{"title":"Response to Association of healthy sleep patterns with risk of mortality and life expectancy.","authors":"Haibin Li, Frank Qian","doi":"10.1093/qjmed/hcaf129","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf129","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chung-Chu Tung, Yen Chin, Wen-Bin Yeh, Renin Chang
{"title":"Association of healthy sleep patterns with risk of mortality and life expectancy.","authors":"Chung-Chu Tung, Yen Chin, Wen-Bin Yeh, Renin Chang","doi":"10.1093/qjmed/hcaf128","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf128","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Danon disease.","authors":"Shichu Liang, Jie Wang, Yucheng Chen","doi":"10.1093/qjmed/hcaf134","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf134","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Mo, Huiyu Liu, Qingting Chen, Jiaqi Liu, Ka Wu
{"title":"Pharmacological effects and mechanisms of Mahonia Fortunei in treating aerobic vaginitis through regulation of vaginal microbiota.","authors":"Jie Mo, Huiyu Liu, Qingting Chen, Jiaqi Liu, Ka Wu","doi":"10.1093/qjmed/hcaf132","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf132","url":null,"abstract":"<p><strong>Background: </strong>Aerobic vaginitis (AV) caused by abnormal aerobic bacterial infections, is characterized by inflammation, and dysbiosis of vaginal microbiota. The traditional herbal medicine, Mahonia Fortunei, has shown potential anti-inflammatory and antimicrobial properties, which could be beneficial for treating AV.</p><p><strong>Methods: </strong>In this study, both low-dose and high-dose Mahonia Fortunei treatments were administered to AV model rats induced by Staphylococcus aureus infection. Vaginal pH levels, bacterial infection, and neutrophil infiltration were measured. Network pharmacology analysis was conducted to identify bioactive ingredients, and 16S rDNA analysis was used to study the vaginal microbiota composition and explain the mechanisms of inflammatory action.</p><p><strong>Results: </strong>The results indicated that Mahonia Fortunei significantly reduced vaginal pH, alleviated bacterial infections, and decreased neutrophil infiltration in AV rats. Bioactive compounds such as berberine, coptisine, and palmatine were selected for network pharmacological analysis. KEGG analysis showed that Mahonia Fortunei downregulated inflammatory pathways such as JAK-STAT and NF-κB, thereby reducing pro-inflammatory cytokines IL-1. Additionally, Mahonia Fortunei restored vaginal microbiota diversity, particularly increasing Gammaproteobacteria, a crucial biomarker for vaginal dysbiosis, and downregulating oxidative phosphorylation and stress-related pathways, reducing oxidative stress and inflammation.</p><p><strong>Conclusion: </strong>Mahonia Fortunei exhibited significant therapeutic potential in treating AV by regulating vaginal microbiota, reducing inflammation, and restoring vaginal health.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Median canaliform dystrophy of Heller.","authors":"Si-Qi Li, Yanhong Shou","doi":"10.1093/qjmed/hcaf133","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf133","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The bullseye sign: A variant of the reverse halo sign in pulmonary tuberculosis.","authors":"Meng Li, Jun Qiang","doi":"10.1093/qjmed/hcaf125","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf125","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to: Incorporating multi-omics technologies with traditional chinese medicine.","authors":"Qin Fan","doi":"10.1093/qjmed/hcaf122","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf122","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incorporating multi-omics technologies with traditional Chinese medicine.","authors":"T L Ting, C-C Chen, S-C Chen","doi":"10.1093/qjmed/hcaf120","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf120","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}