Losartan: Comprehensive Profile.

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-04-09 DOI:10.1016/bs.podrm.2015.02.003

Abdul-Rahman A Al-Majed, Ebrahim Assiri, Nasr Y Khalil, Hatem A Abdel-Aziz

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引用次数: 35

Abstract

Losartan (Cozaar™) is an angiotensin II receptor antagonist with antihypertensive activity. It is used in the management of hypertension and heart failure. Nomenclature, formulae, elemental analysis, and appearance of the drug are included in this review. The uses, applications, and the variety of synthetic pathways of this drug are outlined. Physical characteristics including: ionization constant, solubility, X-ray powder diffraction pattern, thermal methods of analysis, UV spectrum, IR spectrum, mass spectrum with fragmentation patterns, and NMR (1H and 13C) spectra of losartan together with the corresponding figures and/or tables are all produced. This profile also includes the monograph of British Pharmacopoeia, together with several reported analytical methods including: spectrophotometric, electrochemical, chromatographic, and capillary electrophoretic methods. The stability, the pharmacokinetic behavior and the pharmacology of the drug are also provided.

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氯沙坦:综合概况。

氯沙坦(Cozaar™)是一种具有抗高血压活性的血管紧张素II受体拮抗剂。它被用于高血压和心力衰竭的治疗。命名法，配方，元素分析，和外观的药物包括在这篇综述。概述了该药物的用途、应用和各种合成途径。给出氯沙坦的物理特性，包括:电离常数、溶解度、x射线粉末衍射图、热分析方法、紫外光谱、红外光谱、带碎裂图的质谱、核磁共振(1H和13C)谱以及相应的图表和/或表格。该简介还包括英国药典的专著，以及几种报道的分析方法，包括:分光光度法，电化学法，色谱法和毛细管电泳法。并提供了该药物的稳定性、药代动力学行为和药理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量