Radiologia Medica最新文献

{"title":"Correlation between nova volume flow rate and TOF signal intensity ratio: value in unilateral internal carotid artery occlusion.","authors":"Fabian Wolf, Elisa Colombo, Tilman Schubert, Lara Maria Höbner, Susanne Wegener, Jorn Fierstra, Martina Sebök, Bas van Niftrik, Andreas Luft, Luca Regli, Giuseppe Esposito","doi":"10.1007/s11547-024-01917-5","DOIUrl":"10.1007/s11547-024-01917-5","url":null,"abstract":"<p><strong>Background and purposes: </strong>Non-invasive optimal vessel analysis quantitative magnetic resonance angiography (NOVA-QMRA) has emerged as a valuable tool to characterize cerebral hemodynamics in intracranial atherosclerotic disease (ICAD). Our aim was to explore the eventual correlation between volume flow rate (VFR) measured via NOVA-QMRA and signal intensity ratio (SIR) of time-of-flight (TOF) MRA in M1- and P2-segments bilaterally in patients with unilateral internal carotid artery (ICA) occlusion.</p><p><strong>Materials and methods: </strong>Patients with acute, subacute or chronic unilaterall ICA occlusion receiving NOVA-QMRA between June 2019 and June 2021 were retrospectively included. In bilateral M1- and P2-segments VFR was assessed by means of NOVA-QMRA and a region of interest (ROI) was selected to measure TOF SIR. A correlation between TOF SIR and VFR was tested by means of Pearson correlation coefficient. Mean difference of TOF SIR and VFR between ipsilateral (to occluded ICA) and contralateral M1- and P2-segments was analyzed using a two-sided Welch's t test.</p><p><strong>Results: </strong>Fifty-five patients with unilateral ICA occlusion were included (acute: 28; subacute: 8; chronic: 19). Both ipsilateral (r = 0.536, p < 0.001) and contralateral (r = 0.757, p < 0.001) TOF SIR correlated significantly with NOVA VFR. This observation proved especially true for patients with chronic ICA occlusion. Both VFR (165.18 vs 110.60, p < 0.001) and TOF SIR (4.96 vs 2.70, p < 0.001) were higher in contralateral than ipsilateral M1-segments; whereas, the contrary was observed for P2-segments (VFR 72.35 vs 102.12, p < 0.001, TOF SIR 2.87 vs 3.39, p = 0.016).</p><p><strong>Conclusion: </strong>The study results showed that TOF SIR significantly correlated with phase-contrast derived flow volume in patients with symptomatic ICA occlusion. This correlation remains the same regardless of the stage of the ischemic stroke (acute vs subacute vs chronic). Furthermore, significantly high VFR and TOF SIR in ipsilateral P2-segments may provide evidence of leptomeningeal collateralization in acute patients. Standardly performed TOF SIR Sequences might be of help for a qualitative evaluation of the flow in M1- and P2-segments in patients with unilateral ICA occlusions. NOVA QMRA allows precise quantitative measurements of the flow in cerebral vessels.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"37-45"},"PeriodicalIF":9.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric radiology: a call to action for a new approach to diagnostic imaging for elderly and frail patients.","authors":"Julian Dobranowski, Kate Hanneman, Ania Kielar, Katharine Halliday, Stephen Harden, Oliver Reichardt, Noriko Aida, Masahiro Jinzaki, Noryiuki Tomiyama, Marie-France Bellin, Alain Luciani, Jean-Pierre Tasu, Konstantin Nikolaou, Christiane Kuhl, Isabelle Redenius, Nicoletta Gandolfo, Emanuele Neri, Andrea Giovagnoni","doi":"10.1007/s11547-025-01959-3","DOIUrl":"10.1007/s11547-025-01959-3","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1-3"},"PeriodicalIF":9.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lean body weight-based contrast injection protocol in liver CT: optimization of contrast medium dose.","authors":"Damiano Caruso, Domenico De Santis, Antonella Del Gaudio, Daniela Valanzuolo, Dominga Pugliese, Marta Zerunian, Michela Polici, Giuseppe Tremamunno, Benedetta Masci, Andrea Laghi","doi":"10.1007/s11547-024-01944-2","DOIUrl":"https://doi.org/10.1007/s11547-024-01944-2","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate liver enhancement and image quality of abdominal CECT examinations acquired with multiple LBW-based contrast medium injection protocols.</p><p><strong>Material & methods: </strong>One hundred fifty patients who underwent a clinically indicated CECT examination were prospectively and randomly assigned to one of the following contrast medium injection protocol groups: A, 700 mg iodine(I)/kg of LBW; B, 650 mgI/kg of LBW; and C, 600 mgI/kg of LBW. Liver signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and magnitude of contrast enhancement (ΔHU) were calculated. Subjective image quality was assessed with 5-point Likert scale.</p><p><strong>Results: </strong>The final population included 145 patients (64 females), with 50, 48, and 47 in group A, B, and C, respectively. Group A showed significantly higher SNR, CNR and ΔHU than group B (p = .018, p = .004, and p = .031, respectively) and group C (p = .024, p = .043, and p = .004). Group B had similar SNR, CNR, and ΔHU to group C (all p = 1). ΔHU was < 50 HU in 2, 7, and 11 patients in group A (48.2 ± 0.1), B (43.7 ± 5), and C (44.4 ± 5), respectively. Group A achieved the highest scores in terms of overall image quality, artifacts, and diagnostic confidence (both scores: 4; IQRs: 4-5) compared to group B (both scores: 3; IQRs: 3-5; p ≥ .037) and group C (overall image quality score: 3; IQR: 2-5; p = .011. Artifact and diagnostic confidence score: 3; IQR: 1-4; p ≥ .009).</p><p><strong>Conclusions: </strong>A dosage of 700 mgI/kg of LBW yields optimal liver enhancement and grants higher image quality compared to lower contrast medium dosages.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-brain axis and neuroplasticity in health and disease: a systematic review.","authors":"Alberto Di Napoli, Luca Pasquini, Emiliano Visconti, Maria Vaccaro, Maria Camilla Rossi-Espagnet, Antonio Napolitano","doi":"10.1007/s11547-024-01938-0","DOIUrl":"https://doi.org/10.1007/s11547-024-01938-0","url":null,"abstract":"<p><p>The gut microbiota emerged as a potential modulator of brain connectivity in health and disease. This systematic review details current evidence on the gut-brain axis and its influence on brain connectivity. The initial set of studies included 532 papers, updated to January 2024. Studies were selected based on employed techniques. We excluded reviews, studies without connectivity focus, studies on non-human subjects. Forty-nine papers were selected. Employed techniques in healthy subjects included 15 functional magnetic resonance imaging studies (fMRI), 5 diffusion tensor imaging, (DTI) 1 electroencephalography (EEG), 6 structural magnetic resonance imaging, 2 magnetoencephalography, 1 spectroscopy, 2 arterial spin labeling (ASL); in patients 17 fMRI, 6 DTI, 2 EEG, 9 structural MRI, 1 transcranial magnetic stimulation, 1 spectroscopy, 2 R2*MRI. In healthy subjects, the gut microbiota was associated with connectivity of areas implied in cognition, memory, attention and emotions. Among the tested areas, amygdala and temporal cortex showed functional and structural differences based on bacteria abundance, as well as frontal and somatosensory cortices, especially in patients with inflammatory bowel syndrome. Several studies confirmed the connection between microbiota and brain functions in healthy subjects and patients affected by gastrointestinal to renal and psychiatric diseases.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the art of CT myocardial perfusion.","authors":"Giuseppe Muscogiuri, Pierpaolo Palumbo, Kakuya Kitagawa, Satoshi Nakamura, Alberto Senatieri, Carlo Nicola De Cecco, Gabrielle Gershon, Gregorio Chierchia, Jessica Usai, Daniele Sferratore, Tommaso D'Angelo, Marco Guglielmo, Serena Dell'Aversana, Sonja Jankovic, Rodrigo Salgado, Luca Saba, Riccardo Cau, Paolo Marra, Ernesto Di Cesare, Sandro Sironi","doi":"10.1007/s11547-024-01942-4","DOIUrl":"https://doi.org/10.1007/s11547-024-01942-4","url":null,"abstract":"<p><p>Coronary computed tomography angiography (CCTA) is a powerful tool to rule out coronary artery disease (CAD). In the last decade, myocardial perfusion CT (CTP) technique has been developed for the evaluation of myocardial ischemia, thereby increasing positive predictive value for diagnosis of obstructive CAD. A diagnostic strategy combining CCTA and perfusion acquisitions provides both anatomical coronary evaluation and functional evaluation of the stenosis, increasing the specificity and the positive predictive value of cardiac CT. This could improve risk stratification and guide revascularization procedures, reducing unnecessary diagnostic procedures in invasive coronary angiography. Two different acquisitions protocol have been developed for CTP. Static CTP allows a qualitative or semiquantitative evaluation of myocardial perfusion using a single scan during the first pass of iodinated contrast material in the myocardium. Dynamic CTP is capable of a quantitative evaluation of perfusion through multiple acquisitions, providing direct measure of the myocardial blood flow. For both, CTP acquisition hyperemia is reached using stressor agents such as adenosine or regadenoson. CTP in addition to CCTA acquisition shows good diagnostic accuracy compared to invasive fractional flow reserve (FFR). Furthermore, the evaluation of late iodine enhancement (LIE) could be performed allowing the detection of myocardial infarction.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioembolization for Hepatocellular Carcinoma: a Comparison on Dual-phase Cone-beam CT, Contrast-enhanced CT (CECT) and ^99mTc-macroaggregated albumin-SPECT/CT in predicting final distribution volumes and dosimetry of the post-embolization ⁹⁰Y PET/CT.","authors":"Ettore di Gaeta, Michela Olivieri, Annarita Savi, Patrizia Magnani, Carla Canevari, Simone Gusmini, Diego Palumbo, Giorgia Guazzarotti, Luigi Augello, Francesca Calabrese, Stephanie Steidler, Federica Cipriani, Margherita Rimini, Andrea Casadei-Gardini, Luca Aldrighetti, Arturo Chiti, Francesco De Cobelli","doi":"10.1007/s11547-024-01946-0","DOIUrl":"https://doi.org/10.1007/s11547-024-01946-0","url":null,"abstract":"<p><strong>Purpose: </strong>Personalized treatment schemes are being systematically applied to ensure best treatment outcome in oncologic patients. This is true also for personalized dosimetry in transarterial radioembolization (TARE) in hepatocellular carcinoma (HCC) patients. Precise and detailed volumetric and functional data derived from radiological and nuclear imaging methods are essential for personalized dosimetry. We sought to evaluate accuracy of dual-phase cone-beam CT (CBCT) in comparison to pre-treatment contrast-enhanced CT (CECT), and ^99mTc-macroaggregated albumin-SPECT/CT ([^99mTc]MAA SPECT/CT) to predict and assess the efficacy of TARE based on post-treatment ⁹⁰Y PET/CT.</p><p><strong>Material and methods: </strong>Thirty consecutive patients with HCC treated with TARE were included. Intraprocedural dual-phase CBCT acquisition protocol was developed to distinguish tumor volume in the early arterial phase and perfused volume of non-affected liver in the late arterial phase. Volumetric data obtained from pre-treatment CECT, dual-phase CBCT and [⁹⁹^mTc]MAA SPECT/CT were compared to post-treatment ⁹⁰Y PET/CT considered the standard reference. Treatment simulations for final calculated dose from the different imaging derived volumes were then compared to post-treatment ⁹⁰Y PET/CT.</p><p><strong>Results: </strong>CBCT resulted as the most accurate method in predicting tumor- (R² 0.88) and perfused volumes (R² 0.82). Dosimetry prediction planning performed on derived volumes from the different methods did not show significant difference (p < 0.05), yet highest concordance with ⁹⁰Y PET/CT data was observed with dual-phase CBCT.</p><p><strong>Conclusion: </strong>Our study shows that dual-phase CBCT acquisition is a novel alternative method for correctly and safely administering more accurate and defined doses during TARE.</p><p><strong>Clinicaltrials: </strong>gov ID: NCT03981497.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ladies project: large database in endometrial cancers for a personalized treatment.","authors":"Rosa Autorino, Raffaella Michela Rinaldi, Gabriella Macchia, Mariangela Boccardi, Inga Mihoci Roshanian, Rita Sebastiani, Bianca Santo, Donatella Russo, Martina Ferioli, Anna Benini, Elisabetta Perrucci, Arcangela Raguso, Sabrina Cossa, Paolo Matteucci, Claudia Talocco, Lisa Vicenzi, Fabio Trippa, Lorena Draghini, Antonietta Augurio, Fiorella Cristina Di Guglielmo, Paola Cocuzza, Francesca Pistis, Francesca De Felice, Sofia Meregalli, Elisa Maria Bonetto, Maria Tamburo, Vittorio Bini, Andrea Vavassori, Maria Antonietta Gambacorta, Cynthia Aristei","doi":"10.1007/s11547-024-01940-6","DOIUrl":"https://doi.org/10.1007/s11547-024-01940-6","url":null,"abstract":"<p><strong>Purpose: </strong>To compare Italian use with current international guidelines and to evaluate oncological outcomes and toxicity patterns of adjuvant radiation therapy (RT) for endometrial cancer (EC) in Italian women.</p><p><strong>Materials and methods: </strong>To conduct a retrospective multicentre Italian study a large database was set up. Inclusion criteria were: accrual between 2010 and 2020, treatment with surgery, post-operative external beam RT (EBRT) and/or interventional radiotherapy (IRT) associated or not with adjuvant chemotherapy. Oncological outcomes, acute and late toxicities were analysed according to RT schedule and risk group.</p><p><strong>Results: </strong>A total of 1848 patients, from 16 Italian RT centres were enrolled (median age 65 years, range 27-88). All patients received post-operative RT associated with chemotherapy in 31%. Patients were stratified on the basis of standard risk factors (Bosse et al. in Eur J Cancer 51:1742-50, 2015). After merging intermediate and high-intermediate risk classes into one intermediate group and including advanced and oligometastatic disease in the high-risk group, the low-risk group encompassed 124 patients, the intermediate-risk 1140, and the high risk 576. No low-risk patient developed local relapse (LR). Multivariate analysis showed that intermediate risk patients had a 2.5-fold increased risk of LR if treated with IRT alone vs EBRT-IRT boost. RT schedule did not impact significantly on LR in high risk patients. All acute toxicity parameters were highest in patients who received EBRT with simultaneous integrated boost (EBRT-SIB) and lowest in patients who received only IRT (p < 0.0001). Late toxicity was highest patients who received EBRT-SIB and lowest in those who were given EBRT with sequential boost (p < 0.0001).</p><p><strong>Conclusions: </strong>This retrospective study showed that Italian administration of adjuvant RT for EC is in accordance with current international guidelines. IRT alone for low-risk patients and EBRT associated with vaginal IRT remain standard adjuvant approaches for EC.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Italian radiation oncologists use ChatGPT: a survey by the young group of the Italian association of radiotherapy and clinical oncology (yAIRO).","authors":"Antonio Piras, Federico Mastroleo, Riccardo Ray Colciago, Ilaria Morelli, Andrea D'Aviero, Silvia Longo, Roberta Grassi, Giuseppe Carlo Iorio, Francesca De Felice, Luca Boldrini, Isacco Desideri, Viola Salvestrini","doi":"10.1007/s11547-024-01945-1","DOIUrl":"https://doi.org/10.1007/s11547-024-01945-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the awareness and the spread of ChatGPT and its possible role in both scientific research and clinical practice among the young radiation oncologists (RO).</p><p><strong>Material and methods: </strong>An anonymous, online survey via Google Forms (including 24 questions) was distributed among young (< 40 years old) ROs in Italy through the yAIRO network, from March 15, 2024, to 31, 2024. These ROs were officially registered with yAIRO in 2023. We particularly focused on the emerging use of ChatGPT and its future perspectives in clinical practice.</p><p><strong>Results: </strong>A total of 76 young physicians answered the survey. Seventy-three participants declared to be familiar with ChatGPT, and 71.1% of the surveyed physicians have already used ChatGPT. Thirty-one (40.8%) participants strongly agreed that AI has the potential to change the medical landscape in the future. Additionally, 79.1% of respondents agreed that AI will be mainly successful in research processes such as literature review and drafting articles/protocols. The belief in ChatGPT's potential results in direct use in daily practice in 43.4% of the cases, with mainly a fair grade of satisfaction (43.2%). A large part of participants (69.7%) believes in the implementation of ChatGPT into clinical practice, even though 53.9% fear an overall negative impact.</p><p><strong>Conclusions: </strong>The results of the present survey clearly highlight the attitude of young Italian ROs toward the implementation of ChatGPT into clinical and academic RO practice. ChatGPT is considered a valuable and effective tool that can ease current and future workflows.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are background breast parenchymal features on preoperative breast MRI associated with disease-free survival in patients with invasive breast cancer?","authors":"Jin You Kim, Jin Joo Kim, Ji Won Lee, Nam Kyung Lee, Suk Kim, Kyung Jin Nam, Kyeyoung Lee, Ki Seok Choo","doi":"10.1007/s11547-024-01914-8","DOIUrl":"10.1007/s11547-024-01914-8","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether breast parenchymal features of the contralateral breast on preoperative MRI are associated with primary breast cancer characteristics and disease-free survival (DFS) in women with invasive breast cancer.</p><p><strong>Materials and methods: </strong>Women with newly diagnosed invasive breast cancer who underwent preoperative breast MRI followed by surgery were retrospectively evaluated. Background parenchymal enhancement (BPE) on dynamic contrast-enhanced MRI and background diffusion signal (BDS) on diffusion-weighted MRI of the contralateral breast were qualitatively assessed using a four-category scale: minimal, mild, moderate, or marked. Primary breast cancer characteristics were compared based on the degree of BPE or BDS. Cox proportional hazards models were used to evaluate the association between MRI parenchymal features and DFS after adjusting for clinicopathologic features.</p><p><strong>Results: </strong>A total of 515 women (mean age, 54 years) were included. Of whom, 46 (8.9%) patients who developed disease recurrence at a median follow-up of 60 months were observed. A high level (moderate/marked) of BPE or BDS was associated with younger age (≤ 45) and premenopausal status (all P < 0.05) compared to a low level (minimal/mild), but it was not associated with primary cancer characteristics such as tumor stage, grade, or subtype. Multivariable Cox proportional hazards analysis demonstrated that larger tumor size (> 2 cm) (hazard ratio [HR], 3.877; P < . 001), triple-negative subtype (HR, 2.440; P = .013), and axillary node metastasis (HR, 1.823; P = .049) were associated with worse DFS. No associations were observed between background parenchymal features and disease outcomes.</p><p><strong>Conclusions: </strong>MRI parenchymal features, including BPE and BDS, of the contralateral breast showed no associations with primary breast cancer characteristics or DFS in women with invasive breast cancer.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1790-1801"},"PeriodicalIF":9.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors of interobserver variability in prostate tumor MRI delineation: impact of PI-QUAL score.","authors":"Emile Salgues, Thibaut Jeganathan, Ulrike Schick, Truong An Nguyen, Valentin Tissot, Georges Fournier, Antoine Valéri, Vincent Bourbonne","doi":"10.1007/s11547-024-01920-w","DOIUrl":"10.1007/s11547-024-01920-w","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer ranks as the second most common cancer in men worldwide. Dose escalation to the tumor and/or the prostate improves biochemical recurrence-free survival. However, interobserver variability in lesion contouring poses a significant limitation to such therapeutic approaches. Therefore, a study of factors influencing this variability is necessary.</p><p><strong>Materials and methods: </strong>Three independent readers delineated the index prostate lesion (DIL) using T2w and ADC sequences for each patient. Clinical data were retrospectively collected for all participants. Logistic regression analysis was employed to examine the correlation between clinical features and a mean DICE coefficient > 0.7. Features exhibiting a p value < 0.05 on univariate analysis were subjected to multivariate analysis.</p><p><strong>Results: </strong>The study comprised 68 patients, with a median DICE coefficient of 0.69 (95% CI 0.65-0.71), wherein 42.6% (29/68) attained a mean DICE > 0.7. Univariate analysis identified the PI-QUAL score, maximum diameter of DIL, and mean DIL volume as significant (p < 0.05) predictors. In multivariate analysis, only the PI-QUAL score (p = 0.008) remained statistically associated with a DICE coefficient > 0.7.</p><p><strong>Conclusion: </strong>The PI-QUAL score emerges as the primary predictive factor for minimizing inter-reader variability in intraprostatic dominant lesion segmentation. These findings underscore the importance of considering PI-QUAL scores when devising focal treatment plans. Adoption of a multi-reader approach involving diverse medical specialists (radiologists, radiotherapists, urologists) is advocated, particularly for MRIs with low PI-QUAL scores.</p><p><strong>Clinical relevance statement: </strong>Radiotherapy is a major treatment for patients with localized prostate cancer. Dose escalation to the tumor leads to improved cancer control. Precise delineation of the dominant intraprostatic lesion (DIL) remains a limitation to focal treatments. Features influencing inter-reader variability were never evaluated. In this study, we identified that the PI-QUAL score was the sole predictor of the inter-reader delineation variability of the DIL.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1890-1897"},"PeriodicalIF":9.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}