Psychiatry Research最新文献

{"title":"Suicide following discharge from inpatient psychiatric care: A retrospective case control study","authors":"Chase Thompson ,&nbsp;Weam Sieffien ,&nbsp;Tomisin Iwajomo ,&nbsp;Joyce Mason ,&nbsp;Claire de Oliveira ,&nbsp;David Rudoler ,&nbsp;Ishrat Husain ,&nbsp;Paul Kurdyak ,&nbsp;Juveria Zaheer","doi":"10.1016/j.psychres.2025.116645","DOIUrl":"10.1016/j.psychres.2025.116645","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The period following discharge from psychiatric hospitalization is associated with high suicide risk. This study sought to determine the rate and associated risk factors of individuals who die by suicide after discharge in Ontario, Canada.</div></div><div><h3>Methods</h3><div>This retrospective case-control study, spanning from 2006-2018, utilized Ontario data to compare individuals who died by suicide within 7, 30, and 90 days of discharge with controls. Clinical, demographic, and healthcare utilization factors were compared. A Cox proportional hazards model was utilized to determine factors independently associated with suicide.</div></div><div><h3>Results</h3><div>Across 615,067 psychiatric discharges, there were 320, 771, and 1325 suicide deaths within a 7-, 30-, and 90-day period respectively. These deaths correspond to a suicide rate of 2713, 1525, and 882 deaths per 100,000 person-years and 0.52, 1.25, and 2.15 suicides per 1000 discharged individuals. Cases were more likely to be male, aged 45-54, involve unplanned discharge and a history of suicidal behaviour, and admitted for mood or adjustment disorders. Rural residence, income, medical comorbidity, alcohol, substance use disorder, and psychotic illness were not significantly associated with suicide. Healthcare service utilization did not differ significantly.</div></div><div><h3>Conclusions</h3><div>The suicide rate is highest immediately following discharge and remains elevated above that of the general Canadian population throughout the 90 days afterward. Risk factors identified include mood disorders, male sex, middle age, shorter length of stay, and unplanned discharge - consistent with previous work. Individuals with unplanned discharges and shorter lengths of stay may be good candidates for closer follow-up to mitigate risk.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116645"},"PeriodicalIF":4.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-grade inflammation, cognitive dysfunction, impulsivity, and appetite hormone dysregulation in adolescents with attention deficit hyperactivity disorder","authors":"Li-Chi Chen ,&nbsp;Ya-Mei Bai ,&nbsp;Shih-Jen Tsai ,&nbsp;Ju-Wei Hsu ,&nbsp;Mu-Hong Chen","doi":"10.1016/j.psychres.2025.116644","DOIUrl":"10.1016/j.psychres.2025.116644","url":null,"abstract":"<div><h3>Background</h3><div>Research has identified an inflammatory biotype of attention deficit hyperactivity disorder (ADHD). However, the relation between low-grade inflammation (LGI), subjective clinical symptoms, appetite hormone regulation, and cognitive function in adolescents with ADHD remain unclear.</div></div><div><h3>Methods</h3><div>In all, 88 adolescents with ADHD and 65 healthy adolescents participated in this study. Low-grade inflammation was defined using biochemical criteria (C-reactive protein levels ≥ 3 mg/L) or phenotypic criteria (body mass index ≥ 30 kg/m²). All adolescents answered questions on the Barratt Impulsiveness Scale (BIS) and completed two cognitive tasks: the go/no-go task and the Wisconsin Card Sorting Test (WCST). Parents answered questions on the Swanson, Nolan, and Pelham IV (SNAP-IV) scale for their children’s attention and behavior symptoms.</div></div><div><h3>Results</h3><div>Among the adolescents with ADHD, 16 (18.2 %) were categorized into the low-grade inflammation group. Generalized linear models, adjusted for age, sex, and SNAP-IV scores, revealed that adolescents with ADHD and low-grade inflammation had the highest self-reported overall impulsiveness (BIS total scores; <em>p</em> = 0.006), inattention (BIS-attention subscale scores; <em>p</em> = 0.005), and poor self-control (BIS-self-control subscale scores; <em>p</em> = 0.006). Additionally, this group had the highest insulin (<em>p</em> = 0.003) and leptin levels (<em>p</em> &lt; 0.001) relative to the control group and to the group with ADHD without low-grade inflammation. Adolescents with ADHD and low-grade inflammation, in particular, exhibited poor cognitive performance as measured by the go/no-go task and WCST.</div></div><div><h3>Discussion</h3><div>These findings suggest an immune-metabolic subtype of ADHD, indicating that adolescents with ADHD and low-grade inflammation experience more severe impulsivity, disrupted appetite hormone levels, and impaired cognitive function.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116644"},"PeriodicalIF":4.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The psychological consequences of the sedating side effects of antipsychotic medication: A systematic review","authors":"Sarah Reeve ,&nbsp;Kate Robbins ,&nbsp;Jo Hodgekins","doi":"10.1016/j.psychres.2025.116641","DOIUrl":"10.1016/j.psychres.2025.116641","url":null,"abstract":"<div><h3>Background</h3><div>Sedation is a common side effects of antipsychotic medication. It is poorly defined but is generally understood to encompass excessive daytime sleepiness, difficulty thinking or concentrating, and oversleeping. Sedation is often cited as impacting on functioning and wellbeing, however no review to date has assessed this relationship.</div></div><div><h3>Aims of review</h3><div>This review aims to explore the impact of the sedating side effects of antipsychotic medication on patient functioning and wellbeing.</div></div><div><h3>Methods</h3><div>Papers were identified by searching the databases PubMed, PsycINFO, EBSCO, CINAHL, and Clarivate Web of Science. A narrative synthesis and quality appraisal was conducted.</div></div><div><h3>Results</h3><div>Eleven peer reviewed papers met the eligibility criteria. Sedation was often identified as the most common side effect, but was not uniformly defined. Results consistently supported a negative effect of sedation on functioning (e.g. ability to perform day-to-day tasks and motivation). With respect to wellbeing, a negative impact of sedation was identified on quality of life and anhedonia, but less consistent interactions with other domains (e.g. anxiety), with few papers reporting on these links.</div></div><div><h3>Conclusion</h3><div>Despite the plausible impact of sedation on patients being widely discussed, there is surprisingly little empirical research in this area. The research that exists broadly supports a negative impact of sedation on functioning and wellbeing, although there are some complexities requiring further investigation, and many domains (e.g. interaction with mood) have not been substantively investigated. Sedation may be an important adverse side effect that is relevant to consider in improving recovery from psychosis.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116641"},"PeriodicalIF":4.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Hallucinations across sensory domains in people with post-traumatic stress disorder and psychosis, Psychiatry Research, Vol 342, December 2024, 116229","authors":"Robert Dudley ,&nbsp;Sarah White ,&nbsp;Rebecca Miskin ,&nbsp;Libby Oakes ,&nbsp;Eleanor Longden ,&nbsp;Craig Steel ,&nbsp;Sarah Swan ,&nbsp;Raphael Underwood ,&nbsp;Emmanuelle Peters","doi":"10.1016/j.psychres.2025.116642","DOIUrl":"10.1016/j.psychres.2025.116642","url":null,"abstract":"","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116642"},"PeriodicalIF":4.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catatonia in autism spectrum disorder: Analysis of clinical characteristics, stressful life events, and validation of the attenuated behavior questionnaire (ABQ)","authors":"Makbule Esen Öksüzoğlu ,&nbsp;Tahsin Rollas ,&nbsp;İ. Mert Erdoğan ,&nbsp;E. Selin Akbaş Aliyev ,&nbsp;Dilek Ünal ,&nbsp;Sevilay Karahan ,&nbsp;Tuna Çak Esen ,&nbsp;A. Elif Anıl Yağcıoğlu","doi":"10.1016/j.psychres.2025.116643","DOIUrl":"10.1016/j.psychres.2025.116643","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) and catatonia exhibit overlapping motor and behavioral symptoms; however, catatonia is often underdiagnosed in individuals with ASD. This study evaluates the validity and reliability of the Turkish version of the Attenuated Behavior Questionnaire (ABQ) and explores the clinical characteristics of individuals with ASD and catatonia. The study involved 300 participants with ASD, aged 12–25 years. Parents completed the ABQ, Repetitive Behavior Scale (RBS), and Aberrant Behavior Checklist (ABC), while clinicians evaluated catatonia using DSM-5 criteria, the Bush Francis Catatonia Rating Scale (BFCRS), KANNER Scale, and Childhood Autism Rating Scale (CARS). Regression in social and language skills and stressful life events from the previous six months were also assessed. The mean age of participants was 16.0 years, with 32 (10.7 %) diagnosed with catatonia; among these, 15.3 % experienced regression, and 25.0 % reported stressful life events. The ABQ showed strong validity and reliability (Spearman-Brown coefficient = 0.979), with ROC analysis determining diagnostic (92.5) and screening (39.5) cut-off points. Participants with ASD and catatonia had significantly elevated rates of late regression, impairments in social and language skills, psychiatric comorbidities, and stressful life events, and they scored considerably higher on BFCRS, KANNER, CARS, RBS, and ABC (all <em>p</em> &lt; .05). Our findings highlight high prevalence of catatonia among individuals with ASD and its association with late regression, social and language impairments, psychiatric comorbidities, and stressful life events and underscore the clinical utility of the ABQ in identifying catatonic symptoms in ASD and emphasize the importance of early recognition and intervention.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116643"},"PeriodicalIF":4.2,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural basis of GAD improvement following a mindfulness-based intervention and antidepressant treatment: an analysis from a randomized controlled trial","authors":"Marianna de Abreu Costa ,&nbsp;Patrícia Bado ,&nbsp;Maiko Schneider ,&nbsp;Maurício Anes ,&nbsp;Julia Karl Schwinn ,&nbsp;Sofia Giusti Alves ,&nbsp;Giovanni Abrahão Salum ,&nbsp;Gisele Gus Manfro","doi":"10.1016/j.psychres.2025.116637","DOIUrl":"10.1016/j.psychres.2025.116637","url":null,"abstract":"<div><h3>Background</h3><div>The brain mechanisms underlying patient improvement after interventions remain poorly understood. Identifying the shared and distinct neural pathway between improvement mechanisms across distinct treatment modalities might improve our understanding of brain-behavior relationships and inform personalized approaches.</div></div><div><h3>Aims</h3><div>To investigate the neural correlations of symptom improvement in Generalized Anxiety Disorder (GAD) by examining changes in brain functional connectivity (FC) following two distinct treatments: mindfulness (body-in-mind training, BMT) and fluoxetine (FLX).</div></div><div><h3>Method</h3><div>Twenty GAD patients from a randomized clinical trial underwent resting-state fMRI before and after their respective interventions. FC of the amygdala with the prefrontal cortex, Default Mode (DMN), and Salience Network (SN) was analyzed. Regression analyses assessed the relationship between symptom improvement and amygdala-related FC changes.</div></div><div><h3>Results</h3><div>Increased FC between the left amygdala and right orbitofrontal cortex (OFC) was found after the interventions and associated with symptom improvement. Treatment-specific patterns of connectivity emerged: in the BMT group, symptom improvement correlated with amygdala connectivity to the DMN and SN, whereas in the FLX group, improvement was linked to amygdala-OFC coupling. However, interaction analysis did not reveal significant differences between groups.</div></div><div><h3>Conclusion</h3><div>Symptom improvement in GAD may involve enhanced functional coupling between brain regions and circuits critical for emotional regulation, self-referential processing, and stimulus selection, particularly between the left amygdala and right OFC. Larger sample studies are needed to elucidate treatment-specific neural mechanisms and refine personalized therapeutic strategies.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116637"},"PeriodicalIF":4.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive disorder with hoarding behavior: unravelling key differences","authors":"Cristiana Nicoli de Mattos ,&nbsp;Megan E. Cooke ,&nbsp;Cole Whiteman ,&nbsp;Michele Pato","doi":"10.1016/j.psychres.2025.116640","DOIUrl":"10.1016/j.psychres.2025.116640","url":null,"abstract":"<div><h3>Objective</h3><div>Hoarding disorder remains underexplored and poorly understood despite its significant impact on individuals and communities. While historically linked to obsessive-compulsive disorder (OCD), emerging evidence suggests they may be distinct conditions. This study aims to investigate these differences.</div></div><div><h3>Methods</h3><div>Adults aged 18–88 years old (<em>M</em> = 39.86, SD = 14.86) were part of the Genomic Psychiatry Cohort study, including 1247 individuals with OCD without presumed hoarding disorder (OCD-pHD) and 663 individuals with OCD and presumed hoarding disorder (OCD+pHD). Sociodemographic data were collected, and participants were screened for other psychiatric conditions. All met DSM-5 criteria for OCD, with severity assessed using the Florida Obsessive-Compulsive Inventory and Y-BOCS. Statistical significance was set at <em>p</em> ≤ 0.0007, adjusted for multiple comparisons.</div></div><div><h3>Results</h3><div>The OCD+pHD group had significantly lower educational attainment, was more likely to live alone or in supervised living, and less likely to be married. This group also had more severe OCD and poorer insight. All types of obsessions and compulsions were more frequent in the OCD+pHD group, except for obsessions related to harming others. Additionally, the OCD+pHD group had higher rates of major depressive disorder, post-traumatic stress disorder, bipolar disorder, schizophrenia, body dysmorphic disorder, trichotillomania and previous diagnosis and/or symptoms of attention deficit and hyperactivity disorder. No significant difference was found for substance use and Tic/Tourette disorders.</div></div><div><h3>Conclusions</h3><div>Significant clinical differences were observed between the groups, highlighting the need for further research to improve diagnosis, conceptualization, awareness, and support for individuals with hoarding disorder in the context of OCD.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116640"},"PeriodicalIF":4.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online mindfulness-based vs. cognitive-behavioural stress reduction for medical students: A randomized controlled trial","authors":"Aysegul Yay-Pence ,&nbsp;Selcuk Aslan ,&nbsp;Merve Coldur ,&nbsp;Zumra Atalay ,&nbsp;Berna Beba ,&nbsp;Canan Coskun-Sayin ,&nbsp;Ecem Aydin ,&nbsp;Zehra Gumus ,&nbsp;Ahsen Sueda Uckan ,&nbsp;Elif Nur Sahinoglu ,&nbsp;Irem Arslanyurek ,&nbsp;Sule Sok Cakici ,&nbsp;Irem Ekmekci-Ertek","doi":"10.1016/j.psychres.2025.116632","DOIUrl":"10.1016/j.psychres.2025.116632","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the effects of Mindfulness-based stress reduction(MBSR) and cognitive behavioural stress reduction(CBSR) on depression, anxiety, and perceived stress in medical students.</div></div><div><h3>Method</h3><div>A total of 323 medical students studying in Ankara, Turkey, applied to participate and were assessed using the Mini International Neuropsychiatric Interview. Medical students with a psychotic disorder, manic episode, major depressive disorder with suicidal ideation, or previous experience with MBSR or cognitive-behavioural treatment were excluded from the study. After randomization, 253 students were allocated to either online MBSR (<em>n</em> = 127) or CBSR (<em>n</em> = 126). Symptoms of anxiety, depression, and perceived stress were assessed at baseline and post-intervention (week 8). Both intention-to-treat (ITT) and per-protocol (PP) analyses were conducted. Multiple imputation was used to address missing data. All interventions and assessments were conducted online, making this one of the few studies to evaluate digital mental health interventions in this population.</div></div><div><h3>Results</h3><div>In the ITT analysis, both interventions had small to moderate effects on improving depression (MBSR: <em>d</em> = 0.50; CBSR: <em>d</em> = 0.40), anxiety (MBSR: <em>d</em> = 0.73; CBSR: <em>d</em> = 0.52), and perceived stress (MBSR: <em>d</em> = 0.48; CBSR: <em>d</em> = 0.42), with no significant differences between them. The PP analysis revealed moderate to strong improvements in depression (MBSR: <em>d</em> = 1.03; CBSR: <em>d</em> = 0.74), anxiety (MBSR: <em>r</em>=-0.74; CBSR: <em>r</em>=-0.72), and perceived stress (MBSR: <em>r</em>=-0.80; CBSR: <em>r</em>=-0.68). While both interventions were comparable in reducing depressive symptoms and perceived stress, MBSR demonstrated superior efficacy in reducing anxiety.</div></div><div><h3>Conclusions</h3><div>The findings indicate that both MBSR and CBSR may be effective in reducing anxiety, depression, and perceived stress in medical students. Greater adherence appears to enhance outcomes, particularly for MBSR in alleviating anxiety symptoms<strong>.</strong></div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116632"},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of a nurse-assisted digital thinking healthy program for postpartum depression: A randomized controlled trial","authors":"Lei Yang ,&nbsp;Yiping Nan ,&nbsp;Jie Zhou ,&nbsp;Jingwen Sun ,&nbsp;Lanting Huo ,&nbsp;Fang Liu ,&nbsp;Duolao Wang ,&nbsp;Atif Rahman ,&nbsp;Xiaomei Li","doi":"10.1016/j.psychres.2025.116639","DOIUrl":"10.1016/j.psychres.2025.116639","url":null,"abstract":"<div><div><strong>Background:</strong> Postpartum depression (PPD) is a prevalent mental health issue with significant adverse consequences for both mothers and their infants. The Thinking Healthy Program (THP) is an effective intervention for perinatal depression in non-specialized healthcare settings. This study aimed to evaluate the effectiveness of a nurse-assisted digital THP in treating PPD among postpartum women experiencing elevated depression symptoms in China based on elevated Edinburgh Postnatal Depression Scale (EPDS) scores through a randomized controlled trial.</div><div><strong>Methods:</strong> Postpartum women experiencing elevated depression symptoms were recruited and randomly assigned to either a six-week nurse-assisted digital THP intervention group or a treatment-as-usual control group using computer-generated random sequences. The primary outcome was self-reported depression symptoms measured by the EPDS. Secondary outcomes included general health status (Five-level EuroQol 5-Dimensions Questionnaire), mother-infant attachment (Maternal Postnatal Attachment Scale), and perceived social support (Multidimensional Scale of Perceived Social Support). Measurements were conducted online at baseline, post-intervention, and at a three-month follow-up.</div><div><strong>Results:</strong> A total of 120 postpartum women were allocated to either the intervention (<em>n</em> = 60) or the control (<em>n</em> = 60) group. Participants in the intervention group showed a greater reduction in depression symptoms compared to the control group at post-intervention (β=-1.70, <em>P</em> = 0.047) and at three-month follow-up (β=-1.90, <em>P</em> = 0.007). However, there were no significant effects on general health status. The intervention also led to significantly greater improvements in mother-infant attachment (β=3.05, <em>P</em> = 0.006) and perceived social support at post-intervention (β=6.52, <em>P</em> = 0.027) and at three-month follow-up (β=6.96, <em>P</em> = 0.015).</div><div><strong>Conclusions:</strong> Our results suggest that the nurse-assisted digital THP intervention is effective in reducing maternal depression levels, enhancing mother-infant attachment and increasing perceived social support. Delivering THP via mobile apps is feasible, and nurse assistance can facilitate postpartum women's acceptance of digital psychological interventions.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116639"},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational linguistic investigation in schizophrenia and autism spectrum disorders","authors":"Berat Arslan ,&nbsp;Elif Kizilay ,&nbsp;Yaren Ecesu Turan ,&nbsp;Burcu Verim ,&nbsp;Cemal Demirlek ,&nbsp;Muhammed Demir ,&nbsp;Özge İlhan ,&nbsp;Ezgi Cesim ,&nbsp;Emre Bora","doi":"10.1016/j.psychres.2025.116633","DOIUrl":"10.1016/j.psychres.2025.116633","url":null,"abstract":"<div><div>Computational linguistic analysis has been increasingly used to capture formal thought disorder in schizophrenia. Despite promising outcomes, investigations of the computational linguistic disturbances of schizophrenia in a transdiagnostic context are limited. Particularly, shared characteristics, neurodevelopmental origins, and the role of speech in the diagnosis of schizophrenia and autism indicate a need to explore both the commonalities and distinctions in the computational linguistic profiles of these groups. In this study, we investigated the semantic and structural properties of speech samples of 35 patients with schizophrenia spectrum disorder, 25 patients with autism spectrum disorder, and 25 healthy controls in free speech and picture description tasks. Our findings showed that only 5 of 45 features differed between the clinical groups. All of these were from the structural domain, while semantic features did not differ between these neurodevelopmental disorders. The clinical groups demonstrated elevated local and global semantic similarity, and negative sentiment compared to controls. Moreover, the speech of autism spectrum disorder included lower unique word frequency in picture description, alongside shorter pronouns and adverbs in free speech relative to other groups. Schizophrenia spectrum disorder used shorter adjectives than autism spectrum disorder and controls in free speech. Importantly, adjective frequency in schizophrenia spectrum disorder was lower than in autism spectrum disorder in free speech. Overall, our findings demonstrated an extensive dominance of similar computational linguistic traits between schizophrenia and autism spectrum disorders, indicating shared communication disturbances in these disorders. This outcome highlights the critical role of transdiagnostic and neurodevelopmental perspectives in computational linguistic investigations.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"351 ","pages":"Article 116633"},"PeriodicalIF":4.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}