QJM: An International Journal of Medicine最新文献

{"title":"WPW-related atrial fibrillation and its differential diagnosis.","authors":"Oscar M P Jolobe","doi":"10.1093/qjmed/hcaf228","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf228","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between codes and connection!","authors":"Amit Hooda, Amol Kodan","doi":"10.1093/qjmed/hcaf226","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf226","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oleander poisoning: Treatment principles.","authors":"A K Pannu","doi":"10.1093/qjmed/hcaf227","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf227","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Metric: Reassessing the Role of the h-index in Academic Medicine.","authors":"Atanu Chandra, Rupak Chatterjee, Shatavisa Mukherjee, Sugata Dasgupta, Nandini Chatterjee, Jyotirmoy Pal","doi":"10.1093/qjmed/hcaf225","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf225","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential Immunotherapy with Tofacitinib and Low-Dose IL-2 Induces Sustained Remission in Alopecia Areata: A Proof-of-concept monocentric study.","authors":"Jundong Huang, Jia Jian, Min Li, Ruxin Ji, Tian Tian, Xiaobing Liang, Zhixiang Zhao, Yan Tang, Ji Li, Fangfen Liu, Wei Shi","doi":"10.1093/qjmed/hcaf221","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf221","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) is a chronic autoimmune condition that causes non-scarring hair loss and often leads to significant psychosocial distress. Although Janus kinase (JAK) inhibitors such as tofacitinib are effective, relapse after stopping treatment remains a major challenge. New evidence indicates that low-dose interleukin-2 (IL-2) may help maintain remission by increasing regulatory T cells, which can restore immune tolerance.</p><p><strong>Objective: </strong>This proof-of-concept study aimed to evaluate the efficacy of sequential immunotherapy combining tofacitinib and low-dose IL-2 in inducing sustained remission for AA patients after treatment withdrawal.</p><p><strong>Methods: </strong>A monocentric, retrospective case series was conducted at Xiangya Hospital, China, from September 2022 to May 2025. The IL-2 regimen comprised subcutaneous injections (0.5-1 million IU/day for 5 consecutive days per cycle), repeated every 3 weeks for 2-3 cycles. Tofacitinib was tapered and discontinued post-IL-2 therapy. Clinical outcomes, including relapse-free survival and safety, were monitored longitudinally.</p><p><strong>Results: </strong>Four refractory AA patients (median follow-up: 32.5 months) with complete hair regrowth (SALT = 0) after ≥6 months of tofacitinib received adjunctive IL-2. Three patients maintained complete remission for 11-20 months after treatment cessation, while one experienced localized recurrence at 5 months but achieved control with low-dose tofacitinib maintenance. No adverse events were reported.</p><p><strong>Conclusion: </strong>Sequential tofacitinib and low-dose IL-2 therapy may reestablish immune tolerance, offering a potential strategy for drug-free remission. Larger trials are needed to confirm efficacy and optimize protocols.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental tuberculosis secondary to tuberculous peritonitis.","authors":"Yuki Ohnishi, Chiyoko Kono, Yasuhiro Suyama","doi":"10.1093/qjmed/hcaf223","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf223","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Atrioventricular conduction block caused by Nerium Oleander Leaves.","authors":"Yang-Jian Zheng, Qi-Le Dai, Bo Chen, Wang Wen-Na","doi":"10.1093/qjmed/hcaf222","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf222","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the Inflammatory Signature: A Review for Biomarkers in Inflammatory Breast Cancer.","authors":"Yingjia Hu, Jian Li, Xinyi Wang, Hongfei Ji, Xingjian Niu","doi":"10.1093/qjmed/hcaf219","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf219","url":null,"abstract":"<p><p>Inflammatory breast cancer (IBC) is a highly aggressive breast cancer subtype characterized by rapid progression and poor survival outcomes. In recent years, research on the clinical and molecular features of IBC has brought new hope for its diagnosis and treatment. However, the prognosis of IBC remains extremely poor and novel biomarkers to identify the individual characteristics of patients with IBC are warranted. This review discussed the latest research on IBC biomarkers, especially the unique clinical IBC characterization-related biomarkers, including tumor emboli-related markers and tumor microenvironment (TME)-related markers. Biomarkers based on immune cells in the TME, such as tumor-associated macrophages (TAMs), tumor-infiltrating lymphocytes (TILs), mast cells, cytokines, and chemokines (e.g., CCL2), may be involved in the development, progression, and treatment resistance of IBC. This study also identified effective biomarkers for IBC and emphasized unique clinical IBC characterization-related biomarkers that may provide strong evidence in IBC diagnosis, prognosis, and therapeutics.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of age-specific predictive model on the risk of post-acute mortality within one year of COVID-19 infection.","authors":"Ivan Chun Hang Lam, Jiayi Zhou, Wenlong Liu, Kenneth Keng Cheung Man, Qingpeng Zhang, Hao Luo, Carlos King Ho Wong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Esther Wai Yin Chan, Ian Chi Kei Wong, Eric Yuk Fai Wan","doi":"10.1093/qjmed/hcaf218","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf218","url":null,"abstract":"<p><strong>Background: </strong>The existing risk prediction models for COVID-19 associated mortality have not considered the difference in risk factors in patients across an aging population.</p><p><strong>Aim: </strong>To develop age-specific prediction models to forecast the risk of all-cause mortality in patients recovering from COVID-19 infection.</p><p><strong>Design: </strong>Population-based, retrospective cohort study.</p><p><strong>Methods: </strong>Patients with COVID-19 between 1 April 2020 and 31 July 2022 survived beyond the acute phase of infection were stratified into separate age cohorts (<45, 45-64, ≥65) and followed-up for one year. Backward stepwise logistic regression and four statistical and machine learning algorithms were employed to develop age-specific models on the risk of post-acute mortality following COVID-19 infection, based on a comprehensive set of clinical parameters including demographics, COVID-19 vaccination status, pre-existing comorbidities and laboratory-test findings.</p><p><strong>Results: </strong>Of the 891,246 patients with COVID-19 identified, 13,578 (1.05%) died within one year of the index date. Age, COVID-19 vaccination status and history of acute respiratory syndrome prior infection were identified as predictors in the models for separate age groups. The model for patients aged ≥65 exhibited excellent prediction performance with an AUROC of 0.87 (95% CI: 0.87, 0.88), followed by the model for patients aged 45-64 [AUROC=0.83 (95% CI: 0.81, 0.85)] and those aged <45 [AUROC=0.79 (95% CI: 0.72, 0.86)].</p><p><strong>Conclusion: </strong>The age-specific models reported accurately predicted the risk of post-acute mortality in their corresponding age-group of patients, providing valuable asset in optimising clinical strategies and resource allocation in the management of the global burden of Long COVID.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the clinicopathological diversity of Castleman disease: report of three cases.","authors":"Yan Liu, Mingqin Zhong, Liuqing Yang, Chunyan Jiang, Yuhui Wang, Xinying Bi","doi":"10.1093/qjmed/hcaf216","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf216","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}