光生物调节和/或阿奇霉素治疗对 III-IV 期 C 级牙周炎患者牙龈缝液中骨吸收生物标志物的影响。

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Quintessence international Pub Date : 2025-01-30 DOI:10.3290/j.qi.b5798358

Malike Aslan Kehribar, Esra Baltacıoğlu, Kıvanç Dülger, Ahmet Alver

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引用次数: 0

摘要

研究目的本研究旨在探讨光生物调制（PBM）和/或阿奇霉素（AZM）疗法联合全口龈下器械治疗（FSI）对III-IV期C级牙周炎患者龈沟液（GCF）中核因子κB配体受体激活剂（RANKL）和骨保护gerin（OPG）水平以及RANKL/OPG比率的影响：研究对象为 77 名 III-IV 期 C 级牙周炎患者和 20 名牙周健康对照组。将 III-IV 期 C 级牙周炎患者分为四个治疗组：1）仅 FSI（FSI）组；2）FSI+AZM（AZM）组；3）FSI+PBM（PBM）组；4）FSI+PBM+AZM（AZM+PBM）组。在治疗基线期和第3个月测量临床牙周参数和GCF中RANKL、OPG水平及RANKL/OPG比值：与牙周健康的对照组相比，III-IV期C级牙周炎组的所有基线临床参数都更高（P< 0.05），但III-IV期C级牙周炎组之间的差异无统计学意义（P>0.05）。在第 3 个月，抗生素组的所有临床参数值普遍最低，而 FSI 组的临床参数值最高。此外，抗生素组的 RANKL 和 OPG 值最高，PBM 组的 RANKL/OPG 比率最高。治疗后，FSI 组和抗生素组的 RANKL/OPG 比值没有变化，但 PBM 组的 RANKL/OPG 比值显著增加：结论：PBM治疗联合FSI可增加RANKL水平，而AZM可增加OPG水平。此外，PBM+AZM 治疗还具有额外的临床和免疫学疗效。

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The effects of photobiomodulation and/or azithromycin treatment on bone resorption biomarkers in gingival crevicular fluid from patients with stage III-IV grade C periodontitis.

Objectives: This study aimed to investigate the impact of photobiomodulation and/or azithromycin therapy in combination with full-mouth subgingival instrumentation on receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin levels and RANKL/osteoprotegerin ratios in gingival crevicular fluid on patients with stage III-IV grade C periodontitis.

Method and materials: The study was conducted on 77 stage III-IV grade C periodontitis patients and 20 periodontally healthy controls. Patients with stage III-IV grade C periodontitis were categorized into four treatment groups: 1) only full-mouth subgingival instrumentation (FSI) group; 2) full-mouth subgingival instrumentation + azithromycin (AZM) group; 3) full-mouth subgingival instrumentation + photobiomodulation (PBM) group; and 4) full-mouth subgingival instrumentation + photobiomodulation + azithromycin (AZM+PBM) group. Clinical periodontal parameters and RANKL and osteoprotegerin levels and RANKL/osteoprotegerin ratios in gingival crevicular fluid were measured at baseline and at the third month of therapy.

Results: Compared with the periodontally healthy controls, all the baseline clinical parameters were higher in the stage III-IV grade C periodontitis groups (P .05); however, there were no statistically significant differences between the stage III-IV grade C periodontitis groups (P > .05). At month 3, the lowest values in all clinical parameters were generally observed in the antibiotics groups, whereas the highest values were observed in the FSI group. Furthermore, the highest RANKL and osteoprotegerin values in antibiotic groups and the highest RANKL/osteoprotegerin ratio in the PBM group were observed in month 3. RANKL/osteoprotegerin ratios did not change in the FSI and antibiotics groups after the treatment, but increased significantly in the PBM group.

Conclusion: While photobiomodulation treatment combined with full-mouth subgingival instrumentation increases the RANKL levels, azithromycin increases osteoprotegerin levels. Also, AZM + PBM treatment shows additional clinical and immunologic beneficial efficacy.

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来源期刊

Quintessence international 医学-牙科与口腔外科

CiteScore

3.30

自引率

5.30%

发文量

审稿时长

1 months

期刊介绍： QI has a new contemporary design but continues its time-honored tradition of serving the needs of the general practitioner with clinically relevant articles that are scientifically based. Dr Eli Eliav and his editorial board are dedicated to practitioners worldwide through the presentation of high-level research, useful clinical procedures, and educational short case reports and clinical notes. Rigorous but timely manuscript review is the first order of business in their quest to publish a high-quality selection of articles in the multiple specialties and disciplines that encompass dentistry.