QJM: An International Journal of Medicine最新文献

{"title":"Response letter to the Letter to the Editor 'Refining the synthesis of age-related biomarkers in CKD.'","authors":"Caoimhe McGarvey, Rose Anne Kenny, Donal J Sexton","doi":"10.1093/qjmed/hcaf151","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf151","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shengmai Jianghuang San Enhances Radiosensitivity of Hypoxic Nasopharyngeal Carcinoma by Inhibiting Cancer Stemness.","authors":"Chao Su, Fengying Gong, Yanyi You, Ziqing Jiang, Xiaohui Wen, Yaran Wang, Sijie Lin, Fei Li, Jingjun Li, Ying Liu, Daoqi Zhu, Qin Fan","doi":"10.1093/qjmed/hcaf147","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf147","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy is the preferred treatment for nasopharyngeal carcinoma (NPC). Previous studies by our research team have shown that Shengmai Jianghuang San (SMJHS) inhibits the proliferation and migration of hypoxic NPC cells, thereby enhancing their radiosensitivity.</p><p><strong>Aim: </strong>This study aimed to explore the effects and potential molecular mechanisms of action of SMJHS on NPC cell stemness.</p><p><strong>Methods: </strong>Sprague-Dawley rats were administered SMJHS intragastrically, and blood samples were collected from the abdominal aorta. Serum containing the drug was obtained by low-speed centrifugation. The components of the SMJHS-containing serum were analysed using Ultra-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Cobalt chloride was used to simulate cell hypoxia. Methyl Thiazolyl Tetrazolium, colony formation, and tumour sphere formation assays were conducted to assess cell viability, radiosensitivity, and stemness markers, respectively. Stable knockdown cell lines were established using lentivirus transduction. The interactions between NPC cancer stem cells and the tenascin-C (TNC)/HIF-1α/YAP1 pathway were assessed using western blotting and RT-qPCR. The effect of SMJHS on NPC radioresistance was analysed using subcutaneous tumour xenografts in nude mice.</p><p><strong>Results: </strong>Our study showed that SMJHS inhibited NPC cell growth in vitro, enhanced NPC radiosensitivity, and reduced NPC cell stemness. Compared with the control group, SMJHS significantly suppressed tumour growth, inhibited the expression of TNC, HIF-1α, YAP1, and CD44, and reduced the growth of xenograft tumours in nude mice. These findings suggest that SMJHS enhances radiosensitivity by suppressing cell stemness through the TNC/HIF-1α/YAP1 pathway.</p><p><strong>Conclusion: </strong>SMJHS improves NPC radiosensitivity by downregulating NPC cell stemness through inhibition of the TNC/HIF-1α/YAP1 signalling pathway.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The H-Index: Is it time for a more equitable role-weighted citation index for scientific contribution?","authors":"Arundhati Garud, Subhabrata Moitra","doi":"10.1093/qjmed/hcaf150","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf150","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochleovestibular nerve involvement in sarcoidosis: a case series and a literature review.","authors":"Tristan Dietrich, Arthur Renaud, Gwenvael Danic, Géraldine Mineur, Guillaume Michel, Christian Lavigne, Christian Agard","doi":"10.1093/qjmed/hcaf153","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf153","url":null,"abstract":"<p><strong>Background: </strong>Sarcoidosis is a systemic inflammatory disease of unknown etiology. Cochleovestibular nerve involvement (CVNI) may occur as a rare manifestation of neurosarcoidosis. Comprehensive data on CVNI in neurosarcoidosis are scarce and outdated. This study aimed to provide an updated characterization of this condition.</p><p><strong>Method: </strong>We analyzed medical records from Nantes University Hospital (2010-2023) and conducted a systematic literature review, identifying cases of neurosarcoidosis with CVNI. Data included demographics, clinical features, diagnostic findings (MRI, CSF), treatments, and outcomes.</p><p><strong>Results: </strong>Among 39 patients (51% women, median age 40), CVNI appeared during the first flare of sarcoidosis in 90%, with hearing loss in 92%, often bilateral (78%) but rarely symmetrical (28%). Diagnostic imaging revealed internal auditory canal enhancement in 57% of cases and meningeal enhancement in 27%. CSF analysis demonstrated pleocytosis in 80% and elevated protein levels in 75%. No case had both normal MRI and CSF. Corticosteroids were used in 97%, with conventional immunosuppressants and anti-TNF-α agents in 46% and 19%, respectively. CVNI-specific improvement occurred in 59%, but only 17% achieved complete recovery. Addition of anti-TNF-α agents or conventional immunosuppressants did not improve outcomes beyond corticosteroid monotherapy.</p><p><strong>Conclusion: </strong>CVNI in sarcoidosis is rare and diagnostically challenging. MRI and CSF analysis are key for diagnosis. Early corticosteroid treatment is essential, while additional immunosuppressive therapies offer limited short-term benefit. Prospective studies are needed to guide management.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of multimorbidity with biological age acceleration in acute ischemic stroke patients: a cross-sectional study.","authors":"Hanbing Zhao, Yiwei Qian, Yifang Zhou, Ding Zhang, Zhaoyang Zhao, Wan Zhang, Chenjia Shan, Yamin Wang, Zixin Chen, Jiaxin Wang, Lulu Pei, Qiang Zhang, Qianyu Zhou, Yuming Xu, Mingming Ning, Ferdinando S Buonanno, Changqing Sun, Bo Song","doi":"10.1093/qjmed/hcaf148","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf148","url":null,"abstract":"<p><strong>Background: </strong>Multimorbidity may influence biological aging, particularly in acute ischemic stroke (AIS) patients with high comorbidity burden. However, evidence on associations between multimorbidity and biological aging in AIS remains limited, with unclear differential impacts of specific multimorbidity clusters. This study evaluated latent multimorbidity patterns in AIS patients and quantified relationships between multimorbidity and biological age (BA) acceleration.</p><p><strong>Methods: </strong>This study included AIS patients from Ischemic Cerebrovascular Disease Database of the First Affiliated Hospital of Zhengzhou University between 2018 and 2019. BA was assessed using the Klemera-Doubal method biological age (KDM-BA) and Phenotypic Age (PhenoAge). Latent class analysis (LCA) identified multimorbidity clusters. Generalized linear model evaluated associations between multimorbidity and BA acceleration.</p><p><strong>Results: </strong>A total of 2539 AIS patients were included, with 90% exhibiting multimorbidity (≥2 comorbidities). Each additional chronic condition was associated with a 3.78-year increase in KDM-based age acceleration (95%CI: 3.00-4.55, fully adjusted) and 0.78-year increase in phenotypic age acceleration (95%CI: 0.56-1.00, fully adjusted). Among multimorbidity patterns, the hyperglycemia-hypertension pattern showed the strongest association with KDM-AA (β = 11.59, 95%CI : 9.61-13.58), followed by cardiac dysfunction (β = 7.89, 95%CI : 3.11-12.66).</p><p><strong>Conclusion: </strong>The overwhelming majority of AIS patients exhibit multimorbidity, which is associated with accelerated biological aging. Metabolic-vascular multimorbidity show the strongest links to this association. Prospective studies are needed to further explore the causal relationship between multimorbidity and biological aging acceleration.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advance Healthcare Planning: One Size Does Not Fit All.","authors":"Maria Redahan, Brendan D Kelly","doi":"10.1093/qjmed/hcaf146","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf146","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression of cutaneous xanthomata in a patient with homozygous familial hypercholesterolemia following liver transplant.","authors":"Eamon P Mccarron, Andrew Mcneice, Johnny Cash, Michael Heneghan, Clodagh Loughery","doi":"10.1093/qjmed/hcaf084","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf084","url":null,"abstract":"<p><p>Homozygous familial hypercholesterolemia (HoFH), is a rare, aggressive metabolic disorder characterised by elevated levels of low density lipoprotein (LDL) and premature cardiovascular disease. Heterogeneity is seen among patients in relation to mutation and clinical phenotype. We present a case of a 36-year-old Syrian woman with debilitating cutaneous xanthomata which have regressed post liver transplant.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two closely spaced missense PKD1 variants in cis cause autosomal dominant polycystic kidney disease in a chinese family.","authors":"Haiyu Zhang, Xinying Bi, Liuqing Yang, Xiaowei Zhao, Chunyan Jiang","doi":"10.1093/qjmed/hcaf145","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf145","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tongue Involvement in Light Chain Amyloidosis.","authors":"Paula Matias, Jorge Almeida, Pedro Marques","doi":"10.1093/qjmed/hcaf142","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf142","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sister Mary Joseph's Nodule in Gallbladder Carcinoma.","authors":"Venkatesh Vaithiyam, Sanjeev Sachdeva, Ravi Teja Reddy, Lalit Chandra Kummetha, Puja Sakhuja","doi":"10.1093/qjmed/hcaf144","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf144","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}