{"title":"Caring for the older adults in disasters: lessons from Japan's Aging Society.","authors":"Makoto Kosaka, Toshiki Abe, Akihiko Ozaki, Hiroyuki Beniya, Masahiro Kami","doi":"10.1093/qjmed/hcaf073","DOIUrl":"10.1093/qjmed/hcaf073","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"553-554"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aortic dissection and other treatable causes of cardiogenic right-sided pulmonary oedema.","authors":"Oscar M P Jolobe","doi":"10.1093/qjmed/hcaf059","DOIUrl":"10.1093/qjmed/hcaf059","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"549-550"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From blue to clarity: unravelling the mystery of eccrine acrospiroma.","authors":"Ilangovane Soumiya, Ariharasudhan Varadharajan, Ramamoorthy Logamoorthy, Kaliaperumal Karthikeyan","doi":"10.1093/qjmed/hcaf058","DOIUrl":"10.1093/qjmed/hcaf058","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"539-540"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"'Polo mint sign' in pulmonary thromboembolism with Ig a vasculitis.","authors":"Ashish Chandwani, J Sankar, Vikas Marwah, Akhil K Ravi, Ruchira Mukherji, Ramakant Singh, Kartik Sivasami, Vivek Vasdev","doi":"10.1093/qjmed/hcaf010","DOIUrl":"10.1093/qjmed/hcaf010","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"528-529"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sex- and age-specific differences in the associations between comorbidity and incident heart failure.","authors":"Weida Qiu, Anping Cai, Shiping Wu, Yanchen Zhu, He Zheng, Yingqing Feng","doi":"10.1093/qjmed/hcaf080","DOIUrl":"10.1093/qjmed/hcaf080","url":null,"abstract":"<p><strong>Background: </strong>Little evidence exists regarding the sex- and age-specific differences in the associations of comorbidities and incident heart failure (HF).</p><p><strong>Aims: </strong>This study aims to evaluate the sex- and age-specific associations of comorbidities and incident HF, and further calculate the population attributable fractions (PAFs) of comorbid diseases for HF by sex and age.</p><p><strong>Methods: </strong>Data were from a sub-cohort of the Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project from Southern China. Participants were stratified by sex and age (<60 or ≥60). The seven comorbidities were collected at baseline, and the study outcome was HF-related hospitalization identified from the Inpatients Registry.</p><p><strong>Results: </strong>A total of 102 278 participants (mean age: 54.3 years, 60.5% were women) without prevalent HF were included. After a median follow-up of 3.5 years, 1588 participants had incident HF. Men, older age (≥60 years) and most comorbidities were significantly associated with a higher risk of HF. The associations between several comorbidities with incident HF were more prominent in women and young participants aged <60 than in men and seniors. The seven comorbidities collectively explained a significant proportion of PAF for HF (47.1%, 95% confidence interval: 41.4, 52.2), and several sex- and age-specific differences in PAFs of comorbidities for incident HF were also observed.</p><p><strong>Conclusions: </strong>In this large, prospective cohort study, several sex- and age-specific differences in the associations between common comorbidities and incident HF were found among Chinese general adults, highlighting the importance of sex- and age-specific preventive strategies for HF.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"514-523"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invisible foes: how air pollution and lifestyle conspire in the rise of colorectal cancer.","authors":"Di Zhao, Meng Zhu","doi":"10.1093/qjmed/hcaf074","DOIUrl":"10.1093/qjmed/hcaf074","url":null,"abstract":"<p><strong>Background: </strong>Air pollution is a recognized risk factor for colorectal cancer (CRC), but its specific impact in China, especially among older populations, remains underexplored.</p><p><strong>Methods: </strong>We used multivariable Cox models with restricted cubic splines to assess the dose-response relationship between air pollution and CRC risk. Subgroup analyses by sex, residence (urban vs. rural) and pre-existing health conditions (hypertension, diabetes) were conducted. Mediation analysis assessed the indirect effects of smoking and alcohol on CRC risk.</p><p><strong>Results: </strong>Exposure to PM2.5, NO2 and SO2 was linked to increased CRC risk. For PM2.5, the hazard ratio (HR) for the highest exposure quartile was 2.35 (95% CI: 1.85-3.03) in urban residents and 1.93 (95% CI: 1.45-2.56) in rural residents. For NO2, the HR per 10 µg/m³ increase was 1.82 (95% CI: 1.56-2.12), and for SO2, it was 1.56 (95% CI: 1.31-1.85). Smoking mediated 14.03% of the effect of PM2.5 on CRC, while alcohol consumption mediated 5.12%. Subgroup analysis showed higher susceptibility in females (HR = 3.47, 95% CI: 2.63-4.63) compared to males (HR = 2.98, 95% CI: 2.25-3.79), and individuals with hypertension (HR = 2.67, 95% CI: 1.98-3.60) or diabetes (HR = 2.10, 95% CI: 1.55-2.86) were at significantly higher risk.</p><p><strong>Conclusion: </strong>Long-term exposure to PM2.5, NO2 and SO2 significantly increases CRC risk in older Chinese adults, with smoking as a key mediator. Females, urban residents and those with hypertension or diabetes are especially vulnerable. Public health strategies should focus on reducing pollution in these high-risk groups.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"501-513"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ocular ischemic syndrome secondary to severe internal carotid stenosis.","authors":"Bangtao Yao, Hongning Li, Xiaogui Zhao, Jin Qian","doi":"10.1093/qjmed/hcaf071","DOIUrl":"10.1093/qjmed/hcaf071","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"545-547"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eamon P Mccarron, Andrew Mcneice, Johnny Cash, Michael Heneghan, Clodagh Loughery
{"title":"Regression of cutaneous xanthomata in a patient with homozygous familial hypercholesterolemia following liver transplant.","authors":"Eamon P Mccarron, Andrew Mcneice, Johnny Cash, Michael Heneghan, Clodagh Loughery","doi":"10.1093/qjmed/hcaf084","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf084","url":null,"abstract":"<p><p>Homozygous familial hypercholesterolemia (HoFH), is a rare, aggressive metabolic disorder characterised by elevated levels of low density lipoprotein (LDL) and premature cardiovascular disease. Heterogeneity is seen among patients in relation to mutation and clinical phenotype. We present a case of a 36-year-old Syrian woman with debilitating cutaneous xanthomata which have regressed post liver transplant.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two closely spaced missense PKD1 variants in cis cause autosomal dominant polycystic kidney disease in a chinese family.","authors":"Haiyu Zhang, Xinying Bi, Liuqing Yang, Xiaowei Zhao, Chunyan Jiang","doi":"10.1093/qjmed/hcaf145","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf145","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}