Quintessence international最新文献

{"title":"Association between migration history and oral health: results of the 6th German Oral Health Study (DMS • 6).","authors":"Berit Lieske, Liane Schenk, Kathrin Kuhr, Vinay Pitchika, Katrin Borof, A Rainer Jordan, Ghazal Aarabi","doi":"10.3290/j.qi.b5982024","DOIUrl":"10.3290/j.qi.b5982024","url":null,"abstract":"<p><strong>Objectives: </strong>Studies have demonstrated a significant association between migration history and oral health. Even after adjusting for confounders, migration history remains an independent risk factor for poorer oral health. As part of the 6th German Oral Health Study (DMS • 6), disease and care prevalence among individuals with migration history was surveyed at the population level. This article aims to assess the relationship between migration history, education status, and oral health.</p><p><strong>Method and materials: </strong>The analyses of the relationship between migration history and various oral health outcomes were conducted separately for younger adolescents (12-year-olds), adults (20-year-olds, 35- to 44-year-olds, 43- to 52-year-olds), and seniors (65- to 74-year-olds, 73- to 82-year-olds).</p><p><strong>Results: </strong>A significant association between migration history and poorer oral health outcomes, as well as less favorable oral health behaviors, was observed across all age groups. After adjusting for age, gender, and education, individuals with migration history exhibited higher levels of plaque, more bleeding sites, a higher prevalence of decayed teeth, insufficient tooth brushing frequency, and complaint-oriented dental service utilization.</p><p><strong>Conclusion: </strong>Previous studies have consistently identified education as a risk factor for poorer oral health. In the present study, even after adjusting for education status in multivariate models, the association between migration history and oral health outcomes remained significant. This finding underscores migration history as an independent risk factor for poorer oral health outcomes. This is the first large-scale cohort study in Germany to analyze the relationship between migration history and multiple oral health outcomes across different age groups. Future research should focus on uncovering migration-related factors, health literacy, and health behaviors to better explain the observed differences and improve oral health for migrant populations.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 11","pages":"S126-S134"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between smoking and oral health: results of the 6th German Oral Health Study (DMS • 6).","authors":"Laura Krause, Anne Starker, Katrin Hertrampf, Nicolas Frenzel Baudisch, A Rainer Jordan, Vinay Pitchika, Kathrin Kuhr","doi":"10.3290/j.qi.b5982019","DOIUrl":"10.3290/j.qi.b5982019","url":null,"abstract":"<p><strong>Objectives: </strong>Smoking is the most significant individual health risk and the leading cause of premature mortality in industrialized nations. International studies demonstrate that smoking also affects oral health adversely. This study aimed to investigate the association between smoking and oral health using population-representative data for Germany.</p><p><strong>Method and materials: </strong>The data source was the 6th German Oral Health Study (DMS • 6), conducted between 2021 and 2023. Data from a total of 2,135 individuals were included in the analyses. The distribution of sociodemographic characteristics (gender, age, education status), oral health behaviors (frequency of toothbrushing, interdental cleaning, and dental visits), and oral health-related parameters (self-assessed oral health, oral health-related quality of life, root caries, periodontitis, oral mucosal changes, and the number of teeth present) were reported separately for smoking status (daily smokers, former smokers, and never smoked). To estimate the associations between smoking status and oral health outcomes, mixed-effects regression models were employed.</p><p><strong>Results: </strong>Daily smokers exhibited worse outcomes in both self-assessed oral health parameters and clinical oral health measures compared to individuals who had never smoked. These associations persisted even after adjusting for sociodemographic factors and oral health behaviors. Similar trends were observed for former smokers compared to never smokers.</p><p><strong>Conclusion: </strong>Smoking is a well-established risk factor for poorer oral health. The findings of DMS • 6 confirm this association and are consistent with those of other national and international studies. Given the strong impact of smoking on oral health, comprehensive measures to curb smoking are essential. Evidence-based behavioral and structural preventive interventions exist to reduce tobacco consumption and promote smoking cessation. Dental offices can also contribute to tobacco prevention and cessation by providing brief counseling on the risks of smoking for both oral and general health.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 11","pages":"S96-S103"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in periodontal status: results from the German Oral Health studies from 2005 to 2023.","authors":"Thomas Kocher, Peter Eickholz, Kathrin Kuhr, A Rainer Jordan, Dominic Sasunna, Vinay Pitchika, Birte Holtfreter","doi":"10.3290/j.qi.b5981996","DOIUrl":"10.3290/j.qi.b5981996","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was twofold: firstly, to provide an overview of trends in periodontal status among younger adults aged 35 to 44 years and younger seniors aged 65 to 74 years between 2005 and 2023, based on data from the German Oral Health Studies (DMS); secondly, to quantify the extent to which observed differences in tooth count variables between consecutive studies can be attributed to differences in characteristics.</p><p><strong>Method and materials: </strong>The data from DMS IV (2005), DMS V (2014), and DMS • 6 (2023) were analyzed. The participants completed questionnaires concerning their oral health behaviors, and general and oral health. For this analysis, probing depths (PD) were calculated from three sites on 12 index teeth as a common denominator. The number of teeth, severity, and extent of PD and the Community Periodontal Index (CPI) were reported. Multivariate decomposition was employed to analyze differences by time.</p><p><strong>Results: </strong>The proportion of edentate younger seniors notably declined, from 23.2% to 5.4%, between 2005 and 2023. Similarly, the mean number of teeth for dentate younger seniors was 2.4 teeth higher in DMS • 6. While the mean PD remained 2.4 mm for younger adults and 2.8 mm for younger seniors, inconsistent patterns were observed for extent variables. In most cases, a decline of the extent variables was observed between DMS IV and DMS V, with a rebound at DMS • 6 for severe cases in younger seniors (with PD ≥ 6 mm). The proportion of younger adults and seniors with CPI scores of 0 to 2 increased considerably between DMS IV and DMS V, but rebounded at DMS • 6. Overall, the prevalence of these cases increased by approximately 10% points and 5% points, respectively. The majority of the observed reduction in the number of missing teeth (in younger adults) or the prevalence of having less than 20 teeth (in younger seniors) between DMS IV and DMS V and between DMS V and DMS • 6 were explained by an increase in the proportion of highly educated individuals, an increase in the proportion of those who have never smoked (only younger adults), an increase in the proportion of individuals using electric toothbrushes or interdental cleaning devices, and a reduction in the proportion of individuals with lifetime periodontal treatment.</p><p><strong>Conclusion: </strong>Over the last two decades, there has been a significant improvement in periodontal health in Germany, with the most notable enhancements occurring between DMS IV and DMS V. The prevalence of periodontal disease has decreased significantly in recent decades, largely due to the implementation of preventive measures. This underscores the importance of integrating preventive measures into dental practice as a public health strategy.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 11","pages":"S48-S58"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DMS • 6: All new !","authors":"A Rainer Jordan, Jörg Wiltfang, Werner Geurtsen, Guido Heydecke","doi":"10.3290/j.qi.b6044427","DOIUrl":"https://doi.org/10.3290/j.qi.b6044427","url":null,"abstract":"","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 11","pages":"S2-S3"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molar incisor hypomineralization: results of the 6th German Oral Health Study (DMS • 6).","authors":"Katrin Bekes, Hendrik Meyer-Lueckel, A Rainer Jordan, Kathrin Kuhr, Ulrich Schiffner","doi":"10.3290/j.qi.b5986273","DOIUrl":"10.3290/j.qi.b5986273","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to determine the prevalence of molar incisor hypomineralization (MIH) in Germany. A secondary goal was to analyze a possible connection between MIH and caries, as well as to investigate the influence of MIH on oral health-related quality of life (OHRQoL).</p><p><strong>Method and materials: </strong>All younger adolescents (12-year-olds) from the 6th German Oral Health Study (DMS • 6) were examined for MIH according to the criteria of the European Academy of Paediatric Dentistry (EAPD). The caries experience and OHRQoL were also determined.</p><p><strong>Results: </strong>In total, 922 younger adolescents were included in the analysis. The prevalence of MIH was 15.3%; 63.3% of cases were mild forms; 8.2% of affected subjects had a caries experience. OHRQoL did not vary significantly between healthy and MIH-affected children.</p><p><strong>Conclusion: </strong>In Germany, every seventh child aged 12 years old suffers from MIH. These data on MIH in younger adolescents in Germany conform to data from regional studies; the prevalence is in the upper middle range in an international comparison.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 11","pages":"S70-S74"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth loss and denture status: results of the 6th German Oral Health Study (DMS • 6).","authors":"Bernd Wöstmann, Stefanie Samietz, A Rainer Jordan, Kathrin Kuhr, Ina Nitschke, Helmut Stark","doi":"10.3290/j.qi.b5986257","DOIUrl":"10.3290/j.qi.b5986257","url":null,"abstract":"<p><strong>Objectives: </strong>The German Oral Health Study (DMS) is a series of consecutive studies designed to assess the oral health status of adults, seniors, and children in Germany. DMS is a major program of the Institute of German Dentists (Institut der Deutschen Zahnärzte) with the aim to produce health statistics for Germany. Tooth loss, edentulism, and prosthetic care have considerable socioeconomic significance; it is the aim of this paper to report findings on these aspects.</p><p><strong>Method and materials: </strong>The survey combines interviews and clinical examinations. Previous DMS studies focused primarily on tooth loss, edentulism, and prosthetic care. In the DMS • 6 survey, the condition of removable dentures and need for adjustments were additionally recorded, as well as necessary repair measures that were grouped according to their complexity (chairside or laboratory).</p><p><strong>Results: </strong>The prevalence of edentulism decreased considerably compared to that in the Fifth German Oral Health Study (DMS V) in 2014. Among younger adults (35- to 44-year-olds), the prevalence of edentulism was negligible, with an average of 26.6 teeth present. The younger senior group (65- to 74-year-olds) had an average of 19.3 teeth; the prevalence of edentulism was 5%, which is a reduction of > 50% compared to 2014 (12.4%). Lower education status was an important prognostic factor for tooth loss. Owing to the low prevalence of edentulism in younger adults, removable dentures were not prevalent in this age group, whereas combined fixed-removable dentures were most frequently used in seniors. Regarding the type of denture, a shift towards fixed as well as implant-supported types was observed. Of the removable dentures, 50% to 60% were in a very good or good clinical condition. Problems were mainly identified with simple acrylic dentures. Nonetheless, participants' satisfaction with removable dentures was extremely high, and the dentures were used almost continuously.</p><p><strong>Conclusion: </strong>The most important finding in this study is the continued significant decline in the prevalence of complete edentulism among seniors that suggests a further reduction in edentulism in the future with an estimate of around 4% in 2030. The shift observed in primary prosthetic care from removable to fixed prostheses as well as the increasing prevalence of implants placed are positive developments. The data revealed further compression of morbidity compared to DMS V. Complete edentulism declined, and fixed partial dentures, including implant-supported prostheses, were increasingly used. Lower education status was an important predictor for tooth loss.</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"56 11","pages":"S60-S68"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergies in dentistry and potential cofactors: a case-control study.","authors":"Lisa Corvin, Sandra Freitag-Wolf, Christof Dörfer, Guido Heine","doi":"10.3290/j.qi.b5907068","DOIUrl":"10.3290/j.qi.b5907068","url":null,"abstract":"<p><strong>Objective: </strong>Allergic reactions during dental procedures are suspected frequently. Still, data on the confirmed allergens are rare. This study aimed to identify allergens in dentistry and potential cofactors in sensitization.</p><p><strong>Method and materials: </strong>Patients with suspected allergic reactions in the context of dental (study group) or surgical (control group) procedures were analyzed in a monocentric 3-year retrospective and 2-year prospective file chart analysis between 2018 and 2023. Descriptive statistics and multiple logistic regression analysis were performed.</p><p><strong>Results: </strong>In total, 129 patients were allocated to the study group and 123 to the control group. Confirmed allergy was less frequent in the study group (10%) than in the control group (28%, P .001). Local anesthetics triggered most dental reactions, but were rarely confirmed allergic (1 of 55 cases). Dental materials and implant material in the control group were confirmed in 16% and 15% of clinically relevant sensitizations, respectively. Multiple logistic regression identified reactions to local anesthetics or dental materials/implant material with a 33.33- or 2.63-fold lower risk of sensitization. A concomitant immune disease was associated with higher risk for a confirmed allergic reaction in dentistry in the cohort (OR 9.12, 95% CI 2.40 to 35.10).</p><p><strong>Conclusion: </strong>Allergy to dentally administered drugs is rare. Most local anesthetic-triggered reactions were unspecific. Reactions to dental materials resulting in objective symptoms require allergy diagnostics. (Quintessence Int 2025;56:162-170; doi: 10.3290/j.qi.b5907068).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"162-170"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of chlorhexidine mouthwash and diagnosis of primary hypertension in a large hospital cohort.","authors":"Joseph Katz, Isabel Garcia","doi":"10.3290/j.qi.b5872795","DOIUrl":"10.3290/j.qi.b5872795","url":null,"abstract":"<p><strong>Objectives: </strong>Small-scale studies reported increased blood pressure in patients using chlorhexidine mouthwash with the rationale that the rinse mitigates nitric oxide production by oral bacteria. The present study evaluated whether prior use of chlorhexidine mouthwash can be associated with an increased odds ratio (OR) for primary hypertension in a large hospital cohort.</p><p><strong>Method and materials: </strong>The i2b2 NIH-established platform was used to search for deidentified medical information coded by ICD-10 for subjects with a hypertension diagnosis who have used chlorhexidine rinses before between October 2015 and May 2024. Binary statistics and logistic regression were used to calculate the OR for hypertension in the group that used chlorhexidine mouth rinse before and after adjustments for demographic data, diabetes, and periodontal disease.</p><p><strong>Results: </strong>The unadjusted OR for primary hypertension in subjects who used chlorhexidine gluconate mouthwash before was significantly elevated (OR 3.09, 95% CI 3.03 to 3.16, P .0001). It remained significant after adjusting for male sex (OR 3.07, 95% CI 3.00 to 3.13, P .0001), age 45 years (OR 4.00, 95% CI 3.92 to 4.09, P .0001), White race (OR 2.49, 95% CI 2.44 to 2.55, P .0001), diabetes (OR 2.68, 95% CI 2.61 to 2.74, P .001), and periodontal disease (OR 3.21, 95% CI 3.21 to 3.34, P .0001). The OR for hypertension for subjects with gingivitis or periodontal disease after adjustment for chlorhexidine mouthwash was elevated (OR 20.11, 95% CI 20.11 to 21.44, P .0001).</p><p><strong>Conclusions: </strong>With the caveat of a retrospective study design, the results indicate an increased OR for primary hypertension for subjects with prior use of chlorhexidine mouthwash. (Quintessence Int 2025;56:138-142; doi: 10.3290/j.qi.b5872795).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"138-142"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic image legend quality in the oral and maxillofacial radiology published literature: a pilot study.","authors":"Mel Mupparapu, Anwar Almuzaini, Derek Hong, Brad Hong, Steven Singer, Irene Kim","doi":"10.3290/j.qi.b5907061","DOIUrl":"10.3290/j.qi.b5907061","url":null,"abstract":"<p><strong>Objectives: </strong>This pilot study aimed to evaluate the quality of legends associated with diagnostic images in the published oral and maxillofacial radiology literature using a novel rating scale.</p><p><strong>Method and materials: </strong>Images and their corresponding legends were randomly selected from published manuscripts over the last 10 years in the Oral Radiology journals, namely Dentomaxillofacial Radiology, Imaging Science in Dentistry, Oral Radiology, and Oral Surgery Oral Medicine Oral Pathology Oral Radiology. An Image Legend Quality Scale (ILQS) was introduced to assess the quality of the legends associated with images. A program was developed for the rating scale form using Google Apps Script API to gather and analyze the data. The rating scale ranged from 1 to 5, with 5 as the highest rating.</p><p><strong>Results: </strong>The highest average ILQS rating for one journal was 3.04. The overall ILQS rating average across all four journals was 2.87, which is a 2.13 rating score lower than the ideal score of 5.</p><p><strong>Conclusions: </strong>There is room for improvement in the legends that accompany diagnostic images and figures in the oral and maxillofacial radiology literature. A proper legend provides an excellent diagnostic teaching opportunity for the reader and enhances the quality of a publication. (Quintessence Int 2025;56:144-152; doi: 10.3290/j.qi.b5907061).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"144-152"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What to do if a patient presents with an iatrogenic trigeminal nerve injury.","authors":"Tyler Jacobs, Mina Ayoub, John Zuniga, Vincent Ziccardi","doi":"10.3290/j.qi.b5984306","DOIUrl":"10.3290/j.qi.b5984306","url":null,"abstract":"<p><strong>Objective: </strong>Injuries to branches of the trigeminal nerve can occur during various dental procedures, leading to neurosensory deficits. The aim of this article is to educate those who are not specialized in diagnosis and management of iatrogenic trigeminal nerve injuries what to do if such a situation arises in their practice.</p><p><strong>Data sources: </strong>Treatment protocols, prospective and retrospective studies, and literature reviews were reviewed.</p><p><strong>Results: </strong>Patient history, neurosensory testing, and radiographic imaging are used to diagnose trigeminal nerve injuries. Based on findings, patients are either immediately referred to a specialist or managed conservatively. Conservative management includes pharmacologic treatment, neurosensory training exercises, and serial neurosensory testing. Consulting with local oral and maxillofacial surgeons or orofacial pain specialists, contacting local and state societies, or searching for providers on websites such as the American Association of Oral and Maxillofacial Surgeons, Academy for Orofacial Pain, American Board of Orofacial Pain, Oral and Maxillofacial Surgery National Insurance Company, or Axogen are different methods that can be used to find a specialist to refer to if indicated.</p><p><strong>Conclusions: </strong>Many providers are not trained to diagnose and manage iatrogenic trigeminal nerve injuries. Understanding indications for monitoring, conservative treatment, and when to refer these patients to orofacial pain specialists or oral and maxillofacial surgeons trained in trigeminal nerve microsurgery is critical to maximize positive patient outcomes and to minimize medicolegal exposure. (Quintessence Int 2025;56:154-160; doi: 10.3290/j.qi.b5984306).</p>","PeriodicalId":20831,"journal":{"name":"Quintessence international","volume":"0 0","pages":"154-160"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}