Psychiatry Research最新文献

{"title":"Fractured trust amidst war: The role of institutional betrayal and childhood maltreatment in shattered world assumptions and multilevel distress","authors":"Ada Talmon ,&nbsp;Rachel Hasson ,&nbsp;Yael Hollander ,&nbsp;Noga Tsur","doi":"10.1016/j.psychres.2026.116959","DOIUrl":"10.1016/j.psychres.2026.116959","url":null,"abstract":"<div><h3>Background</h3><div>The October 7th, 2023, terrorist attacks and subsequent war in Israel constituted an unprecedented assault on the civilian population, resulting in widespread trauma, a collapse of physical and psychological safety, and civilians' perceptions that the government's actions did not prioritize their safety and interests. This study investigates how the disruption of world assumptions, experiences of institutional betrayal, and childhood maltreatment (CM) contributed to multilevel stress outcomes, affecting Israeli civilians' perceptions of their mind, body, and relationships.</div></div><div><h3>Methods</h3><div>A community sample of 690 Israeli adults completed questionnaires assessing war exposure, CM, institutional betrayal, world assumptions, acute stress disorder (ASD), disturbances in self-organization (DSO), and somatization. A moderated mediation model was tested to examine whether CM and institutional betrayal moderated the relationship between war exposure and the distress outcomes, via world assumptions.</div></div><div><h3>Results</h3><div>War exposure was indirectly associated with ASD, DSO, and somatization through shattered world assumptions. This relationship was significantly moderated by institutional betrayal (<em>B</em> = −.075, <em>p</em> = .002); higher levels of institutional betrayal amplified the impact of war exposure on world assumptions. The indirect effects of war exposure on ASD, DSO, and somatization via world assumptions were moderated by institutional betrayal (ps &lt; 0.05), but not CM (ps &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Institutional betrayal plays a significant role in shaping trauma responses to war exposure and societal crises by eroding trust and contributing to multidimensional distress. Interventions should address institutional betrayal to promote healing and restore societal trust.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116959"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common and distinct patterns of aberrant amygdala functional connectivity in major depressive disorder and bipolar disorder: A voxel-wise comparative meta-analysis","authors":"Lisha Zhang ,&nbsp;Kun Qin ,&nbsp;Nanfang Pan ,&nbsp;Haoran Xu ,&nbsp;Qiyong Gong","doi":"10.1016/j.psychres.2026.116989","DOIUrl":"10.1016/j.psychres.2026.116989","url":null,"abstract":"<div><div>As a central hub of emotional processing, alterations in amygdala functional connectivity (FC) have garnered significant attention in both major depressive disorder (MDD) and bipolar disorder (BD), which holds promise in identifying differential biomarkers and highlighting their similarities. However, current findings are limited by inconsistency. To address this, we conducted a comparative and conjunction analysis using the Seed-based d Mapping (SDM) toolbox to examine amygdala FC alterations in MDD and BD patients. Our results revealed distinct amygdala FC alterations between MDD and BD were primarily identified in the left temporal pole, cingulate cortex, and left supramarginal gyrus, while shared amygdala FC abnormalities were particularly observed in the fronto-limbic regions and occipitotemporal gyrus. These findings highlight both commonalities and differences in amygdala FC alterations across MDD and BD, providing insights into the underlying pathophysiology of mood disorders and offering potential neural biomarkers for differential diagnosis, thereby aiding in the improvement of treatment strategies.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116989"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders","authors":"Lilit Antonyan ,&nbsp;S-M Shaheen ,&nbsp;Christie L. Burton ,&nbsp;William J. Gehring ,&nbsp;Noam Soreni ,&nbsp;Pamela Falzarano Szura ,&nbsp;Julia Bellamy ,&nbsp;Usha Rajan ,&nbsp;David Rosenberg ,&nbsp;Gregory L. Hanna ,&nbsp;Paul D. Arnold","doi":"10.1016/j.psychres.2026.116977","DOIUrl":"10.1016/j.psychres.2026.116977","url":null,"abstract":"<div><div>Here, we present the first genome-wide association study and polygenic risk score analysis of obsessive-compulsive symptoms in a sample of 661 clinically diagnosed pediatric participants diagnosed with mental illness and healthy controls. Using a psychiatric questionnaire score as a quantitative trait we conducted a large-scale genetic analysis and ran multiple post-association analyses to investigate the mediating role of obsessive-compulsive symptoms in six comorbid mental disorders. Polygenic risk scores were computed for OCS using genome-wide summary statistics from obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, anxiety disorders, depression, autism spectrum disorder, and tic disorders. Across all models, the PRS of OCS explained modest yet significant proportion of shared genetic risk across six mental disorders consistent with effect sizes typically observed in complex psychiatric traits. Furthermore, Mendelian randomization analysis suggested a potential causal pathway in which OCS mediates the genetic risk for anxiety. These findings highlight shared polygenic mechanisms between OCS and a range of neuropsychiatric conditions. We observed a potential causal pathway in which OCS mediates the genetic risk for anxiety, supporting the hypothesis that OCS may serve as a transdiagnostic mediator within the pediatric population. This study underscores the value of examining genetic risk across the symptom spectrum of mental illnesses, rather than relying solely on binary diagnostic categories.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116977"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of and changes in psychosis symptoms and clinical insight: Exploring the impact of differential antipsychotic mechanisms","authors":"Lena Antonsen Stabell ,&nbsp;Erik Johnsen ,&nbsp;Rune Kroken ,&nbsp;Else-Marie Løberg ,&nbsp;Eirik Kjelby ,&nbsp;Inge Joa ,&nbsp;Solveig Klæbo Reitan ,&nbsp;Maria Rettenbacher ,&nbsp;Kenneth Hugdahl ,&nbsp;Rolf Gjestad","doi":"10.1016/j.psychres.2026.116948","DOIUrl":"10.1016/j.psychres.2026.116948","url":null,"abstract":"<div><h3>Background</h3><div>Impaired clinical insight is common in schizophrenia spectrum disorders (SSDs) and predicts poor treatment adherence and outcomes. It is linked to disorganised, positive, negative, and hostility symptoms. However, few studies repeatedly assess insight after antipsychotic initiation while comparing pharmacologically distinct agents. This study examined how symptom levels and changes predict the development and endpoint of clinical insight over 6 weeks, contrasting the partial dopamine agonist aripiprazole (PDA) with two dopamine antagonists (DAs).</div></div><div><h3>Methods</h3><div>Data from 144 SSD patients in the Bergen-Stavanger-Innsbruck-Trondheim (BeSt InTro) trial, a pragmatic, semi-randomised study of amisulpride, aripiprazole, and olanzapine, were analysed using latent growth curve models. Insight was measured by PANSS Item G12; symptom factors (positive, negative, hostility, cognitive/disorganised) were derived from PANSS.</div></div><div><h3>Results</h3><div>Lower baseline symptoms and greater improvement between weeks 3 and 6 predicted better insight at 6 weeks across all factors. For positive symptoms, improvement between weeks 1 and 3 (<em>b</em> = 0.57, <em>p</em> = 0.009) also predicted better insight. Patients on aripiprazole showed less improvement in insight, though some findings lost significance after correction.</div></div><div><h3>Conclusion</h3><div>Symptom reduction is associated with improved insight, with early changes in positive symptoms exerting the fastest effect. Despite symptom improvement, aripiprazole PDA treatment was linked to less insight gain than DA treatment. These preliminary findings warrant further study.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116948"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconvulsive therapy induces cortical and subcortical structural changes in adolescents with major depressive disorder","authors":"Jing Min ,&nbsp;Tong Zhu ,&nbsp;Mengqi Liu ,&nbsp;Jingbo Zhang ,&nbsp;Taocui Yan ,&nbsp;Shuo Zhu ,&nbsp;Yuhang Yang ,&nbsp;Xumeng Zhu ,&nbsp;Renqiang Yu ,&nbsp;Yang Huang ,&nbsp;Xue Mo ,&nbsp;Kewei He ,&nbsp;Xinke Li ,&nbsp;Fajin Lv ,&nbsp;Chao Li ,&nbsp;Robert K. McNamara ,&nbsp;Xiangqian He ,&nbsp;Du Lei","doi":"10.1016/j.psychres.2025.116845","DOIUrl":"10.1016/j.psychres.2025.116845","url":null,"abstract":"<div><h3>Background</h3><div>Although electroconvulsive therapy (ECT) is an effective intervention for adolescents with major depressive disorder (MDD), the underlying neuroanatomical mechanisms remain poorly understood. This structural magnetic resonance imaging (sMRI) study investigated cortical and subcortical morphology in adolescents with MDD and suicidal ideation before and after ECT.</div></div><div><h3>Methods</h3><div>The study included 27 adolescent MDD patients with suicidal ideation and 31 demographically similar healthy controls (HC). Cortical thickness, surface area, and subcortical volumes were quantified from MRI scans using the FreeSurfer. General linear models and linear mixed models were employed to evaluate morphological differences between patients and HCs at baseline, as well as longitudinal changes in patients following ECT. Partial correlation and multiple regression analyses further explored associations between structural alterations and symptom improvement.</div></div><div><h3>Results</h3><div>At baseline, MDD patients showed widespread morphological deficits within the cingulate-insula-dorsolateral prefrontal cortical circuit and subcortical regions including the hippocampus and thalamus. Following ECT, significant structural increases were observed in the hippocampus, amygdala, insula, and dorsolateral prefrontal cortex. Subcortical volumetric changes were not linearly associated with symptom improvement, while dorsolateral prefrontal alterations were negatively correlated with changes in suicidal ideation.</div></div><div><h3>Conclusion</h3><div>ECT partially reversed baseline cortical-subcortical structural deficits in patients, particularly in the insula, dorsolateral prefrontal cortex (DLPFC), and hippocampus. Structural alterations in the DLPFC may be associated with the alleviation of suicidal ideation, whereas no significant linear relationships were observed between subcortical volumetric changes and symptom improvement.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116845"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cost–utility analysis of mindfulness-based cognitive therapy versus cognitive behavioral therapy for major depressive disorder relapse prevention in primary care","authors":"Waseem Abu-Ashour ,&nbsp;Rick Audas ,&nbsp;John-Michael Gamble ,&nbsp;John Hawboldt ,&nbsp;Joanna E.M. Sale","doi":"10.1016/j.psychres.2026.116996","DOIUrl":"10.1016/j.psychres.2026.116996","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a chronic condition with high relapse rates affecting patients and health systems. Cognitive behavioral therapy (CBT) and mindfulness-based cognitive therapy (MBCT) are strategies for relapse prevention, but their comparative long-term cost-effectiveness remains unclear.</div></div><div><h3>Methods</h3><div>We developed a cohort-based Markov model with three health states, depressive episode, remission, and death, to compare MBCT and CBT in adults with MDD. The model used a lifetime horizon, six-month cycles, with healthcare payer and societal perspectives. Costs included direct medical and productivity losses discounted at 1.5%. Health-state utilities were drawn from published sources. Incremental cost-effectiveness ratios (ICERs) and net monetary benefit (NMB) were estimated at willingness-to-pay (WTP) thresholds of $50,000 and $100,000 per quality-adjusted life-year (QALY). Deterministic and probabilistic sensitivity analyses, plus scenario analyses with alternative horizons and discount rates, assessed uncertainty.</div></div><div><h3>Results</h3><div>In the base case, MBCT was associated with 14.71 QALYs at a cost of $543,861, while CBT yielded 15.07 QALYs at $549,487. CBT provided an incremental 0.37 QALYs at $5625 higher cost, producing an ICER of $15,266 per QALY gained, well below both thresholds. NMB favored CBT ($204,242 vs. $191,443 at $50,000; $957,971 vs. $926,746 at $100,000). Sensitivity analyses highlighted remission- and depression-related costs as main drivers. Probabilistic analyses showed CBT optimal in 56% of simulations at $50,000 and 61% at $100,000, with MBCT preferred at lower thresholds.</div></div><div><h3>Conclusion</h3><div>CBT may be more cost-effective relative to MBCT for relapse prevention in MDD, though differences are modest. MBCT remains a competitive alternative where CBT access is limited.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116996"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG microstate beta-band abnormalities in obsessive–compulsive disorder: Associations with disease symptoms and sensitivity to repetitive transcranial magnetic stimulation","authors":"Ke Wan ,&nbsp;Yueling Liu ,&nbsp;Ke Chen ,&nbsp;Mengyao He ,&nbsp;Woxin Pan ,&nbsp;Yian Xiao ,&nbsp;Wanying Zhang ,&nbsp;Xuemeng Chen ,&nbsp;Fengqiong Yu ,&nbsp;Kai Wang ,&nbsp;Chunyan Zhu","doi":"10.1016/j.psychres.2026.116952","DOIUrl":"10.1016/j.psychres.2026.116952","url":null,"abstract":"<div><h3>Introduction</h3><div>The objectives of this study are to describe the disease-specific characteristics of EEG microstates in obsessive–compulsive disorder (OCD) and to evaluate the effects of 1-Hz repetitive transcranial magnetic stimulation (rTMS) on both OCD symptoms and microstate characteristics by a randomized controlled trial (RCT).</div></div><div><h3>Methods</h3><div>Thirty-nine patients with OCD and 34 healthy controls (HCs) were included in the first study phase examining disease-specific differences in EEG microstate characteristics. Subsequently, all patients were included in a double-blind, randomized, and sham-controlled trial comparing microstate changes in response to active 1-Hz rTMS (<em>n</em> = 20) or sham rTMS N(<em>n</em> = 19) over the right pre-supplementary motor area (pre-SMA) for 15 consecutive days.</div></div><div><h3>Results</h3><div>Microstate C (MS C) was stronger in the beta band at baseline among OCD patients compared to HCs, but these differences did not remain significant after correction for multiple comparisons. In the RCT, linear mixed-effects model revealed a significant group × time interaction for Y-BOCS scores, with greater symptom reduction following active rTMS compared to sham rTMS (<em>P</em> = 0.003). A significant group × time interaction was also found for beta-band microstate D (MS D). Post hoc tests showed that the active group exhibited significant post-treatment increase in MS D duration (<em>P</em> = 0.020) and coverage (<em>P</em> = 0.033) relative to the sham group. Additionally, within the sham group, changes in beta-band microstate dynamics were significantly associated with changes in Y-BOCS scores, suggesting a potential link between spontaneous brain activity and symptom improvement in the absence of active stimulation.</div></div><div><h3>Conclusion</h3><div>Patients with OCD exhibit a trend toward aberrant EEG microstates in the beta band. Administration of 1-Hz rTMS targeting the right pre-SMA can alleviate OCD symptoms and modulate beta-band microstate properties. Nonetheless, beta-band microstate dynamics may serve as state-sensitive neural markers of OCD, reflecting disease progression or spontaneous symptom fluctuations. Their clinical relevance in informing individualized or stratified neuromodulation strategies warrants further investigation.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116952"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-suicidal self-injury in individuals with attention-deficit/hyperactivity disorder: A systematic review and Meta-analysis with Age- and Sex-stratified findings","authors":"Liliane Smaniotto,&nbsp;Arthur Tolentino,&nbsp;Felipe M.R. Barros,&nbsp;Eduardo Barreto,&nbsp;Barbara Colnaghi,&nbsp;Lais Ker,&nbsp;Eloisa Helena Rubello Valler Celeri,&nbsp;Osmar Della-Torre,&nbsp;Renata C.S. Azevedo","doi":"10.1016/j.psychres.2026.116975","DOIUrl":"10.1016/j.psychres.2026.116975","url":null,"abstract":"<div><h3>Background</h3><div>Non-suicidal self-injury (NSSI) is a significant mental health concern that often co-occurs with attention-deficit/hyperactivity disorder (ADHD). Although growing evidence suggests a link between ADHD and NSSI, the prevalence and moderating factors of this association remain unclear.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis to quantify the prevalence of NSSI in individuals with ADHD and to examine age- and sex-stratified differences across studies conducted in clinical, community, convenience, and population-based samples. A comprehensive search was performed across MEDLINE, EMBASE, and PsycINFO. Fourteen studies met inclusion criteria. Pooled prevalence estimates and odds ratios (ORs) were calculated using random-effects models. Subgroup analyses were performed by age group (adolescents vs. adults) and sex.</div></div><div><h3>Results</h3><div>The overall pooled prevalence of NSSI among individuals with ADHD was 27% (95% CI: 19%–37%), with similar rates among adolescents (28%) and adults (25%). Compared to individuals without ADHD, those with ADHD had twice the odds of engaging in NSSI (OR = 2.26, 95% CI: 1.69–3.00). Sex-stratified analysis, based on three eligible studies, suggested a higher risk in females with ADHD compared to males with ADHD (OR = 4.07, 95% CI: 3.09–5.36). High heterogeneity was observed across studies, potentially attributable to differences in diagnostic criteria, assessment tools, sample characteristics, and sociocultural contexts.</div></div><div><h3>Conclusions</h3><div>Individuals with ADHD show elevated rates of NSSI across developmental stages, with preliminary evidence indicating a potentially greater risk among females. However, these sex-specific findings should be interpreted cautiously due to the limited number of studies. Future research should investigate underlying mechanisms and longitudinal trajectories to better inform targeted interventions and prevention strategies. PROSPERO: CRD420251017948.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116975"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative incidence of schizophrenia-spectrum disorders in children and adolescents with neurodevelopmental disorders: A retrospective cohort study","authors":"Taeyoung Lee ,&nbsp;Bum-Sung Choi ,&nbsp;Ji-Hoon Kim","doi":"10.1016/j.psychres.2026.116981","DOIUrl":"10.1016/j.psychres.2026.116981","url":null,"abstract":"<div><div>Adolescent-onset schizophrenia is rare but clinically severe. While neurodevelopmental disorders (NDDs) are recognized antecedents, the absolute risk of transition to psychosis in pediatric NDD clinic populations has not been clearly quantified relative to other psychiatric conditions. We conducted a retrospective cohort study using electronic medical records from Pusan National University Children’s Hospital (2008–2023). We compared the cumulative incidence of schizophrenia-spectrum disorders between a cohort of youth diagnosed with NDDs (<em>N</em> = 558) and an internal clinical control group of youth treated for non-neurodevelopmental psychiatric disorders (<em>N</em> = 824) during the same period. The 10-year cumulative incidence of schizophrenia-spectrum disorders was significantly higher in the NDD group (2.3 %, 13/558) compared to the internal clinical control group (0.1 %, 1/824) (Log-rank test, <em>p</em> &lt; 0.01). Sensitivity analysis in the ADHD subgroup found no association between stimulant medication use and psychosis onset. Youth with NDDs in a tertiary care setting face a distinct and significantly higher risk of developing schizophrenia-spectrum disorders compared to psychiatric controls. These findings underscore the importance of routine monitoring for emerging psychotic symptoms in this high-risk population.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116981"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening brief CAT in self-harm interventions: A commentary on the RELATE study","authors":"Elia Firda Mufidah ,&nbsp;Novita Toding ,&nbsp;Alya Nurmaya ,&nbsp;Agus Setiawan ,&nbsp;Lutfi Isni Badiah","doi":"10.1016/j.psychres.2026.116991","DOIUrl":"10.1016/j.psychres.2026.116991","url":null,"abstract":"","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"358 ","pages":"Article 116991"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}