QJM: An International Journal of Medicine最新文献

Cat whiskers on the hip：a case of sarcoid myopathy. 臀部的猫须：一例肉样肌病。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-06 DOI: 10.1093/qjmed/hcae215

Koki Nakamura, Masatoshi Kanda, Hiroyuki Nakamura, Hiroki Takahashi

引用次数: 0

Addressing Vaccine Hesitancy and misinformation amidst Japan's self-amplifying mRNA COVID-19 Vaccine Rollout. 在日本自我扩增的 mRNA COVID-19 疫苗推广过程中解决疫苗犹豫和误导问题。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-05 DOI: 10.1093/qjmed/hcae214

Hayase Hakariya, Rio Ohashi

{"title":"Addressing Vaccine Hesitancy and misinformation amidst Japan's self-amplifying mRNA COVID-19 Vaccine Rollout.","authors":"Hayase Hakariya, Rio Ohashi","doi":"10.1093/qjmed/hcae214","DOIUrl":"https://doi.org/10.1093/qjmed/hcae214","url":null,"abstract":"As of October 1, 2024, Japan implemented a revised COVID-19 vaccination strategy, shifting from a fully publicly funded model to one where costs are partially or fully borne by recipients. This new annual program targets individuals aged 65 and above, and those aged 60-64 at higher risk of severe illness, requiring them to cover some vaccination expenses. For others, the vaccine remains voluntary and self-funded. Notably, this program includes the world's first self-amplifying mRNA COVID-19 vaccine, zapomeran (Kostaive®, Meiji Seika Pharma Co., Ltd) approved on November 28, 2023. This vaccine's innovative self-amplifying feature has ignited debates across media platforms, with widespread public division and confusion. The new vaccine encodes replicase proteins and the spike protein antigen, allowing for reduced doses of 5 ug compared to traditional mRNA vaccines that require 30 ug. However, concerns have been raised, primarily around four misconceptions: shedding, perpetual mRNA replication, integration into human DNA, and its non-approval situation outside Japan. Despite these scientifically unfounded concerns, they have fueled vaccine hesitancy, influenced by misleading information spreading rapidly on social media. Alarmingly, biased statements from an academic university and an academic society aggravate this hesitancy. Japan's history has experienced vaccine hesitancies in human papillomavirus and diphtheria-tetanus-pertussis vaccination cases. To prevent a public health crisis, it is crucial that governmental bodies and academic groups actively counter misinformation, advocating for evidence-based understanding and encouraging vaccination among those most at risk.","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubercular dactylitis/Spina ventosa-A rare skeletal form of extrapulmonary tuberculosis. 结核性半身不遂/文胸--肺外结核的一种罕见骨骼形式。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae209

Pradeep Kumar Gunasekaran, Arushi Gahlot Saini, Manish Rohilla

{"title":"Tubercular dactylitis/Spina ventosa-A rare skeletal form of extrapulmonary tuberculosis.","authors":"Pradeep Kumar Gunasekaran, Arushi Gahlot Saini, Manish Rohilla","doi":"10.1093/qjmed/hcae209","DOIUrl":"https://doi.org/10.1093/qjmed/hcae209","url":null,"abstract":"A 9-year-old girl presented with progressive, painful swelling over the left index finger, associated with local signs of inflammation and restriction of finger movements. After the swelling was punctured using a needle, chronic discharging sinus formed. Examination revealed firm swelling over the right parotid area, bilateral cervical and left axillary lymphadenopathy, and firm swelling over the left index finger with a chronic discharging sinus over the lateral aspect of proximal phalanx. Mantoux intradermal injection was reactive (22x24 mm induration). Blood and pus cultures were sterile. Hand radiograph revealed dactylitis (Figure 1A-C). Fine aspiration and cytology of the cervical lymph node showed degenerated inflammatory cells, epithelioid granuloma and acid-fast bacilli. She was initiated on 4-drug antitubercular therapy (ATT). At 2-months follow-up, she was asymptomatic and had the pain and swelling over the left finger have reduced with significant radiological improvement. Tubercular dactylitis or 'spina ventosa' (wind-filled sail) refers to cystic expansion of short, tubular bones. It is commonly seen in younger children (between 1 and 6 years of age) and adults (between 20 and 50 years of age). A common presentation in endemic areas is presence of a painless, fusiform swelling over a single digit, most commonly the proximal phalanx of index or middle finger as in the index case, or over the metacarpals of middle and ring fingers. Earliest radiological clues include periosteitis followed by gradual destruction of bone and cyst formation in the cavity giving a ballooned-out appearance.","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombotic Microangiopathy Following Snake Envenomation in Pregnancy. 妊娠期蛇咬伤后的血栓性微血管病。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae213

Sayan Mazumder, Suresh Selvam, P J Karthikashri, Pradeeth Sundar Reddy Gollamudi, Anashwara Merin Jacob, Ripudaman Sharma, Ankur Gupta, Ashok Kumar Pannu

引用次数: 0

Black pleural effusion. 黑色胸腔积液

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-10-30 DOI: 10.1093/qjmed/hcae210

Shintaro Kakimoto, Yukinori Harada, Taro Shimizu

引用次数: 0

Analysis of the genetic etiology of CDH23 gene variation in a child with hearing loss. 听力损失儿童 CDH23 基因变异的遗传病因分析。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-10-30 DOI: 10.1093/qjmed/hcae212

Xue Zhong, Yingzi Wang, Yaning Jia, Fengqi Wang, Shiguo Liu

引用次数: 0

The 'Chokubi' Phenomenon: Young Physicians' Exodus from State Service to Private Medicine in Japan. Chokubi "现象：日本年轻医生从国立医院流向私立医院。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-10-30 DOI: 10.1093/qjmed/hcae201

Momoka Yamamura, Akihiko Ozaki, Yudai Kaneda, Masaharu Tsubokura, Tetsuya Tanimoto

引用次数: 0

Breast Erdheim-Chester disease: an unusual presentation of a rare disorder. 乳腺 Erdheim-Chester 病：一种罕见疾病的不寻常表现。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-10-29 DOI: 10.1093/qjmed/hcae211

Jielin Jia, Tengwei Deng, Tao Zhang

引用次数: 0

Hymenolepsis Nana: The Dwarf Tape Worm. 侏儒带绦虫矮胶带虫

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-10-28 DOI: 10.1093/qjmed/hcae193

Sanjeev Sachdeva, Ravi Teja Reddy, Venkatesh Vaithiyam

引用次数: 0

Maternal Human Papillomavirus Infection and Offspring Neurodevelopmental Disorders. 母体人类乳头瘤病毒感染与后代神经发育障碍

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-10-24 DOI: 10.1093/qjmed/hcae207

Dian-Jeng Li, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen, Chih-Sung Liang

{"title":"Maternal Human Papillomavirus Infection and Offspring Neurodevelopmental Disorders.","authors":"Dian-Jeng Li, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen, Chih-Sung Liang","doi":"10.1093/qjmed/hcae207","DOIUrl":"https://doi.org/10.1093/qjmed/hcae207","url":null,"abstract":"Background: Human papillomavirus (HPV) infection can lead to multiple comorbidities in women, including mental health problems. However, few studies have examined the association between maternal HPV infection and risk of neurodevelopmental disorders in their offspring.Aim: We aimed to investigate the association between maternal HPV infection and risk of attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) among their offspring.Design and methods: Data from the Taiwan National Health Insurance Research Database were used for analysis. Offspring of mothers with HPV infection were identified as the index group, and a demographic-matched group (offspring of mothers without HPV infection) was selected as the controls. The primary outcome was risk of ADHD or ASD. Cox regression models with multiple adjustments were used to estimate hazard ratios (HRs) with 95% of confidence intervals (CIs).Results: We included 7,762 individuals in the index group and 31,048 in the control group. After adjusting for potential confounding factors, the index group had a higher risk of ADHD (HR: 1.39, 95% CI: 1.15-1.67) than the controls. Importantly, the risk remained significance when HPV infection was diagnosed either before (HR: 1.29, 95% CI: 1.05-1.59) or during pregnancy (HR: 1.79, 95% CI: 1.28-2.51). No increased risk of ASD was identified in the index group compared to the control group.Conclusions: This study highlights the importance of preventing and treating HPV infection during and before pregnancy. Clinicians should be aware of the association between maternal HPV infection and ADHD in their offspring.","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0