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Profiles of drug substances, excipients, and related methodology最新文献

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Propranolol. 普萘洛尔。
Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-04-06 DOI: 10.1016/bs.podrm.2017.02.006
Abdulrahman A Al-Majed, Ahmed H H Bakheit, Hatem A Abdel Aziz, Fahad M Alajmi, Haitham AlRabiah
{"title":"Propranolol.","authors":"Abdulrahman A Al-Majed,&nbsp;Ahmed H H Bakheit,&nbsp;Hatem A Abdel Aziz,&nbsp;Fahad M Alajmi,&nbsp;Haitham AlRabiah","doi":"10.1016/bs.podrm.2017.02.006","DOIUrl":"https://doi.org/10.1016/bs.podrm.2017.02.006","url":null,"abstract":"<p><p>Propranolol is a noncardioselective β-blocker. It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. It is also used to control symptoms of sympathetic overactivity in the management of hyperthyroidism, anxiety disorders, and tremor. Other indications cover the prophylaxis of migraine and of upper gastrointestinal bleeding in patients with portal hypertension. This study provides a detailed, comprehensive profile of propranolol, including formulas, elemental analysis, and the appearance of the drug. In addition, the synthesis of the drug is described. The chapter covers the physicochemical properties, including X-ray powder diffraction, pK, solubility, melting point, and procedures of analysis (spectroscopic, electrochemical, and chromatographic). In-depth pharmacology is also presented (pharmacological actions, therapeutic dosing, uses, Interactions, and adverse effects and precautions). More than 60 references are given as a proof of the abovementioned studies.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"42 ","pages":"287-338"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2017.02.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34932372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Calcium Carbonate. 碳酸钙。
Profiles of drug substances, excipients, and related methodology Pub Date : 2016-12-31 DOI: 10.1016/bs.podrm.2015.11.003
M.M.H. Al Omari, Iyad Rashid, N. Qinna, A. Jaber, A. A. Badwan
{"title":"Calcium Carbonate.","authors":"M.M.H. Al Omari, Iyad Rashid, N. Qinna, A. Jaber, A. A. Badwan","doi":"10.1016/bs.podrm.2015.11.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.11.003","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"20 1","pages":"31-132"},"PeriodicalIF":0.0,"publicationDate":"2016-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86823321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Bupropion Hydrochloride. 盐酸安非他酮。
Profiles of drug substances, excipients, and related methodology Pub Date : 2016-01-01 DOI: 10.1016/bs.podrm.2015.12.001
Saeed R. Khan, R. T. Berendt, C. D. Ellison, Anthony B. Ciavarella, E. B. Asafu-Adjaye, Mansoor A. Khan, P. Faustino
{"title":"Bupropion Hydrochloride.","authors":"Saeed R. Khan, R. T. Berendt, C. D. Ellison, Anthony B. Ciavarella, E. B. Asafu-Adjaye, Mansoor A. Khan, P. Faustino","doi":"10.1016/bs.podrm.2015.12.001","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.12.001","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"14 1","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74755517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Preface to Volume 41. 第41卷序言。
Profiles of drug substances, excipients, and related methodology Pub Date : 2016-01-01 DOI: 10.1016/S1871-5125(16)00009-1
H. Brittain
{"title":"Preface to Volume 41.","authors":"H. Brittain","doi":"10.1016/S1871-5125(16)00009-1","DOIUrl":"https://doi.org/10.1016/S1871-5125(16)00009-1","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"20 1","pages":"vii"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82015973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Valsartan. 缬沙坦。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-03-21 DOI: 10.1016/bs.podrm.2015.01.004
Febry Ardiana, Suciati, Gunawan Indrayanto
{"title":"Valsartan.","authors":"Febry Ardiana,&nbsp;Suciati,&nbsp;Gunawan Indrayanto","doi":"10.1016/bs.podrm.2015.01.004","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.01.004","url":null,"abstract":"<p><p>Valsartan is an antihypertensive drug which selectively inhibits angiotensin receptor type II. Generally, valsartan is available as film-coated tablets. This review summarizes thermal analysis, spectroscopy characteristics (UV, IR, MS, and NMR), polymorphism forms, impurities, and related compounds of valsartan. The methods of analysis of valsartan in pharmaceutical dosage forms and in biological fluids using spectrophotometer, CE, TLC, and HPLC methods are discussed in details. Both official and nonofficial methods are described. It is recommended to use LC-MS method for analyzing valsartan in complex matrices such as biological fluids and herbal preparations; in this case, MRM is preferred than SIM method. </p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"40 ","pages":"431-93"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33367690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Losartan: Comprehensive Profile. 氯沙坦:综合概况。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-04-09 DOI: 10.1016/bs.podrm.2015.02.003
Abdul-Rahman A Al-Majed, Ebrahim Assiri, Nasr Y Khalil, Hatem A Abdel-Aziz
{"title":"Losartan: Comprehensive Profile.","authors":"Abdul-Rahman A Al-Majed,&nbsp;Ebrahim Assiri,&nbsp;Nasr Y Khalil,&nbsp;Hatem A Abdel-Aziz","doi":"10.1016/bs.podrm.2015.02.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.02.003","url":null,"abstract":"<p><p>Losartan (Cozaar™) is an angiotensin II receptor antagonist with antihypertensive activity. It is used in the management of hypertension and heart failure. Nomenclature, formulae, elemental analysis, and appearance of the drug are included in this review. The uses, applications, and the variety of synthetic pathways of this drug are outlined. Physical characteristics including: ionization constant, solubility, X-ray powder diffraction pattern, thermal methods of analysis, UV spectrum, IR spectrum, mass spectrum with fragmentation patterns, and NMR (1H and 13C) spectra of losartan together with the corresponding figures and/or tables are all produced. This profile also includes the monograph of British Pharmacopoeia, together with several reported analytical methods including: spectrophotometric, electrochemical, chromatographic, and capillary electrophoretic methods. The stability, the pharmacokinetic behavior and the pharmacology of the drug are also provided.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"40 ","pages":"159-94"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33368737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Cinnarizine: Comprehensive Profile. Cinnarizine:综合概况。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-04-01 DOI: 10.1016/bs.podrm.2015.01.001
Nadia G Haress
{"title":"Cinnarizine: Comprehensive Profile.","authors":"Nadia G Haress","doi":"10.1016/bs.podrm.2015.01.001","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.01.001","url":null,"abstract":"<p><p>Cinnarizine is a piperazine derivative with antihistaminic, antiserotonergic, antidopaminergic, and calcium channel-blocking activities. A comprehensive profile was performed on cinnarizine including its description and the different methods of analysis. The 1H NMR and 13C one- and two-dimensional NMR methods were used. In addition, infrared and mass spectral analyses were performed which all confirmed the structure of cinnarizine.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"40 ","pages":"1-41"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33368735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Salmeterol Xinafoate. 沙美特罗Xinafoate。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-04-01 DOI: 10.1016/bs.podrm.2015.02.002
Manal M Anwar, Radwan S El-Haggar, Wafaa A Zaghary
{"title":"Salmeterol Xinafoate.","authors":"Manal M Anwar,&nbsp;Radwan S El-Haggar,&nbsp;Wafaa A Zaghary","doi":"10.1016/bs.podrm.2015.02.002","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.02.002","url":null,"abstract":"<p><p>Salmeterol xinafoate is a potent and a long-acting β2-adrenoceptor agonist. It is prescribed for the treatment of severe persistent asthma and chronic obstructive pulmonary disease. Different methods were used to prepare (R)-(-)-salmeterol such as: mixing a sample of 4-benzyloxy-3-hydroxymethyl-ω-bromoacetophenone with sodium lauryl sulfate and the mixture was added to the microbial culture of Rhodotorula rubra, treatment of p-hydroxyacetophenone with Eschenmoser's salt and carbonate exchange resin followed by a sequence of supported reagents and scavenging agents or via Rh-catalyzed asymmetric transfer hydrogenation. The enantioselective synthesis of (S)-salmeterol was achieved via asymmetric reduction of the azidoketone 4 by Pichia angusta yeast. Physical characteristics of salmeterol xinafoate were confirmed via: X-ray powder diffraction pattern, thermal analysis and UV, vibrational, nuclear magnetic resonance, and mass spectroscopical data. Initial improvement in asthma control may occur within 30 min following oral inhalation of salmeterol in fixed combination with fluticasone propionate. Clinically important improvements are maintained for up to 12 h in most patients. It is extensively metabolized in the liver by hydroxylation, thus increased plasma concentrations may occur in patients with hepatic impairment.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"40 ","pages":"321-69"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33367688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Preface to Volume 40. 第40卷序言。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 DOI: 10.1016/S1871-5125(15)00016-3
Harry G Brittain
{"title":"Preface to Volume 40.","authors":"Harry G Brittain","doi":"10.1016/S1871-5125(15)00016-3","DOIUrl":"https://doi.org/10.1016/S1871-5125(15)00016-3","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"40 ","pages":"ix-xii"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1871-5125(15)00016-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33367691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prasugrel Hydrochloride. 盐酸普拉格雷。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-03-23 DOI: 10.1016/bs.podrm.2015.01.002
Mahmoud M H Al Omari, Nidal A Qinna, Iyad S Rashid, Khaldoun A Al-Sou'od, Adnan A Badwan
{"title":"Prasugrel Hydrochloride.","authors":"Mahmoud M H Al Omari,&nbsp;Nidal A Qinna,&nbsp;Iyad S Rashid,&nbsp;Khaldoun A Al-Sou'od,&nbsp;Adnan A Badwan","doi":"10.1016/bs.podrm.2015.01.002","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.01.002","url":null,"abstract":"<p><p>A comprehensive profile of prasugrel HCl is reported herein with 158 references. A full description including nomenclature, formulae, elemental analysis, and appearance is included. Methods of preparation for prasugrel HCl, its intermediates, and derivatives are fully discussed. In addition, the physical properties, analytical methods, stability, uses and applications, and pharmacology of prasugrel HCl are also discussed. </p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"40 ","pages":"195-320"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33367687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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