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Profiles of drug substances, excipients, and related methodology最新文献

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Clenbuterol Hydrochloride. 盐酸克仑特罗。
Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-03-31 DOI: 10.1016/bs.podrm.2017.02.002
Abdulrahman A Al-Majed, Nasr Y Khalil, Ibraheem Khbrani, Hatem A Abdel-Aziz
{"title":"Clenbuterol Hydrochloride.","authors":"Abdulrahman A Al-Majed,&nbsp;Nasr Y Khalil,&nbsp;Ibraheem Khbrani,&nbsp;Hatem A Abdel-Aziz","doi":"10.1016/bs.podrm.2017.02.002","DOIUrl":"https://doi.org/10.1016/bs.podrm.2017.02.002","url":null,"abstract":"<p><p>Clenbuterol (Broncodil and trade) is a direct-acting sympathomimetic agent with mainly beta-adrenergic activity and a selective action on β2 receptors (a β2 agonist). It has properties similar to those of salbutamol. It is used as a bronchodilator in the management of reversible airways obstruction, as in asthma and in certain patients with chronic obstructive pulmonary disease. The uses, applications, and the synthetic pathways of this drug are outlined. Physical characteristics including: ionization constant, solubility, X-ray powder diffraction pattern, thermal methods of analysis, UV spectrum, IR spectrum, mass spectrum are all produced. This profile also includes the monograph of British Pharmacopoeia, together with several reported analytical methods including spectrophotometric, electrochemical, chromatographic, immunochemical methods, and capillary electrophoretic methods. The stability, the pharmacokinetic behavior, and the pharmacology of the drug are also provided.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2017.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34934278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Gliclazide. 格列齐特。
Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-04-12 DOI: 10.1016/bs.podrm.2017.02.003
Fatmah A M Al-Omary
{"title":"Gliclazide.","authors":"Fatmah A M Al-Omary","doi":"10.1016/bs.podrm.2017.02.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2017.02.003","url":null,"abstract":"<p><p>Gliclazide is a second-generation oral hypoglycemic drug used for the treatment of noninsulin-dependent diabetes mellitus. It belongs to the sulfonylurea class that stimulates insulin secretion from pancreatic β-cells by inhibiting ATP-dependent potassium channels. Gliclazide also possesses unique antioxidant properties and other beneficial hemobiological effects. This profile represents a comprehensive description of the physical properties, chemical synthesis, spectroscopic characterization (FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, UV, and single-crystal X-ray), methods of analysis, pharmacological actions, and pharmacokinetic and pharmacodynamic properties of the title drug.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2017.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34932374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Lomefloxacin. Lomefloxacin。
Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-03-31 DOI: 10.1016/bs.podrm.2017.02.004
Reem I Al-Wabli
{"title":"Lomefloxacin.","authors":"Reem I Al-Wabli","doi":"10.1016/bs.podrm.2017.02.004","DOIUrl":"https://doi.org/10.1016/bs.podrm.2017.02.004","url":null,"abstract":"<p><p>Lomefloxacin is a second-generation difluorinated broad-spectrum quinolone antibiotic. It is used for the treatment of bronchitis, urinary tract infection, conjunctivitis, otitis externa, and otitis media. A comprehensive profile was performed on lomefloxacin including nomenclature, formulae, elemental composition appearance, and physical characteristics. Spectral methods including ultraviolet spectrum, vibrational spectrum, <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance one- and two-dimensional spectra, and mass spectrum were used for both identification and analysis of the drug. The profile also contains the reported methods of analysis such as voltammetric, polarographic, spectrophotometric, fluorimetric, chromatographic, capillary electrophoresis, and immunoassay methods. In addition, the uses, pharmacokinetics, and chemical synthesis of lomefloxacin are described.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2017.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34932375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Propranolol. 普萘洛尔。
Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-04-06 DOI: 10.1016/bs.podrm.2017.02.006
Abdulrahman A Al-Majed, Ahmed H H Bakheit, Hatem A Abdel Aziz, Fahad M Alajmi, Haitham AlRabiah
{"title":"Propranolol.","authors":"Abdulrahman A Al-Majed,&nbsp;Ahmed H H Bakheit,&nbsp;Hatem A Abdel Aziz,&nbsp;Fahad M Alajmi,&nbsp;Haitham AlRabiah","doi":"10.1016/bs.podrm.2017.02.006","DOIUrl":"https://doi.org/10.1016/bs.podrm.2017.02.006","url":null,"abstract":"<p><p>Propranolol is a noncardioselective β-blocker. It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. It is also used to control symptoms of sympathetic overactivity in the management of hyperthyroidism, anxiety disorders, and tremor. Other indications cover the prophylaxis of migraine and of upper gastrointestinal bleeding in patients with portal hypertension. This study provides a detailed, comprehensive profile of propranolol, including formulas, elemental analysis, and the appearance of the drug. In addition, the synthesis of the drug is described. The chapter covers the physicochemical properties, including X-ray powder diffraction, pK, solubility, melting point, and procedures of analysis (spectroscopic, electrochemical, and chromatographic). In-depth pharmacology is also presented (pharmacological actions, therapeutic dosing, uses, Interactions, and adverse effects and precautions). More than 60 references are given as a proof of the abovementioned studies.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2017.02.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34932372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Calcium Carbonate. 碳酸钙。
Profiles of drug substances, excipients, and related methodology Pub Date : 2016-12-31 DOI: 10.1016/bs.podrm.2015.11.003
M.M.H. Al Omari, Iyad Rashid, N. Qinna, A. Jaber, A. A. Badwan
{"title":"Calcium Carbonate.","authors":"M.M.H. Al Omari, Iyad Rashid, N. Qinna, A. Jaber, A. A. Badwan","doi":"10.1016/bs.podrm.2015.11.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.11.003","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86823321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Bupropion Hydrochloride. 盐酸安非他酮。
Profiles of drug substances, excipients, and related methodology Pub Date : 2016-01-01 DOI: 10.1016/bs.podrm.2015.12.001
Saeed R. Khan, R. T. Berendt, C. D. Ellison, Anthony B. Ciavarella, E. B. Asafu-Adjaye, Mansoor A. Khan, P. Faustino
{"title":"Bupropion Hydrochloride.","authors":"Saeed R. Khan, R. T. Berendt, C. D. Ellison, Anthony B. Ciavarella, E. B. Asafu-Adjaye, Mansoor A. Khan, P. Faustino","doi":"10.1016/bs.podrm.2015.12.001","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.12.001","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74755517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Preface to Volume 41. 第41卷序言。
Profiles of drug substances, excipients, and related methodology Pub Date : 2016-01-01 DOI: 10.1016/S1871-5125(16)00009-1
H. Brittain
{"title":"Preface to Volume 41.","authors":"H. Brittain","doi":"10.1016/S1871-5125(16)00009-1","DOIUrl":"https://doi.org/10.1016/S1871-5125(16)00009-1","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82015973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Valsartan. 缬沙坦。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-03-21 DOI: 10.1016/bs.podrm.2015.01.004
Febry Ardiana, Suciati, Gunawan Indrayanto
{"title":"Valsartan.","authors":"Febry Ardiana,&nbsp;Suciati,&nbsp;Gunawan Indrayanto","doi":"10.1016/bs.podrm.2015.01.004","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.01.004","url":null,"abstract":"<p><p>Valsartan is an antihypertensive drug which selectively inhibits angiotensin receptor type II. Generally, valsartan is available as film-coated tablets. This review summarizes thermal analysis, spectroscopy characteristics (UV, IR, MS, and NMR), polymorphism forms, impurities, and related compounds of valsartan. The methods of analysis of valsartan in pharmaceutical dosage forms and in biological fluids using spectrophotometer, CE, TLC, and HPLC methods are discussed in details. Both official and nonofficial methods are described. It is recommended to use LC-MS method for analyzing valsartan in complex matrices such as biological fluids and herbal preparations; in this case, MRM is preferred than SIM method. </p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33367690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Losartan: Comprehensive Profile. 氯沙坦:综合概况。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-04-09 DOI: 10.1016/bs.podrm.2015.02.003
Abdul-Rahman A Al-Majed, Ebrahim Assiri, Nasr Y Khalil, Hatem A Abdel-Aziz
{"title":"Losartan: Comprehensive Profile.","authors":"Abdul-Rahman A Al-Majed,&nbsp;Ebrahim Assiri,&nbsp;Nasr Y Khalil,&nbsp;Hatem A Abdel-Aziz","doi":"10.1016/bs.podrm.2015.02.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.02.003","url":null,"abstract":"<p><p>Losartan (Cozaar™) is an angiotensin II receptor antagonist with antihypertensive activity. It is used in the management of hypertension and heart failure. Nomenclature, formulae, elemental analysis, and appearance of the drug are included in this review. The uses, applications, and the variety of synthetic pathways of this drug are outlined. Physical characteristics including: ionization constant, solubility, X-ray powder diffraction pattern, thermal methods of analysis, UV spectrum, IR spectrum, mass spectrum with fragmentation patterns, and NMR (1H and 13C) spectra of losartan together with the corresponding figures and/or tables are all produced. This profile also includes the monograph of British Pharmacopoeia, together with several reported analytical methods including: spectrophotometric, electrochemical, chromatographic, and capillary electrophoretic methods. The stability, the pharmacokinetic behavior and the pharmacology of the drug are also provided.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33368737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Cinnarizine: Comprehensive Profile. Cinnarizine:综合概况。
Profiles of drug substances, excipients, and related methodology Pub Date : 2015-01-01 Epub Date: 2015-04-01 DOI: 10.1016/bs.podrm.2015.01.001
Nadia G Haress
{"title":"Cinnarizine: Comprehensive Profile.","authors":"Nadia G Haress","doi":"10.1016/bs.podrm.2015.01.001","DOIUrl":"https://doi.org/10.1016/bs.podrm.2015.01.001","url":null,"abstract":"<p><p>Cinnarizine is a piperazine derivative with antihistaminic, antiserotonergic, antidopaminergic, and calcium channel-blocking activities. A comprehensive profile was performed on cinnarizine including its description and the different methods of analysis. The 1H NMR and 13C one- and two-dimensional NMR methods were used. In addition, infrared and mass spectral analyses were performed which all confirmed the structure of cinnarizine.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2015.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33368735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
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