Psychiatry Research最新文献

The economic burden of schizophrenia spectrum disorders: clinical and functional correlates and predictors of direct costs. A retrospective longitudinal study 精神分裂症谱系障碍的经济负担：临床和功能相关性以及直接成本的预测因素。一项回顾性纵向研究。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-31 DOI: 10.1016/j.psychres.2024.116240

{"title":"The economic burden of schizophrenia spectrum disorders: clinical and functional correlates and predictors of direct costs. A retrospective longitudinal study","authors":"","doi":"10.1016/j.psychres.2024.116240","DOIUrl":"10.1016/j.psychres.2024.116240","url":null,"abstract":"<div><div>The economic burden of schizophrenia amounts for 1.5-3 % of healthcare expenses in developed countries, and ∼50 % derives from direct costs: 81 % of these are due to hospitalization, residential facilities and semi-residential facilities. Therefore, a better characterization of variables that influence direct costs represents a relevant issue.</div><div>A total of 276 individuals with schizophrenia spectrum disorders receiving treatment from the Community Mental Health Centers of Brescia (Italy) were included in the study: for each participant socio-demographic, clinical and functional characteristics were assessed, and data related to the use of services in 2022 (then converted to costs) were collected. Regression analyses were performed to identify predictors of costs.</div><div>A direct healthcare expenditure of 16477.23 (±32856.47) € per patient per year was identified. The main cost predictor was the PSP total score (p=0.005), followed by age of onset (p=0.020), and PANSS total score (p=0.033). Including PANSS sub-scales scores and PSP single items as potential predictors, the main predictor was the “socially useful activities” PSP item (p=0.002), followed by age of onset (p=0.011), and PANSS negative scale score (p=0.027).</div><div>Our findings underline the need to implement rehabilitative intervention focused on the improvement of psychosocial functioning and negative symptoms, also to reduce healthcare expenses.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder 外周和中枢神经系统免疫标记物水平升高反映了自闭症谱系障碍的先天免疫失调

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-30 DOI: 10.1016/j.psychres.2024.116245

{"title":"Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder","authors":"","doi":"10.1016/j.psychres.2024.116245","DOIUrl":"10.1016/j.psychres.2024.116245","url":null,"abstract":"<div><h3>Background</h3><div>Evidence suggests dysregulated immune functions in the pathophysiology of Autism spectrum disorder (ASD), although specific immune mechanisms are yet to be identified.</div></div><div><h3>Methods</h3><div>We assessed circulating levels of 25 immune/neuroinflammatory markers in a large ASD sample (<em>n</em> = 151) and matched controls (<em>n</em> = 72) using linear models. In addition, we performed global brain transcriptomics analyses of relevant immune-related genes. We also assessed the expression and function of factors and pathway elements of the inflammasome system in peripheral blood mononuclear cells (PBMC) isolated from ASD and controls using <em>in vitro</em> methods.</div></div><div><h3>Results</h3><div>We found higher circulating levels of IL-18 and adhesion factors (ICAM-1, MADCAM1) in individuals with ASD relative to controls. Consistent with this, brain levels of <em>ICAM1</em> mRNA were also higher in ASD compared to controls. Furthermore, we found higher expression/activity of Caspase-1 and the inflammasome sensor NLRP3 in PBMCs in ASD, both at baseline and following inflammatory challenge. This corresponded with higher levels of secreted IL-18, IL-1β, and IL-8, as well as increased expression of adhesion factors following inflammasome activation in ASD PBMC cultures. Inhibition of the NLRP3-inflammasome rescued the observed immune phenotype in ASD <em>in vitro</em>.</div></div><div><h3>Conclusion</h3><div>Our results suggest a role for inflammasome dysregulation in ASD pathophysiology.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting mid- and late-life dementia risk in primary care: A prognostic study from a national health screening cohort 预测初级保健中的中晚期痴呆症风险：一项来自全国健康检查队列的预后研究。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-30 DOI: 10.1016/j.psychres.2024.116237

{"title":"Predicting mid- and late-life dementia risk in primary care: A prognostic study from a national health screening cohort","authors":"","doi":"10.1016/j.psychres.2024.116237","DOIUrl":"10.1016/j.psychres.2024.116237","url":null,"abstract":"<div><div>The objective of this study is to develop and validate dementia risk prediction models for mid- and late-life individuals that are based on accessible variables within a primary care setting. Using the Korean National Health Insurance Service database (2010–2019), we analyzed 6,696,073 individuals aged 40 and older who participated in a national health screening program over a mean follow-up of 8.95 years. Potential predictors were selected based on a literature review and the available data. Dementia cases were identified using claim-based codes and validated by corresponding prescription information. 5-year dementia risk prediction models for mid-life (40–59 years), and late-life (60+ years) stages were developed using the Cox proportional hazards model. Model performance was assessed through discrimination and calibration. Both models included age, sex, body mass index, smoking, alcohol consumption, physical activity, diabetes, hypertension, dyslipidemia, and chronic kidney disease. The models’ AUROCs were 0.764 for mid-life and 0.743 for late-life. The impact of predictors on dementia risk was consistently stronger in mid-life than in late-life stages. Our models showed good calibration with low-risk estimates in mid-life and overall in late-life. These findings underscore the crucial role of managing modifiable risk factors, particularly during mid-life to reduce dementia risk.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional brain networks in clinical high-risk for bipolar disorder and psychosis 躁郁症和精神病临床高危人群的大脑功能网络。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-28 DOI: 10.1016/j.psychres.2024.116251

{"title":"Functional brain networks in clinical high-risk for bipolar disorder and psychosis","authors":"","doi":"10.1016/j.psychres.2024.116251","DOIUrl":"10.1016/j.psychres.2024.116251","url":null,"abstract":"<div><div>Abnormal connectivity in the brain has been linked to the pathophysiology of severe mental illnesses, including bipolar disorder and schizophrenia. The current study aimed to investigate large-scale functional networks and global network metrics in clinical high-risk for bipolardisorder (CHR-BD, <em>n</em> = 25), clinical high-risk for psychosis (CHR-P, <em>n</em> = 30), and healthy controls (HCs, <em>n</em> = 19). Help-seeking youth at CHR-BD and CHR-P were recruited from the early intervention program at Dokuz Eylul University, Izmir, Turkey. Resting-state functional magnetic resonance imaging scans were obtained from youth at CHR-BD, CHR-P, and HCs. Graph theoretical analysis and network-based statistics were employed to construct and examine the topological features of the whole-brain metrics and large-scale functional networks. Connectivity was increased (i) between the visual and default mode, (ii) between the visual and salience, (iii) between the visual and cingulo-opercular networks, and decreased (i) within the default mode and (ii) between the default mode and fronto-parietal networks in the CHR-P compared to HCs. Decreased global efficiency was found in CHR-P compared to CHR-BD. Functional networks were not different between CHR-BD and HCs. Global efficiency was negatively correlated with subthreshold positive symptoms and thought disorder in the high-risk groups. The current results suggest disrupted networks in CHR-P compared to HCs and CHR-BD. Moreover, transdiagnostic psychosis features are linked to functional brain networks in the at-risk groups. However, given the small, medicated sample, results are exploratory and hypothesis-generating.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does depression with current suicidal ideation lead to treatment-resistant depression? Two large naturalistic cohorts of outpatients with depression and current suicidal ideation 有自杀倾向的抑郁症会导致耐药性抑郁症吗？对患有抑郁症并有自杀倾向的门诊患者进行的两项大型自然研究。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-28 DOI: 10.1016/j.psychres.2024.116249

{"title":"Does depression with current suicidal ideation lead to treatment-resistant depression? Two large naturalistic cohorts of outpatients with depression and current suicidal ideation","authors":"","doi":"10.1016/j.psychres.2024.116249","DOIUrl":"10.1016/j.psychres.2024.116249","url":null,"abstract":"<div><div>As treatment-resistant depression (TRD) is linked to suicidal behaviors and suicidal risk is a predictor of TRD, depression with current suicidal ideation (SI) may lead to TRD. Early identification of TRD risk factors in patients with depression and current SI is crucial. The aims of our study were: i) to identify risk factors for depression non-remission and TRD in patients with depression and current SI; ii) to assess if SI at baseline mediated the relationship between depression severity at baseline and depression remission at week 6. We analyzed data from two large, prospective, naturalistic French cohorts of adult outpatients with depression (DSM-IV criteria) followed for 6 weeks after starting or changing antidepressants (LUEUR and GENESE). Sociodemographic and clinical characteristics, along with early symptom improvement, were compared between patients with and without current SI using logistic regression models (univariate and multivariate). Patients with antidepressant change or initiation were analyzed separately. Those without depression remission at week 6 after an antidepressant change were considered TRD cases. In patients with antidepressant change, the major predictor of non-remission was poorer early improvement (at week 2) of anxiety. For patients with treatment initiation, SI at baseline mediated the relation between depression severity at baseline and depression remission. Depression severity at baseline alone did not explain depression remission. Clinicians should systematically target with specific pharmacological and non-pharmacological treatments anxiety and SI and assess their changes in the short term to increase the chance of depression remission in depressed patients with current SI.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catatonia in autism spectrum disorders: Prevalence, functional impact, and diagnostic insights 自闭症谱系障碍中的紧张症：发病率、对功能的影响和诊断见解。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-28 DOI: 10.1016/j.psychres.2024.116250

{"title":"Catatonia in autism spectrum disorders: Prevalence, functional impact, and diagnostic insights","authors":"","doi":"10.1016/j.psychres.2024.116250","DOIUrl":"10.1016/j.psychres.2024.116250","url":null,"abstract":"<div><div>The current study aimed to evaluate subtle catatonia behaviors and functionality in adolescents with autism spectrum disorders (ASD). The sample consisted of 48 patients (11 female, 37 male) aged 12–18 (13.77 ± 2.01). DSM-5 catatonia criteria and Bush-Francis Catatonia Rating Scale (BCRS) was utilized to assess catatonia, while the impairment in functionality was appraised using the Global Assessment Scale. Parents fulfilled the Revised Child Anxiety and Depression Scale-Parent version (RCADS-PV) and Repetitive Behavior Scale-Revised (RBS-R). The presence of catatonia was detected in 18 out of 48 (37.5 %) participants according to BCRS, and in 16 cases (35.4 %) according to DSM-5 criteria. A significant association between two diagnostic tools was observed (<em>p</em> < 0.001). In the group with mild impairment in functionality, 2 cases had catatonia (12.5 %), while in the group with more impaired functionality, 16 cases (50 %) had catatonia (<em>p</em> = 0.011) according to BCRS. Major depressive disorder subscale scores of RCADS-PV and stereotypic movements (RBS-R) were correlated with the presence of catatonia (<em>p</em> < 0.05). The findings suggest a higher prevalence of catatonia in ASD, and a potential correlation between the presence of catatonia and functionality. More research is warranted to highlight the presence and course of catatonia beginning from the early years of ASD.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Letter to the editor, associated with the article entitled “efficacy and safety of eight enhanced therapies for treatment-resistant depression: A systematic review and network meta-analysis of RCTs.” (Guo et al., Psychiatry Res, 2024 Jun 20:339:116,018.) 致编辑的一封信，与题为 "八种增强疗法治疗耐药性抑郁症的疗效和安全性：RCTs的系统综述和网络荟萃分析"（Guo等人，Psychiatry Res，2024年6月20日：339：116-116(Guo等，《精神病学研究》，2024年6月20日：339:116,018）。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-28 DOI: 10.1016/j.psychres.2024.116252

引用次数: 0

Association of social support with depression and anxiety among the migrant population of Henan, China: Based on a large cross-sectional study 中国河南流动人口中社会支持与抑郁和焦虑的关系：基于一项大型横断面研究。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-28 DOI: 10.1016/j.psychres.2024.116246

{"title":"Association of social support with depression and anxiety among the migrant population of Henan, China: Based on a large cross-sectional study","authors":"","doi":"10.1016/j.psychres.2024.116246","DOIUrl":"10.1016/j.psychres.2024.116246","url":null,"abstract":"<div><div>Amid China’s rapid urbanization, the growing migrant population has increasingly drawn attention due to the rising prevalence of mental health concerns. Based on a large cross-sectional study, we explored the relationship between social factors and depression and anxiety among the migrant population and also quantified the correlations of different dimensions of social support and the varying levels of depression and anxiety. Results showed that the prevalence of depression and anxiety are 47.0% and 34.9%, respectively, among the 19,498 migrant populations. Females and individuals with chronic conditions were found to be more vulnerable to experiencing symptoms of anxiety and depression within the migrant population. Participants who received higher levels of social support were less likely to experience symptoms of depression and anxiety. Additionally, various dimensions of social support (including subjective, objective, and utilization) exhibited significant negative associations with different levels of depression and anxiety within the migrant population. Social support plays a crucial role in alleviating depression and anxiety among the migrant population, particularly in mitigating moderate and severe symptoms, which provides an important reference for improving the mental well-being of the migrant population.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A qualitative analysis of participant experience during an EEG-linked auditory targeted cognitive training exercise: Implications for implementation and protocol optimization. 定性分析参与者在与脑电图相连的听觉定向认知训练中的体验：对实施和方案优化的影响。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-28 DOI: 10.1016/j.psychres.2024.116254

Carmen Conroy, Francesca Li, Joyce Sprock, Borsika A Rabin, Yash B Joshi

{"title":"A qualitative analysis of participant experience during an EEG-linked auditory targeted cognitive training exercise: Implications for implementation and protocol optimization.","authors":"Carmen Conroy, Francesca Li, Joyce Sprock, Borsika A Rabin, Yash B Joshi","doi":"10.1016/j.psychres.2024.116254","DOIUrl":"https://doi.org/10.1016/j.psychres.2024.116254","url":null,"abstract":"<p><p>Auditory-based targeted cognitive training (ATCT) is an emerging adaptive neuroplasticity-based intervention. Previous studies have shown that electroencephalographic (EEG) biomarkers of auditory information processing assessed at the start of ATCT have predicted cognitive, clinical, and functional gains from a full 30-40 hour ATCT program, but participant attitudes related to coupling EEG to ATCT are not well-known. This study assessed stakeholder feedback related to EEG biomarker collection as part of ATCT to optimize future EEG-informed ATCT studies. Semi-structured interviews assessed attitudes of ATCT-naïve participants (n=50) living with a range of psychiatric disorders and cognitive function who underwent EEG assessment associated with a 1 hour ATCT exercise. A deductive approach was used to code the data and an iterative approach was employed to identify key emerging themes. Interview data yielded 62 unique themes related to EEG biomarker collection and ATCT. Qualitative analysis identified positive and negative elements of participants' experience of EEG-informed ATCT as well as ways to streamline the EEG experience. Results suggest EEG-informed ATCT studies may be optimized using actionable improvements to current protocols leveraged from themes identified.</p>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mental health toll of the Russian-Ukraine war across 11 countries: Cross-sectional data on war-related stressors, PTSD and CPTSD symptoms 俄乌战争在 11 个国家造成的心理健康损失：与战争有关的压力源、创伤后应激障碍和 CPTSD 症状的横断面数据。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-10-25 DOI: 10.1016/j.psychres.2024.116248

{"title":"The mental health toll of the Russian-Ukraine war across 11 countries: Cross-sectional data on war-related stressors, PTSD and CPTSD symptoms","authors":"","doi":"10.1016/j.psychres.2024.116248","DOIUrl":"10.1016/j.psychres.2024.116248","url":null,"abstract":"<div><div>Exposure to war is a severe traumatic experience with disastrous mental health effects. This study examined the mental health among 5,560 residents in 11 countries worldwide at different geographic distances from the epicenter of the Russian-Ukrainian War (RUW). An online questionnaire assessed war-related variables (e.g., personal experiences with RUW, perceived concern and threat), previous life stress experiences, and mental health (i.e., resilience, anxiety, depression, perceived stress, ICD-11 PTSD, and CPTSD). Results showed regional differences. Ukrainians had the worst mental health indices, followed by participants in the bordering countries, and then by those in the distal ones. War-related variables were associated with worse mental health. The common predictors for PTSD and CPTSD were previous mental disorder, anxiety, and perceived stress, whereas unique predictors were also found (PTSD: female gender and impact of news on mental health; CPTSD: being single, overall impact of war on mental health, sum of lifetime traumatic experiences, resilience (inversely), and depression). Given the continuing uncertainty about the threat of war for many of the nations in this study, findings suggest the need for practitioners to support concerned populations.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0