Quintessence international最新文献

{"title":"Computer-assisted contouring combined with bone ostectomy for dental implant placement of craniofacial fibrous dysplasia involving the right maxilla.","authors":"Fares Kablan, Shadi Daoud, Iris Slutzky-Golberg, Samer Srouji, Adeeb Zoabi","doi":"10.3290/j.qi.b5826619","DOIUrl":"10.3290/j.qi.b5826619","url":null,"abstract":"<p><strong>Objective: </strong>Craniofacial fibrous dysplasia affecting the jaws can result in facial asymmetry, posing a unique challenge for dental implant placement in edentulous areas. This case report introduces an innovative approach for rehabilitating the posterior maxilla affected by craniofacial fibrous dysplasia using a computer-guided technique for maxillary recontouring and substitution bone grafting at implant sites.</p><p><strong>Case presentation: </strong>A 58-year-old edentulous woman with a craniofacial fibrous dysplasia bone lesion affecting the right maxilla was referred for correction of asymmetry and dental implant placement. A computer guide was devised for shaving and contouring the right maxilla. Following virtual maxillary reduction, a second guide was created over the osteomized 3D model to plan the location of future dental implants and guide bone ostectomies for allograft substitution. Particulate bone substitute was applied to ostectomy sites in the affected maxillary alveolar ridge. Four implants were placed successfully 4 months postoperatively, with integration confirmed by clinical examination after 1 year of follow-up.</p><p><strong>Conclusion: </strong>This treatment approach emerges as a reliable and effective modality for simultaneous dental implant rehabilitation in edentulous alveolar bone and jaw contouring in craniofacial fibrous dysplasia cases. (Quintessence Int 2025;56:130-137; doi: 10.3290/j.qi.b5826619).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"130-137"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of technology to address access-to-care barriers in remote and rural communities.","authors":"Amrinderbir Singh, Elis Batistella, Liran Levin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 2","pages":"96-98"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational prospective study to determine the association and diagnostic utility of salivary nitrite levels in periodontitis.","authors":"Leonardo Lorente, Esther Hernández Marrero, Pedro Abreu González, Angel Daniel Lorente Martín, Agustín F González-Rivero, María José Marrero González, Carmen Hernández Marrero, Olga Hernández Marrero, Alejandro Jiménez, Cándido Manuel Hernández Padilla","doi":"10.3290/j.qi.b5872791","DOIUrl":"10.3290/j.qi.b5872791","url":null,"abstract":"<p><strong>Objective: </strong>It has been found that patients with chronic periodontitis showed higher salivary concentrations of reactive nitrogen species than healthy subjects. However, only a study of elderly Koreans has reported that high salivary reactive nitrogen species concentrations are associated independently with periodontitis. The objective of the present study was to determine whether salivary nitrite concentrations are associated with periodontitis-controlling risk factors in other populations (such as a European population).</p><p><strong>Method and materials: </strong>This was a prospective and observational study carried out in a dental clinic including European subjects without periodontitis (including subjects with periodontal health or with localized gingivitis in 30% sites) or with periodontitis (thus, with loss of periodontal tissue). The levels of nitrite in saliva were assessed using the Griess method. A multivariate regression analysis was performed to determine that variables were associated independently with periodontitis. To determine the association between salivary malondialdehyde levels and the severity of periodontitis, Spearman rho correlation coefficient was used. A receiver operating characteristic analysis with salivary nitrite levels and periodontitis diagnosis was performed.</p><p><strong>Results: </strong>Subjects with periodontitis (n = 54) in comparison to subjects without periodontitis (n = 30) had higher salivary nitrite levels (P = .003), a higher rate of arterial hypertension history (P = .02), and were older (P .001). Nevertheless, differences between subjects with and without periodontitis in other variables were not found. A positive correlation was found between salivary nitrite levels and periodontitis severity (rho = 0.23; P = .04). Multiple logistic regression analysis showed that elevated salivary nitrite levels > 209 nmol/mL were associated with periodontitis, controlling for arterial hypertension history and age (OR = 10.212; 95% CI = 2.665 to 39.128; P = .001) and controlling for diabetes mellitus and smoking (OR = 8.793; 95% CI = 3.038 to 24.450; P .001). The area under the curve for periodontitis diagnosis by salivary nitrite levels was 69% (95% CI = 58% to 79%; P .001). The selected point of salivary nitrite levels > 209 nmol/mL for periodontitis diagnosis had 72% sensitivity (58% to 84%), 77% specificity (58% to 90%), a 3.1 positive likelihood ratio (1.6 to 6.1), 0.4 negative likelihood ratio (0.2 to 0.6), 85% positive predictive value (74% to 92%), and 61% negative predictive value (49% to 71%).</p><p><strong>Conclusions: </strong>Salivary nitrite concentrations could be associated independently with periodontitis, could be associated with periodontitis severity, and could help in periodontitis diagnosis in a European population according to the results of this preliminary study. (Quintessence Int 2025;56:100-107; doi: 10.3290/j.qi.b5872791).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"100-107"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal stability and treatment needs in patients under antiresorptive therapy during supportive periodontal care: a retrospective case-control study.","authors":"Antonio Ciardo, Marlinde Simon, Hanna-Sophie Rosse, Sinclair Awounvo, Ti-Sun Kim","doi":"10.3290/j.qi.b5876508","DOIUrl":"10.3290/j.qi.b5876508","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate periodontal stability and treatment needs in patients under antiresorptive therapy (ART) during supportive periodontal care (SPC), with a focus on medication-related osteonecrosis of the jaw (MRONJ) risk and reasons for tooth loss.</p><p><strong>Method and materials: </strong>In this retrospective case-control study, records of 100 stage III/IV SPC patients (50 ART-exposed, 50 unexposed) were analyzed for probing pocket depth, clinical attachment level, bleeding on probing, history of periodontal surgery, tooth loss, and MRONJ risk over a period of up to 15 years after active periodontal therapy.</p><p><strong>Results: </strong>Baseline patient characteristics were similar between ART-exposed and unexposed patients. Osteoporosis was the underlying condition for ART in 72% of cases, and 74% exhibited an intermediate MRONJ risk profile. Over time, no significant differences between the groups were found in number of teeth, clinical attachment level, probing pocket depth, or bleeding on probing. Periodontal retreatment needs (teeth with probing pocket depth ≥ 4 mm or ≥ 6 mm) were relatively low and comparable between exposed and unexposed patients. However, periodontal surgery was performed more frequently in unexposed patients, also due to the risk of MRONJ in exposed patients. Both groups showed similar numbers of tooth loss, primarily due to periodontal and endodontic causes. Regression analyses identified ART, age, and diabetes mellitus as significant factors associated with higher bleeding on probing, while smoking and diabetes mellitus were linked to higher probing pocket depths.</p><p><strong>Conclusion: </strong>Achieving periodontal stability during SPC in ART-patients, most of whom had an intermediate MRONJ risk profile, appeared comparable to unexposed patients. However, the different MRONJ risk profiles should be taken into consideration and further investigated. (Quintessence Int 2025;56:108-118; doi: 10.3290/j.qi.b5876508).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"108-118"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zirconia endocrown with intracanal extension and zirconia posts on maxillary molars: in silico study.","authors":"İrfan Akpınar, Deniz Yanık","doi":"10.3290/j.qi.b5798352","DOIUrl":"10.3290/j.qi.b5798352","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate the stress distribution on tooth and zirconia endocrown restoration with pulp chamber or intracanal extension and zirconia post, performed on maxillary first molars, using finite element analysis.</p><p><strong>Method and materials: </strong>Three 3D endodontically treated maxillary molars were modeled. Cortical bone and cementum were modeled at 2 mm and 200 µm in thickness. Periodontal ligament of 250 µm thickness was constructed. Zirconia endocrown with pulp chamber extension of 2 mm (Model E&#43;PCE), zirconia endocrown with intracanal extension of 4 mm (Model E&#43;ICE), and zirconia post of 4 mm and crown (ZP) were modeled using software. All restoration models were placed on the maxillary molars. Models were subjected to 400 N loading from the three occlusal contact points. Von Mises stress was recorded.</p><p><strong>Results: </strong>Points where the stress was applied showed high stress compared to other regions of the models. The stress did not occur at the trifurcation in any of the models. For the stresses occurring in the restoration material, these were 14.67 MPa, 57.79 MPa, and 155.56 MPa, in Models E&#43;PCE, E&#43;ICE, and ZP, respectively. At the remaining dentin, these values were 47.04 MPa, 32.85 MPa, and 33.42 MPa in Models E&#43;PCE, E&#43;ICE, and ZP, respectively.</p><p><strong>Conclusions: </strong>Within the limitations of the study, zirconia endocrowns with intracanal extension exhibit more favorable stress distribution in both restoration material and dentin compared to zirconia posts and pulpal extension endocrowns. These findings suggest that endocrown with intracanal extension may be a better restorative option for reducing stress. (Quintessence Int 2025;56:120-129; doi: 10.3290/j.qi.b5798352).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"120-129"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of mandibular anatomy associated with inferior alveolar nerve block anesthesia using 3D mandible models reconstructed by CBCT.","authors":"Zhixuan Chen, Xinghan Li","doi":"10.3290/j.qi.b5788802","DOIUrl":"10.3290/j.qi.b5788802","url":null,"abstract":"<p><strong>Objective: </strong>The objective was to evaluate the anatomical relationship between the mandibular foramen and surrounding structures using CBCT and to investigate the potential causes of inferior alveolar nerve block (IANB) failure.</p><p><strong>Method and materials: </strong>In this retrospective study, CBCT images of 222 mandibular sides from 111 patients (55 men, 56 women; aged 18-45 years) who underwent CBCT examination at the Shenzhen University General Hospital between January 2018 and December 2020 were analyzed. Three-dimensional models were reconstructed, and measurements of angles and distances related to the mandibular foramen were performed. The presence of a bony protuberance on the medial side of the mandibular ramus was evaluated. Differences between sexes were assessed using paired t tests or Wilcoxon rank-sum tests (α = .05).</p><p><strong>Results: </strong>The angle between the anterior-posterior line of the mandibular ramus and the line connecting the innermost point to the mandibular foramen (angle AP-IF) was significantly greater than zero (P .05), indicating the presence of a bony protuberance. The angle between the midline and the line connecting the mandibular premolar contact point to the mandibular foramen (angle F45MnLP-ML) was 49.69 ± 2.17 degrees in men and 48.19 ± 2.20 degrees in women (P .001). The distance from the occlusal plane to the mandibular foramen was 9.45 ± 3.40 mm in men and 8.28 ± 3.41 mm in women (P = .011).</p><p><strong>Conclusion: </strong>The presence of a bony protuberance on the medial side of the mandibular ramus may contribute to IANB failure. Adjusting the needle insertion angle and height/vertical distance according to the reported measurements may improve IANB success rates. These findings may help clinicians optimize IANB techniques and improve success rates by adjusting needle insertion angles and heights/vertical distances based on individual patient anatomy.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"74-80"},"PeriodicalIF":1.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate implant placement in damaged extraction sockets: a systematic review and meta-analysis of randomized controlled trials.","authors":"Marco Campi, Bruno Leitão-Almeida, Miguel Pereira, Jamil Awad Shibli, Liran Levin, Juliana Campos Hasse Fernandes, Gustavo Vicentis Oliveira Fernandes, Tiago Borges","doi":"10.3290/j.qi.b5768294","DOIUrl":"10.3290/j.qi.b5768294","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to observe whether immediate implant placement into damaged extraction sockets is a successful modality for treating hopeless teeth that require extraction.</p><p><strong>Data sources: </strong>An electronic search was carried out through four databases (PubMed/MEDLINE, Web of Science, Scopus, and ScienceDirect) to identify randomized controlled trials (2013 to 2023) to understand whether immediate implant placement in damaged sockets is a successful treatment. The focus question was, 'In a patient with a hopeless tooth that needs extraction with the indication for dental implant treatment, is immediate implant placement in damaged extraction sockets, compared to undamaged sockets or healed sites, an effective method for the replacement of hopeless teeth and achieving a favorable clinical result?' The risk of bias was appraised and a meta-analysis using random effect was applied.</p><p><strong>Results: </strong>Five studies with 135 patients and 138 implants were included. The implant survival rate was 100% for all studies and period evaluated; the pink esthetic score (PES) scores had no statistically significant result for all articles that evaluated this parameter; the soft tissue changes was reported by two studies: one found no significant differences and the other showed that the test group experienced reduced soft tissue loss at the 1-year evaluation (measured with digital intraoral scanners); another two studies assessed the marginal bone loss, presenting no differences between groups. The meta-analysis showed homogeneity between the studies. There was an equilibrium among the groups in the various studies included, and age tended to be lower in the test group. The buccal bone tissue and pink esthetic score showed favoritism for the test group but without statistical significance.</p><p><strong>Conclusion: </strong>This study suggests that immediate implant placement in the presence of buccal bone defects can achieve comparable clinical and radiologic outcomes to traditional methods in the short term of the limited studies available. It was not possible to evaluate the buccal aspect through radiographs. Bone regeneration was essential to reach optimal results. It is important to emphasize that immediate implant placement requires adherence to rigorous criteria to ensure functionally acceptable results.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"34-45"},"PeriodicalIF":1.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of photobiomodulation and/or azithromycin treatment on bone resorption biomarkers in gingival crevicular fluid from patients with stage III-IV grade C periodontitis.","authors":"Malike Aslan Kehribar, Esra Baltacıoğlu, Kıvanç Dülger, Ahmet Alver","doi":"10.3290/j.qi.b5798358","DOIUrl":"10.3290/j.qi.b5798358","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the impact of photobiomodulation and/or azithromycin therapy in combination with full-mouth subgingival instrumentation on receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin levels and RANKL/osteoprotegerin ratios in gingival crevicular fluid on patients with stage III-IV grade C periodontitis.</p><p><strong>Method and materials: </strong>The study was conducted on 77 stage III-IV grade C periodontitis patients and 20 periodontally healthy controls. Patients with stage III-IV grade C periodontitis were categorized into four treatment groups: 1) only full-mouth subgingival instrumentation (FSI) group; 2) full-mouth subgingival instrumentation &#43; azithromycin (AZM) group; 3) full-mouth subgingival instrumentation &#43; photobiomodulation (PBM) group; and 4) full-mouth subgingival instrumentation &#43; photobiomodulation &#43; azithromycin (AZM&#43;PBM) group. Clinical periodontal parameters and RANKL and osteoprotegerin levels and RANKL/osteoprotegerin ratios in gingival crevicular fluid were measured at baseline and at the third month of therapy.</p><p><strong>Results: </strong>Compared with the periodontally healthy controls, all the baseline clinical parameters were higher in the stage III-IV grade C periodontitis groups (P .05); however, there were no statistically significant differences between the stage III-IV grade C periodontitis groups (P > .05). At month 3, the lowest values in all clinical parameters were generally observed in the antibiotics groups, whereas the highest values were observed in the FSI group. Furthermore, the highest RANKL and osteoprotegerin values in antibiotic groups and the highest RANKL/osteoprotegerin ratio in the PBM group were observed in month 3. RANKL/osteoprotegerin ratios did not change in the FSI and antibiotics groups after the treatment, but increased significantly in the PBM group.</p><p><strong>Conclusion: </strong>While photobiomodulation treatment combined with full-mouth subgingival instrumentation increases the RANKL levels, azithromycin increases osteoprotegerin levels. Also, AZM &#43; PBM treatment shows additional clinical and immunologic beneficial efficacy.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"14-24"},"PeriodicalIF":1.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking boundaries: the growing need for team science in oral health research.","authors":"Alfred Vitale, Shasha Cui, Jin Xiao, Eli Eliav, Kevin Fiscella","doi":"10.3290/j.qi.b5955862","DOIUrl":"https://doi.org/10.3290/j.qi.b5955862","url":null,"abstract":"","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 1","pages":"2-4"},"PeriodicalIF":1.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal pain is associated with poor sleep quality and increased daytime sleepiness in dental students: a cross-sectional pilot study.","authors":"Linda Sangalli, Alberto Herrero Babiloni, Davis C Thomas, Anna Alessandri-Bonetti","doi":"10.3290/j.qi.b5826634","DOIUrl":"10.3290/j.qi.b5826634","url":null,"abstract":"<p><strong>Objective: </strong>While a bidirectional relationship between sleep health and musculoskeletal pain has been established among chronic pain patients, few studies explored it among dental students. This cross-sectional study assessed the relationship of self-reported musculoskeletal pain with sleep health and psychological outcomes among dental students, and whether differences existed as a function of number and location of painful body-sites.</p><p><strong>Method and materials: </strong>Validated questionnaires were sent through REDCap to dental students at a predoctoral dental school, assessing presence, location (head, shoulder/neck, jaw, back, body), and intensity of musculoskeletal pain, sleep health (risk of sleep apnea, insomnia severity symptoms, sleep quality, daytime sleepiness, and chronotype), and psychological outcomes (anxiety/depression). Differences between those with and without musculoskeletal pain, and across participants with different number and location of painful sites were tested with t tests and ANOVA, adjusting for age/gender.</p><p><strong>Results: </strong>Out of 80 participants (82.5% women), 76.3% reported musculoskeletal pain (68.9% in neck/shoulders). Those with musculoskeletal pain scored significantly worse in sleep quality (P .001) and daytime sleepiness (P .001). Those with more than three painful body-sites reported worse sleep quality (P = .006) and daytime sleepiness (P = .003) than pain-free controls. There were no differences on sleep and psychological outcomes as a function of number of painful body-sites. Those reporting back pain scored worse in insomnia (P = .037), daytime sleepiness (P = .002), and sleep quality (P = .006) than those without back pain.</p><p><strong>Conclusion: </strong>Musculoskeletal pain is prevalent among dental students and associated with worse sleep health. While number of painful sites may not influence sleep/psychological health, specific locations (eg, back pain) were associated with worse sleep functioning.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"60-73"},"PeriodicalIF":1.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}