Psychopharmacology最新文献_第7页

Relative to females, male rats are more willing to forego obtaining sucrose reward in order to prevent harm to their cage mate. 与雌鼠相比，雄鼠更愿意放弃获得蔗糖奖励，以防止伤害笼中的同伴。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2023-08-02 DOI: 10.1007/s00213-023-06435-2

Evan M Hess, Marco Venniro, Todd D Gould

{"title":"Relative to females, male rats are more willing to forego obtaining sucrose reward in order to prevent harm to their cage mate.","authors":"Evan M Hess, Marco Venniro, Todd D Gould","doi":"10.1007/s00213-023-06435-2","DOIUrl":"10.1007/s00213-023-06435-2","url":null,"abstract":"Rationale: Empathy, or the ability to perceive, share, and act upon the emotions of another, is a crucial social skill and is dysfunctional in autism and schizophrenia. While the complexities of human empathy are difficult to model in rodents, behavioral paradigms utilizing rats which study decision-making in social contexts may provide a translational framework for assessing biological, pharmacotherapeutic, and environmental interventions.Objectives: Modify and expand upon the three-session rat harm aversion task, which measures the willingness of rats to cease pressing a lever that earns them sucrose reward but delivers a shock to their cage mate. We sought to test the sustainability of harm aversion across seven sessions in male and female rats.Methods: Same-sex pair-housed rats were assigned as either the observer, which had access to the lever, or the demonstrator, which would receive shocks. After training the observer to press the lever to receive sucrose pellets, the demonstrator was placed into an adjacent chamber at which point lever responses would also deliver a shock. If the observer did not press the lever, no shock and no sucrose was delivered.Results: A sex difference in harm aversion was observed with female rats having significantly higher response rates and decreased response latencies across the seven test sessions, thus delivering more shocks and obtaining more sucrose, relative to males.Conclusions: These data demonstrate that male rats sustain harm aversion to a greater extent relative to females.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"965-978"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9923527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence. 眼下丘高频深部脑刺激可减少类似上瘾的酒精使用以及同伴可能带来的负面影响。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2024-02-03 DOI: 10.1007/s00213-024-06532-w

Lucie Vignal, Cassandre Vielle, Maya Williams, Nicolas Maurice, Mickael Degoulet, Christelle Baunez

{"title":"Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence.","authors":"Lucie Vignal, Cassandre Vielle, Maya Williams, Nicolas Maurice, Mickael Degoulet, Christelle Baunez","doi":"10.1007/s00213-024-06532-w","DOIUrl":"10.1007/s00213-024-06532-w","url":null,"abstract":"Rationale: The immediate social context significantly influences alcohol consumption in humans. Recent studies have revealed that peer presence could modulate drugs use in rats. The most efficient condition to reduce cocaine intake is the presence of a stranger peer, naive to drugs. Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN), which was shown to have beneficial effects on addiction to cocaine or alcohol, also modulates the protective influence of peer's presence on cocaine use.Objectives: This study aimed to: 1) explore how the presence of an alcohol-naive stranger peer affects recreational and escalated alcohol intake, and 2) assess the involvement of STN on alcohol use and in the modulation induced by the presence of an alcohol-naïve stranger peer.Methods: Rats with STN DBS and control animals self-administered 10% (v/v) ethanol in presence, or absence, of an alcohol-naive stranger peer, before and after escalation of ethanol intake (observed after intermittent alcohol (20% (v/v) ethanol) access).Results: Neither STN DBS nor the presence of an alcohol-naive stranger peer modulated significantly recreational alcohol intake. After the escalation procedure, STN DBS reduced ethanol consumption. The presence of an alcohol-naive stranger peer increased consumption only in low drinkers, which effect was suppressed by STN DBS.Conclusions: These results highlight the influence of a peer's presence on escalated alcohol intake, and confirm the role of STN in addiction-like alcohol intake and in the social influence on drug consumption.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"1055-1067"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling social cognition in alcohol use disorder: lessons from schizophrenia. 建立酒精使用障碍的社会认知模型：从精神分裂症中汲取教训。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2024-05-18 DOI: 10.1007/s00213-024-06601-0

Irene Perini, Arthur Pabst, Diana Martinez, Pierre Maurage, Markus Heilig

{"title":"Modeling social cognition in alcohol use disorder: lessons from schizophrenia.","authors":"Irene Perini, Arthur Pabst, Diana Martinez, Pierre Maurage, Markus Heilig","doi":"10.1007/s00213-024-06601-0","DOIUrl":"10.1007/s00213-024-06601-0","url":null,"abstract":"A better understanding of social deficits in alcohol use disorder (AUD) has the potential to improve our understanding of the disorder. Clinical research shows that AUD is associated with interpersonal problems and the loss of a social network which impedes response to treatment. Translational research between animal models and clinical research may benefit from a discussion of the models and methods that currently guide research into social cognition in AUD. We propose that research in AUD should harness recent technological developments to improve ecological validity while maintaining experimental control. Novel methods allow us to parse naturalistic social cognition into tangible components, and to investigate previously neglected aspects of social cognition. Furthermore, to incorporate social cognition as a defining element of AUD, it is critical to clarify the timing of these social disturbances. Currently, there is limited evidence to distinguish factors that influence social cognition as a consequence of AUD, and those that precede the onset of the disorder. Both increasing the focus on operationalization of social cognition into objective components and adopting a perspective that spans the clinical spectrum will improve our understanding in humans, but also possibly increase methodological consistency and translational dialogue across species. This commentary underscores current challenges and perspectives in this area of research.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"1157-1166"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress-induced social avoidance and anxiety-like behaviors in male rats. 外周脂肪酰基乙醇酰胺信号传导的增强可防止雄性大鼠应激诱导的社交回避和焦虑样行为。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2023-11-07 DOI: 10.1007/s00213-023-06473-w

Luca Carnevali, Margherita Barbetti, Yannick Fotio, Francesca Ferlenghi, Federica Vacondio, Marco Mor, Daniele Piomelli, Andrea Sgoifo

{"title":"Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress-induced social avoidance and anxiety-like behaviors in male rats.","authors":"Luca Carnevali, Margherita Barbetti, Yannick Fotio, Francesca Ferlenghi, Federica Vacondio, Marco Mor, Daniele Piomelli, Andrea Sgoifo","doi":"10.1007/s00213-023-06473-w","DOIUrl":"10.1007/s00213-023-06473-w","url":null,"abstract":"Rationale: Exposure to traumatic events can lead to alterations in social and anxiety-related behaviors. Emerging evidence suggests that peripheral host-defense processes are implicated in the expression of stress-induced behavioral responses and may be targeted to mitigate the negative sequalae of stress exposure.Objectives: In this study, we used the peripherally restricted FAAH inhibitor URB937 to investigate the effects of the fatty acyl ethanolamide (FAE) family of lipid mediators - which include the endocannabinoid anandamide and the endogenous PPAR-α agonists, oleoylethanolamide and palmitoylethanolamide - on behavioral and peripheral biochemical responses to two ethologically distinct rat models of stress.Methods: Male adult rats were exposed to acute social defeat, a model of psychological stress (Experiment 1), or to the predator odor 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), a test of innate predator-evoked fear (Experiment 2), and subsequently treated with URB937 (1 or 3 mg/kg, intraperitoneal) or vehicle. Behavioral analyses were conducted 24 h (Experiment 1) or 7 days (Experiment 2) after exposure.Results: URB937 administration prevented the emergence of both social avoidance behavior after social defeat stress and anxiety-related behaviors after TMT exposure. Further, URB937 administration blocked social defeat-induced transient increase in plasma concentrations of pro-inflammatory cytokines and the elevation in plasma corticosterone levels observed 24 h after social defeat CONCLUSIONS: Enhancement of peripheral FAAH-regulated lipid signaling prevents the emergence of stress-induced social avoidance and anxiety-like behaviors in male rats through mechanisms that may involve an attenuation of peripheral cytokine release induced by stress exposure.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"997-1009"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats. 大鼠在与世隔绝后对新同伴的操作性社交寻求与核团外壳的激活有关。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2022-11-30 DOI: 10.1007/s00213-022-06280-9

Adedayo Olaniran, Kristine T Garcia, Megan A M Burke, Hongyu Lin, Marco Venniro, Xuan Li

{"title":"Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats.","authors":"Adedayo Olaniran, Kristine T Garcia, Megan A M Burke, Hongyu Lin, Marco Venniro, Xuan Li","doi":"10.1007/s00213-022-06280-9","DOIUrl":"10.1007/s00213-022-06280-9","url":null,"abstract":"Rationale and objective: Deprivation of social interaction promotes social reward seeking in rodents, assessed primarily by the conditioned place preference procedure. Here, we used an operant social procedure in rats and examined the effect of the housing condition (pair-housing vs. single-housing) during or after social self-administration on social reward seeking.Methods: We first trained paired-housed or single-housed rats to gain access to an age- and sex-matched novel peer. On post-training day 1 (PTD1), we tested both groups for social seeking without the presence of the novel peer. Next, we divided each group into pair-housing or single-housing conditions and tested all four groups (pair-pair, pair-single, single-pair, and single-single) for social seeking on post-training day 12 (PTD12). Finally, we analyzed Fos expression in the striatum associated with social seeking on PTD12.Result: Single-housed rats earned more social rewards during social self-administration than pair-housed rats. Social isolation during social self-administration also promoted social seeking on PTD1 and PTD12, regardless of their housing conditions after social self-administration training. Additionally, in pair-housed rats, social isolation during the post-training period led to a time-dependent increase of social seeking on PTD12 compared with PTD1. Finally, the Fos analyses revealed an increase of Fos expression in NAc shell of single-single rats after social seeking test on PTD12 compared with pair-pair rats.Conclusion: Our data suggest that social isolation promotes operant social self-administration and social seeking. In addition, neuronal activation of NAc shell is associated with social seeking after social isolation.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"901-911"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice. 青春期的自愿车轮运动可以防止雄性小鼠因社交失败而导致的乙醇摄入增加。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2023-09-22 DOI: 10.1007/s00213-023-06461-0

Marina D Reguilón, Carmen Ferrer-Pérez, Carmen Manzanedo, José Miñarro, Marta Rodríguez-Arias

{"title":"Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice.","authors":"Marina D Reguilón, Carmen Ferrer-Pérez, Carmen Manzanedo, José Miñarro, Marta Rodríguez-Arias","doi":"10.1007/s00213-023-06461-0","DOIUrl":"10.1007/s00213-023-06461-0","url":null,"abstract":"Rationale: Exposure to social defeat (SD) induces a depressive phenotype, increased ethanol seeking and consumption, accompanied by activation of the neuroinflammatory response. However, a resilient response can be potentiated through physical exercise in the form of voluntary wheel running (VWR) during or after exposure to social stress. Therefore, the aim of this study was to test whether physical exercise during adolescence prior to being exposed to SD can enhance resilience to the increase in ethanol intake.Methods: Male mice had access to VWR during adolescence and the effects of social defeat (4 sessions every 72 h) on oral ethanol self-administration (SA) was evaluated. Based on the social interaction test, mice were classified as resilient or susceptible to depressive-like behavior. Two weeks after the last encounter, mice were subjected to the drinking in the dark and oral ethanol SA paradigms. Mice were then sacrificed to measure brain-derived neurotrophic factor (BDNF) levels in the striatum and hippocampus.Results: As expected, susceptible mice increased ethanol intake in the oral SA protocol. However, susceptible mice in the exercise condition did not increase ethanol intake, showing similar consumption and motivation for ethanol than the control and resilient groups. On the other hand, decreased BDNF levels were observed in susceptible mice in both experimental conditions compared to the control groups after ethanol SA.Conclusions: The pre-exposure of VWR prevented the increase in consumption and motivation for ethanol induced by SD in susceptible mice. On the other hand, it appears that VWR did not exhibit any significant long-term effects on BDNF signaling, which is mainly affected in susceptible mice after ethanol intake.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"979-996"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41179701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Spanning the spectrum of social behavior: towards more translationally relevant animal models. 社论：跨越社会行为的光谱：朝向更多翻译相关的动物模型。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI: 10.1007/s00213-025-06755-5

Daniele Caprioli, Sam A Golden, Christelle Baunez, Marco Venniro

引用次数: 0

Early life social complexity shapes adult neural processing in the communal spiny mouse Acomys cahirinus. 生活早期的社会复杂性塑造了群居棘鼠成年后的神经处理过程。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2023-12-06 DOI: 10.1007/s00213-023-06513-5

Kelly J Wallace, Solanch Dupeyron, Mutian Li, Aubrey M Kelly

{"title":"Early life social complexity shapes adult neural processing in the communal spiny mouse Acomys cahirinus.","authors":"Kelly J Wallace, Solanch Dupeyron, Mutian Li, Aubrey M Kelly","doi":"10.1007/s00213-023-06513-5","DOIUrl":"10.1007/s00213-023-06513-5","url":null,"abstract":"Rationale: Early life social rearing has profound consequences on offspring behavior and resilience. Yet, most studies examining early life development in rodents use species whose young are born immobile and do not produce complex social behavior until later in development. Furthermore, models of rearing under increased social complexity, rather than deprivation, are needed to provide alternative insight into the development of social neural circuitry.Objectives: To understand precocial offspring social development, we manipulated early life social complexity in the communal spiny mouse Acomys cahirinus and assessed long-term consequences on offspring social behavior, exploration, and neural responses to novel social stimuli.Methods: Spiny mouse pups were raised in the presence or absence of a non-kin breeding group. Upon adulthood, subjects underwent social interaction tests, an open field test, and a novel object test. Subjects were then exposed to a novel conspecific and novel group and neural responses were quantified via immunohistochemical staining in brain regions associated with social behavior.Results: Early life social experience did not influence behavior in the test battery, but it did influence social processing. In animals exposed to non-kin during development, adult lateral septal neural responses toward a novel conspecific were weaker and hypothalamic neural responses toward a mixed-sex group were stronger.Conclusions: Communal species may exhibit robust behavioral resilience to the early life social environment. But the early life environment can affect how novel social information is processed in the brain during adulthood, with long-term consequences that are likely to shape their behavioral trajectory.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"1025-1040"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Operant social self-administration in male CD1 mice. 雄性 CD1 小鼠的操作性社会自我管理

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2024-03-08 DOI: 10.1007/s00213-024-06560-6

Samantha S Lee, Marco Venniro, Yavin Shaham, Bruce T Hope, Leslie A Ramsey

{"title":"Operant social self-administration in male CD1 mice.","authors":"Samantha S Lee, Marco Venniro, Yavin Shaham, Bruce T Hope, Leslie A Ramsey","doi":"10.1007/s00213-024-06560-6","DOIUrl":"10.1007/s00213-024-06560-6","url":null,"abstract":"Rationale and objective: We recently introduced a model of operant social reward in which female CD1 mice lever press for access to affiliative social interaction with a cagemate peer mouse of the same sex and strain. Here we determined the generality of the operant social self-administration model to male CD1 mice who, under certain conditions, will lever press to attack a subordinate male mouse.Methods: We trained male CD1 mice to lever press for food and social interaction with a same sex and strain cagemate peer under different fixed-ratio (FR) schedule response requirements (FR1 to FR6). We then tested their motivation to seek social interaction after 15 days of isolation in the presence of cues previously paired with social self-administration. We also determined the effect of housing conditions on operant social self-administration and seeking. Finally, we determined sex differences in operant social self-administration and seeking, and the effect of housing conditions on unconditioned affiliative and antagonistic (aggressive) social interactions in both sexes.Results: Male CD1 mice lever pressed for access to a cagemate peer under different FR response requirements and seek social interaction after 15 isolation days; these effects were independent of housing conditions. There were no sex differences in operant social self-administration and seeking. Finally, group-housed CD1 male mice did not display unconditioned aggressive behavior toward a peer male CD1 mouse.Conclusions: Adult socially housed male CD1 mice can be used in studies on operant social reward without the potential confound of operant responding to engage in aggressive interactions.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"1091-1102"},"PeriodicalIF":3.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senegenin ameliorates diabetic encephalopathy via promoting mitophagy and repressing NLRP3 inflammasome activation. 仙原素通过促进线粒体自噬和抑制NLRP3炎性体激活来改善糖尿病性脑病。

IF 3.5 3区医学

Psychopharmacology Pub Date : 2025-04-26 DOI: 10.1007/s00213-025-06796-w

Xiao-Dan Yan, Yu Yang, Wan-Ting Zhang, Qing-Quan Kong, Xi-Tong Zheng, Lin-Sen Li, Qing Yu

{"title":"Senegenin ameliorates diabetic encephalopathy via promoting mitophagy and repressing NLRP3 inflammasome activation.","authors":"Xiao-Dan Yan, Yu Yang, Wan-Ting Zhang, Qing-Quan Kong, Xi-Tong Zheng, Lin-Sen Li, Qing Yu","doi":"10.1007/s00213-025-06796-w","DOIUrl":"https://doi.org/10.1007/s00213-025-06796-w","url":null,"abstract":"Rationale: Diabetic encephalopathy (DE) remains a severe complication of diabetes in central nervous system with limited effective therapy.Objectives: This study investigated the beneficial effect of senegenin on DE and its possible mechanisms.Methods: Type 2 diabetes mellitus mouse model and high-glucose (HG)-stimulated PC-12 cells were used as the in vivo and in vitro DE models. Learning and memory ability was evaluated by MWM test. Pathological changes in the brain tissues were determined by HE staining. Cell viability was detected by CCK-8. Mitochondrial membrane potential was measured by JC-1 probe. Target protein levels were assessed by Western blotting. Nucleotide-binding domain-like receptor protein 3 (NLRP3) expression was observed by immunofluorescent staining.Results: Cognitive impairment and obvious pathological changes were found in DE mice, which were effectively attenuated by senegenin treatment. In addition, senegenin induced mitophagy and maintained homeostasis of mitochondrial dynamics to relieve mitochondrial dysfunction. Moreover, NLRP3 inflammation activation induced by DE was inhibited by senegenin. Finally, inhibition of mitophagy counteracted senegenin-mediated inactivation of NLRP3 inflammation and neuroprotection.Conclusions: Senegenin relieved diabetic encephalopathy via inducing mitophagy to inactivate NLRP3 inflammasome. Senegenin might be an effective therapy for treating DE.","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0