auditory stimulation. Dental anxiety was assessed using the CORAH-Modified Dental Anxiety Scale (CORAH-MDAS) preoperatively, immediately postoperatively, and at 1 and 2 weeks. Perceived stress was evaluated using the 10-item Perceived Stress Scale (PSS-10) at baseline and 1 month. Postoperative pain was assessed using a visual analog scale (VAS) on postoperative days 1, 3, and 7.Heart rate, blood pressure, and oxygen saturation were measured perioperatively.</p><p><strong>Results: </strong>The Music Group demonstrated significantly lower postoperative CORAH-MDAS and 1-month PSS-10 scores than the Control Group. Music exposure was also associated with lower systolic and diastolic blood pressure, reduced pulse rate, and lower postoperative pain scores, particularly on days 1 and 3. Most participants reported positive experiences and preferred music for future procedures.</p><p><strong>Conclusion: </strong>Listening to standardized instrumental music during diode-laser frenectomy was associated with lower postoperative dental anxiety, perceived stress, and early postoperative pain, together with favorable changes in selected physiological parameters. Music listening may therefore represent a simple and feasible non-pharmacological adjunct for improving patient comfort during minor periodontal surgical procedures.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diode laser gingivectomy and gingivoplasty in the anterior esthetic zone: a clinical review of indications, operative parameters, and evidence limitations.","authors":"Ioannis Papadimitriou, Sven Glindemann","doi":"10.3290/j.qi.b7086304","DOIUrl":"https://doi.org/10.3290/j.qi.b7086304","url":null,"abstract":"<p><strong>Objectives: </strong>To summarise the tissue-interaction basis, esthetic indications, and operative parameters of diode laser gingivectomy and gingivoplasty in the anterior esthetic zone, and to set out a decision pathway for case selection.</p><p><strong>Data sources: </strong>PubMed/MEDLINE and Scopus were searched from database inception to June 2026 for clinical and ex vivo studies and reviews relevant to diode laser soft-tissue surgery in the anterior dentition; reference lists were hand-searched. This is a topic review rather than a systematic review. Reported power spans roughly 0.9 to 5 W across continuous-wave, pulsed, and micropulsed modes; quantitative ex vivo data show that cut depth and thermal damage rise with power but less than proportionally, while cutting efficiency improves at higher settings, so an effective operative window exists rather than a single safe value. Clinical comparisons with the scalpel report less intraoperative bleeding and similar or lower postoperative pain, although directly applicable esthetic-zone trials remain few and patient-reported outcomes are seldom measured with validated instruments.</p><p><strong>Conclusion: </strong>The diode laser is a practical instrument for esthetic-zone gingival surgery when case selection is correct; standardised parameter reporting and longer prospective studies are the priority for strengthening the evidence.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siddhi Yeshwant Sonare, Abhay Pandurang Kolte, Rajashri Abhay Kolte, Vrushali N Lathiya, Aishwarya S Ikhar
{"title":"Comparative evaluation of vestibular incision subperiosteal tunnel access (VISTA) technique with and without A-PRF impregnated with DFDBA in the treatment of recession defects in maxillary anterior region: a randomized controlled trial.","authors":"Siddhi Yeshwant Sonare, Abhay Pandurang Kolte, Rajashri Abhay Kolte, Vrushali N Lathiya, Aishwarya S Ikhar","doi":"10.3290/j.qi.b7085699","DOIUrl":"https://doi.org/10.3290/j.qi.b7085699","url":null,"abstract":"<p><strong>Objectives: </strong>The present randomized controlled trial was planned to compare the effectiveness of the Vestibular incision subperiosteal tunnel access (VISTA) performed alone and VISTA with Advanced platelet-rich fibrin (A-PRF) impregnated with Demineralized freeze-dried bone allograft (DFDBA) for the management of multiple adjacent gingival recession defects (MAGRD) in the maxillary anterior region.</p><p><strong>Method and materials: </strong>Thirty patients exhibiting bilateral Miller's Class I and II recession defects were treated using a split-mouth protocol. Clinical evaluation included assessment of probing depth (PD), clinical attachment level (CAL), gingival recession depth (GRD), gingival recession width (GRW), width of keratinized gingiva (WKG), gingival thickness (GT), and percentage of root coverage (%RC) before treatment and reassessed at 3, 6, and 12 months postoperatively. Changes in labial plate thickness (LPT) were determined radiographically with cone beam computed tomography (CBCT) at baseline and after a 12-month follow-up period.</p><p><strong>Result: </strong>A-PRF impregnated with DFDBA resulted in more pronounced clinical benefits at 12 months, evidenced by gain in CAL (P< .001), greater reductions in GRD (P< .001) and GRW (P= .031), and an enhanced increase in the WKG, GT (P< .001) and % RC (P= .002). Radiographically, a significant increase in LPT (P< .001) in the Test group was observed as compared to the Control group at 1, 3 and 5 mm apical to CEJ.</p><p><strong>Conclusion: </strong>Both therapeutic approaches produced favourable clinical improvements over time. A-PRF impregnated with DFDBA may enhance the regenerative potential of VISTA and contributeto more predictable and stable esthetic outcomes.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia Rojas-Rueda, Mark Adam Antal, Carlos A Jurado, J R Gonzalez, Franciele Floriani, Abdulrahman Alshabib
{"title":"Surface roughness and gloss comparison of CAD/CAM resin-based composite crowns polished with various systems.","authors":"Silvia Rojas-Rueda, Mark Adam Antal, Carlos A Jurado, J R Gonzalez, Franciele Floriani, Abdulrahman Alshabib","doi":"10.3290/j.qi.b7086315","DOIUrl":"https://doi.org/10.3290/j.qi.b7086315","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to investigate the surface roughness and gloss of maxillary central incisor crowns fabricated from CAD/CAM resin-based composite (RBC) after polishing with six different polishing systems.</p><p><strong>Materials and methods: </strong>One hundred and five maxillary central incisor crowns (n=15 per group) were milled from a CAD/CAM resin-based composite material (Cerasmart) and divided into seven groups according to the polishing protocol: (1) Shofu Composite Polishing; (2) DiaComp; (3) OptraGloss Composite Polishing; (4) Dialite LD; (5) OptraFine; (6) Dialite ZR; and (7) no polishing (control) 15n per group. Surface roughness (Ra) and gloss of the facial surface of each crown were evaluated using a contact profilometer and a glossmeter. A noncontact optical profilometer was used to obtain three-dimensional surface topography images.</p><p><strong>Results: </strong>Polishing significantly reduced surface roughness and increased gloss compared with unpolished crowns. Among the polishing systems evaluated, OptraFine produced the smoothest surfaces, followed by OptraGloss, Dialite LD, Shofu Composite, and DiaComp. The highest gloss values were observed for OptraFine, followed by Dialite LD, Shofu Composite, OptraGloss, Dialite ZR, and DiaComp. Unpolished crowns exhibited the highest surface roughness and the lowest gloss.</p><p><strong>Conclusion: </strong>Ceramic and composite polishing systems significantly reduced surface roughness and increased gloss for CAD/CAM resin-based composite crowns compared with unpolished crowns. Among the ceramic and composite polishing systems evaluated, OptraFine produced the smoothest surfaces, while OptraFine and Dialite LD achieved the highest gloss values.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zein Al Abedine Kanso, Alexandra Manibo, Hans J Lee, Alexandre Piotto Assunção, Tristan Hensley, Thomas Y H Yoon
{"title":"Computer-guided minimally invasive sinus augmentation with the Hiossen OneCAS system: a case report.","authors":"Zein Al Abedine Kanso, Alexandra Manibo, Hans J Lee, Alexandre Piotto Assunção, Tristan Hensley, Thomas Y H Yoon","doi":"10.3290/j.qi.b7068655","DOIUrl":"https://doi.org/10.3290/j.qi.b7068655","url":null,"abstract":"<p><strong>Background: </strong>Implant placement in the posterior maxilla is often limited by insufficient bone height. This report demonstrates a minimally invasive, guided crestal sinus lift using the Hiossen OneCAS hydraulic system.</p><p><strong>Case description: </strong>A 74-year-old female presented with a non-restorable maxillary molar. Extraction, ridge preservation, and guided crestal sinus augmentation were performed using the Hiossen OneCAS system. Implants were simultaneously placed at the molar and premolar sites with successful osseointegration and prosthetic rehabilitation. The guided approach minimized complications and achieved favorable stability and esthetic outcomes despite limited crestal bone height (4.02 mm).</p><p><strong>Practical implications: </strong>The Hiossen OneCAS system represents a feasible, minimally invasive approach for guided hydraulic sinus elevation and implant placement in atrophic posterior maxillae, reducing surgical morbidity while supporting prosthetically driven accuracy. Long-term prospective studies are needed to establish predictability and functional outcomes.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kimberly Leotta, Ralf J Kohal, Sebastian B M Patzelt
{"title":"Accuracy of the craniofacial position of the maxilla captured by different computerized optical methods: a systematic review.","authors":"Kimberly Leotta, Ralf J Kohal, Sebastian B M Patzelt","doi":"10.3290/j.qi.b7064562","DOIUrl":"https://doi.org/10.3290/j.qi.b7064562","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this literature review was to systematically evaluate and analyze the current state of knowledge on methods and their accuracy in computerized optical craniofacial registration of the maxillary position.</p><p><strong>Materials and methods: </strong>Following Cochrane guidelines and the PRISMA scheme, relevant publications were identified in February 2023 via PubMed (Medline), Cochrane Library and Web of Science. The focus was on evaluating the accuracy of computerized optical methods for craniofacial registration. Two investigators selected studies based on predefined criteria. Data were analyzed tabularly and descriptively. The risk of bias was assessed using QUADAS-2.</p><p><strong>Results: </strong>From 2,837 publications, 8 studies were eligible for final analyses. Outcomes varied across workflows utilizing landmarks, CAD/CAM facebows or transfer splints validated against reference standards such as CT, CBCT or 3D electromagnetic digitizer. Structured light trueness deviations ranged from 0.19 to 0.46 mm with high local precision. Stereophotogrammetry demonstrated trueness errors between 0.07 and 1.46 mm, showing high axial stability but a topographic precision decrease toward posterior landmarks. Mobile devices exhibited the lowest trueness (0.50 to 1.64 mm) and highly variable precision. No superior digital integration method could be determined. Due methodological and device heterogeneity a meta-analysis was not applicable, limiting direct comparisons.</p><p><strong>Conclusion: </strong>Computerized optical methods offer high potential for accurate craniofacial registration of the maxillary position compared to conventional facebows. Structured light scanners demonstrated the highest accuracy, followed by stereophotogrammetry systems, while mobile devices were the least accurate. Further studies require larger populations, standardized protocols, clearly defined outcome and detailed documentation.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheetal Sharma, Rameshwari Singhal, Abbas Ali Mahdi, Nand Lal, Pavitra Rastogi, Umesh Pratap Verma, Shambhavi Mishra, Shalini Jaiswal
{"title":"Minimally invasive periodontal surgery with antimicrobial photodynamic therapy versus regenerative surgery for intrabony defects: a split-mouth randomized controlled trial.","authors":"Sheetal Sharma, Rameshwari Singhal, Abbas Ali Mahdi, Nand Lal, Pavitra Rastogi, Umesh Pratap Verma, Shambhavi Mishra, Shalini Jaiswal","doi":"10.3290/j.qi.b7064481","DOIUrl":"https://doi.org/10.3290/j.qi.b7064481","url":null,"abstract":"<p><strong>Background: </strong>Residual intrabony periodontal defects often require surgical intervention. Minimally invasive periodontal surgery with adjunctive antimicrobial photodynamic therapy (MIPS+aPDT) may improve microbial control and healing while reducing treatment-related morbidity.</p><p><strong>Objectives: </strong>To compare the effects of non-surgical periodontal therapy (NSPT), open flap debridement with demineralised freeze-dried bone allograft (OFD+DFDBA), and MIPS+aPDT on red-complex bacterial activity (primary outcome) and on clinical, radiographic, biochemical, wound-healing, and patient-reported outcomes in intrabony periodontal defects.</p><p><strong>Materials and methods: </strong>In this split-mouth randomised controlled clinical trial, 20 patients with Stage III/IV periodontitis contributed three comparable intrabony defects (60 sites), allocated to NSPT (control, Group1), OFD+DFDBA (test, Group2), or MIPS+aPDT (test, Group3). Dysbiosis was assessed using BANA enzymatic activity at baseline, 1 and 6 months (primary outcome). Secondary outcomes included probing pocket depth (PPD), clinical attachment level (CAL), gingival recession (GR), early wound healing score (EHS-24), radiographic bone fill, gingival crevicular fluid MMP-1 levels (baseline, 24 h, 48 h), and patient-reported outcomes (VAS). Data were analysed using mixed-effects models and multilevel ordinal regression (α=0.05).</p><p><strong>Results: </strong>All groups demonstrated a significant reduction in BANA positivity over 6 months (p<0.01). Compared with NSPT, OFD+DFDBA reduced the odds of higher BANA scores by 83.8% (OR=0.162; 95% CI: 0.039-0.680; p=0.013), while MIPS+aPDT reduced the odds by 93.5% (OR=0.065; 95% CI: 0.016-0.265; p<0.001). Both surgical groups showed significantly greater PPD reduction and CAL gain compared with NSPT (p<0.001). OFD+DFDBA demonstrated the highest radiographic bone fill, whereas MIPS+aPDT achieved significantly less GR, superior early wound healing, and better patient-reported outcomes (p<0.01). MMP-1 increased significantly at 24 h across groups without differences between treatments, indicating a common acute inflammatory response.</p><p><strong>Conclusion: </strong>MIPS+aPDT provided the most favorable reduction in dysbiosis, alongside comparable clinical and radiographic improvements, and reduced postoperative morbidity, suggesting it as a clinically advantageous approach for intrabony defect management.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Davis C Thomas, Radhika Thakkar, Bindu Chanamolu, Roba Hadad, Meera Madgavkar, Anu Priya Guruswamy Pandian
{"title":"Systemic factors in temporomandibular disorders: current status, latest research, and implications in clinical dentistry.","authors":"Davis C Thomas, Radhika Thakkar, Bindu Chanamolu, Roba Hadad, Meera Madgavkar, Anu Priya Guruswamy Pandian","doi":"10.3290/j.qi.b7064557","DOIUrl":"https://doi.org/10.3290/j.qi.b7064557","url":null,"abstract":"<p><p>Temporomandibular disorders constitute a diverse group of pain conditions, usually presenting to the dental clinician with complaints of jaw tiredness, jaw pain, and dysfunction. Systemic conditions and factors can have a profound effect on the causality and the perpetuation of these pains. Dentists have a special position in the comprehensive care of these patients with a unique opportunity to screen for and initiate prompt medical referrals, thereby optimizing patient care. The focus of this review article is to explore the association between temporomandibular disorders (TMDs) and systemic factors such as arthritides, autoimmune diseases, endocrinological disorders, infections, sleep disorders, central sensitization syndromes, and drug- induced myalgia. The results suggest that systemic factors play an important role in initiating, perpetuating, and aggravating TMD pain, and making the pain resistant to conventional modalities of pain management. Further, these factors may have a causal relationship with pain. Systemic conditions such as arthritides, autoimmune disorders, anemias, chronic infections, thyroid disorders, and medication- induced myalgia seem to have the most impact. It may be desirable for the clinician attempting to manage TMDs and TMD pain to consider the effect of systemic factors on the pain experience of the patient.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sherif M Elsaraj, Raquel Kasha-Blois, Renée Wint-White, Anthony M Iacopino, Lina Shoppoff, Iacopo Cioffi
{"title":"Trigeminal neuralgia: a primer for dental practitioners.","authors":"Sherif M Elsaraj, Raquel Kasha-Blois, Renée Wint-White, Anthony M Iacopino, Lina Shoppoff, Iacopo Cioffi","doi":"10.3290/j.qi.b7060092","DOIUrl":"https://doi.org/10.3290/j.qi.b7060092","url":null,"abstract":"<p><strong>Objective: </strong>Trigeminal neuralgia (TN) is a severe neuropathic facial pain disorder that is frequently misdiagnosed in dental settings, leading to delays in appropriate management and unnecessary irreversible dental procedures. This narrative review aims to synthesize current knowledge on the pathophysiology, diagnostic challenges, and management of TN, with particular emphasis on issues relevant to dental practitioners involved in the differential diagnosis of orofacial pain.</p><p><strong>Data sources: </strong>A comprehensive literature search was conducted using the PubMed database, covering studies published between January 2000 and March 2025. Eligible sources comprised controlled clinical trials, systematic reviews, meta-analyses, and selected case reports addressing diagnostic approaches and therapeutic strategies for TN. Findings were synthesized thematically to highlight clinical relevance, emerging therapies, and persisting gaps in care.</p><p><strong>Conclusion: </strong>TN remains a complex disorder with a substantial impact on quality of life. Accurate diagnosis relies on careful clinical history, recognition of characteristic pain features, and exclusion of odontogenic sources of pain, often requiring iterative assessment over time. Pharmacological therapies, including carbamazepine and oxcarbazepine, remain first-line treatments, while surgical interventions-particularly microvascular decompression-offer durable relief in refractory cases. Dental professionals play a critical gatekeeping role in early recognition, exclusion of dental pathology, and timely referral to medical specialists. Optimal management of TN requires an interdisciplinary approach integrating neurology, neurosurgery, dental specialties, and psychosocial care to minimize misdiagnosis, avoid unnecessary dental interventions, and improve patient outcomes.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"0"},"PeriodicalIF":1.4,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}