QJM: An International Journal of Medicine最新文献

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Novel approaches for bacterial toxin neutralization; current advances and future perspectives. 细菌毒素中和的新方法;当前进展和未来展望。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae113
M Doroudian, M A Ardalan, M Beheshti, M Soezi
{"title":"Novel approaches for bacterial toxin neutralization; current advances and future perspectives.","authors":"M Doroudian, M A Ardalan, M Beheshti, M Soezi","doi":"10.1093/qjmed/hcae113","DOIUrl":"10.1093/qjmed/hcae113","url":null,"abstract":"<p><p>This review outlines diverse strategies for neutralizing bacterial toxins which are a significant threat to human health. Effective toxin neutralization is crucial in preventing and treating bacterial infections, especially those caused by antibiotic-resistant strains. Promising approaches include using monoclonal antibodies that target toxins and combining them with agents that directly target bacteria. Aptamers, synthetic molecules that bind to specific targets, provide a rapid and tailored method for inhibiting toxin activity and detecting pathogens. Cell-membrane-coated nanoparticles mimic host cells and effectively neutralize toxins by diverting them and stimulating immune responses. These advancements have the potential to combat bacterial infections and alleviate the associated public health burden.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"763-767"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefit treatment using traditional Chinese medicine in an ulcerative colitis patient: a case report. 溃疡性结肠炎患者的中药治疗获益:病例报告。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae130
C-S Chen, T-Y Yang, T-W Chen, Y-M Chang, C-K Chen
{"title":"Benefit treatment using traditional Chinese medicine in an ulcerative colitis patient: a case report.","authors":"C-S Chen, T-Y Yang, T-W Chen, Y-M Chang, C-K Chen","doi":"10.1093/qjmed/hcae130","DOIUrl":"10.1093/qjmed/hcae130","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"803-805"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tubercular dactylitis/Spina ventosa-A rare skeletal form of extrapulmonary tuberculosis. 结核性半身不遂/文胸--肺外结核的一种罕见骨骼形式。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae209
Pradeep Kumar Gunasekaran, Arushi Gahlot Saini, Manish Rohilla
{"title":"Tubercular dactylitis/Spina ventosa-A rare skeletal form of extrapulmonary tuberculosis.","authors":"Pradeep Kumar Gunasekaran, Arushi Gahlot Saini, Manish Rohilla","doi":"10.1093/qjmed/hcae209","DOIUrl":"https://doi.org/10.1093/qjmed/hcae209","url":null,"abstract":"<p><p>A 9-year-old girl presented with progressive, painful swelling over the left index finger, associated with local signs of inflammation and restriction of finger movements. After the swelling was punctured using a needle, chronic discharging sinus formed. Examination revealed firm swelling over the right parotid area, bilateral cervical and left axillary lymphadenopathy, and firm swelling over the left index finger with a chronic discharging sinus over the lateral aspect of proximal phalanx. Mantoux intradermal injection was reactive (22x24 mm induration). Blood and pus cultures were sterile. Hand radiograph revealed dactylitis (Figure 1A-C). Fine aspiration and cytology of the cervical lymph node showed degenerated inflammatory cells, epithelioid granuloma and acid-fast bacilli. She was initiated on 4-drug antitubercular therapy (ATT). At 2-months follow-up, she was asymptomatic and had the pain and swelling over the left finger have reduced with significant radiological improvement. Tubercular dactylitis or 'spina ventosa' (wind-filled sail) refers to cystic expansion of short, tubular bones. It is commonly seen in younger children (between 1 and 6 years of age) and adults (between 20 and 50 years of age). A common presentation in endemic areas is presence of a painless, fusiform swelling over a single digit, most commonly the proximal phalanx of index or middle finger as in the index case, or over the metacarpals of middle and ring fingers. Earliest radiological clues include periosteitis followed by gradual destruction of bone and cyst formation in the cavity giving a ballooned-out appearance.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eagle syndrome: revealed by the background disease. 老鹰综合征:由背景疾病揭示
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae142
U Shimada, Y Takahashi, Y Mine, M Suzuki, K Kondo, Y Ikenouchi, G A Deshpande, T Naito
{"title":"Eagle syndrome: revealed by the background disease.","authors":"U Shimada, Y Takahashi, Y Mine, M Suzuki, K Kondo, Y Ikenouchi, G A Deshpande, T Naito","doi":"10.1093/qjmed/hcae142","DOIUrl":"10.1093/qjmed/hcae142","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"809-810"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal lupus erythematosus with severe persistent pulmonary hypertension. 新生儿红斑狼疮伴严重持续性肺动脉高压。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae134
B Zhuang, Y L Chen, S P Han
{"title":"Neonatal lupus erythematosus with severe persistent pulmonary hypertension.","authors":"B Zhuang, Y L Chen, S P Han","doi":"10.1093/qjmed/hcae134","DOIUrl":"10.1093/qjmed/hcae134","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"806-808"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombotic Microangiopathy Following Snake Envenomation in Pregnancy. 妊娠期蛇咬伤后的血栓性微血管病。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae213
Sayan Mazumder, Suresh Selvam, P J Karthikashri, Pradeeth Sundar Reddy Gollamudi, Anashwara Merin Jacob, Ripudaman Sharma, Ankur Gupta, Ashok Kumar Pannu
{"title":"Thrombotic Microangiopathy Following Snake Envenomation in Pregnancy.","authors":"Sayan Mazumder, Suresh Selvam, P J Karthikashri, Pradeeth Sundar Reddy Gollamudi, Anashwara Merin Jacob, Ripudaman Sharma, Ankur Gupta, Ashok Kumar Pannu","doi":"10.1093/qjmed/hcae213","DOIUrl":"https://doi.org/10.1093/qjmed/hcae213","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statins the 'new' aspirin. 他汀类药物是“新型”阿司匹林。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae223
Seamas C Donnelly
{"title":"Statins the 'new' aspirin.","authors":"Seamas C Donnelly","doi":"10.1093/qjmed/hcae223","DOIUrl":"https://doi.org/10.1093/qjmed/hcae223","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":"117 11","pages":"757"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Central nervous system infection by Chryseobacterium indologenes diagnosed using metagenomic next-generation sequencing. 利用元基因组下一代测序技术诊断出罕见的吲哚绿脓杆菌中枢神经系统感染。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae150
B Yao, S Li, P Zhao
{"title":"Rare Central nervous system infection by Chryseobacterium indologenes diagnosed using metagenomic next-generation sequencing.","authors":"B Yao, S Li, P Zhao","doi":"10.1093/qjmed/hcae150","DOIUrl":"10.1093/qjmed/hcae150","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"815-817"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to: Association between dietary thiamine intake and new-onset diabetes in general Chinese adults. 对题为 "中国成年人膳食硫胺素摄入量与新发糖尿病之间的关系 "的致编辑函的回复。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae141
Y Zhang, X Qin
{"title":"Response to: Association between dietary thiamine intake and new-onset diabetes in general Chinese adults.","authors":"Y Zhang, X Qin","doi":"10.1093/qjmed/hcae141","DOIUrl":"10.1093/qjmed/hcae141","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"823-824"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The forearm elevation-compression test: a novel test for carpal tunnel syndrome. 前臂抬高加压试验:一种新型的腕管综合征试验。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2024-11-01 DOI: 10.1093/qjmed/hcae121
C H Hawkes, G Cutter
{"title":"The forearm elevation-compression test: a novel test for carpal tunnel syndrome.","authors":"C H Hawkes, G Cutter","doi":"10.1093/qjmed/hcae121","DOIUrl":"10.1093/qjmed/hcae121","url":null,"abstract":"<p><strong>Background: </strong>As the time available to spend with patients decreases, a rapid test for bedside diagnosis of carpal tunnel syndrome (CTS) could be useful.</p><p><strong>Design and methods: </strong>We describe the forearm elevation-compression test (FECT) in this context. The FECT was assessed in 40 patients with clinically suspected CTS and compared to Tinel's and Phalen's signs. Routine electromyography and nerve conduction tests (EMG/NCT) were performed in all cases. In addition, 85 healthy controls were examined by FECT and compared to the patient group.</p><p><strong>Results: </strong>All three provocative tests, particularly FECT, were frequently positive in suspected CTS. Neurophysiological tests were normal in 5 of 40 cases of clinically suspected CTS, and the FECT was positive in all of these suggesting a positive predictive value of 87.5% if one accepts EMG/NCT as the reference. Amongst the healthy controls, 18 of 85 (21.2%) were positive on the FECT suggestive of a high false-positive rate or subclinical disease.</p><p><strong>Conclusion: </strong>It is proposed that the FECT is a useful addition to the clinical examination of suspected CTS. Although the positive rate may be falsely elevated, this is offset by restricting the latency for tingling onset to 10 s or less (FECT2).</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"777-780"},"PeriodicalIF":7.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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