Psychiatry Research最新文献_第2页

Psychological trauma of evacuated Israeli residents following the October 7th Hamas terror attack 10 月 7 日哈马斯恐怖袭击后撤离的以色列居民的心理创伤

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-21 DOI: 10.1016/j.psychres.2024.116210

引用次数: 0

Developmental language disorder – heritability and genetic correlations with other disorders affecting language 发育性语言障碍--遗传率以及与其他影响语言障碍的遗传相关性。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-21 DOI: 10.1016/j.psychres.2024.116212

{"title":"Developmental language disorder – heritability and genetic correlations with other disorders affecting language","authors":"","doi":"10.1016/j.psychres.2024.116212","DOIUrl":"10.1016/j.psychres.2024.116212","url":null,"abstract":"<div><div>Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's GABA got to do with it? A potential link between the microbiome, schizophrenia, and the endo-cannabinoid system GABA 与此有何关系？微生物组、精神分裂症与内源性大麻素系统之间的潜在联系

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-20 DOI: 10.1016/j.psychres.2024.116196

{"title":"What's GABA got to do with it? A potential link between the microbiome, schizophrenia, and the endo-cannabinoid system","authors":"","doi":"10.1016/j.psychres.2024.116196","DOIUrl":"10.1016/j.psychres.2024.116196","url":null,"abstract":"<div><div>The microbiome has been linked to numerous neurological and psychiatric diseases, including schizophrenia. Nevertheless, correlating microbial perturbations to pathophysiological aspects of schizophrenia remains elusive, as study participants are typically medicated when sampled, complicating mechanistic investigation. Here we explored specific microbial and metabolic alterations in schizophrenia patients, while explicitly considering their medications. We recruited 30 patients and 14 healthy controls. Fecal and serum samples were collected for microbiota and (untargeted) metabolome characterization, respectively. While significant differences were detected between microbiome of controls and schizophrenia patients overall, patients not taking GABA-enhancing drugs had profiles similar to the control group. This pattern was preserved, but to a lesser extent, when comparing metabolomes. Several key metabolic pathways differed between patients and controls, even after filtering out those directly related to pharmaceuticals and their metabolism, and the citric acid cycle and amino acid biosynthesis pathways were enriched in the group prescribed antipsychotics without GABA-enhancers. Administration of exogenous GABA affected overall patient homeostasis, not just disease course, supporting our hypothesis that microbiota play a part in cognitive, emotional, and mental function, and that this role must be considered in the full context of an individual's state, including medication.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer characteristics in patients with schizophrenia: a 25-year retrospective analysis 精神分裂症患者的癌症特征：25 年的回顾性分析

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-19 DOI: 10.1016/j.psychres.2024.116206

{"title":"Cancer characteristics in patients with schizophrenia: a 25-year retrospective analysis","authors":"","doi":"10.1016/j.psychres.2024.116206","DOIUrl":"10.1016/j.psychres.2024.116206","url":null,"abstract":"<div><div>Schizophrenia is associated with higher cancer-related mortality, perhaps due to delayed diagnosis and limited access to treatment. The study aimed to compare patients diagnosed with cancer with and without schizophrenia to determine whether these groups differ in terms of oncological variables and survival outcomes. This was a retrospective, observational cohort study that included 30.990 patients diagnosed with cancer between 1997 and 2021. We performed univariate and bivariate analyses for the sociodemographic and clinical variables, and constructed Kaplan-Meier survival curves and used the log-rank test to perform the comparisons. All variables were compared for each cancer type. One hundred and sixty-two (0.52 %) patients had a confirmed diagnosis of schizophrenia (ICD-9 criteria). The mean age at diagnosis was significantly lower in the schizophrenia group. A significantly higher proportion of the schizophrenia group was diagnosed with cancer through the emergency department and a lower percentage through scheduled appointments. A smaller percentage of patients in the schizophrenia group received radical treatment for cancer. The mortality rate was higher in the schizophrenia group and median survival was lower. These findings suggest that cancer patients with schizophrenia have worse outcomes than patients without schizophrenia in terms of oncological variables and survival.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why do some Mexicans with psychosis risk symptoms seek mental health care and others do not? 为什么一些有精神病风险症状的墨西哥人会寻求心理保健，而其他人则不会？

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-19 DOI: 10.1016/j.psychres.2024.116199

{"title":"Why do some Mexicans with psychosis risk symptoms seek mental health care and others do not?","authors":"","doi":"10.1016/j.psychres.2024.116199","DOIUrl":"10.1016/j.psychres.2024.116199","url":null,"abstract":"<div><div>Help-seeking barriers differ according to the sociocultural context and country-specific mental healthcare system. More research is needed in low-middle-income countries, where early psychosis programs are still scarce, and the mental health care gap is wide. This study aims to explore predisposing, enabling, and need factors associated with mental health service utilization in 481 Mexicans self-reporting psychosis risk symptoms, as well as differences between those who were currently mental health service users (MHSU) and those who were not (non-MHSU). Participants responded to self-reported measures through an online survey. The factors associated with an increased probability of using mental health services were having an occupation, having a medium/high socioeconomic status, an intention to seek help from a mental health professional, fewer help-seeking barriers, moderate/severe anxious symptoms, higher distress associated with psychosis risk symptoms and social functioning impairment. Findings provide relevant information for designing more effective strategies to improve help-seeking, early identification, and timely treatment delivery in Mexico. The need to generate strategies focused on reducing stigma, enhancing psychosis literacy in the community, and increasing the identification of emerging signs of psychosis in primary healthcare professionals is highlighted, mainly when co-occurring with other psychiatric symptoms.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incremental predictive value of genetic risk and functional brain connectivity in determining antipsychotic response in schizophrenia 遗传风险和大脑功能连接在确定精神分裂症患者抗精神病药物反应方面的增量预测价值

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-18 DOI: 10.1016/j.psychres.2024.116201

{"title":"Incremental predictive value of genetic risk and functional brain connectivity in determining antipsychotic response in schizophrenia","authors":"","doi":"10.1016/j.psychres.2024.116201","DOIUrl":"10.1016/j.psychres.2024.116201","url":null,"abstract":"<div><div>We aimed to assess the incremental value of schizophrenia polygenic risk score (PgRS) and resting-state functional brain connectivity (rsFC) when added to clinical data in predicting the six-week response to oral risperidone (Risperdal) in schizophrenia. Fifty-seven, 54, and 43 individuals in a group of never-before-treated first-episode schizophrenia had good quality whole-genome sequencing (10x), rsFC, and both genomic and rsFC data, respectively, at baseline. Symptom severity ratings were obtained at baseline and six-weeks of oral risperidone (Risperdal) treatment. The primary outcome was the percentage change in the Positive and Negative Syndrome Scale Total scores after risperidone (Risperdal) treatment. Clinical, PgRS, and rsFC determinants of treatment response were first evaluated independently. Subsequently, three blocks of hierarchical multiple regression analyses with leave-one-out cross-validation (<em>n</em> = 43), were implemented to study clinical, clinical + PgRS and clinical + PgRS + rsFC determinants of treatment response. While the combined clinical variables did not show a statistically significant prediction of treatment response, adding PgRS (9 % R<sup>2</sup> change) and rsFC (26 % R<sup>2</sup> change) in hierarchical steps, significantly improved the overall proportion of variance explained in treatment response. This proof-of-concept investigation underscores the incremental benefits offered by genetic and neuroimaging metrics over clinical measures in determining prospectively-ascertained short-term treatment response in first-episode schizophrenia.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing PTSD symptom profiles in special forces operators and support personnel: Justification for a Precision Medicine Approach 描述特种部队操作员和辅助人员的创伤后应激障碍症状特征：采用精准医学方法的理由。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-17 DOI: 10.1016/j.psychres.2024.116204

引用次数: 0

The genetic architecture of substance use and its diverse correlations with mental health traits 药物使用的基因结构及其与心理健康特征的不同相关性

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-16 DOI: 10.1016/j.psychres.2024.116200

{"title":"The genetic architecture of substance use and its diverse correlations with mental health traits","authors":"","doi":"10.1016/j.psychres.2024.116200","DOIUrl":"10.1016/j.psychres.2024.116200","url":null,"abstract":"<div><p>Although harmful substance use is common and represented by shared symptom features and high genetic correlations, the underlying genetic relationships between substance use traits have not been fully explored. We have investigated the genetic architecture of substance use traits through exploratory and confirmatory factor analyses using genomic structural equation modeling (Genomic SEM), and explored genetic correlations between different aspects of substance use and mental health-related traits. Genomic SEM was used to identify latent factors representing the relationships between 14 substance use traits (alcohol, nicotine, cannabis and opioid use), and to confirm or modify existing latent factors for 38 mental health-related traits. A bi-factor model best explained the genetic overlap between substance use traits, including a general substance use factor and two sub-factors representing genetic liability specific to alcohol use or smoking. The SNP-based heritability of these factors ranged from 2 to 7 % and each factor had 10 or more independent significant SNPs identified. Bivariate correlations revealed patterns of genetic overlap with other mental health-related factors unique to each substance use factor. Variations in the genetic overlap between psychiatric traits and different aspects of substance use can be used to further investigate the pleiotropy present between these traits, and explore commonalities in etiology.</p></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating digital intelligence into mental health interventions: Problems, evaluation, recommendations 将数字智能融入心理健康干预措施：问题、评估、建议

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-16 DOI: 10.1016/j.psychres.2024.116205

引用次数: 0

Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: New insights from a network analysis 了解躁郁症患者童年受虐与情感症状之间的关系：网络分析的新见解

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-16 DOI: 10.1016/j.psychres.2024.116197

{"title":"Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: New insights from a network analysis","authors":"","doi":"10.1016/j.psychres.2024.116197","DOIUrl":"10.1016/j.psychres.2024.116197","url":null,"abstract":"<div><div>The impact of childhood abuse on the presentation of bipolar disorder could be further elucidated by comparing the networks of affective symptoms among individuals with and with no history of childhood abuse. Data from 476 participants in the Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study were used to fit several regularised Gaussian Graphical Models. Differences in the presentation of depressive and manic symptoms were uncovered: only among participants with a history of childhood abuse, <em>inadequacy</em> and <em>pessimism</em> were central symptoms in the network of depressive symptoms, while <em>racing thoughts</em> was an important symptom in the network of manic symptoms. Following network theory, focusing treatments at the symptom-level and on central symptoms – like <em>inadequacy, pessimism</em>, and <em>racing thoughts</em> – could be an effective approach for managing affective symptoms among the sizeable proportion of people with bipolar disorder who have experienced childhood abuse. This study contributes a thorough investigation of the networks of affective symptoms among participants with and with no history of childhood abuse, albeit limited by the use of a binary, self-report measure of childhood abuse, thereby emphasising the importance of assessing for childhood abuse and taking needed steps towards identifying novel targets for treating bipolar disorder.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165178124004827/pdfft?md5=fa9a5926712aae207d277d3ddf14cf2b&pid=1-s2.0-S0165178124004827-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0