缬沙坦。

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-03-21 DOI:10.1016/bs.podrm.2015.01.004

Febry Ardiana, Suciati, Gunawan Indrayanto

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引用次数: 5

摘要

缬沙坦是一种选择性抑制II型血管紧张素受体的降压药。一般来说，缬沙坦是薄膜包衣片剂。本文综述了缬沙坦的热分析、光谱特征(紫外、红外、质谱和核磁共振)、多态形式、杂质和相关化合物。详细讨论了分光光度计法、毛细管电泳法、薄层色谱法和高效液相色谱法分析药物剂型和生物液中缬沙坦的方法。描述了官方和非官方的方法。建议采用LC-MS法分析生物体液和草药制剂等复杂基质中的缬沙坦;在这种情况下，MRM比SIM方法更可取。

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Valsartan.

Valsartan is an antihypertensive drug which selectively inhibits angiotensin receptor type II. Generally, valsartan is available as film-coated tablets. This review summarizes thermal analysis, spectroscopy characteristics (UV, IR, MS, and NMR), polymorphism forms, impurities, and related compounds of valsartan. The methods of analysis of valsartan in pharmaceutical dosage forms and in biological fluids using spectrophotometer, CE, TLC, and HPLC methods are discussed in details. Both official and nonofficial methods are described. It is recommended to use LC-MS method for analyzing valsartan in complex matrices such as biological fluids and herbal preparations; in this case, MRM is preferred than SIM method.

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量