Profiles of drug substances, excipients, and related methodology最新文献_第5页

Paclitaxel. 紫杉醇。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-04-22 DOI: 10.1016/bs.podrm.2018.11.001

Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Eram El Tahir, Hamad M Alkahtani, Bushra T AlQuadeib

引用次数: 0

Sorafenib. 索拉非尼。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-01-18 DOI: 10.1016/bs.podrm.2018.11.003

Ahmed A Abdelgalil, Hamad M Alkahtani, Fahad I Al-Jenoobi

{"title":"Sorafenib.","authors":"Ahmed A Abdelgalil, Hamad M Alkahtani, Fahad I Al-Jenoobi","doi":"10.1016/bs.podrm.2018.11.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2018.11.003","url":null,"abstract":"Sorafenib (BAY-43-9006), marketed by Bayer as Nexavar® (USA), is anticancer drug approved by US-FDA for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. Sorafenib inhibited tumor growth and angiogenesis through targeting both the RAF/MEK/ERK pathway and receptor tyrosine kinases. This study presents a comprehensive profile of sorafenib, including detailed nomenclature, formula, elemental analysis, methods of preparation, physico-chemical characteristics, and methods of analysis (including spectroscopic, electrochemical, and chromatographic methods of analysis). Spectroscopic and spectrometric analyses include UV/vis spectroscopy, vibrational spectroscopy, nuclear magnetic resonance spectrometry ((1)H and (13)C NMR), and mass spectrometry. Chromatographic methods of analyses include thin layer chromatography and high-performance liquid chromatography. Only few stability indicating methods were found for quantification of sorafenib after exposing tablet dosage form to various stress conditions such as hydrolysis, oxidation, thermal stress, photo and UV light. However, none of these described methods were made to separate and quantify the degradation products. Pharmacology studies including pharmacodynamics, mechanism of action, pharmacokinetics and drug-drug interactions were also presented. An appropriate table and figures were attached to each of the above mentioned sections along with total of 55 references.","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2018.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37366647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributors 贡献者

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 DOI: 10.1016/s1871-5125(19)30011-1

引用次数: 0

Sucrose octaacetate. 蔗糖八乙酸酯。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-03-08 DOI: 10.1016/bs.podrm.2019.02.002

William Craig Stagner, Shalini Gaddam, Rudrangi Parmar, Ajay Kumar Ghanta

引用次数: 4

Topiramate: Comprehensive profile. 托吡酯:综合概况。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-01-14 DOI: 10.1016/bs.podrm.2018.11.005

Nasr Y Khalil, Haitham K AlRabiah, Saad S Al Rashoud, Ahmed Bari, Tanveer A Wani

{"title":"Topiramate: Comprehensive profile.","authors":"Nasr Y Khalil, Haitham K AlRabiah, Saad S Al Rashoud, Ahmed Bari, Tanveer A Wani","doi":"10.1016/bs.podrm.2018.11.005","DOIUrl":"https://doi.org/10.1016/bs.podrm.2018.11.005","url":null,"abstract":"Topiramate, 2,3:4,5-di-O-isopropylidene-β-d-fructopyranose sulfamate, is a potent antiepileptic drug with a broad spectrum of activity. It is effective in both partial and generalized seizures. Topiramate was also found to have significant efficacy in migraine prevention with considerable reductions in the frequency of migraine headaches. The most common adverse events, which may accompany the use of topiramate, are paresthesia, fatigue, decreased appetite, nausea, diarrhea, weight decrease and taste perversion. The weight loss observed with the use of topiramate in obese, epileptic patients, afforded the approval of this drug as an anti-obesity medication. This action is thought to be based on the selective inhibition of mitochondrial carbonic anhydrase isoforms. This profile is prepared to discuss and explain physical characteristics, proprietary and nonproprietary names of topiramate. It also includes methods of preparation, thermal and spectral behavior and methods of analysis. Pharmacokinetics, metabolism, excretion and pharmacology together with its uses and applications are also discussed.","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2018.11.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37191231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Cefpodoxime proxetil. 头孢泊肟酯。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-04-16 DOI: 10.1016/bs.podrm.2019.02.001

Gamal A E Mostafa, Yazeed H Al-Otaibi, Abdullah A Al-Badr

引用次数: 1

Preface. 前言。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 DOI: 10.1016/S1871-5125(19)30012-3

Harry G. Brittain

引用次数: 0

Levetiracetam. Levetiracetam。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2019-03-25 DOI: 10.1016/bs.podrm.2019.02.003

Haitham Alrabiah

引用次数: 0

Multicomponent spectrometric analysis of drugs and their preparations. 药物及其制剂的多组分光谱分析。

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 Epub Date: 2018-12-21 DOI: 10.1016/bs.podrm.2018.11.002

Iqbal Ahmad, Muhammad Ali Sheraz, Sofia Ahmed, Zubair Anwar

{"title":"Multicomponent spectrometric analysis of drugs and their preparations.","authors":"Iqbal Ahmad, Muhammad Ali Sheraz, Sofia Ahmed, Zubair Anwar","doi":"10.1016/bs.podrm.2018.11.002","DOIUrl":"https://doi.org/10.1016/bs.podrm.2018.11.002","url":null,"abstract":"Pharmaceutical preparations may contain a single ingredient or multi-ingredients as well as excipients. In multicomponent systems, specific analytical methods are required to determine the concentrations of individual components in the presence of interfering substances. Ultraviolet and visible spectrometric methods have widely been developed for the analysis of drugs in mixtures and pharmaceutical preparations. These methods are based on ultraviolet and visible multicomponent analysis and chemometrics (multivariate data analysis). The commonly used chemometric methods include principal component analysis (PCA); regression involving classical least squares (CLS), partial least squares (PLS), inverse least squares (ILS), principal component regression (PCR), multiple linear regression (MLR), artificial neural networks (ANNs); soft independent modeling of class anthology (SIMCA), PLS-discriminant analysis (DA); and functional data analysis (FDA). In this chapter, the applications of multicomponent ultraviolet and visible, derivative, infrared and mass spectrometric and spectrofluorimetric methods to the analysis of multi-ingredient pharmaceutical preparations, biological samples and the kinetics of drug degradation have been reviewed. Chemometric methods provide an efficient solution to calibration problems in the analysis of spectral data for the simultaneous determination of drugs in multicomponent systems. These methods facilitate the assessment of product quality and enhance the efficiency of quality control systems.","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2018.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37191232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Series Page 系列页面

Profiles of drug substances, excipients, and related methodology Pub Date : 2019-01-01 DOI: 10.1016/s1871-5125(19)30007-x

引用次数: 0