Psychiatry Research最新文献

{"title":"Measuring suicidal behavior in the era of rapid-acting antidepressants: A systematic review of ketamine studies","authors":"Flávia Vieira ,&nbsp;Ana Teresa Caliman-Fontes ,&nbsp;Breno Souza-Marques ,&nbsp;Daniela Faria-Guimarães ,&nbsp;Daniel H. Lins-Silva ,&nbsp;Cassio Santos-Lima ,&nbsp;Ana Paula Jesus-Nunes ,&nbsp;Lucas C. Quarantini","doi":"10.1016/j.psychres.2025.116443","DOIUrl":"10.1016/j.psychres.2025.116443","url":null,"abstract":"<div><div>Assessment measures for suicidal behavior range from depression scales to longer suicide-specific instruments. In this review, we systematically summarize and discuss the currently used instruments for assessing suicidal behavior in the context of ketamine and its enantiomers. We searched Medline/PubMed, Embase, and PsycINFO databases for ketamine (and its enantiomers) human studies exploring this drug's antisuicidal effects on major depressive disorder patients, published from February 2000 to June 2023. Forty-six studies were included, identifying 16 assessment tools, mostly explicit and clinician-rated measures. Prominent tools included the Montgomery-Åsberg Depression Rating Scale (MADRS), Hamilton Depression Rating Scale (HAM-D), and both the clinician and patient-rated Beck Scales for Suicide Ideation (SSI and BSS). With the exception of the Suicide Ideation and Behavior Assessment Tool (SIBAT), to the best of our knowledge, no other instrument that assesses suicidality seems to be specifically developed for measuring treatment response in rapid-acting antidepressants trials. Most scales have been validated in conventional antidepressant or psychotherapy contexts, though, for MADRS, as well as for SSI, BDI, and HAM-D, efforts have been made towards investigating their psychometric properties in the field of rapid-acting antidepressants. The heterogeneity of suicidal behavior assessment in ketamine studies may hinder adequate comparisons between them. Although there does not seem to be a universally preferable instrument for measuring suicidal behavior to date, the MADRS potentially emerges as an adequately recommended choice.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116443"},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal behaviours in people seeking treatment for substance use disorder","authors":"Leire Leza ,&nbsp;José J. López-Goñi ,&nbsp;Alfonso Arteaga ,&nbsp;Ana M. Sánchez-Torres ,&nbsp;Javier Fernández-Montalvo","doi":"10.1016/j.psychres.2025.116444","DOIUrl":"10.1016/j.psychres.2025.116444","url":null,"abstract":"<div><div>Little is known about the specific characteristics of suicidal behaviour in people receiving treatment for substance use disorder (SUD). The aim of this study was to describe the number and types of suicide attempts and the methods used by 215 patients with SUD, according to sex. A face to face interview (Columbia Scale Severity Rate) was conducted. Lifetime suicidal ideation was reported by 48.8 % (<em>n</em> = 105) of the patients, and lifetime suicide attempts by 28.4 % (<em>n</em> = 61). Forty-five patients reported actual suicide attempts (20.9 %), and overdose was the most common method used (52.5 %; <em>n</em> = 32). Women had more aborted attempts than men did. Most of the participants who attempted suicide made only one attempt (<em>n</em> = 34; 55.7 %). The projection of these figures is alarming. These results justify the need to integrate suicide prevention interventions into addiction treatment programmes.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116444"},"PeriodicalIF":4.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving mental health access in Mexico: Addressing stigma and policy challenges","authors":"Rikas Saputra ,&nbsp;Isnaria Rizki Hayati ,&nbsp;Yenni Lidyawati ,&nbsp;Rizky Andana Pohan ,&nbsp;Erfan Ramadhani ,&nbsp;Ramtia Darma Putri ,&nbsp;Kadek Suhardita ,&nbsp;Sesilianus Fau","doi":"10.1016/j.psychres.2025.116442","DOIUrl":"10.1016/j.psychres.2025.116442","url":null,"abstract":"","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116442"},"PeriodicalIF":4.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical health correlates of co-occurring chronic pain and PTSD Among U.S. Veterans: Results from a nationally representative study","authors":"David E. Reed II ,&nbsp;Ian C. Fischer ,&nbsp;Rhonda M. Williams ,&nbsp;Peter J. Na ,&nbsp;Charles C. Engel ,&nbsp;Robert H. Pietrzak","doi":"10.1016/j.psychres.2025.116440","DOIUrl":"10.1016/j.psychres.2025.116440","url":null,"abstract":"<div><div>Co-occurring chronic pain and posttraumatic stress disorder (PTSD) affects between 4%-8% of the U.S. veteran population. A large body of research has documented the psychosocial burden of the co-occurrence, but fewer studies have examined physical health conditions and functioning. The current study aimed to address this gap by examining physical health conditions and functioning of co-occurring chronic pain and PTSD. Data were analyzed from the National Health and Resilience in Veterans Study, which surveyed a nationally representative sample of 4,069 (age=62.2 years) U.S. veterans in 2019–2020. The sample was predominantly male (<em>N</em> = 3,564; 90.2%) and non-Hispanic White (<em>N</em> = 3,318; 78.0%). PTSD diagnoses were determined using the PTSD Checklist for DSM-5 and chronic pain and other physical health conditions using self-report and validated measures. Logistic regression analyses revealed that veterans with co-occurring chronic pain and PTSD were generally more likely to have a physical health condition (<em>OR</em>s 2.79–9.53) or a cognitive disorder (<em>OR</em>=16.55) relative to controls (<em>OR</em>s 2.79–9.53). ANCOVA analyses revealed that relative to veterans with chronic pain or PTSD only, those with both chronic pain and PTSD had worse physical functioning across several domains (<em>d</em>s=0.32–1.13). Results underscore the importance of approaching co-occurring chronic pain and PTSD using a whole person approach to care that targets both physical and mental health concerns.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116440"},"PeriodicalIF":4.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new model to study season-of-conception effects on child neurodevelopment based on maternal history of seasonal affective disorder","authors":"Robert D. Levitan ,&nbsp;Cindy Xin Wen Zhang ,&nbsp;Julia A. Knight ,&nbsp;Rayjean J. Hung ,&nbsp;Mark Wade ,&nbsp;Katherine Finegold ,&nbsp;Stephanie Ameis ,&nbsp;Kashtin Bertoni ,&nbsp;Jody Wong ,&nbsp;Kellie E. Murphy ,&nbsp;Stephen J. Lye ,&nbsp;Stephen G. Matthews","doi":"10.1016/j.psychres.2025.116430","DOIUrl":"10.1016/j.psychres.2025.116430","url":null,"abstract":"<div><div>Season of birth/conception has been used to study neurodevelopmental risk in hundreds of studies, however the translational impact of this work remains limited. We propose a new model to study season-of- conception effects on neurodevelopment using maternal fall-winter seasonality as a key moderating variable, and provide initial empirical data to support this new approach. In an ongoing pregnancy cohort study we evaluated associations between season-of conception and maternal history of fall-winter Seasonal Affective Disorder (SAD) on child executive functioning in 520 children at age 54 months. Executive functioning was measured using computerized administration of the Flanker test (a measure of attention) and the Dimensional Change Card Sort (a measure of cognitive flexibility). Results indicated that sixty-four mothers (12.3 %) met criteria for historical fall-winter SAD. MANCOVA found a significant season of conception (fall-winter vs. spring-summer) by maternal SAD (yes/no) by sex (female/male) interaction predicting the two child outcomes (<em>F</em> = 4.11, df= 2,509, <em>p</em>=.017). In the subgroup of children in the SAD group, girls conceived in the fall-winter vs. spring-summer months had significantly lower scores on the Dimensional Change Card Sort. No significant effects related to season of conception and/or maternal SAD were found in boys. Similar results were found after controlling for maternal depressive symptoms during pregnancy. In summary, season-of-conception was associated with impaired child executive functioning at age 54 months, but only in girls of mothers with a history of fall-winter SAD. The use of maternal seasonality and sex as moderating variables may be critical to early neuro- developmental research based on pregnancy timing, particularly at more northern latitudes.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116430"},"PeriodicalIF":4.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality vs. mental health: A complex relationship with psychosis","authors":"Alfrina Mewengkang ,&nbsp;Tesalonika Pandolos ,&nbsp;Marssel Michael Sengkey ,&nbsp;Stevi Becher Sengkey ,&nbsp;Raup Padillah","doi":"10.1016/j.psychres.2025.116441","DOIUrl":"10.1016/j.psychres.2025.116441","url":null,"abstract":"","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116441"},"PeriodicalIF":4.2,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of psychological interventions for mental health problems among war refugees: A systematic review and meta-analysis","authors":"Eslavath Rajkumar ,&nbsp;Jose Mariya Lipsa ,&nbsp;Shrivastava Harshit ,&nbsp;Aswathy Gopi","doi":"10.1016/j.psychres.2025.116432","DOIUrl":"10.1016/j.psychres.2025.116432","url":null,"abstract":"<div><h3>Background</h3><div>Globally 117.3 million people are displaced due to war, with one in five refugees experiencing psychological distress. Despite the availability of numerous psychological interventions for war refugees, their overall efficacy is still unexplored. Thus, this review examines the effectiveness of psychological interventions in reducing the mental health issues of war refugees.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in PubMed, Web of Science, APA PsycNET, ScienceDirect and Google Scholar for studies published on the effectiveness of psychological interventions for mental health issues among war refugees in July 2024. JBI and NHLBI checklists were employed to appraise the risk of bias in the included studies. Review Manager version 5.4 was used to run the meta-analysis.</div></div><div><h3>Results</h3><div>Out of 22,197 initially identified records, a total of 21 studies were included for systematic review and eight randomized controlled trials (RCTs) for meta-analysis. Random effects meta-analysis showed significant medium effect size for psychological interventions (SMD = -0.69; 95 % CI:0.87, -0.51; <em>p</em> &lt; .00001) in reducing the mental health issues among war refugees. Sub group analysis based on the mode of delivery revealed that interventions delivered through in-person mode reported a significant large effect size <em>(SMD</em> = <em>-1.03; 95 % CI:1.36, -0.71; p</em> &lt; <em>.00001)</em> while, telehealth interventions showed significant small effect size <em>(SMD</em> = <em>-0.44; 95 % CI:0.61, -0.28; p</em> &lt; <em>.00001)</em>.</div></div><div><h3>Conclusion</h3><div>In-person and telehealth based psychological interventions offer promising findings in addressing mental health issues among war refugees. However, given the barriers to accessing face to face treatments and limited evidence on telehealth interventions, future research on digital interventions is recommended.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116432"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in adolescent violence victimization pre-, intra-, and post-COVID–19 pandemic in South Korea, 2012–2023: a nationwide cross-sectional study","authors":"Seoyoung Park ,&nbsp;Kyeongeun Kim ,&nbsp;Minji Kim ,&nbsp;Hyeongyu Jung ,&nbsp;Yejun Son ,&nbsp;Jaeyu Park ,&nbsp;Damiano Pizzol ,&nbsp;Guillaume Fond ,&nbsp;Laurent Boyer ,&nbsp;Guillermo F López Sánchez ,&nbsp;Selin Woo ,&nbsp;Dong Keon Yon","doi":"10.1016/j.psychres.2025.116429","DOIUrl":"10.1016/j.psychres.2025.116429","url":null,"abstract":"<div><h3>Background</h3><div>Adolescent violence victimization is a major public health concern, but research has been limited by short durations and small samples, restricting long-term understanding. This study examined its trends and vulnerabilities in South Korea, focusing on the impact of COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>Data were collected from 740,687 nationally representative samples (7–12th grade adolescents) through the Korean Youth Risk Behavior Web-based Survey from 2012 to 2023. Violence victimization was defined as treatment at a hospital in the past 12 months due to physical, mental, or property victimization. To assess the impact of the COVID–19 pandemic, the data were categorized into pre-(2012–2019), intra-(2020–2022), and post-(2023) pandemic periods, and analyzed using weighted regression models.</div></div><div><h3>Results</h3><div>A total of 740,687 participants (379,021 boys [51.17 %]) were included in this analysis from 2012 to 2023. The overall prevalence of adolescent violence victimization significantly declined from 2.91 % [95 % CI, 2.77–3.04] to 1.94 % [1.86–2.02] in pre-pandemic, then decreased to 1.13 % [1.03–1.24] during the early intra-pandemic, before rising to 2.29 % [2.12–2.46] in the post-pandemic. Vulnerable subgroups included students in 7–9th grades, those with depressive symptoms, attendees of all-boys schools, residents of facilities, current substance users, all exhibiting greater susceptibility to violence victimization.</div></div><div><h3>Conclusion</h3><div>This study identified a U-shaped trend in adolescent violence victimization in South Korea throughout the pandemic. Relative risk was associated with school and living environments, psychosocial factors, and substance use. Findings highlight the need for a systemic approach to interventions, addressing both individual vulnerabilities and structural factors to strengthen prevention.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116429"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of digital therapeutic applications for cognitive training among older adults with mild cognitive impairment or dementia: A systematic review and network meta-analysis of randomized controlled trials","authors":"Hye Su Jeong ,&nbsp;Yeo Wool Lee ,&nbsp;Taeho Greg Rhee ,&nbsp;Sung Ryul Shim","doi":"10.1016/j.psychres.2025.116426","DOIUrl":"10.1016/j.psychres.2025.116426","url":null,"abstract":"<div><div>Various digital therapeutics (DTx), which utilize computerized cognitive training (CCT) to improve cognitive functioning, have been tested and released. However, the efficacy of these DTx approaches may be diverse. This study aims to meta-synthesize the associations between mobile applications and cognitive functioning outcomes in older adults with mild cognitive impairment (MCI) or dementia from randomized controlled trials (RCTs). We searched PubMed, EMBASE, Scopus, and Cochrane Library from the inception through the end of June 2024. We selected RCTs using mobile application interventions in older adults with MCI or dementia. Interventions and comparisons included: CCT, intensive CCT (CCT2x), computerized cognitive engagement, progressive resistance training (PRT), CCT plus medication, CCT plus PRT, and medications only. Outcomes of interest included cognitive functioning and other measures of functioning (e.g., activities of daily living [ADLs]). Network meta-analysis was conducted to estimate pooled standardized mean differences (SMDs) with corresponding 95 % confidence intervals (CIs). Of 1,189 studies extracted, 10 RCTs were included in our analysis. CCT2x demonstrated statistically significant improvements in global cognitive function (SMD, 1.21 [95 % CI, 0.69–1.73]), episodic memory (SMD, 0.87 [0.47–1.27]), and working memory (SMD, 0.93 [0.44–1.42]) when compared with controls. For ADLs, CCT significantly reduced functional impairment (SMD, -0.80 [-1.40 to -0.21]). In depressive symptoms, CCT2x was the most effective in reducing symptoms (SMD, -0.77 [-1.08 to -0.45]). Overall, the DTx may be effective in improving cognitive and other functioning outcomes in older adults with MCI or dementia.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116426"},"PeriodicalIF":4.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathic pain and its association with intimate partner violence: The patient's perception in contrast to the intimate partner violence scale","authors":"Jéssica Paula Martins ,&nbsp;Fernando Augusto Lima Marson","doi":"10.1016/j.psychres.2025.116433","DOIUrl":"10.1016/j.psychres.2025.116433","url":null,"abstract":"<div><h3>Introduction</h3><div>The potential contribution of intimate partner violence (IPV) to the development of neuropathic pain (NP) is not fully elucidated. Therefore, this study aimed to describe self-reported IPV in patients with NP undergoing treatment and to associate the findings with the values ​​obtained on the Intimate Partner Violence Scale (EVIPI, from Portuguese <em>Escala de Violência entre Parceiros Íntimos</em>).</div></div><div><h3>Methods</h3><div>This study was conducted with a group of patients undergoing treatment for chronic NP. The EVIPI was used to assess exposure to violence. This instrument was administered to participants who had been in an intimate relationship in the last six months.</div></div><div><h3>Results</h3><div>The study involved 124 participants, of whom 73 (58.9 %) had been in a relationship in the last six months. All selected participants self-declared being in a heterosexual relationship. Among them, 44 (60.3 %) were women, 53 (72.6 %) self-identified as white, and 33 (45.2 %) had incomplete basic education. When asked if they had experienced any form of violence within the intimate relationship in the last six months, 68 (93.2 %) self-reported that they had not. Additionally, 66 (90.4 %) reported that they had not experienced childhood violence. Cross-tabulation between the EVIPI and self-reported exposure to violence did not show a significant association in the three categories of the EVIPI. Despite the lack of statistical significance, among those who denied having suffered violence in childhood, 29 and 19 participants scored positive in the “injury and physical violence” and “behavioral control” categories of the EVIPI, respectively. Among those who denied having suffered IPV, 30 and 19 participants scored positive in the “injury and physical violence” and “behavioral control” categories of the EVIPI, respectively.</div></div><div><h3>Conclusions</h3><div>No significant association was found between the markers evaluated; however, there was a gap in understanding the concept of violence, as most participants denied exposure to violence despite the EVIPI results indicating certain levels of exposure.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116433"},"PeriodicalIF":4.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}