Comparing the Effect of Acupuncture, Sham Acupuncture, and Waiting-List Control on Patients with Post-stroke Cognitive Impairment: A Randomized Clinical Trial.
Xiaolin Chen, Lili Zhang, Wenhui Mao, Jian Wen, Yuting Wang, Kaixuan Ma, Xi Nan, Xiayu Li, Hui Yang, Wei Liu, Xiaochan Tan, Lingling Luo, Geshu Du, He Bu, Yanhong Wang, Yuzheng Du
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引用次数: 0
Abstract
Background: There remains no global consensus on the use of acupuncture therapy in post-stroke cognitive impairment (PSCI), particularly in large sample multi-center RCTs.
Aim: To determine whether acupuncture can enhance cognitive function in PSCI.
Design and methods: This RCT was conducted from December 2019 to February 2024. A total of 360 participants were recruited and randomly assigned to manual acupuncture (MA), sham acupuncture (SA), or waiting-list control (WC) groups in a 1:1:1 ratio. This study utilized centralized randomization with allocation concealment by Minimpy software and was executed in five hospitals located in Tianjin, Changchun, Changsha, Baotou, and Changzhi, China. The MA group underwent 36 acupuncture sessions for 12 weeks. Participants were observed for a further 24 weeks without any intervention. The primary outcome was measured by MoCA scale. Secondary outcomes were evaluated by MMSE, CDR, NPI, FAQ, WHOQOL-BREF, and Aβ-42. Statistical analysis was conducted by t-tests, the Kruskal-Wallis test, one-way ANOVA, and linear mixed-effects model.
Results and conclusion: 307 of the 360 patients were analyzed. The MA group showed significant improvement in MoCA scores compared to the SA and WC groups, with increases of 2.21 [95% CI, 1.28 to 3.13; P < 0.001] and 2.76 [95% CI, 1.74 to 3.77; P < 0.001] at week 36. The results derived from the MMSE, CDR, NPI, FAQ, and WHOQOL-BREF indicate that acupuncture therapy may enhance cognitive function and overall quality of life, although it does not appear to affect Aβ-42 levels when contrasting the MA group with the SA or WC groups. Acupuncture therapy could significantly improve cognitive function in adults with PSCI.
Trial registration: Chinese Clinical Trial Registry: ChiCTR2000033801.
期刊介绍：
QJM, a renowned and reputable general medical journal, has been a prominent source of knowledge in the field of internal medicine. With a steadfast commitment to advancing medical science and practice, it features a selection of rigorously reviewed articles.
Released on a monthly basis, QJM encompasses a wide range of article types. These include original papers that contribute innovative research, editorials that offer expert opinions, and reviews that provide comprehensive analyses of specific topics. The journal also presents commentary papers aimed at initiating discussions on controversial subjects and allocates a dedicated section for reader correspondence.
In summary, QJM's reputable standing stems from its enduring presence in the medical community, consistent publication schedule, and diverse range of content designed to inform and engage readers.
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