Psychiatry Research最新文献

{"title":"Peripheral inflammatory and metabolic markers as potential biomarkers in treatment-resistant schizophrenia: Insights from a Qatari Cohort","authors":"Mohamed Adil Shah Khoodoruth ,&nbsp;Tarteel Hussain ,&nbsp;Sami Ouanes ,&nbsp;Nuzhah Widaad Chut-kai Khoodoruth ,&nbsp;Adel Hmissi ,&nbsp;Samuel L. Lachica Jr ,&nbsp;Mustafa Nissar Bankur ,&nbsp;Abdul Waheed Khan ,&nbsp;Mohamad Samir Makki ,&nbsp;Yasser Saeed Khan ,&nbsp;James Currie ,&nbsp;Majid Alabdullah ,&nbsp;Farhan Mohammad","doi":"10.1016/j.psychres.2024.116307","DOIUrl":"10.1016/j.psychres.2024.116307","url":null,"abstract":"<div><div>Schizophrenia presents significant diagnostic and treatment challenges, particularly in distinguishing between treatment-resistant (TRS) and non-treatment-resistant schizophrenia (NTRS). This cross-sectional study analyzed routine laboratory parameters as potential biomarkers to differentiate TRS, NTRS, and healthy individuals within a Qatari cohort. The study included 31 TRS and 38 NTRS patients diagnosed with schizophrenia, alongside 30 control subjects from the Qatar Biobank. Key measurements included complete blood count, lipid panel, HbA1c, and ferritin levels. Our findings indicated elevated body mass index (BMI) and triglyceride (TG) levels in both patient groups compared to controls. The NTRS group also showed higher HbA1c levels. Variations in inflammatory markers were noted, with the NTRS group exhibiting a higher platelet/lymphocyte ratio (PLR). Multivariate analysis highlighted significant differences in platelet count, mean platelet volume (MPV), TG, HbA1c, BMI, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and ferritin among the groups. Linear regression analysis revealed that MLR and clozapine treatment were significantly correlated with the severity of schizophrenia symptoms. The Random Forest model, a supervised machine learning algorithm, efficiently differentiated between cases and controls and between TRS and NTRS, with accuracies of 86.87 % and 88.41 %, respectively. However, removing PANSS scores notably decreased the model's diagnostic effectiveness. These results suggest that accessible peripheral laboratory parameters can serve as useful biomarkers for schizophrenia, potentially aiding in the early identification of TRS, enhancing personalized treatment strategies, and contributing to precision psychiatry. Future longitudinal studies are necessary to confirm these findings and further explore the role of inflammation in schizophrenia pathophysiology and treatment response.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116307"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety outcomes of ketamine for treatment-resistant depression in clinical settings and development of the ketamine side effect tool-revised (KSET-R)","authors":"Adam Bayes ,&nbsp;Thanh Vinh Cao ,&nbsp;Ana Rita Barreiros ,&nbsp;Clara Massaneda-Tuneu ,&nbsp;Vanessa Dong ,&nbsp;Nicollette Thornton ,&nbsp;Nicholas Glozier ,&nbsp;Laura Beesley ,&nbsp;Dalia Moreno ,&nbsp;Verònica Gálvez-Ortiz ,&nbsp;Brooke Short ,&nbsp;Donel Martin ,&nbsp;Colleen Loo","doi":"10.1016/j.psychres.2024.116334","DOIUrl":"10.1016/j.psychres.2024.116334","url":null,"abstract":"<div><h3>Background</h3><div>Ketamine and its derivates (e.g. esketamine) are increasingly used in clinical settings for treatment-resistant depression (TRD). Ketamine can give rise to acute, cumulative and longer-term side effects (SEs) across a treatment course. The Ketamine Side Effect Tool (KSET) examines adverse effects though its length has affected feasibility for use in clinical settings.</div></div><div><h3>Objective</h3><div>To estimate the frequency of ketamine SEs occurring in real-world settings using the KSET, additional validated scales and laboratory measures. Utilising this naturalistic data, to develop a shorter, more feasible and validated tool (KSET-Revised; KSET-R).</div></div><div><h3>Methods</h3><div>Retrospective patient and safety data from three outpatient services were collected which included KSET symptom questions, standardised scales and laboratory measures. We calculated frequency of SEs occurring intra-session, intersession and at follow-up. Revision of the KSET included removal of items based on a priori criteria. Construct and concurrent validity were examined by comparison of specific KSET items and the overall tolerability rating with standardised scales.</div></div><div><h3>Results</h3><div>Descriptive statistics including SE frequencies are reported and the KSET-R is detailed: a shorter tool with construct and concurrent validity for specific items, along with the overall tolerability rating.</div></div><div><h3>Limitations</h3><div>small sample size for follow-up data; predominantly subcutaneous racemic and intranasal esketamine analysed - other routes and formulations not examined; and subjective not objective cognition measured.</div></div><div><h3>Conclusions</h3><div>Naturalistic data gives an estimate of frequency of ketamine SEs within session, between sessions and at follow-up. The KSET-R has improved feasibility and clinical utility and is recommended for use in clinical practice where ketamine is prescribed.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116334"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between autism diagnosis rates and adolescent depression: A population-based study in Sweden","authors":"Adrian E. Desai Boström ,&nbsp;Peter Andersson ,&nbsp;Lee E. Wachtel ,&nbsp;Håkan Jarbin ,&nbsp;Jussi Jokinen ,&nbsp;Johan Lundberg","doi":"10.1016/j.psychres.2024.116341","DOIUrl":"10.1016/j.psychres.2024.116341","url":null,"abstract":"<div><h3>Introduction</h3><div>The association between increasing diagnosis rates of autism-related disorders (ASD-R) in Swedish regions and diagnosis rates of major depressive disorders (MDD) in adolescents remains unexplored.</div></div><div><h3>Methods</h3><div>Following STROBE guidelines, this pre-registered (<span><span>https://osf.io/duvq7</span><svg><path></path></svg></span>) observational study, utilizing registry data from 2008 to 2022 across the 21 Swedish regions, employed a generalized linear mixed model (GLMM) to analyze the association between ASD-R (ICD-10: F84) and MDD diagnosis rates (ICD-10: F32) in 15–19 year olds, with registered primary diagnoses considered. The GLMM included psychiatric care affiliation rates (PCAR) as fixed effects and variations across years and regions as random intercepts. The model incorporated bipolar disorder (BD) rates and the male-to-female ratio of ASD-R diagnoses when justified. Separate models were created for combined sexes, males, and females.</div></div><div><h3>Results</h3><div>A significant inverse relationship was observed between ASD-R and MDD diagnosis rates across all sex groups. In the combined-sex model, the mean ratio was 0.40 (<em>P =</em> 0.003), while the sex-specific models showed ratios of 0.28 for males (<em>P &lt;</em> 0.001) and 0.37 for females (<em>P =</em> 0.017). All ratios were significantly below 1, indicating a negative association between ASD-R and MDD diagnosis rates.</div></div><div><h3>Conclusions</h3><div>The study's observational nature limits causal inferences, but findings reveal that higher primary diagnosis rates of ASD-R correlate with lower primary diagnosis rates of MDD in adolescents of both sexes, although more pronounced in males. These results highlight the importance of further research on the relationship between ASD-R and MDD diagnosis rates, emphasizing the need for prospective, longitudinal, and individualized register data that include both primary and co-diagnoses.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116341"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilayer network instability underlying persistent auditory verbal hallucinations in schizophrenia","authors":"Jinguang Li ,&nbsp;Jingqi He ,&nbsp;Honghong Ren ,&nbsp;Zongchang Li ,&nbsp;Xiaoqian Ma ,&nbsp;Liu Yuan ,&nbsp;Lijun Ouyang ,&nbsp;Chunwang Li ,&nbsp;Xiaogang Chen ,&nbsp;Ying He ,&nbsp;Jinsong Tang","doi":"10.1016/j.psychres.2024.116351","DOIUrl":"10.1016/j.psychres.2024.116351","url":null,"abstract":"<div><h3>Background</h3><div>Auditory verbal hallucinations (AVHs) in schizophrenia (SCZ) are linked to brain network abnormalities. Resting-state fMRI studies often assume stable networks during scans, yet dynamic changes related to AVHs are not well understood.</div></div><div><h3>Methods</h3><div>We analyzed resting-state fMRI data from 60 SCZ patients with persistent AVHs (p-AVHs), 39 SCZ patients without AVHs (n-AVHs), and 59 healthy controls (HCs), matched for demographics. Using graph theory, we constructed a time-varying modular structure of brain networks, focusing on multilayer modularity. Network switching rates at global, subnetwork, and nodal levels were compared across groups and related to AVH severity.</div></div><div><h3>Results</h3><div>SCZ groups had higher switching rates in the subcortical network compared to HCs. Increased switching was found in two thalamic nodes for both patient groups. The p-AVH group showed lower switching rates in the default mode network (DMN) and two superior frontal gyrus nodes compared to HC and n-AVH groups. DMN switching rates negatively correlated with AVH severity in the p-AVH group.</div></div><div><h3>Conclusions</h3><div>Dynamic changes in brain networks, especially lower DMN and frontal region switching rates, may contribute to the development and persistence of AVHs in SCZ.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116351"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and substance use differentially impact suicidal ideation in a longitudinal cohort of bipolar disorder","authors":"Julia L. Smith,&nbsp;Melvin G. McInnis,&nbsp;Sarah H. Sperry","doi":"10.1016/j.psychres.2025.116357","DOIUrl":"10.1016/j.psychres.2025.116357","url":null,"abstract":"<div><h3>Background</h3><div>Across bipolar disorders (BSDs), alcohol and substance use and suicidal ideation (SI) contribute to increased rates of morbidity and mortality. The goal of the present study was to investigate temporal relationships between the intensity/frequency (I/F) of use and impairment related to alcohol and substance use and SI in a longitudinal BSD cohort.</div></div><div><h3>Methods</h3><div>Participants with BDI (<em>n</em>=565), BDII (<em>n</em>=162), and BD NOS (<em>n</em>=61) were included (median enrollment=72 months). Alcohol and substance use were measured using a modified version of the AUDIT administered every 6 months. SI was measured every 2 months using item 9 from the PHQ-9. Linear mixed effects models tested concurrent associations and Dynamic Structural Equation Models tested prospective associations between alcohol and substance use I/F and impairment with SI.</div></div><div><h3>Results</h3><div>Cocaine I/F and alcohol and substance use impairment were concurrently associated with SI. When a person had more frequent and intense cannabis use compared to average, they had higher SI at the next timepoint. When individuals experienced more alcohol and substance use impairment than average, they had higher SI at the next timepoint.</div></div><div><h3>Conclusions</h3><div>I/F of cannabis use and alcohol and substance use impairment appear to lead to future increases in SI for those with BSDs.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116357"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection and COVID-19 outcomes across mental disorders and the role of sex: A register-based study from Catalonia","authors":"Anna Monistrol-Mula ,&nbsp;Iago Giné-Vázquez ,&nbsp;Giulia Caggiu ,&nbsp;Claudia Conflitti ,&nbsp;Katalin Gemes ,&nbsp;Irwin Hecker ,&nbsp;Roberto Mediavilla ,&nbsp;Matteo Monzio Compagnoni ,&nbsp;Irene Pinucci ,&nbsp;Jutta Stoffers-Winterling ,&nbsp;Anke B. Witteveen ,&nbsp;Pierre Smith ,&nbsp;Henrik Walter ,&nbsp;Jose Luis Ayuso-Mateos ,&nbsp;Maria Melchior ,&nbsp;Ellenor Mittendorfer-Rutz ,&nbsp;Marit Sijbrandij ,&nbsp;Josep Maria Haro ,&nbsp;Mireia Felez-Nobrega","doi":"10.1016/j.psychres.2024.116325","DOIUrl":"10.1016/j.psychres.2024.116325","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigated the risk of SARS-CoV-2 infection and severe COVID-19 outcomes among different mental health diagnoses and the role of sex in these associations.</div></div><div><h3>Methods</h3><div>Using electronic records from Catalonia, we identified adults receiving mental health care from 2017–2019 with diagnoses of non-affective psychosis (NAP), bipolar disorder (BD), depressive disorder (DEP), stress-related disorders, neurotic/somatoform disorders (NSD), and substance misuse (SUB) (exposed). The outcomes assessed were SARS-CoV-2 infection, COVID-19 hospitalization, and COVID-19-related death, compared to matched individuals without these mental disorders (unexposed). Adjusted logistic regression analyses were conducted.</div></div><div><h3>Results</h3><div>785,378 adults were included (70.3% &lt; 65 years old; 57.1% women). Compared to unexposed, those with NAP, BD, DEP, and SUB had a lower risk of SARS-CoV-2 infection, while those with NSD had an increased risk. Infected individuals with DEP, NSD, and SUB had a lower risk of hospitalization but a higher risk of COVID-19-related death. Higher COVID-19-related death was also observed in individuals with NAP and BD. Sex-stratified analysis revealed that women with NSD were especially vulnerable to infection, and women with DEP and NSD had a higher risk of COVID-19-related death.</div></div><div><h3>Conclusions</h3><div>These findings emphasize the need for tailored public health strategies to reduce excess mortality risk among individuals with certain mental disorders, while accounting for sex differences.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116325"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for co-morbid anxiety and depression in pregnant women","authors":"Wei Zhang ,&nbsp;Ling Li ,&nbsp;Xiabidan Tuxunjiang ,&nbsp;Bahedana Sailike ,&nbsp;Xiaoting Wang ,&nbsp;Weicui Meng ,&nbsp;Sufeila Shalayiding ,&nbsp;Ting Jiang","doi":"10.1016/j.psychres.2024.116323","DOIUrl":"10.1016/j.psychres.2024.116323","url":null,"abstract":"<div><div>Co-morbid anxiety and depression (CAD) is defined as the co-existence of anxiety and depression. During pregnancy, women are more prone to negative emotions, such as anxiety and depression, than the general female population. The incidence of CAD during pregnancy is 1–26 %. The aims of this study were to investigate the incidence and influencing factors of CAD during pregnancy. The study cohort included 3053 pregnant women who underwent maternity check-ups at a tertiary hospital in China. Demographic characteristics, level of social support, and psychological characteristics were collected from participants via a self-reported questionnaire, which included the General Demographic Information Questionnaire, Pregnancy Stress Scale, the Generalized Anxiety Scale, Patient Health Questionnaire-9, and Perceived Social Support Scale. A binary logistic regression model and a categorical decision tree based on the Chi-square Automatic Interaction Detector algorithm were used to identify factors influencing CAD during pregnancy, and the differences between the two models were analysed and compared. The results of the logistic regression and decision tree models identified pregnancy stress, social support, pregnancy knowledge, couple relationship satisfaction, advanced maternal age, and occupation as factors influencing CAD during pregnancy. Pregnancy stress was the most influential factor. The areas under the curve of the classification decision tree and logistic regression models were 0.801 (95 % CI: 0.778–0.823) and 0.827 (95 % CI: 0.807–0.847), respectively, with specificities of 63 and 77 %, and sensitivities of 83.9 and 76.3 %. Logistic regression excels when dealing with linear relationships, while decision trees are particularly useful when dealing with nonlinear relationships. Therefore, combining logistic regression and decision trees can achieve some degree of model diversity, thus improving predictive power and confidence in the results.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116323"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sleep quality in mediating the relationship between habenula volume and resilience","authors":"Qi Dai ,&nbsp;Yusuke Kyuragi ,&nbsp;Halwa Zakia ,&nbsp;Naoya Oishi ,&nbsp;Lichang Yao ,&nbsp;Morio Aki ,&nbsp;Mami Shibata ,&nbsp;Zhilin Zhang ,&nbsp;Luyao Wang ,&nbsp;Jiajia Yang ,&nbsp;Toshiya Murai ,&nbsp;Hironobu Fujiwara","doi":"10.1016/j.psychres.2025.116358","DOIUrl":"10.1016/j.psychres.2025.116358","url":null,"abstract":"<div><h3>Background</h3><div>Our human volumetric MRI study (Dai et al., 2024) demonstrated that habenula (Hb) volume is associated with psychological resilience, a key protective factor against depression. However, the biological mechanisms underpinning this relationship remain unclear. A recent animal study highlighted that neuronal activity in the Hb modulates rapid eye movement (REM) sleep, influencing depressive behaviors during wakefulness. Based on this, we hypothesized that sleep quality mediates the relationship between Hb volume and psychological resilience in humans.</div></div><div><h3>Methods</h3><div>We utilized a deep learning-based automated segmentation model to estimate Hb volume from 3T-MRI T1-weighted images of 84 healthy participants. Correlation analyses were performed to examine the relationship between Hb volume and questionnaire-based assessments of sleep quality. Mediation analysis was then conducted with Hb volume as the independent variable, psychological resilience as the dependent variable, and sleep quality as the mediator.</div></div><div><h3>Results</h3><div>Hb volume was found to be negatively correlated with sleep disturbance, indicating that individuals with larger Hb volumes experienced better sleep quality. A lateralization effect was also observed, where greater leftward asymmetry (larger left Hb volume compared to right) was associated with more severe sleep disturbances. Moreover, sleep quality was identified as a mediator in the relationship between Hb volume and psychological resilience.</div></div><div><h3>Conclusion</h3><div>This study provides preliminary evidence of the association among Hb volume, sleep quality, and resilience. Sleep quality appears to be a critical mediator in the biological processes linking smaller Hb volumes to decreased psychological resilience. Enhancing sleep quality may be a promising approach for bolstering psychological resilience and reducing the risk of depression.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116358"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The personal and the national: Lessons learned in the aftermath of the October 7 attacks in Israel","authors":"Inbal Reuveni ,&nbsp;Oren Tene ,&nbsp;Craig L. Katz","doi":"10.1016/j.psychres.2024.116332","DOIUrl":"10.1016/j.psychres.2024.116332","url":null,"abstract":"<div><div>On October 7, 2023, terrorist organizations led by Hamas, launched an extensive attack on Israel. Within days following the initial attack, there was a clear need to provide psychological support to individuals who were exposed to the horrors of the October 7 attacks. Tel-Aviv Sourasky Medical Center – Ichilov, a tertiary medical center, launched an emergency mental health service to provide psychological first aid to the first-line victims of the war. As the fighting spread, the services were extended to the entire population.</div><div>The intervention we provided was guided by an integrated approach that promotes introspection and connectedness to one's environment and community, enhancing cognitive functions, emotional regulation and utilizing available resources to reduce distress. The main themes that emerged shifted between feelings of helplessness and a sense of agency; a breach in basic trust and renewed trust, guilt and self-compassion; anger, abandonment and alienation versus solidarity and connecting to the present and the future, despair versus hope and loss versus acceptance and connectedness.</div><div>The following account reflects our experiences from the unique cooperation between the Mount Sinai Medical Center in New York and the Tel Aviv Medical Center in Israel starting from the days following the October 7 attacks, as well as lessons learned at the individual and system level discussed in light of previous literature and experience.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116332"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a schizophrenia literacy scale for individuals diagnosed with schizophrenia","authors":"Chiu-Yueh Hsiao ,&nbsp;Kuan-Yi Wu ,&nbsp;Chin-Kuai Chiu ,&nbsp;Huei-Lan Lu ,&nbsp;Chi-Rong Li ,&nbsp;Yun-Fang Tsai","doi":"10.1016/j.psychres.2024.116344","DOIUrl":"10.1016/j.psychres.2024.116344","url":null,"abstract":"<div><div>Schizophrenia literacy is key to early identification of schizophrenia and diminishment of stigma. This facilitates help-seeking and adherence to mental health treatment for individuals suffering from schizophrenia. However, validated measures assessing schizophrenia literacy among individuals diagnosed with schizophrenia remain limited. This study aimed to develop and examine the psychometric properties of a schizophrenia literacy scale for individuals diagnosed with schizophrenia. The scale development involved three stages: (a) generating an initial 43 items from a review of literature and existing measures assessing literacy about schizophrenia and knowledge of schizophrenia as well as cognitive interviews; (b) assessing content and face validities; and (c) psychometric testing using a cross-sectional design (268 individuals diagnosed with schizophrenia) to examine construct validity and reliability. Twenty-nine items were retained after evaluating content validity, face validity, and item analysis. Exploratory factor analysis yielded 22 items including five factors (awareness of mental health promotion; stigma against schizophrenia; causal beliefs; recognition of psychiatric symptoms; and traditional and religion-based healthcare) explaining 58.85 % of the total variance. Confirmatory factor analysis showed an acceptable fit of the factor structure. Cronbach's α was 0.95 for the total scale with test-retest reliability of 0.91. The newly developed 22-item schizophrenia literacy scale is a valid and reliable five-dimensional measure and could be used to assess schizophrenia literacy for individuals diagnosed with schizophrenia. The scale may help mental healthcare providers design interventions directed at improving literacy about schizophrenia and promoting mental health for individuals diagnosed with schizophrenia in Chinese-speaking regions and adapted for use in Asian countries.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"344 ","pages":"Article 116344"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}