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[Acute radiation cerebral disorders as an effect of neuronal DNA damage]. [神经DNA损伤引起的急性放射性脑疾病]。
Radiobiologiia Pub Date : 1993-05-01
V N Malakhovskiĭ
{"title":"[Acute radiation cerebral disorders as an effect of neuronal DNA damage].","authors":"V N Malakhovskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Early transient incapacity and cerebral radiation syndrome were shown to result from the de-energizing of the brain due to NAD and ATP neuron pools depletion since DNA breaks stimulate the repair enzyme, ADP-ribosyltransferase, that consumes NAD as a substrate. The phenomenology of syndromes, peculiarities of the CNS repair and neutron RBE might be attributed to this mechanism. DNA is thus a common target for stochastic, deterministic and physiological effects of radiation.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The biological action of nuclear fission products. The late sequelae of the lesions]. 核裂变产物的生物作用。病变的晚期后遗症]。
Radiobiologiia Pub Date : 1993-05-01
I Ia Vasilenko
{"title":"[The biological action of nuclear fission products. The late sequelae of the lesions].","authors":"I Ia Vasilenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The paper presents the review of the author's own data and the results obtained by other investigators concerning remote effects of the NFP-induced affection. The information on the metabolism and clinical picture of acute NFP-induced damages was presented in Report 1 (Radiobiologiia, 1982, No 1).</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of whole-body gamma irradiation on 5'-nucleotidase activity in the blood plasma of rats]. 全身照射对大鼠血浆5′-核苷酸酶活性的影响。
Radiobiologiia Pub Date : 1993-05-01
S M Iakubovskiĭ
{"title":"[The effect of whole-body gamma irradiation on 5'-nucleotidase activity in the blood plasma of rats].","authors":"S M Iakubovskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Alteration dynamics of 5'-nucleotidase (EC 3.1.3.5) in rat plasma was studied after whole-body gamma-irradiation. External gamma-irradiation with doses ranging from 0.5 to 11 Gy induced a transient rise of 5'-nucleotidase activity. An increase in the enzyme activity was found to be a function of dosage and post-exposure time. The moment of enzyme activity rise vs dose was represented as an exponential curve. The rise in plasma 5'-nucleotidase activity was assumed to be the result of lesions in flexible tissue (type F).</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of hematoporphyrin derivative on the postradiation recovery of hemopoiesis in mice]. [血卟啉衍生物对小鼠术后造血功能恢复的影响]。
Radiobiologiia Pub Date : 1993-05-01
Iu B Deshevoĭ, B B Moroz, G I Bezin, V Iu Kovtun, G V Ponomarev, G V Kirillova
{"title":"[The effect of hematoporphyrin derivative on the postradiation recovery of hemopoiesis in mice].","authors":"Iu B Deshevoĭ,&nbsp;B B Moroz,&nbsp;G I Bezin,&nbsp;V Iu Kovtun,&nbsp;G V Ponomarev,&nbsp;G V Kirillova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In experiments with mice exposed to gamma quanta (6.0 Gy) it was shown that a single injection of disodium salt of 2,4-di(alpha-methoxyethyl)deuteroporphyrin IX (50 and 12 mg/kg) both 15 min before and 15 min after irradiation promoted postirradiation regeneration of all bone marrow haemopoiesis compartments. The agent produced a more pronounced stimulatory effect when administered after irradiation.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19318250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of ionizing radiation on the vascular bed of the skin in ontogeny. The status of the lymph- and blood-microcirculatory beds of the skin in newborn white rats during sublethal irradiation]. 电离辐射对个体发育中皮肤血管床的影响。亚致死照射下新生大鼠皮肤淋巴和血液微循环床的状态[j]。
Radiobiologiia Pub Date : 1993-05-01
S V Malinovskiĭ, N Ia Kostesha
{"title":"[The effect of ionizing radiation on the vascular bed of the skin in ontogeny. The status of the lymph- and blood-microcirculatory beds of the skin in newborn white rats during sublethal irradiation].","authors":"S V Malinovskiĭ,&nbsp;N Ia Kostesha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Three-day rat pups were X-irradiated (5 Gy) and killed on days 3-4, 6-7, and 10-11. Using the microscopic, histological and morphometric methods it was found that the microcirculation channel was damaged to a greater extent than the hemocirculation one. This was followed up during the radiation sickness. The pathological changes were more pronounced in all structures of the derma papillary layer than in those of the reticular layer. Oedema and reduced cellularity were noted in the connective frame.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of He-Ne laser radiation on the chemiluminescence of human neutrophils]. He-Ne激光辐射对人中性粒细胞化学发光的影响。
Radiobiologiia Pub Date : 1993-05-01
I A Shchepetkin, V V Udut, A B Karpov
{"title":"[The effect of He-Ne laser radiation on the chemiluminescence of human neutrophils].","authors":"I A Shchepetkin,&nbsp;V V Udut,&nbsp;A B Karpov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was made of the influence of He-Ne laser radiation (lambda = 632.8 nm) on spontaneous chemiluminescence (CL) of human neutrophils as well as its effect on CL stimulated by calcium ionophore (A23187) and protein kinase activator (phorbol-12-myristate-13-acetate, PMA). In vitro irradiation of the blood and a neutrophil suspension activated spontaneous CL and modulated that stimulated by A23187 (1 microM) and PMA (10 nM) within the dose range from 0.01 to 6 J/cm3. The modulation effect of irradiation is a function of radiation dose and the initial value of the integral index of stimulated CL.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of the pulsed radiation of a fast electron beam on the fluorescence of solutions of biological molecules]. [快电子束脉冲辐射对生物分子溶液荧光的影响]。
Radiobiologiia Pub Date : 1993-05-01
A L Vasin, A V Ostrovskiĭ, A A Erastov, E A Vaĭner, R E Garibov, V N Ponomarev, M B Kadomtseva
{"title":"[The effect of the pulsed radiation of a fast electron beam on the fluorescence of solutions of biological molecules].","authors":"A L Vasin,&nbsp;A V Ostrovskiĭ,&nbsp;A A Erastov,&nbsp;E A Vaĭner,&nbsp;R E Garibov,&nbsp;V N Ponomarev,&nbsp;M B Kadomtseva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intensity of fluorescence of amino acid and globular protein solutions, exposed to a pulsed electron beam in the presence and absence of the concurrent pulsed electromagnetic field was found to be a function of radiation dose. The observed decline in the fluorescence intensity was slightly dependent on the solution concentration and dependent on the time and dose-rate of irradiation. The effect of the concurrent pulsed radiation of the electromagnetic field was sometimes observed.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of irradiation of the thymus, the hypothalamo-hypophyseal area and the gonads on the growth of a transplanted Lewis carcinoma in mice]. [胸腺、下丘脑-垂体区和性腺照射对小鼠移植性Lewis癌生长的影响]。
Radiobiologiia Pub Date : 1993-05-01
N P Savina, A A Iarilin, A G Konopliannikov
{"title":"[The effect of irradiation of the thymus, the hypothalamo-hypophyseal area and the gonads on the growth of a transplanted Lewis carcinoma in mice].","authors":"N P Savina,&nbsp;A A Iarilin,&nbsp;A G Konopliannikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Irradiation of thymus with doses of 0.5 to 10 Gy and gonads with 10 Gy does not influence the growth of the tumor transplanted 10 days after irradiation and accelerates the growth of the tumor transplanted 11-12 months after exposure. Irradiation of hypophysis and hypothalamus with doses of 1 and 10 Gy accelerates the growth of the tumor transplanted 10 days and 11-12 months after exposure. In the latter case the effect was more pronounced. When thymus, hypothalamus and hypophysis were exposed simultaneously the effect was analogous to that observed after isolated exposure of hypothalamus/hypophysis but somewhat more pronounced. Irradiation of hypothalamus/hypophysis caused earlier and severer changes in the anti-tumor resistance than the exposure of thymus and gonads did.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The functional activity of the hypothalamo-hypophyseal-gonadal system in male rats in the late periods after x-ray irradiation]. x射线照射后后期雄性大鼠下丘脑-下丘脑-性腺系统的功能活动。
Radiobiologiia Pub Date : 1993-05-01
S V Varga, P V Sinitsyn, L V Tarasenko, L V Chaĭkovskaia, A G Reznikov
{"title":"[The functional activity of the hypothalamo-hypophyseal-gonadal system in male rats in the late periods after x-ray irradiation].","authors":"S V Varga,&nbsp;P V Sinitsyn,&nbsp;L V Tarasenko,&nbsp;L V Chaĭkovskaia,&nbsp;A G Reznikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The hypothalamo-hypophysis-gonad system was studied in male rats 1, 3 and 6 months after external irradiation with doses of 2 and 3 Gy. Irradiation with a dose of 3 Gy was shown to cause a decrease in the level of LH and testosterone in blood plasma, impairment of steroidogenesis in the testes and diminution of their mass. All this was most pronounced 6 months after X irradiation. The morphofunctional status of prostate, inhibited by X radiation, was restored by that time.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The display of hormesis in the action of quinoid radiotoxins]. [类醌放射性毒素作用的激效表现]。
Radiobiologiia Pub Date : 1993-05-01
V A Kopylov, A F Revin, A M Kuzin
{"title":"[The display of hormesis in the action of quinoid radiotoxins].","authors":"V A Kopylov,&nbsp;A F Revin,&nbsp;A M Kuzin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two hours before irradiation (7.5 Gy) mice were injected with quinoid radiotoxins in concentrations close to those formed in mouse blood after gamma-irradiation with a dose of 10 cGy. This increased the survival rate (from 10-20% to 80%), prevented the radiation-induced weight loss, and increased catalase activity in the liver and blood of exposed animals.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19319066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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