Psychiatry Research最新文献_第3页

Clinical associations with treatment resistance in depression: An electronic health record study 抑郁症治疗阻力的临床关联：电子健康记录研究

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-16 DOI: 10.1016/j.psychres.2024.116203

{"title":"Clinical associations with treatment resistance in depression: An electronic health record study","authors":"","doi":"10.1016/j.psychres.2024.116203","DOIUrl":"10.1016/j.psychres.2024.116203","url":null,"abstract":"<div><div>Treatment resistance is common in major depressive disorder (MDD), yet clinical risk factors are not well understood. Using a discovery-replication design, we conducted phenome-wide association studies (PheWASs) of MDD treatment resistance in two electronic health record (EHR)-linked biobanks. The PheWAS included participants with an MDD diagnosis in the EHR and at least one antidepressant (AD) prescription. Participant lifetime diagnoses were mapped to phecodes. PheWASs were conducted for three treatment resistance outcomes based on AD prescription data: number of unique ADs prescribed, ≥1 and ≥2 CE switches. Of the 180 phecodes significantly associated with these outcomes in the discovery cohort (<em>n</em> = 12,558), 71 replicated (<em>n</em> = 8,206). In addition to identifying known clinical factors for treatment resistance in MDD, the total unique AD prescriptions was associated with additional clinical variables including irritable bowel syndrome, gastroesophageal reflux disease, symptomatic menopause, and spondylosis. We calculated polygenic risk of specific-associated conditions and tested their association with AD outcomes revealing that genetic risk for many of these conditions is also associated with the total unique AD prescriptions. The number of unique ADs prescribed, which is easily assessed in EHRs, provides a more nuanced measure of treatment resistance, and may facilitate future research and clinical application in this area.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in shared genetic determinants between severe mental disorders and metabolic traits 严重精神障碍与代谢特征之间共同遗传决定因素的性别差异

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-15 DOI: 10.1016/j.psychres.2024.116195

{"title":"Sex differences in shared genetic determinants between severe mental disorders and metabolic traits","authors":"","doi":"10.1016/j.psychres.2024.116195","DOIUrl":"10.1016/j.psychres.2024.116195","url":null,"abstract":"<div><p>High rates of metabolic risk factors contribute to premature mortality in patients with severe mental disorders, but the molecular underpinnings of this association are largely unknown. We performed the first analysis on shared genetic factors between severe mental disorders and metabolic traits considering the effect of sex. We applied an integrated analytical pipeline on the largest sex-stratified genome-wide association datasets available for bipolar disorder (BD), major depressive disorder (MDD), schizophrenia (SZ), and for body mass index (BMI) and waist-to-hip ratio (WHR) (all including participants of European origin). We observed extensive genetic overlap between all severe mental disorders and variants associated with BMI in women or men and identified several genetic loci shared between BD, or SZ and BMI in women (24 and 91, respectively) or men (13 and 208, respectively), with mixed directions of effect. A large part of the identified genetic variants showed sex differences in terms of location, genes modulated in adipose tissue and/or brain regions, and druggable targets. By providing a complete picture of disorder specific and cross-disorder shared genetic determinants, our results highlight potential sex differences in the genetic liability to metabolic comorbidities in patients with severe mental disorders.</p></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165178124004803/pdfft?md5=458c7381aaef804736e141ca3421f4a7&pid=1-s2.0-S0165178124004803-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using physical health apps to promote healthy lifestyles in youth mental healthcare: A nationwide perspective-gathering exercise of over 400 service users 使用身体健康应用程序在青少年心理保健中推广健康的生活方式：在全国范围内收集 400 多名服务用户的观点

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-14 DOI: 10.1016/j.psychres.2024.116187

{"title":"Using physical health apps to promote healthy lifestyles in youth mental healthcare: A nationwide perspective-gathering exercise of over 400 service users","authors":"","doi":"10.1016/j.psychres.2024.116187","DOIUrl":"10.1016/j.psychres.2024.116187","url":null,"abstract":"<div><p>Digital technologies have presented a myriad of new solutions for improving cardiometabolic and behavioural health in the general population. However, the ways in which such advances could be applied to address the heightened health-risk behaviours and associated diseases in mental healthcare is unknown. To examine this, 492 young people with mental illness (YPMI) were recruited from 27 Primary Care and NHS mental healthcare sites across the UK, covering various diagnoses (excluding eating disorders). Participants were presented with four types of physical health apps, delivering: 1) Health Tracking; 2) Health Coaching; 3) Health Connections; and 4) Instructional Videos, and completed an online perspective-gathering exercise on the preferred utility, features, behavioural targets of these technologies, and barriers/facilitators to uptake. Results showed a high level of perceived utility across each of the four app types, with physical activity, sleep and diet emerging as preferred behavioural targets. Feedback on ideal app features indicated a need for integrated physical-mental health tracking, and expert-led instructional content/coaching, with less interest expressed towards sharing data with clinical teams. These findings can improve the development, future trials, and clinical implementation of digital lifestyle interventions in mental healthcare, through better accounting for the needs and preferences of YPMI.</p></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165178124004724/pdfft?md5=41e9ac933687763e0fbbfd88ae9c7b18&pid=1-s2.0-S0165178124004724-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI in substance use recovery: Innovation or risk? A call for caution. 人工智能在药物使用康复中的应用：创新还是风险？请谨慎行事。

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-13 DOI: 10.1016/j.psychres.2024.116193

Erfan Ramadhani, Ramtia Darma Putri, Vasco Delano, M Taheri Akhbar, Erdiansyah Erdiansyah, Muhammad Kurniawan

引用次数: 0

Social cognition interventions for patients with first-episode psychosis: A scoping review 针对首发精神病患者的社会认知干预：范围综述

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-12 DOI: 10.1016/j.psychres.2024.116191

{"title":"Social cognition interventions for patients with first-episode psychosis: A scoping review","authors":"","doi":"10.1016/j.psychres.2024.116191","DOIUrl":"10.1016/j.psychres.2024.116191","url":null,"abstract":"<div><p>This scoping review seeks to identify existing evidence of social cognition interventions for patients with first-episode psychosis. This review followed the five steps of Arksey and O'Malley's scoping review framework. Studies published between October 2002 and June 2023 were examined in the following six databases: PsycArticles, PsycINFO, CINAHL, EMBASE, Medline, and Scopus. We also searched grey literature and references of included studies. Studies reporting on social cognition interventions for adults with first-episode psychosis were included. Review findings were synthesised employing the PAGER framework. The PRISMA Extension for Scoping Reviews guideline was followed to prepare and report this manuscript. Twelve articles were included in this review. Most of the social cognition interventions were provided in out-patient clinics. Four studies provided board-based social cognition interventions, while the remaining eight studies introduced interventions to targeted domains of social cognition. All studies reported an improvement in patients’ social functioning and social skills after receiving the intervention. Barriers and facilitators for patients with first-episode psychosis in receiving social cognition intervention were also summarised. Future studies could be conducted to explore the long-term effects of social cognition interventions, particularly for in-patient setting and the domain of social perception.</p></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165178124004761/pdfft?md5=870217f87a6db4d5fd42852b37bfa2d1&pid=1-s2.0-S0165178124004761-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible errors in a meta-analysis on the efficacy of psychodynamic therapy in social anxiety disorder (Qiqi Zhang et al., 2022) 心理动力学疗法对社交焦虑症疗效的荟萃分析中可能存在的错误（Qiqi Zhang 等人，2022 年）

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-12 DOI: 10.1016/j.psychres.2024.116174

引用次数: 0

Joint-trajectories of clinical severity, social functioning and cannabis use in first-episode psychosis: A 5-year longitudinal study in 2 urban early intervention services 首发精神病患者临床严重程度、社会功能和大麻使用的联合轨迹：两项城市早期干预服务的五年纵向研究

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-11 DOI: 10.1016/j.psychres.2024.116184

{"title":"Joint-trajectories of clinical severity, social functioning and cannabis use in first-episode psychosis: A 5-year longitudinal study in 2 urban early intervention services","authors":"","doi":"10.1016/j.psychres.2024.116184","DOIUrl":"10.1016/j.psychres.2024.116184","url":null,"abstract":"<div><p>Cannabis use is associated with increased psychosis incidence alongside worse outcomes. The role of cannabis may be complex, vary across patients and over time. Yet, few have examined the longer-term trajectories of cannabis use, symptoms and functioning and their inter-relationships. We conducted a 5-year longitudinal study to estimate joint-trajectories of clinical severity, social functioning, and cannabis use via group-based multi-trajectory modelling on a sample of 395 incident FEP cases. Associations of trajectories with socio-demographic and clinical factors were tested using multinomial regression. The best-fitting model identified 5 joint-trajectories. A first group (<em>N</em> = 93,23.7 %) presented only marginal improvement despite not using cannabis, while a second with no cannabis use and a third group with low-decreasing use showed clinical amelioration. Among those with baseline harmful cannabis use, a fourth group progressively discontinued use and improved clinically (<em>N</em> = 78,19.9 %). A fifth group with continued use did not significantly improve over follow-up (<em>N</em> = 74,18.8 %), and also had the highest odds of homelessness (OR = 22.5,95 %CI = 6.25–81.1) and childhood adversities (OR = 2.25,95 %CI = 1.71–2.97). There is substantial heterogeneity in the joint-trajectories of cannabis use and FEP outcomes. Our findings support the need for intervention aimed at cannabis reduction among heavy users. Multi-disciplinary, trauma-informed interventions may benefit those with persistent cannabis use, given its associations with childhood and social adversity.</p></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165178124004694/pdfft?md5=b01744e5a77afec82711db32358d3bed&pid=1-s2.0-S0165178124004694-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal inter-hemispheric effective connectivity from left to right auditory regions during Mismatch Negativity (MMN) tasks in psychosis 精神病患者在错配负性（MMN）任务中左右听觉区域的半球间有效连接异常

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-11 DOI: 10.1016/j.psychres.2024.116189

{"title":"Abnormal inter-hemispheric effective connectivity from left to right auditory regions during Mismatch Negativity (MMN) tasks in psychosis","authors":"","doi":"10.1016/j.psychres.2024.116189","DOIUrl":"10.1016/j.psychres.2024.116189","url":null,"abstract":"<div><div>Anomalous Mismatch Negativity (MMN) in psychosis could be a consequence of disturbed neural oscillatory activity at sensory/perceptual stages of stimulus processing. This study investigated effective connectivity within and between the auditory regions during auditory odd-ball deviance tasks. The analyses were performed on two magnetoencephalography (MEG) datasets: one on duration MMN in a cohort with various diagnoses within the psychosis spectrum and neurotypical controls, and one on duration and pitch MMN in first-episode psychosis patients and matched neurotypical controls. We applied spectral Granger causality to MEG source-reconstructed signals to compute effective connectivity within and between the left and right auditory regions. Both experiments showed that duration-deviance detection was associated with early increases of effective connectivity in the beta band followed by increases in the alpha and theta bands, with the connectivity strength linked to the laterality of the MMN amplitude. Compared to controls, people with psychosis had overall smaller effective connectivity, particularly from left to right auditory regions, in the pathway where bilateral information converges toward lateralized processing, often rightward. Blunted MMN in psychosis might reflect a deficit in inter-hemispheric communication between auditory regions, highlighting a “dysconnection” already at preattentive stages of stimulus processing as a model system of widespread pathophysiology.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165178124004748/pdfft?md5=cc1fca3640a88ead4899969d0ff770dd&pid=1-s2.0-S0165178124004748-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Replicable and robust cellular and biochemical blood marker signatures of depression and depressive symptoms 抑郁和抑郁症状的可复制、稳健的细胞和生化血液标记特征

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-11 DOI: 10.1016/j.psychres.2024.116190

{"title":"Replicable and robust cellular and biochemical blood marker signatures of depression and depressive symptoms","authors":"","doi":"10.1016/j.psychres.2024.116190","DOIUrl":"10.1016/j.psychres.2024.116190","url":null,"abstract":"<div><p>Background: Identification of replicable and robust peripheral blood-based markers associated with depression remains elusive, given that studies frequently identify potential biomarkers that ultimately fail to replicate in other studies, impeding progress in psychiatric research. Peripheral biochemical and cellular markers (PBCs; e.g., albumin) may play an important role in depression. Methods: Using a test-replication design including participants from the NHANES community cohort (n<sub>test</sub>=17,450, n<sub>replication</sub>=17,449), we examined 42 PBCs to identify PBCs that were both replicably and robustly associated with either overall depression severity or individual symptoms of depression across both cohorts across a wide range of possible combinations of analytic decisions (n's = 17,000+). Results<strong>:</strong> We found that a small set of PBCs (e.g., bilirubin) were robustly and replicably associated with overall depression severity, with unique signatures of PBCs linked with individual symptoms of depression when stratified by gender. A varying degree of correlation was found between measures of replicability. Conclusions<strong>:</strong> We identified replicable and robust cellular biochemical blood marker signatures associated with both overall depression severity and individual symptoms of depression. Our findings can be used to enhance other researchers’ abilities to better understand factors associated with depression and potentially drive the development of effective treatments for depression.</p></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to editor regarding “Quality and correctness of AI-generated versus human-written abstracts in psychiatric research papers” 致编辑的信，内容涉及 "人工智能生成与人工撰写的精神病学研究论文摘要的质量和正确性对比"

IF 4.2 2区医学

Psychiatry Research Pub Date : 2024-09-11 DOI: 10.1016/j.psychres.2024.116194

引用次数: 0