Profiles of drug substances, excipients, and related methodology最新文献_第6页

Sucrose octaacetate. 蔗糖八乙酸酯。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-03-08 DOI: 10.1016/bs.podrm.2019.02.002

William Craig Stagner, Shalini Gaddam, Rudrangi Parmar, Ajay Kumar Ghanta

引用次数: 4

Topiramate: Comprehensive profile. 托吡酯:综合概况。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-01-14 DOI: 10.1016/bs.podrm.2018.11.005

Nasr Y Khalil, Haitham K AlRabiah, Saad S Al Rashoud, Ahmed Bari, Tanveer A Wani

{"title":"Topiramate: Comprehensive profile.","authors":"Nasr Y Khalil, Haitham K AlRabiah, Saad S Al Rashoud, Ahmed Bari, Tanveer A Wani","doi":"10.1016/bs.podrm.2018.11.005","DOIUrl":"https://doi.org/10.1016/bs.podrm.2018.11.005","url":null,"abstract":"Topiramate, 2,3:4,5-di-O-isopropylidene-β-d-fructopyranose sulfamate, is a potent antiepileptic drug with a broad spectrum of activity. It is effective in both partial and generalized seizures. Topiramate was also found to have significant efficacy in migraine prevention with considerable reductions in the frequency of migraine headaches. The most common adverse events, which may accompany the use of topiramate, are paresthesia, fatigue, decreased appetite, nausea, diarrhea, weight decrease and taste perversion. The weight loss observed with the use of topiramate in obese, epileptic patients, afforded the approval of this drug as an anti-obesity medication. This action is thought to be based on the selective inhibition of mitochondrial carbonic anhydrase isoforms. This profile is prepared to discuss and explain physical characteristics, proprietary and nonproprietary names of topiramate. It also includes methods of preparation, thermal and spectral behavior and methods of analysis. Pharmacokinetics, metabolism, excretion and pharmacology together with its uses and applications are also discussed.","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"44 ","pages":"333-378"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2018.11.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37191231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Cefpodoxime proxetil. 头孢泊肟酯。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-04-16 DOI: 10.1016/bs.podrm.2019.02.001

Gamal A E Mostafa, Yazeed H Al-Otaibi, Abdullah A Al-Badr

引用次数: 1

Preface. 前言。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 DOI: 10.1016/S1871-5125(19)30012-3

Harry G. Brittain

引用次数: 0

Levetiracetam. Levetiracetam。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-03-25 DOI: 10.1016/bs.podrm.2019.02.003

Haitham Alrabiah

引用次数: 0

Multicomponent spectrometric analysis of drugs and their preparations. 药物及其制剂的多组分光谱分析。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2018-12-21 DOI: 10.1016/bs.podrm.2018.11.002

Iqbal Ahmad, Muhammad Ali Sheraz, Sofia Ahmed, Zubair Anwar

{"title":"Multicomponent spectrometric analysis of drugs and their preparations.","authors":"Iqbal Ahmad, Muhammad Ali Sheraz, Sofia Ahmed, Zubair Anwar","doi":"10.1016/bs.podrm.2018.11.002","DOIUrl":"https://doi.org/10.1016/bs.podrm.2018.11.002","url":null,"abstract":"Pharmaceutical preparations may contain a single ingredient or multi-ingredients as well as excipients. In multicomponent systems, specific analytical methods are required to determine the concentrations of individual components in the presence of interfering substances. Ultraviolet and visible spectrometric methods have widely been developed for the analysis of drugs in mixtures and pharmaceutical preparations. These methods are based on ultraviolet and visible multicomponent analysis and chemometrics (multivariate data analysis). The commonly used chemometric methods include principal component analysis (PCA); regression involving classical least squares (CLS), partial least squares (PLS), inverse least squares (ILS), principal component regression (PCR), multiple linear regression (MLR), artificial neural networks (ANNs); soft independent modeling of class anthology (SIMCA), PLS-discriminant analysis (DA); and functional data analysis (FDA). In this chapter, the applications of multicomponent ultraviolet and visible, derivative, infrared and mass spectrometric and spectrofluorimetric methods to the analysis of multi-ingredient pharmaceutical preparations, biological samples and the kinetics of drug degradation have been reviewed. Chemometric methods provide an efficient solution to calibration problems in the analysis of spectral data for the simultaneous determination of drugs in multicomponent systems. These methods facilitate the assessment of product quality and enhance the efficiency of quality control systems.","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"44 ","pages":"379-413"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2018.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37191232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Series Page 系列页面

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 DOI: 10.1016/s1871-5125(19)30007-x

引用次数: 0

Mid-Infrared Spectroscopy of Pharmaceutical Solids. 药用固体的中红外光谱。

Profiles of drug substances, excipients, and related methodology Pub Date : 2018-01-01 Epub Date: 2018-02-01 DOI: 10.1016/bs.podrm.2017.12.002

Harry G Brittain

引用次数: 3

Validation of Chromatographic Methods of Analysis: Application for Drugs That Derived From Herbs. 色谱分析方法的验证:中草药成分的应用。

Profiles of drug substances, excipients, and related methodology Pub Date : 2018-01-01 Epub Date: 2018-03-06 DOI: 10.1016/bs.podrm.2018.01.003

Gunawan Indrayanto

{"title":"Validation of Chromatographic Methods of Analysis: Application for Drugs That Derived From Herbs.","authors":"Gunawan Indrayanto","doi":"10.1016/bs.podrm.2018.01.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2018.01.003","url":null,"abstract":"It is well known that the quality control (QC) of drugs derived from herbs (DDHs) has two main problems: first, DDHs are chemically complex mixtures, and second, the chemical contents of raw plant materials are affected by the site of cultivation, age of plants, methods of harvesting, and processing. QC is used by manufacturers to ensure the consistency, safety, and efficacy of the DDHs. QC of DDHs can be performed by two approaches, namely, marker-oriented and chemical pattern-oriented (metabolite profiling) using chromatographic methods. For having reliable results of any chemical analysis that will be performed in the QC laboratory, the method of analysis must be validated first before it can be routinely applied. Parameters of the validation method that should be evaluated for marker-oriented approach are stability, selectivity, linearity, trueness, precision, and robustness/ruggedness, while for metabolite profiling approach stability, intra- and interday precisions should be determined. Determination of instrumental and sample detection limit (DL), quantification limit (QL), and cutoff value is described in this review. Some relatively new validation methods that could correlate trueness and precision will be also discussed. The importance and application of metabolite profiling for a QC laboratory at pharmaceutical industry are discussed.","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"43 ","pages":"359-392"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2018.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36029376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Preface to Volume 43. 第43卷序言。

Profiles of drug substances, excipients, and related methodology Pub Date : 2018-01-01 DOI: 10.1016/S1871-5125(18)30012-8

Harry G Brittain

引用次数: 1