Psychiatry Research最新文献

{"title":"Psychometric properties of the Spanish Yale-Brown Obsessive-Compulsive Scale – Second Edition","authors":"Eric A. Storch ,&nbsp;Jessica SC. Cheng ,&nbsp;Miranda Higham ,&nbsp;Josselyn S. Muñoz ,&nbsp;Vanessa Zavala Cruz ,&nbsp;Dayan Berrones ,&nbsp;Diana P. Obando ,&nbsp;Jacey L. Anderberg ,&nbsp;Renee M. Frederick ,&nbsp;Vissente Tapia-Cuevas ,&nbsp;Macarena Churruca Muñoz ,&nbsp;Constanza Uribe Villar ,&nbsp;Pablo R. Moya ,&nbsp;Marcos E. Ochoa-Panaifo ,&nbsp;Mayra C. Martinez Mallen ,&nbsp;Andrew D. Wiese ,&nbsp;Caitlin M. Pinciotti ,&nbsp;Melisa N. Sagarnaga ,&nbsp;Joseph F. McGuire ,&nbsp;Ogechi C. Onyeka ,&nbsp;James J. Crowley","doi":"10.1016/j.psychres.2025.116456","DOIUrl":"10.1016/j.psychres.2025.116456","url":null,"abstract":"<div><div>The Yale-Brown Obsessive-Compulsive Scale, Second Edition (Y-BOCS-II) is an evidence-based clinician-rated measure for assessing the presence and severity of obsessive-compulsive symptoms. The Spanish version of the Y-BOCS-II has not yet been validated. The present study examines the psychometric properties of the Spanish Y-BOCS-II (Spanish-Y-BOCS-II) in adults with obsessive-compulsive disorder (OCD) who are of Hispanic/Latino ancestry. The Spanish-Y-BOCS-II was administered to 1805 adults with OCD. Participants also completed a battery of measures assessing OCD, depression, and anxiety symptoms. The internal consistency for the Symptom Checklist (Kuder-Richardson-20=0.92), Obsession Severity (α=0.87), Compulsion Severity (α=0.86), and Total Severity (α=0.92) were high. The inter-rater reliability for the Severity Scale (intraclass correlations=0.98) was excellent. Confirmatory factor analyses showed a marginally acceptable fit with the Obsessions and Compulsions two-factor model; subsequent exploratory factor analysis revealed a one-factor solution consistent with a Total score including all items. Satisfactory construct validity was observed, supported by the strong correlations with other measures of obsessive-compulsive symptom severity and moderate correlations with measures of depression and anxiety symptoms. Overall, the Spanish-Y-BOCS-II demonstrates acceptable reliability and validity properties.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116456"},"PeriodicalIF":4.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional memory biases in bipolar depressed patients with high suicide risk","authors":"Sung Hun Sim ,&nbsp;Chanhee Park ,&nbsp;Eunhye Jeong ,&nbsp;C. Hyung Keun Park","doi":"10.1016/j.psychres.2025.116463","DOIUrl":"10.1016/j.psychres.2025.116463","url":null,"abstract":"<div><div>Emotional memory bias, a neurocognitive deficit commonly observed in mood disorders, refers to the tendency to remember emotionally charged information more precisely than healthy individuals. While this phenomenon has been explored in various psychiatric conditions, its specific relationship with suicide risk in patients with bipolar disorder during major depressive episodes remains unknown. Given the high prevalence of suicide in bipolar disorder, this study sought to examine the association between emotional memory bias and suicide risk in patients with bipolar depression. A recognition memory task was utilized, where participants (51 high-risk, 21 low-risk) viewed words with positive or negative valence and later identified whether they had been previously presented. Mixed-model analyses of covariance, controlling for age and depression severity, revealed that the high-risk group demonstrated a stronger bias toward negative stimuli. They exhibited more accurate recognition of negative words (“hits”) and a higher tendency to incorrectly identify non-presented negative words as presented (“false alarms”) compared to the low-risk group. These findings suggest that heightened emotional memory bias, particularly toward negative information, may be a key cognitive marker of suicide risk in patients with bipolar depression. Understanding this bias may inform targeted interventions aimed at reducing suicide risk in this population.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116463"},"PeriodicalIF":4.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted default mode network connectivity and its role in negative symptoms of schizophrenia","authors":"Chuanlong Cao ,&nbsp;Wanqing Liu ,&nbsp;Chengshi Hou ,&nbsp;Yu Chen ,&nbsp;Fang Liao ,&nbsp;Hui Long ,&nbsp;Dacai Chen ,&nbsp;Xinyu Chen ,&nbsp;Fang Li ,&nbsp;Ju Huang ,&nbsp;Xuanyi Zhou ,&nbsp;Dinghao Luo ,&nbsp;Haibo Qu ,&nbsp;Guocheng Zhao","doi":"10.1016/j.psychres.2025.116489","DOIUrl":"10.1016/j.psychres.2025.116489","url":null,"abstract":"<div><div>Schizophrenia is a complex mental disorder characterised by positive symptoms, negative symptoms, and cognitive deficits, with recent studies suggesting that disruptions in the default mode network (DMN) may underlie many of these symptoms. In this study, we used graph theory analysis of resting-state functional magnetic resonance imaging data to investigate differences in the topological organisation and functional connectivity of the DMN in patients with schizophrenia, using two independent datasets of patients and healthy controls. The findings revealed significant group differences in the DMN of patients with schizophrenia, particularly within the core-medial temporal lobe (MTL) subsystem, characterised by lower shortest path length, clustering coefficient, and small-worldness, indicating less efficient network organisation. Weaker functional connectivity in the core-MTL subsystem was correlated with higher avolition-apathy scores, highlighting the role of DMN connectivity patterns in negative symptoms. These results, validated across two independent datasets, emphasise the robust and generalisable association between schizophrenia and DMN network features, less efficient topological properties, and weaker functional connectivity. This underscores the importance of targeting DMN connectivity to alleviate negative symptoms, improve clinical outcomes, and potentially serve as a biomarker for monitoring symptom severity and guiding treatment.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116489"},"PeriodicalIF":4.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysfunctional striatal-temporal connectivity is associated with a higher risk for violence in patients with schizophrenia","authors":"Juntao Lu ,&nbsp;Ningzhi Gou ,&nbsp;Simei Zhang ,&nbsp;Jiansong Zhou ,&nbsp;Xiaoping Wang","doi":"10.1016/j.psychres.2025.116488","DOIUrl":"10.1016/j.psychres.2025.116488","url":null,"abstract":"<div><div>Patients with schizophrenia (SZ) exhibit an elevated risk of violence compared to the general population. However, the neural mechanisms of violence in SZ are still unclear. This study examined the neural correlates linked to violence in SZ and determine whether the brain abnormalities were associated with psychotic symptoms of severe delusions. We performed resting-state functional magnetic resonance imaging and assessed the severity of clinical symptoms and personality traits in 140 male participants, aged 18 to 50 years, comprising 39 violent patients with schizophrenia (VSZ), 45 non-violent patients with schizophrenia (NVSZ), and 56 healthy controls (HC). The results showed increased functional connectivity (FC) in the VSZ group in the right insula - middle frontal gyrus coupling(<em>p</em> &lt; 0.001) and right fusiform gyrus (FFG) - left caudate (CAU) coupling (<em>p</em> &lt; 0.001) as well as decreased FC in the right nucleus accumbens (NAcc) – FFG coupling (<em>p</em> = 0.002), compared to the NVSZ and HC groups. Correlation analysis revealed a negative association between affective deficit and FC of the right NAcc - FFG coupling in the VSZ group only (<em>r</em> = -0.350, <em>p</em> = 0.029). Additionally, suspiciousness correlated negatively with the FC value of the right CAU - left middle temporal gyrus coupling in the VSZ (<em>r</em> = -0.387, <em>p</em> = 0.029) and all-patient groups (<em>r</em> = -0.304, <em>p</em> = 0.023). Our findings suggested that aberrant connections between the cortex and subcortical nuclei, especially the striatal-temporal circuit, might be involved in the neurobiological mechanisms of violence in SZ; at the same time, dysfunction of the CAU might be linked to the disease per se. This study highlighting a specific association between violence and psychopathy rather than symptoms of SZ.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116488"},"PeriodicalIF":4.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using speech analysis in virtual agent conversations to differentiate PTSD patients from control participants","authors":"Felix Menne ,&nbsp;Simona Schäfer ,&nbsp;Nicklas Linz ,&nbsp;Johannes Tröger ,&nbsp;Louisa Schwed ,&nbsp;Eric Ettore ,&nbsp;Alexandra König","doi":"10.1016/j.psychres.2025.116486","DOIUrl":"10.1016/j.psychres.2025.116486","url":null,"abstract":"<div><div>Diagnosing posttraumatic stress disorder (PTSD) remains challenging due to clinical overlap with conditions like depression and patients' reluctance to disclose symptoms. This study analyzed pre-existing data to investigate whether speech features extracted from semi-structured interviews with a virtual avatar could enhance traditional diagnostic approaches by utilizing automated voice analysis, which can detect nuances beyond human hearing, potentially improving sensitivity and specificity in diagnosing PTSD. Leveraging the DAIC-WoZ dataset (Gratch et al., 2014), which includes 142 dialogues (average length: 954 s) between participants and a virtual avatar, we extracted content and acoustic features from transcripts and audio recordings. Group comparisons aimed to identify differences between PTSD and non-PTSD participants, as well as distinctions between PTSD participants with and without comorbid depression. Key findings revealed that PTSD participants expressed more negative sentiment in their speech (η²=0.82, <em>p</em> &lt; 0.001) and used less frequent words (η²=0.65, <em>p</em> &lt; 0.001) compared to controls. To demonstrate the utility of speech features, classification models were developed to differentiate PTSD and control participants. A linear model with twenty-one speech features (balanced accuracy = 0.70) outperformed a model based solely on demographic data (balanced accuracy = 0.53). Subgroup analyses found no significant differences in speech features between PTSD participants with and without comorbid depression. These results suggest that automated speech analysis, facilitated by virtual avatars, can identify linguistic markers of PTSD, potentially aiding diagnosis and reducing barriers to disclosure. However, further research is needed to generalize these findings and explore their utility in clinical practice.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116486"},"PeriodicalIF":4.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health of prerelease incarcerated women","authors":"Marion ECK ,&nbsp;Camille LANCELEVEE ,&nbsp;Marielle WATHELET ,&nbsp;Ali AMAD ,&nbsp;Imane BENRADIA ,&nbsp;Kevin D'OVIDIO ,&nbsp;Stéphane DUHEM ,&nbsp;Pierre THOMAS ,&nbsp;Thomas FOVET","doi":"10.1016/j.psychres.2025.116485","DOIUrl":"10.1016/j.psychres.2025.116485","url":null,"abstract":"<div><h3>Background</h3><div>The mental health of incarcerated women is particularly poor, yet little is known about their condition during the prerelease period. This critical transition is shaped by stressors related to incarceration and the challenges of reintegration, raising important concerns. Notably, the release phase that follows is characterized by risks of rehospitalization, reincarceration and suicide among individuals with psychiatric disorders and/or substance use disorders (SUDs). The aim of this study was to estimate the prevalence of psychiatric disorders, SUDs and dual diagnoses (DDs, i.e., the combination of severe psychiatric disorder and SUD) among incarcerated women scheduled to be released soon.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional survey from April 2021 to September 2022 across 4 women's correctional facilities in Northern France. This study included all adult women identified by the prison administration as having a scheduled release date within 30 days. Each participant was interviewed via a structured interviewer-administered questionnaire, which included the Mini International Neuropsychiatric Interview.</div></div><div><h3>Findings</h3><div>Among the 248 women identified by the prison administration, 127 were ultimately enrolled in this study (mean age 36.3 years). We found high prevalences of psychiatric disorders (of the participants, 48.0% had current depressive episodes, 28.3% had current generalized anxiety disorder, and 26.8% had current posttraumatic stress disorder), SUDs (59.1%) and DDs (38.6%).</div></div><div><h3>Interpretation</h3><div>The alarming prevalences of psychiatric disorders, SUDs, and DDs among our sample highlight the urgent need for integrated care that bridges incarceration and postrelease psychiatric settings for incarcerated women. Combining psychiatric, addiction, and social support services is essential for addressing the complex mental health needs and improving reintegration outcomes in this population.</div></div><div><h3>Funding</h3><div>This study was funded by the French <em>Direction Générale la Santé</em> – Directorate-General of Health (DGS) and <em>Santé Publique France</em> – Public Health France (SPF).</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116485"},"PeriodicalIF":4.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood opportunity and response to psychotherapy in anxious youth","authors":"Chase Antonacci ,&nbsp;André Zugman ,&nbsp;Isaac Morales ,&nbsp;Elise M. Cardinale ,&nbsp;Samuel E.C. Frank ,&nbsp;Krystal M. Lewis ,&nbsp;Erin Berman ,&nbsp;Ian H. Gotlib ,&nbsp;Daniel S. Pine","doi":"10.1016/j.psychres.2025.116484","DOIUrl":"10.1016/j.psychres.2025.116484","url":null,"abstract":"<div><div>Early adversity is a well-documented risk factor for anxiety disorders in youth; few studies, however, have examined how exposure to adversity influences treatment outcomes. Emerging research suggests that systemic inequities can affect the efficacy of frontline psychotherapies. The effects of structural disadvantage and, in particular, neighborhood-level features on treatment outcomes for pediatric anxiety are largely under-studied. The current study aimed to examine the impact of neighborhood opportunity on children's response to cognitive behavioral therapy (CBT). A total of 202 youth aged 8–17 years (M_age = 12.030, 56 % F) with a diagnosed anxiety disorder completed 8–12 weeks of exposure-based CBT. Neighborhood disadvantage was quantified using the Child Opportunity Index (COI), and treatment response was measured via the Pediatric Anxiety Rating Scale (PARS) at baseline, post-treatment, and a 6-month follow-up assessment. Following treatment, anxious youth exhibited a significant 31.523 % reduction in symptoms. Across all scoring dimensions of the COI (socioeconomic, education, and health &amp; environment), neighborhood disadvantage did not reliably predict treatment response. These findings suggest that when provided access to high-quality, evidence-based psychotherapy, youth from lower opportunity neighborhoods achieve comparable outcomes to their more advantaged peers. Taken together with prior research, this study suggests that structural disadvantage at the neighborhood level is not a robust predictor of treatment outcomes in the context of pediatric anxiety. These findings raise the possibility that equitable access to treatment could, in certain circumstances, mitigate the negative effects of systemic neighborhood-level inequities on mental health outcomes, underscoring the importance of expanding the availability of treatment services.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116484"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone digital phenotyping in mental health disorders: A review of raw sensors utilized, machine learning processing pipelines, and derived behavioral features","authors":"Jake Linardon ,&nbsp;Kelly Chen ,&nbsp;Shruti Gajjar ,&nbsp;Amrik Eadara ,&nbsp;Shiwei Wang ,&nbsp;Matthew Flathers ,&nbsp;James Burns ,&nbsp;John Torous","doi":"10.1016/j.psychres.2025.116483","DOIUrl":"10.1016/j.psychres.2025.116483","url":null,"abstract":"<div><div>With increased access to digital technology, there has been a surge in the use of and interest in digital phenotyping as a tool to calculate various features from raw smart device data. However, the increased usage of digital phenotyping has created confusion. The vast number of sensors that can be utilized to collect passive data, and diverse methods utilized to convert that sensor data into features has introduced conflicting results and conclusions into the literature. Consequently, there is an identified need for standardizing how digital phenotyping data is measured and collected. This review evaluates the different sensors and methods utilized in digital phenotyping research across 112 papers, with the goal of finding the most common platforms, sensors, and methods for each behavioral measure. This should help guide future digital phenotyping research, and resolve some existing confusion in the field. Information on each study's data sensor variables were tracked and consolidated into a double-coded Codebook. Variables assessed included but were not limited to data sensors, features extracted from data sensors, statistical methods used, phone type, patient access to phones, and characteristics of patient population. This review found that most studies used Android devices (<em>n</em> = 67) or both Android and iPhone (<em>n</em> = 38) with an average duration of 14.3 weeks. The GPS sensor was also found to be the most frequently used sensor. This review underscores the need for standardization in methodological reporting, sensor utilization, and feature extraction across mental health studies.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116483"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between medication adherence and the risk of different violent behaviors: A cohort study in young patients with severe mental illness","authors":"Xiaolan Yin ,&nbsp;Chuanlong Zuo ,&nbsp;Ruoxin Fan ,&nbsp;Jun Liu ,&nbsp;Hu Xiang ,&nbsp;Mingjin Huang ,&nbsp;Xing Zhao ,&nbsp;Xiang Liu ,&nbsp;Xianmei Yang ,&nbsp;Yuanyuan Liu","doi":"10.1016/j.psychres.2025.116481","DOIUrl":"10.1016/j.psychres.2025.116481","url":null,"abstract":"<div><h3>Background</h3><div>Whether poor medication adherence increases the risk of violent behaviors in people with severe mental illness (SMI) is a critical public health issue, but it has not yet been explored in a population of young patients with SMI. This study aims to analyze whether low medication adherence increases the risk of violence to others and self-inflicted violence among young patients with SMI.</div></div><div><h3>Methods</h3><div>Data for this study was obtained from a community-based cohort of patients with SMI from 2006 to 2018 in western China. The association between medication adherence and various violent behaviors was analyzed using a multilevel Cox proportional risk regression model and restricted mean survival time.</div></div><div><h3>Results</h3><div>A total of 52,917 young patients with SMI were included in this study. The incidences were 15.6 % for the total violence to others and 1.9 % for the total self-inflicted violence in the low medication adherence group, both higher than that in the non-low adherence group. After controlling confounders, low medication adherence increased the risk of total violence to others (HR=1.673, 95 % CI 1.582–1.768), minor nuisance (HR=1.770, 95 % CI 1.670–1.876), violating APS law (HR=1.754, 95 % CI 1.542–1.995), total self-inflicted violence (HR=1.654, 95 % CI 1.423–1.923), non-suicidal self-injury (HR=1.628, 95 % CI 1.362–1.947), and suicide attempt (HR=1.628, 95 % CI 1.322–2.004).</div></div><div><h3>Conclusions</h3><div>This study found that low medication adherence increased the risk of violent behaviors in young patients with SMI, suggesting the need for future targeted measures to identify and intervene in the risk of various types of violence that may occur in patients.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116481"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 pandemic-related restrictive measures on overall mental and physical health and well-being, specific psychopathologies and emotional states in representative adult Greek population: Results from the largest multi-wave, online national survey in Greece (COH-FIT)","authors":"Agorastos Agorastos ,&nbsp;Christos Christogiannis ,&nbsp;Dimitris Mavridis ,&nbsp;Georgios Seitidis ,&nbsp;Katerina M. Kontouli ,&nbsp;Sofia Tsokani ,&nbsp;Ourania Koutsiouroumpa ,&nbsp;Kostantinos Tsamakis ,&nbsp;Marco Solmi ,&nbsp;Trevor Thompson ,&nbsp;Cristoph U. Correll ,&nbsp;Elena Dragioti ,&nbsp;Vasilios P. Bozikas","doi":"10.1016/j.psychres.2025.116479","DOIUrl":"10.1016/j.psychres.2025.116479","url":null,"abstract":"<div><h3>Background</h3><div>Greece faced particular COVID-19-pandemic-related challenges, due to specific socio-cultural-economic/public-health factors and drastic restrictive policies.</div></div><div><h3>Objectives</h3><div>To understand trajectories of overall mental and physical health, well-being, emotional states and individual psychopathology in response to pandemic-related restrictive measures within general adult Greek population across the first two pandemic waves.</div></div><div><h3>Methods</h3><div>Using multiple time-point cross-sectional data from the “Collaborative Outcomes study on Health and Functioning during Infection Times” (COH-FIT), we examined changes in outcomes from retrospective pre-pandemic ratings (T0) to three distinct intra-pandemic time points (lockdown 1: T1, between lockdowns: T2, lockdown 2: T3). Primary outcomes included WHO-5 well-being scores and a composite overall psychopathology “P-score”, followed by a wide range of secondary outcomes.</div></div><div><h3>Results</h3><div>10,377 participant responses were evaluated, including 2737 representative-matched participants. Statistically significant differences in well-being and overall psychopathology before and after quarantine (T0 vs. T1-T3), as well as across the assessed time frames (T1, T2, and T3) emerged in both samples. Global mental and physical health, individual psychopathology scores (anxiety, depression, PTSD, OCD, panic, mania, mood swings, sleep and concentration problems), emotional states (anger, helplessness, fear of infection, boredom, frustration, loneliness and overall stress scores), BMI and pain scores also showed statistically significant time differences in both samples, with the exemption of self-injury and suicidal attempt scores, showing lower intra-pandemic scores.</div></div><div><h3>Conclusions</h3><div>This is the largest multi-wave report on well-being, mental and physical health across different pandemic restriction periods in Greece, suggesting a substantial negative effect of lockdowns on most outcomes at least during the acute pandemic waves.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"348 ","pages":"Article 116479"},"PeriodicalIF":4.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}