QJM: An International Journal of Medicine最新文献_第9页

Mitochondrial DNA copy number and risk of cardiovascular disease and all-cause mortality: a systematic review and meta-analysis of observational studies. 线粒体DNA拷贝数与心血管疾病和全因死亡率的风险：观察性研究的系统回顾和荟萃分析

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-28 DOI: 10.1093/qjmed/hcae208

Xueru Fu, Yang Zhao, Yamin Ke, Yajuan Gao, Mengmeng Wang, Yaobing Chen, Weifeng Huo, Longkang Wang, Wenkai Zhang, Yuying Wu, Xi Li, Dongdong Zhang, Fulan Hu, Dongsheng Hu, Ming Zhang

{"title":"Mitochondrial DNA copy number and risk of cardiovascular disease and all-cause mortality: a systematic review and meta-analysis of observational studies.","authors":"Xueru Fu, Yang Zhao, Yamin Ke, Yajuan Gao, Mengmeng Wang, Yaobing Chen, Weifeng Huo, Longkang Wang, Wenkai Zhang, Yuying Wu, Xi Li, Dongdong Zhang, Fulan Hu, Dongsheng Hu, Ming Zhang","doi":"10.1093/qjmed/hcae208","DOIUrl":"https://doi.org/10.1093/qjmed/hcae208","url":null,"abstract":"Increasing studies have explored the correlation of mitochondrial DNA copy number (mtDNA-CN) abnormalities with cardiovascular disease (CVD) and all-cause mortality; however, their findings are contradictory. This systematic review and meta-analysis sought to quantitatively summarize current studies to elucidate the impact of mtDNA-CN on CVD outcomes and all-cause mortality. Relevant studies were searched for in PubMed, Embase, and Web of Science databases, up to October 23, 2023. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated with the random-effects model. In total, 22 articles were included in the systematic review, 13 of which were included in the meta-analysis of CVD outcomes and 8 in all-cause mortality. Compared to the highest mtDNA-CN level, the summary RR (95% CI) for the lowest mtDNA-CN level was 2.09 (95% CI 1.59-2.75) for CVD, 1.70 (95% CI 1.29-2.24) for coronary heart disease (CHD), 1.43 (95% CI 1.15-1.79) for heart failure (HF), 1.88 (95% CI 1.08-3.28) for stroke, and 1.33 (95% CI 1.21-1.47) for all-cause mortality. Lower mtDNA-CN may increase the risk of CVD, including CHD, HF, and stroke, as well as all-cause mortality. MtDNA-CN is a potential predictor of CVD and all-cause mortality.","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Call for Rigorous Research Investment in women's Health. 呼吁对妇女健康进行严格的研究投资。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-21 DOI: 10.1093/qjmed/hcae225

Zhaohui Su, Ruijie Zhang, Francis Mungai Kaburu, Chaojun Tong, Mehak Intizar, Abdulswabul Kudiza, Qiang Kuang, Ruru Chen, Xin Yu, Jianlin Jiang, Dean McDonnell, Ali Cheshmehzangi, Sabina Šegalo, Junaid Ahmad, Claudimar Pereira da Veiga, Yu-Tao Xiang

引用次数: 0

Unmasking Hidden P Waves: A Diagnostic Role for the Modified Valsalva Maneuver in Narrow QRS Complex Tachycardia. 揭开隐藏的 P 波：改良瓦尔萨尔瓦手法在窄 QRS 波群心动过速中的诊断作用

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-20 DOI: 10.1093/qjmed/hcae224

Yi-Shuo Liu, Mae-Ling Tang, Samuel Chin Wei Tan, Yun-Tao Zhao

引用次数: 0

Pericardial effusion, a complication common both to expanded dengue syndrome and to sickle cell disease. 心包积液是扩展性登革热综合征和镰状细胞病的常见并发症。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-18 DOI: 10.1093/qjmed/hcae222

Oscar M P Jolobe

引用次数: 0

Thromboangiitis Obliterans (Buerger's Disease). 血栓闭塞性脉管炎（比尔格氏病）。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-14 DOI: 10.1093/qjmed/hcae221

Hideki Oka, Shuji Sumitomo, Kitae Kim, Koichiro Ohmura

引用次数: 0

Fluorescent under ordinary blacklight in M.canis infection on the hand. 在普通黑光灯下，手部感染犬疫霉菌时会发出荧光。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-08 DOI: 10.1093/qjmed/hcae216

Shintaro Kakimoto, Yukinori Harada, Taro Shimizu

引用次数: 0

The Touch of the Tentacles-Dermoscopy of Jellyfish dermatitis. 触手--水母皮炎的皮肤镜检查。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-08 DOI: 10.1093/qjmed/hcae218

Mira Tharani Srinivasan, Ariharasudhan Varadharajan, Logamoorthy Ramamoorthy, Kaliaperumal Karthikeyan

引用次数: 0

Congenital hyperinsulinemia and diabetes caused by ABCC8 variant in a family: a case report. 一个家族中由 ABCC8 变异引起的先天性高胰岛素血症和糖尿病：病例报告。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-08 DOI: 10.1093/qjmed/hcae217

Ping Yang, Sihan Wang, Hongmin Xi, Xiangyun Yin, Lili Ma, Liangliang Li, Mengya Sun, Hong Jiang, Xianghong Li

引用次数: 0

Cat whiskers on the hip：a case of sarcoid myopathy. 臀部的猫须：一例肉样肌病。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-06 DOI: 10.1093/qjmed/hcae215

Koki Nakamura, Masatoshi Kanda, Hiroyuki Nakamura, Hiroki Takahashi

引用次数: 0

Addressing Vaccine Hesitancy and misinformation amidst Japan's self-amplifying mRNA COVID-19 Vaccine Rollout. 在日本自我扩增的 mRNA COVID-19 疫苗推广过程中解决疫苗犹豫和误导问题。

IF 7.3 4区医学

QJM: An International Journal of Medicine Pub Date : 2024-11-05 DOI: 10.1093/qjmed/hcae214

Hayase Hakariya, Rio Ohashi

{"title":"Addressing Vaccine Hesitancy and misinformation amidst Japan's self-amplifying mRNA COVID-19 Vaccine Rollout.","authors":"Hayase Hakariya, Rio Ohashi","doi":"10.1093/qjmed/hcae214","DOIUrl":"https://doi.org/10.1093/qjmed/hcae214","url":null,"abstract":"As of October 1, 2024, Japan implemented a revised COVID-19 vaccination strategy, shifting from a fully publicly funded model to one where costs are partially or fully borne by recipients. This new annual program targets individuals aged 65 and above, and those aged 60-64 at higher risk of severe illness, requiring them to cover some vaccination expenses. For others, the vaccine remains voluntary and self-funded. Notably, this program includes the world's first self-amplifying mRNA COVID-19 vaccine, zapomeran (Kostaive®, Meiji Seika Pharma Co., Ltd) approved on November 28, 2023. This vaccine's innovative self-amplifying feature has ignited debates across media platforms, with widespread public division and confusion. The new vaccine encodes replicase proteins and the spike protein antigen, allowing for reduced doses of 5 ug compared to traditional mRNA vaccines that require 30 ug. However, concerns have been raised, primarily around four misconceptions: shedding, perpetual mRNA replication, integration into human DNA, and its non-approval situation outside Japan. Despite these scientifically unfounded concerns, they have fueled vaccine hesitancy, influenced by misleading information spreading rapidly on social media. Alarmingly, biased statements from an academic university and an academic society aggravate this hesitancy. Japan's history has experienced vaccine hesitancies in human papillomavirus and diphtheria-tetanus-pertussis vaccination cases. To prevent a public health crisis, it is crucial that governmental bodies and academic groups actively counter misinformation, advocating for evidence-based understanding and encouraging vaccination among those most at risk.","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0