[The effect of hematoporphyrin derivative on the postradiation recovery of hemopoiesis in mice].

Abstract

In experiments with mice exposed to gamma quanta (6.0 Gy) it was shown that a single injection of disodium salt of 2,4-di(alpha-methoxyethyl)deuteroporphyrin IX (50 and 12 mg/kg) both 15 min before and 15 min after irradiation promoted postirradiation regeneration of all bone marrow haemopoiesis compartments. The agent produced a more pronounced stimulatory effect when administered after irradiation.