{"title":"Evaluating ethnoracial differences in treatment outcomes: A critical review of CBT and DBT effectiveness in partial hospital programs","authors":"Mifta Rizka , Rizky Andana Pohan , Santy Andrianie , Taufik Agung Pranowo , Kadek Suhardita","doi":"10.1016/j.psychres.2026.116986","DOIUrl":"10.1016/j.psychres.2026.116986","url":null,"abstract":"<div><div>This critical analysis of the study by Narine et al. (2026) investigates the effectiveness of a non-culturally adapted partial hospital program (PHP) using Cognitive Behavioral Therapy (CBT) and Dialectical Behavior Therapy (DBT) across ethnoracial groups. The study found that Asian participants reported better relationship functioning post-treatment, although the effect size was small. Black participants showed greater perceived improvements in symptoms, including anxiety and depression, potentially due to the PHP's intensive approach. The study also revealed that Black participants reported the highest levels of respect and dignity in treatment, highlighting the importance of interpersonal dynamics in therapeutic success. The findings underscore the need for further exploration into culturally sensitive approaches to therapy, particularly for marginalized ethnoracial groups who may face unique challenges in mental health treatment. The analysis suggests that culturally adapted CBT and DBT may further enhance outcomes for these groups, ensuring more inclusive and effective care in acute psychiatric settings.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116986"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of brain-based neurofeedback interventions for binge eating: a systematic review and meta-analysis of randomized controlled trials","authors":"Jen-Ping Chen , Te-Chang Changchien , Yi-Ya Fang , Wei-Chiang Yeh , Ping-Tao Tseng , Tien-Wei Hsu , Chih-Sung Liang","doi":"10.1016/j.psychres.2026.116979","DOIUrl":"10.1016/j.psychres.2026.116979","url":null,"abstract":"<div><div>Binge eating behavior and food craving are associated with altered reward sensitivity and impaired inhibitory control, contributing to physical and psychological consequences. Neurofeedback (NFB) has emerged as a promising non-invasive intervention for reducing binge eating behaviors, yet its overall efficacy remains unclear and warrants quantitative synthesis. A systematic search was conducted across MEDLINE, CENTRAL, EMBASE, ClinicalTrial.gov, and PubMed to identify randomized controlled trials (RCTs) of NFB interventions for binge eating behaviors or binge eating disorder (BED) in adults. The primary outcome was food craving. The secondary outcomes were binge eating severity, binge eating frequency, and self-efficacy. Data synthesis was performed using a random-effects meta-analysis. Seven RCTs with 251 participants were included. NFB was associated with improved food craving (standard mean difference, SMD = -0.45, 95 % confidence interval, CI = -0.78 to -0.12) and binge eating frequency (SMD = -0.54, 95 % CI = -1.00 to -0.08) with moderate effect sizes. However, NFB did not significantly affect binge eating severity and self-efficacy (SMD = -0.22, 95 % CI = -0.56 to 0.12; SMD = 0.21, 95 % CI = -0.33 to 0.75). For food craving severity, NFB was more effective in non-clinical populations (SMD = -0.58, 95 % CI = -0.98 to -0.17) than in participants with BED (SMD = -0.20, 95 % CI = -0.84 to 0.44). NFB shows promise as a non-invasive intervention to reduce binge eating and food craving. Despite protocol variability and limited generalizability, its favorable safety profile and potential efficacy suggest it may serve as an adjunctive option for individuals with binge eating behaviors; however, the evidence remains preliminary and hypothesis-generating.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116979"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-01-17DOI: 10.1016/j.psychres.2026.116951
Daniel A. Vazquez-Matias, Erik F.J. de Vries, Cyprien G.J. Guerrin, Kavya Prasad, Janine Doorduin
{"title":"Metabolic brain connectivity analysis of a depressive-like phenotype in rats: a graph theory PET study","authors":"Daniel A. Vazquez-Matias, Erik F.J. de Vries, Cyprien G.J. Guerrin, Kavya Prasad, Janine Doorduin","doi":"10.1016/j.psychres.2026.116951","DOIUrl":"10.1016/j.psychres.2026.116951","url":null,"abstract":"<div><div>This study aimed to investigate whether there are metabolic connectivity alterations in the brain of rats with a depressive-like phenotype, using positron emission tomography (PET) and graph theory methods. Male Wistar rats were exposed to 5 days of repeated social defeat (RSD) to induce a depressive-like phenotype, and brain connectivity was assessed with [<sup>18</sup>F]FDG-PET. Sucrose preference tests were conducted to assess anhedonia-like behaviour, a symptom of depression. The results showed that anhedonia-like behaviour was present one day after RSD and recovered after seven days. The analysis of large-scale brain networks revealed a reduction in connectivity in the default mode network of RSD-exposed animals one day after RSD, suggesting a link between reduced connectivity and the presence of anhedonia-like behaviour. Seven days after RSD, an increase in connectivity was observed in the salience network, which coincided with the recovery of sucrose preference. Modular analysis revealed different configurations of brain regions at one and seven days after RSD, with asymmetrical segregation of left and right hemisphere structures. These findings suggest that changes in brain connectivity may play a role in the development and recovery of anhedonia-like behaviour in rats exposed to RSD and may have implications for understanding depressive phenotypes.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116951"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-01-22DOI: 10.1016/j.psychres.2026.116965
Leonor P. Gawron , Maria J. Portella , Esther Pousa
{"title":"Insight and depressive symptoms in eating disorders: the mediating role of disorder-specific psychopathology","authors":"Leonor P. Gawron , Maria J. Portella , Esther Pousa","doi":"10.1016/j.psychres.2026.116965","DOIUrl":"10.1016/j.psychres.2026.116965","url":null,"abstract":"<div><h3>Objective</h3><div>To study whether the insight described in psychosis also occurs in eating disorders (EDs), whether it differs between anorexia nervosa (AN) and bulimia nervosa (BN), and whether diagnosis-specific ED psychopathology mediates this relationship.</div></div><div><h3>Methods</h3><div>Cross-sectional baseline data from a prospective cohort of 103 day-hospital patients with AN or BN were analyzed. Standardized measures of insight, depressive symptoms, and ED psychopathology were administered. Exploratory factor analysis was conducted on depressive symptoms, followed by diagnosis-stratified correlation analyses between insight dimensions and depressive symptom factors. Mediation models were then applied to examine whether diagnosis-specific ED psychopathology accounted for significant associations.</div></div><div><h3>Results</h3><div>Three depressive dimensions were identified: emotional, apathetic, and self-critical, explaining 56.26% of the variance. In AN, affective distress was associated with poorer insight into hypothetical contradiction and treatment engagement, whereas negative self-cognitions where associated with better recognition and relabeling of ED pathology. In BN, depressive symptoms were associated with reduced insight into body weight concerns and treatment engagement. ED–specific psychopathology significantly mediated the relationship between depressive symptoms and insight in both AN and BN.</div></div><div><h3>Conclusion</h3><div>These findings reveal that depressive symptoms and insight are associated in distinct patterns in anorexia and bulimia, and appear to be linked through different ED-specific psychopathological pathways. Highlighting these diagnosis-specific associations contributes to a more nuanced understanding of insight in EDs and underscores the need for tailored clinical approaches.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116965"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-01-29DOI: 10.1016/j.psychres.2026.116983
Adrian Loerbroks , Liwei Chen , Chunqing Lin , Kira Schmidt Stiedenroth , Jian Li
{"title":"Workplace discrimination and risk of alcohol abuse: a prospective cohort study in the United States","authors":"Adrian Loerbroks , Liwei Chen , Chunqing Lin , Kira Schmidt Stiedenroth , Jian Li","doi":"10.1016/j.psychres.2026.116983","DOIUrl":"10.1016/j.psychres.2026.116983","url":null,"abstract":"<div><h3>Objective</h3><div>Prospective studies on the link between workplace discrimination and subsequent alcohol abuse remain markedly sparse. We aimed to address this gap and to expand the current evidence base by exploring i) the potential explanatory role of psychological stress and ii) gender differences.</div></div><div><h3>Methods</h3><div>We included 1097 workers from the Midlife in the United States (MIDUS) study without alcohol abuse at baseline (2004–2006) followed up in 2013–2014. Workplace discrimination at baseline was measured using a validated 6-item instrument and categorized into three levels by tertiles. Alcohol abuse at both baseline and follow-up was assessed using a modified 4-item Michigan Alcoholism Screening Test. We applied multivariable Poisson regression to estimate associations in terms of risk ratios (RRs) for and 95% confidence intervals (CIs). Multivariable RRs were additionally adjusted for a measure of psychological stress (i.e., Kessler 6 scale) and gender differences were examined by interaction terms.</div></div><div><h3>Results</h3><div>The risk of alcohol abuse was increased 2.6-fold in those reporting high workplace discrimination as compared to those with low levels (RR=2.60, 95% CI=1.10–6.15). Stress explained this association only marginally (i.e., RRs for high workplace discriminination were attenuated by 14.47%). Associations did not differ between women and men (i.e., p-values for all interaction terms were > 0.05)</div></div><div><h3>Conclusion</h3><div>Our findings suggest that workplace discrimination is an important risk factor for alcohol abuse among US workers, highlighting the need for organizational interventions to address discrimination at the workplace.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116983"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-02-03DOI: 10.1016/j.psychres.2026.116995
Wen-Huei Siao , Tzong-Shi Wang , Liang-Chun Wang , Mao-Liang Chen , Yi-Chyan Chen
{"title":"Biological variations in ketamine sensitivity: insights from hyperlocomotion to psychotomimetic features in genetically diverse mouse strains","authors":"Wen-Huei Siao , Tzong-Shi Wang , Liang-Chun Wang , Mao-Liang Chen , Yi-Chyan Chen","doi":"10.1016/j.psychres.2026.116995","DOIUrl":"10.1016/j.psychres.2026.116995","url":null,"abstract":"<div><h3>Background</h3><div>Ketamine, a non-competitive NMDA receptor antagonist, induces dissociative and psychotomimetic states and is widely used as an animal model for schizophrenia. However, strain-dependent variability in ketamine sensitivity is poorly understood, especially during adolescence, a developmental period marked by heightened vulnerability to NMDA receptor hypofunction. This study would compare differences in pharmacological susceptibility to ketamine among different mouse strains.</div></div><div><h3>Methods</h3><div>The four mouse strains—C57BL/6 J, DBA, BALB/c, and 129S1—were acclimated during adolescence. A novel open-field test equipped with a video-tracking system was employed as the primary method to assess motor behavioral changes. Following a 30 min baseline free-running session, mice received intraperitoneal injections of ketamine at doses of 0, 25, or 50 mg/kg, and their activity was monitored for an additional 60 min.</div></div><div><h3>Results</h3><div>The results revealed distinct pharmacological reactions to ketamine, influenced by both dose and strain. Locomotor activity varied significantly among the four strains before and after ketamine treatment (<em>p</em> < 0.001), with activity levels ranked as follows: <strong>C57BL/6J > DBA = BALB/<em>c</em> > 129S1</strong>. Ketamine produced dose-dependent robust hyperlocomotion in C57BL/6 J mice, transient excitation in DBA mice at 25 mg/kg, and delayed excitation in BALB/c mice at 50 mg/kg. 129S1 mice showed minimal net changes across doses.</div></div><div><h3>Conclusion</h3><div>The study findings highlight diverse neurobehavioral characteristics among different mouse strains, demonstrating that pharmacological responses to ketamine are modulated by both dose and genetic background. These results indicate variability in ketamine sensitivity across strains, which may be relevant for understanding individual differences in behavioral responses to ketamine during adolescence.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116995"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-01-18DOI: 10.1016/j.psychres.2026.116953
Doron Amsalem , Chana T. Fisch , John C. Markowitz , Amit Lazarov , Yossi Levi-Belz , Ido Lurie , Milton L. Wainberg , Shlomo Mendlovic , Yuval Neria , Shilat Haim-Nachum
{"title":"A year into the war: Longitudinal effects of trauma, displacement, and income loss on mental health in conflict zones","authors":"Doron Amsalem , Chana T. Fisch , John C. Markowitz , Amit Lazarov , Yossi Levi-Belz , Ido Lurie , Milton L. Wainberg , Shlomo Mendlovic , Yuval Neria , Shilat Haim-Nachum","doi":"10.1016/j.psychres.2026.116953","DOIUrl":"10.1016/j.psychres.2026.116953","url":null,"abstract":"<div><h3>Background</h3><div>Research has linked war-related stressors like traumatic loss, forced displacement, and income disruption to acute mental health symptoms. Little is known about how symptoms evolve longitudinally during prolonged conflict. Extending our 90-day studies, we tracked clinical symptoms and betrayal-based moral injury over one full year following the October 7, 2023, attack and ensuing war in Israel. We hypothesized stressor-exposed individuals would report persistent psychological distress and heightened betrayal perceptions one year later.</div></div><div><h3>Methods</h3><div>A four-wave longitudinal study followed 1,052 individuals aged 18–40 living in northern and southern Israel, areas heavily affected by October 7 and the ongoing war. Assessments occurred in February, March, and May 2024 and March 2025. Anxiety, depression, and Post-Traumatic Stress Disorder (PTSD) symptoms The Generalized Anxiety Disorder 7-item scale (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and Primary Care PTSD (PC-PTSD) measured. The Moral Injury Events betrayal subscale assessed betrayal-based moral injury. Linear Mixed Models examined symptom trajectories and associations with baseline war-related traumatic loss, forced displacement, and income loss.</div></div><div><h3>Results</h3><div>At baseline, 75 % of participants reported ≥1 probable clinical condition. Symptoms remained high after 12 months (66 %). Baseline exposure to traumatic loss, displacement, or income loss correlated with significantly higher anxiety, depression, PTSD, and betrayal scores across timepoints (F values 14.4-243.9, <em>p</em><.001). Depression symptoms remained steady over time, whereas betrayal scores significantly increased.</div></div><div><h3>Conclusions</h3><div>This one-year longitudinal study found initial traumatic stressors predicted persistently elevated anxiety, depression, PTSD, and betrayal-based moral injury. Findings highlight the lasting psychological impact of cumulative war-related adversity and call for innovative, sustained treatment strategies that address both acute and evolving effects of prolonged conflict.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116953"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-01-15DOI: 10.1016/j.psychres.2026.116950
Jimin Lee, Yuna Oh, Sungeun You
{"title":"Cutoff scores and predictive validity of the Acute Suicidal Affective Disturbance Inventory (ASADI) for future suicide attempts and suicidal ideation with intent","authors":"Jimin Lee, Yuna Oh, Sungeun You","doi":"10.1016/j.psychres.2026.116950","DOIUrl":"10.1016/j.psychres.2026.116950","url":null,"abstract":"<div><h3>Background</h3><div>Identification of individuals at elevated risk for suicidal behavior is an important component of suicide prevention efforts. This study aimed to examine the predictive validity of the Acute Suicidal Affective Disturbance Inventory (ASADI) and to explore potential cutoff scores in relation to subsequent suicidal outcomes</div></div><div><h3>Methods</h3><div>We analyzed data from a community-based sample of 682 Korean adults who have experienced drastic increase in suicide intent, of whom 373 completed a one-year follow-up assessment. Using a one-year longitudinal data, receiver operating characteristics (ROC) analyses were conducted to examine cutoff scores in predicting future suicide attempts and suicidal ideation with intent. Potential cutoff scores were further evaluated by assessing their predictive performance after controlling for demographic and clinical covariates through multivariate logistic regression.</div></div><div><h3>Results</h3><div>Higher ASADI scores were prospectively associated with suicide attempts and suicidal ideation with intent during the follow-up period. A cutoff score of 248 demonstrated the strongest discriminative performance for suicide attempts, with individuals scoring above this threshold showing an increased likelihood of attempting suicide over one year after adjusting for covariates. Additional cutoffs of 192 and 206 were associated with suicidal ideation with intent.</div></div><div><h3>Conclusion</h3><div>These findings provide preliminary, empirically derived cutoff scores for the ASADI and support its prospective relevance as a measure of identifying at-risk individuals who warrant closer monitoring.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116950"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-02-02DOI: 10.1016/j.psychres.2026.116990
Xue Yang , Yalin Zheng
{"title":"Mindfulness-based therapy for adolescent internet gaming disorder: A feasibility and pilot study","authors":"Xue Yang , Yalin Zheng","doi":"10.1016/j.psychres.2026.116990","DOIUrl":"10.1016/j.psychres.2026.116990","url":null,"abstract":"<div><div>Internet Gaming Disorder (IGD) is prevalent in adolescents and is treatable. Mindfulness-based therapy can benefit addictive behaviors, craving, and emotion regulation. However, evidence on its effectiveness in treating IGD is still lacking. This study aims to test its feasibility and effectiveness in adolescents with IGD. In total, 23 secondary school students finished the 4-week group-based intervention. At posttest, participants reported significantly lower levels of IGD symptoms (mean difference=1.13), craving (mean difference=0.38), and higher levels of emotion regulation (mean difference=–6.91) compared with pre-test. In general, participants rated the intervention positively. The response summary to the open-ended question indicated that participants favored the in-session mindfulness exercises. Suggestions to improve the intervention design were also provided. The current intervention is low cost and time-efficient with high completion rates and acceptability in adolescents with IGD. Future work may further adopt randomized control trial designs and explore the long-term effects of mindfulness-based interventions for IGD.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116990"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146181912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatry ResearchPub Date : 2026-04-01Epub Date: 2026-01-19DOI: 10.1016/j.psychres.2026.116962
Jenny Rickardsson , Mark J. Taylor , Paul Lichtenstein , Henrik Larsson , Sebastian Lundström , Karin Jensen , Maria Lalouni
{"title":"Genetic and environmental factors in pain symptoms and self-harm, and their association. A twin study","authors":"Jenny Rickardsson , Mark J. Taylor , Paul Lichtenstein , Henrik Larsson , Sebastian Lundström , Karin Jensen , Maria Lalouni","doi":"10.1016/j.psychres.2026.116962","DOIUrl":"10.1016/j.psychres.2026.116962","url":null,"abstract":"<div><div>Individuals who self-harm are often insensitive to pain, and consequently pain sensitivity has been proposed as a barrier for self-harm. It is unclear how pain and self-harm interplay in real life settings, and to what extent genetics and environmental factors contribute to the etiology of both.</div><div>This study was registry based using classical twin design. A cohort of 16 948 Swedish twin pairs born between 1992 and 2010, was prospectively assessed for pain symptoms at ages 9 and 18, and followed up for later self-harm until 2016 and a maximum age of 24.</div><div>The relative contributions of genetic and environmental factors to each phenotype were estimated using univariate twin models. Logistic regression models assessed their association, and conditional models adjusted for familial confounding.</div><div>Genetics and non-shared environment contributed to pain and self-harm to a moderate degree at both age 9 and age 18, while the contribution of shared environment was small for both pain and self-harm at both ages. At age 18 the pain symptoms group had higher odds for later self-harm (odds ratio 1.59, 95% CI 1.06–2.41, <em>p</em> = .003), and pain seemed to be partially in the causal pathway as it was not explained by familial confounding. This study adds to the evidence of pain symptoms as a predictor for self-harm.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116962"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146066513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}